Stephen Kritchevsky, Ph.D.Wake Forest School of Medicine

Stephen Kritchevsky, Ph.D.

Deputy Director,

Contact Information

Academic: 336-713-8548 | Department: 336-713-8570

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Education & Training

  • M.S.P.H., University of North Carolina School of Public Hlth, 1986
  • Ph.D., University of North Carolina-Chapel Hill, 1989


  • Am Geriatrics Society
  • Am Heart Association
  • Gerontological Society Of Amer
Stephen Kritchevsky, Ph.D.

Stephen Kritchevsky, Ph.D.

Deputy Director, Translational Science Institute
Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Center on Diabetes, Obesity, and Metabolism

Research Interests

Aging; Body Composition; Aged; Obesity; Female
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Contact Information

Academic: 336-713-8548 | Department: 336-713-8570

Media Medical Expert »

Recent Publications

Sensorimotor peripheral nerve function and the longitudinal relationship with endurance walking in the Health, Aging and Body Composition study. Lange-Maia BS, Newman AB, Cauley JA, Boudreau RM, Jakicic JM, Caserotti P, Glynn NW, Harris TB, Kritchevsky SB, Schwartz AV, Satterfield S, Simonsick EM, Vinik AI, Zivkovic S, Strotmeyer ES.. Arch Phys Med Rehabil. 2016;97(1):45-52.

Depressive trajectories and risk of disability and mortality in older adults: longitudinal findings from the Health, Aging, and Body Composition study. Murphy RA, Hagaman AK, Reinders I, Steeves JA, Newman AB, Rubin SM, Satterfield S, Kritchevsky SB, Yaffe K, Ayonayon HN, Nagin DS, Simonsick EM, Penninx BW, Harris TB.. J Gerontol A Biol Sci Med Sci. 2016;71(2):228-235.

Association of hearing impairment with incident frailty and falls in older adults. Kamil RJ, Betz J, Powers BB, Pratt S, Kritchevsky S, Ayonayon HN, Harris TB, Helzner E, Deal JA, Martin K, Peterson M, Satterfield S, Simonsick EM, Lin FR.. J Aging Health. 2016;28(4):644-660.

Low plasma klotho concentrations and decline of knee strength in older adults. Semba RD, Ferrucci L, Sun K, Simonsick E, Turner R, Miljkovic I, Harris T, Schwartz AV, Asao K, Kritchevsky S, Newman AB.. J Gerontol A Biol Sci Med Sci. 2016;71(1):103-108.

Association of serum erythropoietin with cardiovascular events, kidney function decline, and mortality: the Health Aging and Body Composition Study. Garimella PS, Katz R, Patel KV, Kritchevsky SB, Parikh CR, Ix JH, Fried LF, Newman AB, Shlipak MG, Harris TB, Sarnak MJ.. Circ Heart Fail. 2016;9(1):e002124.

Comparison of handgrip and leg extension strength in predicting slow gait speed in older adults. Fragala MS, Alley DE, Shardell MD, Harris TB, McLean RR, Kiel DP, Cawthon PM, Dam TT, Ferrucci L, Guralnik JM, Kritchevsky SB, Vassileva MT, Gudnason V, Eiriksdottir G, Koster A, Newman A, Siggeirsdottir K, Satterfield S, Studenski SA, Kenny AM.. J Am Geriatr Soc. 2016;64(1):144-150.

Diabetes, hyperglycemia, and the burden of functional disability among older adults in a community-based study. Godino JG, Appel LJ, Gross AL, Schrack JA, Parrinello CM, Kalyani RR, Windham BG, Pankow JS, Kritchevsky SB, Bandeen-Roche K, Selvin E.. J Diabetes. 2016;():.

Cost-effectiveness of the LIFE physical activity intervention for older adults at increased risk for mobility disability. Groessl EJ, Kaplan RM, Castro Sweet CM, Church T, Espeland MA, Gill TM, Glynn NW, King AC, Kritchevsky S, Manini T, McDermott MM, Reid KF, Rushing J, Pahor M.. J Gerontol A Biol Sci Med Sci. 2016;71(5):656-662.

Changes in bone mineral density over time by body mass index in the Health ABC Study. Lloyd JT, Alley DE, Hochberg MC, Waldstein SR, Harris TB, Kritchevsky SB, Schwartz AV, Strotmeyer ES, Womack C, Orwig DL.. Osteoporos Int. 2016;27(6):2109-2116.

Association between anthropometric measures and long-term survival in frail older women: observations from the Women's Health Initiative Study. Zaslavsky O, Rillamas-Sun E, LaCroix AZ, Woods NF, Tinker LF, Zisberg A, Shadmi E, Cochrane B, Edward BJ, Kritchevsky S, Stefanick ML, Vitolins MZ, Wactawski-Wende J, Zelber-Sagi S.. J Am Geriatr Soc. 2016;64(2):277-284.

Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Silverstein-Metzler MG, Shively CA, Clarkson TB [deceased], Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC.. Psychoneuroendocrinology. 2016;68():29-38.

A multidimensional risk score to predict all-cause hospitalization in community-dwelling older individuals with obstructive lung disease. Beijers RJ, van den Borst B, Newman AB, Yende S, Kritchevsky SB, Cassano PA, Bauer DC, Harris TB, Schols AM.. J Am Med Dir Assoc. 2016;17(6):508-513.

Effect of statin use on mobility disability and its prevention in at-risk older adults: the LIFE study. Henderson RM, Lovato L, Miller ME, Fielding RA, Church TS, Newman AB, Buford TW, Pahor M, McDermott MM, Stafford RS, Lee DS, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2016;():.

Self-reported mobility in older patients predicts early postoperative outcomes after elective noncardiac surgery. Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, Rejeski WJ, Groban L.. Anesthesiology. 2016;124(4):815-825.

Association of muscle mass, area, and strength with incident diabetes in older adults: the Health ABC Study. Larsen BA, Wassel CL, Kritchevsky SB, Strotmeyer ES, Criqui MH, Kanaya AM, Fried LF, Schwartz AV, Harris TB, Ix JH.. J Clin Endocrinol Metab. 2016;101(4):1847-1855.

Genome-wide association study for incident myocardial infarction and coronary heart disease in prospective cohort studies: the CHARGE consortium. Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, Cupples LA, Trompet S, Chasman DI, Lumley T, Volker U, Buckley BM, Ding J, Jensen MK, Folsom AR, Kritchevsky SB, Girman CJ, Ford I, Dorr M, Salomaa V, Uitterlinden AG, Eiriksdottir G, Vasan RS,.. PLoS One. 2016;11(3):e0144997.

Hearing impairment and physical function and falls in the Atherosclerosis Risk in Communities Hearing Pilot Study [letter]. Deal JA, Richey Sharrett A, Bandeen-Roche K, Kritchevsky SB, Pompeii LA, Gwen Windham B, Lin FR.. J Am Geriatr Soc. 2016;64(4):906-908.

Atrial fibrillation and declining physical performance in older adults: the Health, Aging, and Body Composition Study. Magnani JW, Wang N, Benjamin EJ, Garcia ME, Bauer DC, Butler J, Ellinor PT, Kritchevsky S, Marcus GM, Newman A, Phillips CL, Sasai H, Satterfield S, Sullivan LM, Harris TB.. Circ Arrhythm Electrophysiol. 2016;9(5):e003525.

Discovery of genetic variation on chromosome 5q22 associated with mortality in heart failure. Smith JG, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlof O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, Sjogren M, Ngwa J, Brandimarto J, Stott DJ, Aguilar D, Rice KM, Sesso HD, Demissie S,.. PLoS Genet. 2016;12(5):e1006034.

Hospitalizations during a physical activity intervention in older adults at risk of mobility disability: analyses from the Lifestyle Interventions and Independence for Elders randomized clinical trial. Marsh AP, Applegate WB, Guralnik JM, Jack Rejeski W, Church TS, Fielding RA, Gill TM, King AC, Kritchevsky SB, Manini TM, McDermott MM, Newman AB, Stowe CL, Walkup MP, Pahor M, Miller ME.. J Am Geriatr Soc. 2016;64(5):933-943.

Metformin as a tool to target aging. Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA.. Cell Metab. 2016;23(6):1060-1065.

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B, Lohman K, Lunetta KL, Mangino M, Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL,.. Aging Cell. 2016;():.

Effects of disease burden and functional adaptation on morbidity and mortality on older adults. Sanders JL, Arnold AM, Hirsch CH, Thielke SM, Kim D, Mukamal KJ, Kizer JR, Ix JH, Kaplan RC, Kritchevsky SB, Newman AB.. J Am Geriatr Soc. 2016;64(6):1242-1249.

Statin use and all-cancer survival: prospective results from the Women's Health Initiative. Wang A, Aragaki AK, Tang JY, Kurian AW, Manson JE, Chlebowski RT, Simon M, Desai P, Wassertheil-Smoller S, Liu S, Kritchevsky S, Wakelee HA, Stefanick ML.. Br J Cancer. 2016;115(1):129-135.

Sarcopenia definition parameters and incident disability [abstract]. Schaap LA, Simonsick EM, Newman AB, Schwartz AV, Caserotti P, Kritchevsky SB, Goodpaster BH, Harris TB, Visser M.. Osteoporos Int. 2016;27(Suppl 1):S53.

Increased cardiovascular stiffness and impaired age-related functional status. Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG.. J Gerontol A Biol Sci Med Sci. 2015;70(5):545-553.

Association of hearing impairment and mortality in older adults. Genther DJ, Betz J, Pratt S, Kritchevsky SB, Martin KR, Harris TB, Helzner E, Satterfield S, Xue QL, Yaffe K, Simonsick EM, Lin FR.. J Gerontol A Biol Sci Med Sci. 2015;70(1):85-90.

Respirometric profiling of muscle mitochondria and blood cells are associated with differences in gait speed among community-dwelling older adults. Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ.. J Gerontol A Biol Sci Med Sci. 2015;70(11):1394-1399.

Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons. Kositsawat J, Kuchel GA, Tooze JA, Houston DK, Cauley JA, Kritchevsky SB, Strotmeyer ES, Kanaya AM, Harris TB, Johnson KC, Barry LC.. J Gerontol A Biol Sci Med Sci. 2015;70(4):525-531.

Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health Sarcopenia Project. Fragala MS, Dam TT, Barber V, Judge JO, Studenski SA, Cawthon PM, McLean RR, Harris TB, Ferrucci L, Guralnik JM, Kiel DP, Kritchevsky SB, Shardell MD, Vassileva MT, Kenny AM.. J Gerontol A Biol Sci Med Sci. 2015;70(2):202-209.

Multisystem physiologic impairments and changes in gait speed of older adults. Rosso AL, Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Carlson MC, Rosano C, Kritchevsky SB, Newman AB.. J Gerontol A Biol Sci Med Sci. 2015;70(3):319-324.

Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength. Ward RE, Boudreau RM, Caserotti P, Harris TB, Zivkovic S, Goodpaster BH, Satterfield S, Kritchevsky S, Schwartz AV, Vinik AI, Cauley JA, Newman AB, Strotmeyer ES.. J Gerontol A Biol Sci Med Sci. 2015;70(4):464-470.

A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory study. Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB.. Obesity (Silver Spring). 2015;23(1):77-84.

Association of hearing impairment with declines in physical functioning and the risk of disability in older adults. Chen DS, Betz J, Yaffe K, Ayonayon HN, Kritchevsky S, Martin KR, Harris TB, Purchase-Helzner E, Satterfield S, Xue QL, Pratt S, Simonsick EM, Lin FR.. J Gerontol A Biol Sci Med Sci. 2015;70(5):654-661.

The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study. Shea MK, Kritchevsky SB, Hsu FC, Nevitt M, Booth SL, Kwoh CK, McAlindon TE, Vermeer C, Drummen N, Harris TB, Womack C, Loeser RF.. Osteoarthritis Cartilage. 2015;23(3):370-378.

Declines in inflammation predict greater white matter microstructure in older adults. Bettcher BM, Yaffe K, Boudreau RM, Neuhaus J, Aizenstein H, Ding J, Kritchevsky SB, Launer LJ, Liu Y, Satterfield S, Rosano C.. Neurobiol Aging. 2015;36(2):948-954.

Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) study. Kalogeropoulos AP, Georgiopoulou VV, Murphy RA, Newman AB, Bauer DC, Harris TB, Yang Z, Applegate WB, Kritchevsky SB.. JAMA Intern Med. 2015;175(3):410-419.

Statins and brain integrity in older adults: secondary analysis of the Health ABC study. Nadkarni NK, Perera S, Hanlon JT, Lopez O, Newman AB, Aizenstein H, Elam M, Harris TB, Kritchevsky S, Yaffe K, Rosano C.. Alzheimers Dement. 2015;11(10):1202-1211.

Resting heart rate and risk of incident heart failure: three prospective cohort studies and a systematic meta-analysis. Khan H, Kunutsor S, Kalogeropoulos AP, Georgiopoulou VV, Newman AB, Harris TB, Bibbins-Domingo K, Kauhanen J, Gheorghiade M, Fonarow GC, Kritchevsky SB, Laukkanen JA, Butler J.. J Am Heart Assoc. 2015;4(1):e001364.

Development and validation of a model to predict 5-year risk of death without ESRD among older adults with CKD. Bansal N, Katz R, De Boer IH, Peralta CA, Fried LF, Siscovick DS, Rifkin DE, Hirsch C, Cummings SR, Harris TB, Kritchevsky SB, Sarnak MJ, Shlipak MG, Ix JH.. Clin J Am Soc Nephrol. 2015;10(3):363-371.

Objective measures of physical activity, white matter integrity and cognitive status in adults over age 80. Tian Q, Glynn NW, Erickson KI, Aizenstein HJ, Simonsick EM, Yaffe K, Harris TB, Kritchevsky SB, Boudreau RM, Newman AB, Lopez OL, Saxton J, Rosano C.. Behav Brain Res. 2015;284():51-57.

Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans. Hansen JG, Tang W, Hootman KC, Brannon PM, Houston DK, Kritchevsky SB, Harris TB, Garcia M, Lohman K, Liu Y, de Boer IH, Kestenbaum BR, Robinson-Cohen C, Siscovick DS, Cassano PA.. J Nutr. 2015;145(4):799-805.

Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ.. PLoS One. 2015;10(3):e0121993.

Transcriptomic profiles of aging in purified human immune cells. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,.. BMC Genomics. 2015;16(1):333.

Changes in insulin-like growth factor-I and its binding proteins are associated with diabetes mellitus in older adults. Aneke-Nash CS, Parrinello CM, Rajpathak SN, Rohan TE, Strotmeyer ES, Kritchevsky SB, Psaty BM, Buzkova P, Kizer JR, Newman AB, Strickler HD, Kaplan RC.. J Am Geriatr Soc. 2015;63(5):902-909.

Translational research in the fastest-growing population: older adults. High KP, Kritchevsky SB. In: Wehling M, ed. Principles of translational science in medicine: from bench to bedside. 2nd ed. Burlington: Elsevier;2015: 299-311.

The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ.. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

The effect of physical activity on mobility disability in obese, abdominally obese and non-obese older adults: the Lifestyle Interventions and Independence for Elders (LIFE) Study [abstract]. Kritchevsky S, Manini T, Blair S, Newman A, Botoseneanu A, Lovato L, Guralnik J, Pahor M.. J Am Geriatr Soc. 2015;63(Suppl 1):S1.

Protein and healthy aging. Paddon-Jones D, Campbell WW, Jacques PF, Kritchevsky SB, Moore LL, Rodriguez NR, van Loon LJ.. Am J Clin Nutr. 2015;101(6 Suppl):1339-1345S.

Arterialized venous bicarbonate is associated with lower bone mineral density and an increased rate of bone loss in older men and women. Tabatabai LS, Cummings SR, Tylavsky FA, Bauer DC, Cauley JA, Kritchevsky SB, Newman A, Simonsick EM, Harris TB, Sebastian A, Sellmeyer DE.. J Clin Endocrinol Metab. 2015;100(4):1343-1349.

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