Profile

Stephen Kritchevsky, Ph.D.Wake Forest School of Medicine

Education & Training

  • M.S.P.H., University of North Carolina School of Public Hlth, 1986
  • Ph.D., University of North Carolina-Chapel Hill, 1989

Memberships

  • Am Geriatrics Society
  • Am Heart Association
  • Gerontological Society Of Amer
Stephen Kritchevsky, Ph.D.

Stephen Kritchevsky, Ph.D.

Deputy Director, Translational Science Institute
Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Translational Science Institute
Center for Comparative Medicine Research
Center for Integrative Medicine
Hypertension and Vascular Research Center
Maya Angelou Center for Health Equity
Sticht Center on Aging
Center on Diabetes, Obesity, and Metabolism
Institute for Regenerative Medicine
Epidemiology & Prevention

Research Interests

aging, anthropology/ethnography, arthritis, cognition/learning, cross(mult/tnslat/inter)discip, diabetes, education/training (all f, t,, epidemiology, fitness/physical, genetics/genome, health services, research/outc, obesity, osteoporosis, physical/muscular function

Contact Information

Academic: 336-713-8548 | Department: 336-713-8570

Media Medical Expert »

Recent Publications

Lange-Maia BS, Newman AB, Cauley JA, Boudreau RM, Jakicic JM, Caserotti P, Glynn NW, Harris TB, Kritchevsky SB, Schwartz AV, Satterfield S, Simonsick EM, Vinik AI, Zivkovic S, Strotmeyer ES. Sensorimotor peripheral nerve function and the longitudinal relationship with endurance walking in the Health, Aging and Body Composition study. Arch Phys Med Rehabil. 2016;97(1):45-52.

Murphy RA, Hagaman AK, Reinders I, Steeves JA, Newman AB, Rubin SM, Satterfield S, Kritchevsky SB, Yaffe K, Ayonayon HN, Nagin DS, Simonsick EM, Penninx BW, Harris TB. Depressive trajectories and risk of disability and mortality in older adults: longitudinal findings from the Health, Aging, and Body Composition study. J Gerontol A Biol Sci Med Sci. 2016;71(2):228-235.

Semba RD, Ferrucci L, Sun K, Simonsick E, Turner R, Miljkovic I, Harris T, Schwartz AV, Asao K, Kritchevsky S, Newman AB. Low plasma klotho concentrations and decline of knee strength in older adults. J Gerontol A Biol Sci Med Sci. 2016;71(1):103-108.

Garimella PS, Katz R, Patel KV, Kritchevsky SB, Parikh CR, Ix JH, Fried LF, Newman AB, Shlipak MG, Harris TB, Sarnak MJ. Association of serum erythropoietin with cardiovascular events, kidney function decline, and mortality: the Health Aging and Body Composition Study. Circ Heart Fail. 2016;9(1):e002124.

Fragala MS, Alley DE, Shardell MD, Harris TB, McLean RR, Kiel DP, Cawthon PM, Dam TT, Ferrucci L, Guralnik JM, Kritchevsky SB, Vassileva MT, Gudnason V, Eiriksdottir G, Koster A, Newman A, Siggeirsdottir K, Satterfield S, Studenski SA, Kenny AM. Comparison of handgrip and leg extension strength in predicting slow gait speed in older adults. J Am Geriatr Soc. 2016;64(1):144-150.

Godino JG, Appel LJ, Gross AL, Schrack JA, Parrinello CM, Kalyani RR, Windham BG, Pankow JS, Kritchevsky SB, Bandeen-Roche K, Selvin E. Diabetes, hyperglycemia, and the burden of functional disability among older adults in a community-based study. J Diabetes. 2016;():.

Groessl EJ, Kaplan RM, Castro Sweet CM, Church T, Espeland MA, Gill TM, Glynn NW, King AC, Kritchevsky S, Manini T, McDermott MM, Reid KF, Rushing J, Pahor M. Cost-effectiveness of the LIFE physical activity intervention for older adults at increased risk for mobility disability. J Gerontol A Biol Sci Med Sci. 2016;71(5):656-662.

Lloyd JT, Alley DE, Hochberg MC, Waldstein SR, Harris TB, Kritchevsky SB, Schwartz AV, Strotmeyer ES, Womack C, Orwig DL. Changes in bone mineral density over time by body mass index in the Health ABC Study. Osteoporos Int. 2016;():.

Zaslavsky O, Rillamas-Sun E, LaCroix AZ, Woods NF, Tinker LF, Zisberg A, Shadmi E, Cochrane B, Edward BJ, Kritchevsky S, Stefanick ML, Vitolins MZ, Wactawski-Wende J, Zelber-Sagi S. Association between anthropometric measures and long-term survival in frail older women: observations from the Women's Health Initiative Study. J Am Geriatr Soc. 2016;64(2):277-284.

Silverstein-Metzler MG, Shively CA, Clarkson TB [deceased], Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC. Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Psychoneuroendocrinology. 2016;68():29-38.

Beijers RJ, van den Borst B, Newman AB, Yende S, Kritchevsky SB, Cassano PA, Bauer DC, Harris TB, Schols AM. A multidimensional risk score to predict all-cause hospitalization in community-dwelling older individuals with obstructive lung disease. J Am Med Dir Assoc. 2016;():.

Henderson RM, Lovato L, Miller ME, Fielding RA, Church TS, Newman AB, Buford TW, Pahor M, McDermott MM, Stafford RS, Lee DS, Kritchevsky SB. Effect of statin use on mobility disability and its prevention in at-risk older adults: the LIFE study. J Gerontol A Biol Sci Med Sci. 2016;():.

Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, Rejeski WJ, Groban L. Self-reported mobility in older patients predicts early postoperative outcomes after elective noncardiac surgery. Anesthesiology. 2016;124(4):815-825.

Larsen BA, Wassel CL, Kritchevsky SB, Strotmeyer ES, Criqui MH, Kanaya AM, Fried LF, Schwartz AV, Harris TB, Ix JH. Association of muscle mass, area, and strength with incident diabetes in older adults: the Health ABC Study. J Clin Endocrinol Metab. 2016;101(4):1847-1855.

Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, Cupples LA, Trompet S, Chasman DI, Lumley T, Volker U, Buckley BM, Ding J, Jensen MK, Folsom AR, Kritchevsky SB, Girman CJ, Ford I, Dorr M, Salomaa V, Uitterlinden AG, Eiriksdottir G, Vasan RS,. Genome-wide association study for incident myocardial infarction and coronary heart disease in prospective cohort studies: the CHARGE consortium. PLoS One. 2016;11(3):e0144997.

Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG. Increased cardiovascular stiffness and impaired age-related functional status. J Gerontol A Biol Sci Med Sci. 2015;70(5):545-553.

Genther DJ, Betz J, Pratt S, Kritchevsky SB, Martin KR, Harris TB, Helzner E, Satterfield S, Xue QL, Yaffe K, Simonsick EM, Lin FR. Association of hearing impairment and mortality in older adults. J Gerontol A Biol Sci Med Sci. 2015;70(1):85-90.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. Respirometric profiling of muscle mitochondria and blood cells are associated with differences in gait speed among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2015;70(11):1394-1399.

Kositsawat J, Kuchel GA, Tooze JA, Houston DK, Cauley JA, Kritchevsky SB, Strotmeyer ES, Kanaya AM, Harris TB, Johnson KC, Barry LC. Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons. J Gerontol A Biol Sci Med Sci. 2015;70(4):525-531.

Fragala MS, Dam TT, Barber V, Judge JO, Studenski SA, Cawthon PM, McLean RR, Harris TB, Ferrucci L, Guralnik JM, Kiel DP, Kritchevsky SB, Shardell MD, Vassileva MT, Kenny AM. Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health Sarcopenia Project. J Gerontol A Biol Sci Med Sci. 2015;70(2):202-209.

Rosso AL, Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Carlson MC, Rosano C, Kritchevsky SB, Newman AB. Multisystem physiologic impairments and changes in gait speed of older adults. J Gerontol A Biol Sci Med Sci. 2015;70(3):319-324.

Ward RE, Boudreau RM, Caserotti P, Harris TB, Zivkovic S, Goodpaster BH, Satterfield S, Kritchevsky S, Schwartz AV, Vinik AI, Cauley JA, Newman AB, Strotmeyer ES. Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength. J Gerontol A Biol Sci Med Sci. 2015;70(4):464-470.

Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB. A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory study. Obesity (Silver Spring). 2015;23(1):77-84.

Chen DS, Betz J, Yaffe K, Ayonayon HN, Kritchevsky S, Martin KR, Harris TB, Purchase-Helzner E, Satterfield S, Xue QL, Pratt S, Simonsick EM, Lin FR. Association of hearing impairment with declines in physical functioning and the risk of disability in older adults. J Gerontol A Biol Sci Med Sci. 2015;70(5):654-661.

Shea MK, Kritchevsky SB, Hsu FC, Nevitt M, Booth SL, Kwoh CK, McAlindon TE, Vermeer C, Drummen N, Harris TB, Womack C, Loeser RF. The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study. Osteoarthritis Cartilage. 2015;23(3):370-378.

Bettcher BM, Yaffe K, Boudreau RM, Neuhaus J, Aizenstein H, Ding J, Kritchevsky SB, Launer LJ, Liu Y, Satterfield S, Rosano C. Declines in inflammation predict greater white matter microstructure in older adults. Neurobiol Aging. 2015;36(2):948-954.

Kalogeropoulos AP, Georgiopoulou VV, Murphy RA, Newman AB, Bauer DC, Harris TB, Yang Z, Applegate WB, Kritchevsky SB. Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) study. JAMA Intern Med. 2015;175(3):410-419.

Nadkarni NK, Perera S, Hanlon JT, Lopez O, Newman AB, Aizenstein H, Elam M, Harris TB, Kritchevsky S, Yaffe K, Rosano C. Statins and brain integrity in older adults: secondary analysis of the Health ABC study. Alzheimers Dement. 2015;11(10):1202-1211.

Khan H, Kunutsor S, Kalogeropoulos AP, Georgiopoulou VV, Newman AB, Harris TB, Bibbins-Domingo K, Kauhanen J, Gheorghiade M, Fonarow GC, Kritchevsky SB, Laukkanen JA, Butler J. Resting heart rate and risk of incident heart failure: three prospective cohort studies and a systematic meta-analysis. J Am Heart Assoc. 2015;4(1):e001364.

Bansal N, Katz R, De Boer IH, Peralta CA, Fried LF, Siscovick DS, Rifkin DE, Hirsch C, Cummings SR, Harris TB, Kritchevsky SB, Sarnak MJ, Shlipak MG, Ix JH. Development and validation of a model to predict 5-year risk of death without ESRD among older adults with CKD. Clin J Am Soc Nephrol. 2015;10(3):363-371.

Tian Q, Glynn NW, Erickson KI, Aizenstein HJ, Simonsick EM, Yaffe K, Harris TB, Kritchevsky SB, Boudreau RM, Newman AB, Lopez OL, Saxton J, Rosano C. Objective measures of physical activity, white matter integrity and cognitive status in adults over age 80. Behav Brain Res. 2015;284():51-57.

Hansen JG, Tang W, Hootman KC, Brannon PM, Houston DK, Kritchevsky SB, Harris TB, Garcia M, Lohman K, Liu Y, de Boer IH, Kestenbaum BR, Robinson-Cohen C, Siscovick DS, Cassano PA. Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans. J Nutr. 2015;145(4):799-805.

Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ. Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. PLoS One. 2015;10(3):e0121993.

Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015;16(1):333.

Aneke-Nash CS, Parrinello CM, Rajpathak SN, Rohan TE, Strotmeyer ES, Kritchevsky SB, Psaty BM, Buzkova P, Kizer JR, Newman AB, Strickler HD, Kaplan RC. Changes in insulin-like growth factor-I and its binding proteins are associated with diabetes mellitus in older adults. J Am Geriatr Soc. 2015;63(5):902-909.

High KP, Kritchevsky SB. Translational research in the fastest-growing population: older adults In: Wehling M, ed. Principles of translational science in medicine: from bench to bedside. 2nd ed. Burlington: Elsevier;2015: 299-311.

Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ. The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Kritchevsky S, Manini T, Blair S, Newman A, Botoseneanu A, Lovato L, Guralnik J, Pahor M. The effect of physical activity on mobility disability in obese, abdominally obese and non-obese older adults: the Lifestyle Interventions and Independence for Elders (LIFE) Study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S1.

Paddon-Jones D, Campbell WW, Jacques PF, Kritchevsky SB, Moore LL, Rodriguez NR, van Loon LJ. Protein and healthy aging. Am J Clin Nutr. 2015;():.

Tabatabai LS, Cummings SR, Tylavsky FA, Bauer DC, Cauley JA, Kritchevsky SB, Newman A, Simonsick EM, Harris TB, Sebastian A, Sellmeyer DE. Arterialized venous bicarbonate is associated with lower bone mineral density and an increased rate of bone loss in older men and women. J Clin Endocrinol Metab. 2015;100(4):1343-1349.

Williams JA, Sink KM, Tooze JA, Atkinson HH, Cauley JA, Yaffe K, Tylavsky FA, Rubin SM, Simonsick EM, Kritchevsky SB, Houston DK. Low 25-hydroxyvitamin D concentrations predict incident depression in well-functioning older adults: the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2015;70(6):757-763.

Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T, Lemaitre RN, Kristiansson K, Nuotio ML, Houston DK, Perala MM, Qi Q, Sonestedt E, Manichaikul A, Kanoni S, Ganna A, Mikkila V, North KE, Siscovick DS,. Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet. 2015;24(16):4728-4738.

Houston DK, Tooze JA, Garcia KR, Visser M, Tylavsky FA, Hue TF, Lee JS, Murphy RA, Simonsick EM, Harris TB, Newman AB, Kritchevsky SB. Protein intake and incident mobility limitations in older adults: the Health ABC Study [abstract]. J Frailty Aging. 2015;4(Suppl 1):30.

Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,. Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Diabetes. 2015;64(10):3464-3474.

Vaz Fragoso CA, Miller ME, King AC, Kritchevsky SB, Liu CK, Myers VH, Nadkarni NK, Pahor M, Spring BJ, Gill TM. Effect of structured physical activity on sleep-wake behaviors in sedentary elderly adults with mobility limitations. J Am Geriatr Soc. 2015;63(7):1381-1390.

Kritchevsky SB, de Cabo R. Energy - a hallmark of physical function [editorial]. J Gerontol A Biol Sci Med Sci. 2015;70(11):1333.

Liu G, Allen B, Lopez O, Aizenstein H, Boudreau R, Newman A, Yaffe K, Kritchevsky S, Launer L, Satterfield S, Simonsick E, Rosano C. Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians. Curr Alzheimer Res. 2015;12(7):648-654.

Metti AL, Aizenstein H, Yaffe K, Boudreau RM, Newman A, Launer L, Gianaros PJ, Lopez OL, Saxton J, Ives DG, Kritchevsky S, Vallejo AN, Rosano C. Trajectories of peripheral interleukin-6, structure of the hippocampus, and cognitive impairment over 14 years in older adults. Neurobiol Aging. 2015;36(11):3038-3044.

Houston DK, Tooze JA, Demons JL, Davis BL, Shertzer-Skinner R, Kearsley LB, Kritchevsky SB, Williamson JD. Delivery of a vitamin D intervention in homebound older adults using a Meals-on-Wheels program: a pilot study. J Am Geriatr Soc. 2015;63(9):1861-1867.

Tranah GJ, Yaffe K, Katzman SM, Lam ET, Pawlikowska L, Kwok PY, Schork NJ, Manini TM, Kritchevsky S, Thomas F, Newman AB, Harris TB, Coleman AL, Gorin MB, Helzner EP, Rowbotham MC, Browner WS, Cummings SR. Mitochondrial DNA heteroplasmy associations with neurosensory and mobility function in elderly adults. J Gerontol A Biol Sci Med Sci. 2015;70(11):1418-1424.

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For a list of earlier publications, visit the Carpenter Library Publication Search.

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