Profile

Stephen Kritchevsky, Ph.D.Wake Forest School of Medicine

Education & Training

  • M.S.P.H., University of North Carolina School of Public Hlth, 1986
  • Ph.D., University of North Carolina-Chapel Hill, 1989

Memberships

  • Am Geriatrics Society
  • Am Heart Association
  • Gerontological Society Of Amer
Stephen Kritchevsky, Ph.D.

Stephen Kritchevsky, Ph.D.

Director, Sticht Center on Aging
Deputy Director, Translational Science Institute
Professor, Gerontology and Geriatric Medicine
Translational Science Institute
Maya Angelou Center for Health Equity
Hypertension and Vascular Research Center
Sticht Center on Aging
Center for Comparative Medicine Research
Center for Integrative Medicine
Institute for Regenerative Medicine
Epidemiology & Prevention

Research Interests

aging, anthropology/ethnography, arthritis, cognition/learning, cross(mult/tnslat/inter)discip, diabetes, education/training (all f, t,, epidemiology, fitness/physical, genetics/genome, health services, research/outc, obesity, osteoporosis, physical/muscular function, radiology imaging/nuclear medi, temporary

Contact Information

Academic: 336-713-8548 | Department: 336-713-8570

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Recent Publications

Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG. Increased cardiovascular stiffness and impaired age-related functional status. J Gerontol A Biol Sci Med Sci. 2015;70(5):545-553.

Genther DJ, Betz J, Pratt S, Kritchevsky SB, Martin KR, Harris TB, Helzner E, Satterfield S, Xue QL, Yaffe K, Simonsick EM, Lin FR. Association of hearing impairment and mortality in older adults. J Gerontol A Biol Sci Med Sci. 2015;70(1):85-90.

Kositsawat J, Kuchel GA, Tooze JA, Houston DK, Cauley JA, Kritchevsky SB, Strotmeyer ES, Kanaya AM, Harris TB, Johnson KC, Barry LC. Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons. J Gerontol A Biol Sci Med Sci. 2015;70(4):525-531.

Fragala MS, Dam TT, Barber V, Judge JO, Studenski SA, Cawthon PM, McLean RR, Harris TB, Ferrucci L, Guralnik JM, Kiel DP, Kritchevsky SB, Shardell MD, Vassileva MT, Kenny AM. Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health Sarcopenia Project. J Gerontol A Biol Sci Med Sci. 2015;70(2):202-209.

Rosso AL, Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Carlson MC, Rosano C, Kritchevsky SB, Newman AB. Multisystem physiologic impairments and changes in gait speed of older adults. J Gerontol A Biol Sci Med Sci. 2015;70(3):319-324.

Ward RE, Boudreau RM, Caserotti P, Harris TB, Zivkovic S, Goodpaster BH, Satterfield S, Kritchevsky S, Schwartz AV, Vinik AI, Cauley JA, Newman AB, Strotmeyer ES. Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength. J Gerontol A Biol Sci Med Sci. 2015;70(4):464-470.

Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB. A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory study. Obesity (Silver Spring). 2015;23(1):77-84.

Chen DS, Betz J, Yaffe K, Ayonayon HN, Kritchevsky S, Martin KR, Harris TB, Purchase-Helzner E, Satterfield S, Xue QL, Pratt S, Simonsick EM, Lin FR. Association of hearing impairment with declines in physical functioning and the risk of disability in older adults. J Gerontol A Biol Sci Med Sci. 2015;70(5):654-661.

Shea MK, Kritchevsky SB, Hsu FC, Nevitt M, Booth SL, Kwoh CK, McAlindon TE, Vermeer C, Drummen N, Harris TB, Womack C, Loeser RF. The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study. Osteoarthritis Cartilage. 2015;23(3):370-378.

Bettcher BM, Yaffe K, Boudreau RM, Neuhaus J, Aizenstein H, Ding J, Kritchevsky SB, Launer LJ, Liu Y, Satterfield S, Rosano C. Declines in inflammation predict greater white matter microstructure in older adults. Neurobiol Aging. 2015;36(2):948-954.

Kalogeropoulos AP, Georgiopoulou VV, Murphy RA, Newman AB, Bauer DC, Harris TB, Yang Z, Applegate WB, Kritchevsky SB. Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) study. JAMA Intern Med. 2015;175(3):410-419.

Nadkarni NK, Perera S, Hanlon JT, Lopez O, Newman AB, Aizenstein H, Elam M, Harris TB, Kritchevsky S, Yaffe K, Rosano C. Statins and brain integrity in older adults: secondary analysis of the Health ABC study. Alzheimers Dement. 2015;():.

Khan H, Kunutsor S, Kalogeropoulos AP, Georgiopoulou VV, Newman AB, Harris TB, Bibbins-Domingo K, Kauhanen J, Gheorghiade M, Fonarow GC, Kritchevsky SB, Laukkanen JA, Butler J. Resting heart rate and risk of incident heart failure: three prospective cohort studies and a systematic meta-analysis. J Am Heart Assoc. 2015;4(1):e001364.

Bansal N, Katz R, De Boer IH, Peralta CA, Fried LF, Siscovick DS, Rifkin DE, Hirsch C, Cummings SR, Harris TB, Kritchevsky SB, Sarnak MJ, Shlipak MG, Ix JH. Development and validation of a model to predict 5-year risk of death without ESRD among older adults with CKD. Clin J Am Soc Nephrol. 2015;10(3):363-371.

Tian Q, Glynn NW, Erickson KI, Aizenstein HJ, Simonsick EM, Yaffe K, Harris TB, Kritchevsky SB, Boudreau RM, Newman AB, Lopez OL, Saxton J, Rosano C. Objective measures of physical activity, white matter integrity and cognitive status in adults over age 80. Behav Brain Res. 2015;284():51-57.

Hansen JG, Tang W, Hootman KC, Brannon PM, Houston DK, Kritchevsky SB, Harris TB, Garcia M, Lohman K, Liu Y, de Boer IH, Kestenbaum BR, Robinson-Cohen C, Siscovick DS, Cassano PA. Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans. J Nutr. 2015;145(4):799-805.

Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ. Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. PLoS One. 2015;10(3):e0121993.

Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015;16(1):333.

Aneke-Nash CS, Parrinello CM, Rajpathak SN, Rohan TE, Strotmeyer ES, Kritchevsky SB, Psaty BM, Buzkova P, Kizer JR, Newman AB, Strickler HD, Kaplan RC. Changes in insulin-like growth factor-I and its binding proteins are associated with diabetes mellitus in older adults. J Am Geriatr Soc. 2015;63(5):902-909.

High KP, Kritchevsky SB. Translational research in the fastest-growing population: older adults In: Wehling M, ed. Principles of translational science in medicine: from bench to bedside. 2nd ed. Burlington: Elsevier;2015: 299-311.

Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ. The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Kritchevsky S, Manini T, Blair S, Newman A, Botoseneanu A, Lovato L, Guralnik J, Pahor M. The effect of physical activity on mobility disability in obese, abdominally obese and non-obese older adults: the Lifestyle Interventions and Independence for Elders (LIFE) Study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S1.

Paddon-Jones D, Campbell WW, Jacques PF, Kritchevsky SB, Moore LL, Rodriguez NR, van Loon LJ. Protein and healthy aging. Am J Clin Nutr. 2015;():.

Tabatabai LS, Cummings SR, Tylavsky FA, Bauer DC, Cauley JA, Kritchevsky SB, Newman A, Simonsick EM, Harris TB, Sebastian A, Sellmeyer DE. Arterialized venous bicarbonate is associated with lower bone mineral density and an increased rate of bone loss in older men and women. J Clin Endocrinol Metab. 2015;100(4):1343-1349.

Williams JA, Sink KM, Tooze JA, Atkinson HH, Cauley JA, Yaffe K, Tylavsky FA, Rubin SM, Simonsick EM, Kritchevsky SB, Houston DK. Low 25-hydroxyvitamin D concentrations predict incident depression in well-functioning older adults: the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2015;70(6):757-763.

Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T, Lemaitre RN, Kristiansson K, Nuotio ML, Houston DK, Perala MM, Qi Q, Sonestedt E, Manichaikul A, Kanoni S, Ganna A, Mikkila V, North KE, Siscovick DS,. Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet. 2015;24(16):4728-4738.

Houston DK, Tooze JA, Garcia KR, Visser M, Tylavsky FA, Hue TF, Lee JS, Murphy RA, Simonsick EM, Harris TB, Newman AB, Kritchevsky SB. Protein intake and incident mobility limitations in older adults: the Health ABC Study [abstract]. J Frailty Aging. 2015;4(Suppl 1):30.

Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,. Alterations of a cellular cholesterol metabolism network is a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Diabetes. 2015;():.

Vaz Fragoso CA, Miller ME, King AC, Kritchevsky SB, Liu CK, Myers VH, Nadkarni NK, Pahor M, Spring BJ, Gill TM. Effect of structured physical activity on sleep-wake behaviors in sedentary elderly adults with mobility limitations. J Am Geriatr Soc. 2015;63(7):1381-1390.

Wilson VK, Houston DK, Kilpatrick L, Lovato J, Yaffe K, Cauley JA, Harris TB, Simonsick EM, Ayonayon HN, Kritchevsky SB, Sink KM. Relationship between 25-hydroxyvitamin d and cognitive function in older adults: the health, aging and body composition study. J Am Geriatr Soc. 2014;62(4):636-641.

Marti CN, Khan H, Mann DL, Georgiopoulou VV, Bibbins-Domingo K, Harris T, Koster A, Newman A, Kritchevsky SB, Kalogeropoulos AP, Butler J. Soluble tumor necrosis factor receptors and heart failure risk in older adults: Health, Aging, and Body Composition (Health ABC) Study. Circ Heart Fail. 2014;7(1):5-11.

Kritchevsky SB. Obesity in the sarcopenia era [editorial]. J Gerontol A Biol Sci Med Sci. 2014;69(1):61-62.

Murphy RA, Register TC, Shively CA, Carr JJ, Ge Y, Heilbrun ME, Cummings SR, Koster A, Nevitt MC, Satterfield S, Tylvasky FA, Strotmeyer ES, Newman AB, Simonsick EM, Scherzinger A, Goodpaster BH, Launer LJ, Eiriksdottir G,. Adipose tissue density, a novel biomarker predicting mortality risk in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(1):109-117.

Vishwanathan R, Iannaccone A, Scott TM, Kritchevsky SB, Jennings BJ, Carboni G, Forma G, Satterfield S, Harris T, Johnson KC, Schalch W, Renzi LM, Rosano C, Johnson EJ. Macular pigment optical density is related to cognitive function in older people. Age Ageing. 2014;43(2):271-275.

Murphy RA, Reinders I, Register TC, Ayonayon HN, Newman AB, Satterfield S, Goodpaster BH, Simonsick EM, Kritchevsky SB, Harris TB. Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults. Am J Clin Nutr. 2014;99(5):1059-1065.

Beavers KM, Gordon M, Beavers D, Hairston K, Nicklas B, Kritchevsky S, Vitolins M. Relationship between change in body composition and physical function in abdominally obese, older adults undergoing 12-weeks of caloric restriction [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S20.

Feng X, Todd T, Hu Y, Lintzenich CR, Carr JJ, Browne JD, Kritchevsky SB, Butler SG. Age-related changes of hyoid bone position in healthy older adults with aspiration. Laryngoscope. 2014;124(6):E231-E236.

Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Int J Obes (Lond). 2014;38(11):1397-1402.

Alley DE, Shardell MD, Peters KW, McLean RR, Dam TT, Kenny AM, Fragala MS, Harris TB, Kiel DP, Guralnik JM, Ferrucci L, Kritchevsky SB, Studenski SA, Vassileva MT, Cawthon PM. Grip strength cutpoints for the identification of clinically relevant weakness. J Gerontol A Biol Sci Med Sci. 2014;69(5):559-566.

Cawthon PM, Peters KW, Shardell MD, McLean RR, Dam TT, Kenny AM, Fragala MS, Harris TB, Kiel DP, Guralnik JM, Ferrucci L, Kritchevsky SB, Vassileva MT, Studenski SA, Alley DE. Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci. 2014;69(5):567-575.

Dam TT, Peters KW, Fragala M, Cawthon PM, Harris TB, McLean R, Shardell M, Alley DE, Kenny A, Ferrucci L, Guralnik J, Kiel DP, Kritchevsky S, Vassileva MT, Studenski S. An evidence-based comparison of operational criteria for the presence of sarcopenia. J Gerontol A Biol Sci Med Sci. 2014;69(5):584-590.

Vaz Fragoso CA, Beavers DP, Hankinson JL, Flynn G, Berra K, Kritchevsky SB, Liu CK, McDermott MM, Manini TM, Rejeski WJ, Gill TM. Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons. J Am Geriatr Soc. 2014;62(4):622-628.

Studenski SA, Peters KW, Alley DE, Cawthon PM, McLean RR, Harris TB, Ferrucci L, Guralnik JM, Fragala MS, Kenny AM, Kiel DP, Kritchevsky SB, Shardell MD, Dam TT, Vassileva MT. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci. 2014;69(5):547-558.

Liu CK, Leng X, Hsu FC, Kritchevsky SB, Ding J, Earnest CP, Ferrucci L, Goodpaster BH, Guralnik JM, Lenchik L, Pahor M, Fielding RA. The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). J Nutr Health Aging. 2014;18(1):59-64.

McLean RR, Shardell MD, Alley DE, Cawthon PM, Fragala MS, Harris TB, Kenny AM, Peters KW, Ferrucci L, Guralnik JM, Kritchevsky SB, Kiel DP, Vassileva MT, Xue QL, Perera S, Studenski SA, Dam TT. Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) Sarcopenia Project. J Gerontol A Biol Sci Med Sci. 2014;69(5):576-583.

Hugenschmidt CE, Burdette JH, Morgan AR, Williamson JD, Kritchevsky SB, Laurienti PJ. Graph theory analysis of functional brain networks and mobility disability in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(11):1399-1406.

Espeland MA, Rapp SR, Bray GA, Houston DK, Johnson KC, Kitabchi AE, Hergenroeder AL, Williamson J, Jakicic JM, van Dorsten B, Kritchevsky SB. Long-term impact of behavioral weight loss intervention on cognitive function. J Gerontol A Biol Sci Med Sci. 2014;69(9):1101-1108.

Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311(23):2387-2396.

Bolandzadeh N, Liu-Ambrose T, Aizenstein H, Harris T, Launer L, Yaffe K, Kritchevsky SB, Newman A, Rosano C.. Pathways linking regional hyperintensities in the brain and slower gait. Neuroimage. 2014;99():7-13.

Vaz Fragoso CA, Miller ME, Fielding RA, King AC, Kritchevsky SB, McDermott MM, Myers V, Newman AB, Pahor M, Gill TM. Sleep-wake disturbances in sedentary community-dwelling elderly adults with functional limitations. J Am Geriatr Soc. 2014;62(6):1064-1072.

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