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Stephen Kritchevsky, Ph.D.Wake Forest School of Medicine

Stephen Kritchevsky, Ph.D.

Deputy Director,

Ctr for Vaccines at Extremes

Contact Information

Academic: 336-713-8548 | Department: 336-713-8570

Media Medical Expert »

Education & Training

  • M.S.P.H., University of North Carolina School of Public Hlth, 1986
  • Ph.D., University of North Carolina-Chapel Hill, 1989


  • Am Geriatrics Society
  • Am Heart Association
  • Gerontological Society Of Amer
Stephen Kritchevsky, Ph.D.

Stephen Kritchevsky, Ph.D.

Deputy Director, Translational Science Institute
Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Center on Diabetes, Obesity, and Metabolism
Ctr for Vaccines at Extremes
Institute for Regenerative Medicine
Epidemiology & Prevention

Research Interests

Aging; Body Composition; Aged; Mobility Limitation; Female
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Contact Information

Academic: 336-713-8548 | Department: 336-713-8570

Media Medical Expert »

Recent Publications

Aspiration as a function of age, sex, liquid type, bolus volume, and bolus delivery across the healthy adult life span. Butler SG, Stuart A, Markley L, Feng X, Kritchevsky SB.. Ann Otol Rhinol Laryngol. 2018;127(1):21-32.

The benefits of reviewing [editorial]. Kritchevsky SB.. J Am Geriatr Soc. 2018;():.

Influence of prehospital function and strength on outcomes of critically ill older adults. Files DC, Neiberg R, Rushing J, Morris PE, Young MP, Ayonayon H, Harris T, Newman A, Rubin S, Shiroma E, Houston D, Miller ME, Kritchevsky SB.. J Am Geriatr Soc. 2018;66(3):525-531.

Trans-ethnic evaluation identifies novel low frequency loci associated with 25-hydroxyvitamin D concentrations. Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP,.. J Clin Endocrinol Metab. 2018;():.

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Volzke H, Zhou A,.. Nat Commun. 2018;9(1):260.

Effect of physical activity on frailty: secondary analysis of a randomized controlled trial. Trombetti A, Hars M, Hsu FC, Reid KF, Church TS, Gill TM, King AC, Liu CK, Manini TM, McDermott MM, Newman AB, Rejeski WJ, Guralnik JM, Pahor M, Fielding RA, Kritchevsky S, Brinkley T, Brubaker P, Demons J, Marsh A, Nicklas B, Sink K, Williamson J.. Ann Intern Med. 2018;168(5):309-316.

A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpelainen TO, Richard MA, Noordam R, Aslibekyan S,.. Am J Hum Genet. 2018;102(3):375-400.

Prospective associations of poor diet quality with long-term incidence of protein-energy malnutrition in community-dwelling older adults: the Health, Aging, and Body Composition (Health ABC) Study. Hengeveld LM, Wijnhoven HAH, Olthof MR, Brouwer IA, Harris TB, Kritchevsky SB, Newman AB, Visser M.. Am J Clin Nutr. 2018;107(2):155-164.

Low 25-hydroxyvitamin D concentrations and risk of incident cognitive impairment in black and white older adults: the Health ABC study. Kilpatrick L, Houston DK, Wilson VK, Lovato J, Ayonayon HN, Cauley JA, Harris T, Simonsick EM, Yaffe K, Kritchevsky SB, Sink KM.. J Nutr Gerontol Geriatr. 2018;37(1):1-13.

Impact of intensive lifestyle intervention on disability-free life expectancy: the Look AHEAD study. Gregg EW, Lin J, Bardenheier B, Chen H, Rejeski WJ, Zhuo X, Hergenroeder AL, Kritchevsky SB, Peters AL, Wagenknecht LE, Ip EH, Espeland MA.. Diabetes Care. 2018;41(5):1040-1048.

Maintenance of physical function 1 year after exercise intervention in at-risk older adults: follow-up from the LIFE study. Henderson RM, Miller ME, Fielding RA, Gill TM, Glynn NW, Guralnik JM, King A, Newman AB, Manini TM, Marsh AP, Pahor M, McDermott MM, Rejeski J, Tudor-Locke C, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2018;73(5):688-694.

Gait speed and mobility disability: revisiting meaningful levels in diverse clinical populations. Miller ME, Magaziner J, Marsh AP, Fielding RA, Gill TM, King AC, Kritchevsky S, Manini T, McDermott MM, Neiberg R, Orwig D, Santanasto AJ, Pahor M, Guralnik J, Rejeski WJ.. J Am Geriatr Soc. 2018;66(5):954-961.

Fibroblast growth factor 23: a biomarker of kidney function decline. Drew DA, Katz R, Kritchevsky S, Ix JH, Shlipak MG, Newman AB, Hoofnagle A, Fried L, Sarnak MJ, Gutierrez OM.. Am J Nephrol. 2018;47(4):242-250.

Association of biomarker and physiologic indices with mortality in older adults: Cardiovascular Health Study. Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Kizer JR, Kaplan RC, Cappola AR, Cushman M, Jacob ME, Kritchevsky SB, Newman AB.. J Gerontol A Biol Sci Med Sci. 2018;():.

Reliability of a novel index of senescent cell abundance in human adipose tissue [abstract]. Raborn L, Justice J, Gregory H, Nicklas B, Ding J, Kritchevsky S, Williamson J.. J Investig Med. 2018;66(2):357.

Self- vs proxy-reported mobility using the mobility assessment tool-short form in elderly preoperative patients. Kim S, Miller ME, Lin M, Rejeski WJ, Kritchevsky SB, Marsh AP, Groban L.. Eur Rev Aging Phys Act. 2018;15(5):.

Effects of age and functional status on the relationship of systolic blood pressure with mortality in mid and late life: the ARIC study. Windham BG, Griswold ME, Lirette S, Kucharska-Newton A, Foraker RE, Rosamond W, Coresh J, Kritchevsky S, Mosley TH Jr.. J Gerontol A Biol Sci Med Sci. 2017;72(1):89-94.

Diabetes, hyperglycemia, and the burden of functional disability among older adults in a community-based study. Godino JG, Appel LJ, Gross AL, Schrack JA, Parrinello CM, Kalyani RR, Windham BG, Pankow JS, Kritchevsky SB, Bandeen-Roche K, Selvin E.. J Diabetes. 2017;9(1):76-84.

Operationalizing frailty in the Atherosclerosis Risk in Communities Study cohort. Kucharska-Newton AM, Palta P, Burgard S, Griswold ME, Lund JL, Capistrant BD, Kritchevsky SB, Bandeen-Roche K, Windham BG.. J Gerontol A Biol Sci Med Sci. 2017;72(3):382-388.

Effects of physical activity intervention on physical and cognitive function in sedentary adults with and without diabetes. Espeland MA, Lipska K, Miller ME, Rushing J, Cohen RA, Verghese J, McDermott MM, King AC, Strotmeyer ES, Blair SN, Pahor M, Reid K, Demons J, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2017;72(6):861-866.

Body composition remodeling and mortality: the Health Aging and Body Composition Study. Santanasto AJ, Goodpaster BH, Kritchevsky SB, Miljkovic I, Satterfield S, Schwartz AV, Cummings SR, Boudreau RM, Harris TB, Newman AB.. J Gerontol A Biol Sci Med Sci. 2017;72(4):513-519.

Effects of longitudinal glucose exposure on cognitive and physical function: results from the Action for Health in Diabetes Movement and Memory study. Beavers KM, Leng I, Rapp SR, Miller ME, Houston DK, Marsh AP, Hire DG, Baker LD, Bray GA, Blackburn GL, Hergenroeder AL, Jakicic JM, Johnson KC, Korytkowski MT, Dorsten BV, Kritchevsky SB.. J Am Geriatr Soc. 2017;65(1):137-145.

Genome-wide association analysis of the sense of smell in U.S. older adults: identification of novel risk loci in African-Americans and European-Americans. Dong J, Wyss A, Yang J, Price TR, Nicolas A, Nalls M, Tranah G, Franceschini N, Xu Z, Schulte C, Alonso A, Cummings SR, Fornage M, Zaykin D, Li L, Huang X, Kritchevsky S, Liu Y, Gasser T, Wilson RS, De Jager PL, Singleton AB, Pinto JM, Harris T,.. Mol Neurobiol. 2017;54(10):8021-8032.

Exercise capacity, heart failure risk, and mortality in older adults: the Health ABC Study. Georgiopoulou VV, Kalogeropoulos AP, Chowdhury R, Binongo JN, Bibbins-Domingo K, Rodondi N, Simonsick EM, Harris T, Newman AB, Kritchevsky SB, Butler J.. Am J Prev Med. 2017;52(2):144-153.

The importance of mid-to-late-life body mass index trajectories on late-life gait speed. Windham BG, Griswold ME, Wang W, Kucharska-Newton A, Demerath EW, Gabriel KP, Pompeii LA, Butler K, Wagenknecht L, Kritchevsky S, Mosley TH Jr.. J Gerontol A Biol Sci Med Sci. 2017;72(8):1130-1136.

Dynapenia and metabolic health in obese and nonobese adults aged 70 years and older: the LIFE Study. Aubertin-Leheudre M, Anton S, Beavers DP, Manini TM, Fielding R, Newman A, Church T, Kritchevsky SB, Conroy D, McDermott MM, Botoseneanu A, Hauser ME, Pahor M.. J Am Med Dir Assoc. 2017;18(4):312-319.

Reply to comment on 'statin use and all-cancer survival: prospective results from the Women's Health Initiative' [reply to letter]. Wang A, Aragaki AK, Tang JY, Kurian AW, Manson JE, Chlebowski RT, Simon M, Desai P, Wassertheil-Smoller S, Liu S, Kritchevsky S, Wakelee HA, Stefanick ML.. Br J Cancer. 2017;116(3):e2.

Association between soluble klotho and change in kidney function: the Health Aging and Body Composition study. Drew DA, Katz R, Kritchevsky S, Ix J, Shlipak M, Gutierrez OM, Newman A, Hoofnagle A, Fried L, Semba RD, Sarnak M.. J Am Soc Nephrol. 2017;28(6):1859-1866.

Metabolites associated with lean mass and adiposity in older black men. Murphy RA, Moore SC, Playdon M, Meirelles O, Newman AB, Milijkovic I, Kritchevsky SB, Schwartz A, Goodpaster BH, Sampson J, Cawthon P, Simonsick EM, Gerszten RE, Clish CB, Harris TB.. J Gerontol A Biol Sci Med Sci. 2017;72(10):1352-1359.

Protein intake and mobility limitation in community-dwelling older adults: the Health ABC study. Houston DK, Tooze JA, Garcia K, Visser M, Rubin S, Harris TB, Newman AB, Kritchevsky SB.. J Am Geriatr Soc. 2017;65(8):1705-1711.

Circulating MiRNAs as biomarkers of gait speed responses to aerobic exercise training in obese older adults. Zhang T, Brinkley TE, Liu K, Feng X, Marsh AP, Kritchevsky S, Zhou X, Nicklas BJ.. Aging (Albany NY). 2017;9(3):900-913.

Clinical trials targeting aging and age-related multimorbidity. Espeland MA, Crimmins EM, Grossardt BR, Crandall JP, Gelfond JA, Harris TB, Kritchevsky SB, Manson JE, Robinson JG, Rocca WA, Temprosa M, Thomas F, Wallace R, Barzilai N.. J Gerontol A Biol Sci Med Sci. 2017;72(3):355-361.

Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG.. Metabolism. 2017;70():98-106.

Integrating frailty research into the medical specialties-report from a U13 conference. Walston J, Robinson TN, Zieman S, McFarland F, Carpenter CR, Althoff KN, Andrew MK, Blaum CS, Brown PJ, Buta B, Ely EW, Ferrucci L, High KP, Kritchevsky SB, Rockwood K, Schmader KE, Sierra F, Sink KM, Varadhan R, Hurria A.. J Am Geriatr Soc. 2017;65(10):2134-2139.

Cardiac troponin T and fast skeletal muscle denervation in ageing. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T.. J Cachexia Sarcopenia Muscle. 2017;8(5):808-823.

Circulating vitamin K is inversely associated with incident cardiovascular disease risk among those treated for hypertension in the Health, Aging, and Body Composition Study (Health ABC). Shea MK, Booth SL, Weiner DE, Brinkley TE, Kanaya AM, Murphy RA, Simonsick EM, Wassel CL, Vermeer C, Kritchevsky SB.. J Nutr. 2017;147(5):888-895.

Pain and function in older black and white adults: a secondary analysis of the Health ABC Study [abstract]. Brooks A, Leng X, Kritchevsky S.. J Pain. 2017;18(4 Suppl 1):S83-S84.

Social participation modifies the effect of a structured physical activity program on major mobility disability among older adults: results from the LIFE study. Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik JM, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J,.. J Gerontol B Psychol Sci Soc Sci. 2017;():.

Self-reported physical function as a predictor of hospitalization in the LIFE Study [abstract]. Callahan KE, Lovato L, Miller ME, Marsh AP, Fielding R, Gill T, Groessl E, Guralnik J, King A, Kritchevsky S, McDermott M, Manini T, Newman AB, Rejeski WJ.. J Am Geriatr Soc. 2017;65(Suppl 1):S5-S6.

Promoting active aging in primary care [abstract]. Callahan KE, Miller ME, Kritchevsky S, Houston DK, Williamson J, Rejeski WJ.. J Am Geriatr Soc. 2017;65(Suppl 1):S36.

Association of urinary uromodulin with kidney function decline and mortality: the Health ABC Study. Garimella PS, Katz R, Ix JH, Fried LF, Kritchevsky SB, Devarajan P, Bennett MR, Parikh CR, Shlipak MG, Harris TB, Gutierrez OM, Sarnak MJ.. Clin Nephrol. 2017;87(6):278-286.

Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women. Justice JN, Gregory H, Tchkonia T, LeBrasseur NK, Kirkland JL, Kritchevsky SB, Nicklas BJ.. J Gerontol A Biol Sci Med Sci. 2017;():.

Exercise's effect on mobility disability in older adults with and without obesity: the LIFE study randomized clinical trial. Kritchevsky SB, Lovato L, Handing EP, Blair S, Botoseneanu A, Guralnik JM, Liu C, King A, Marsh AP, Pahor M, Rejeski WJ, Spring B, Manini T.. Obesity (Silver Spring). 2017;25(7):1199-1205.

Slowing gait and risk for cognitive impairment: the hippocampus as a shared neural substrate. Rosso AL, Verghese J, Metti AL, Boudreau RM, Aizenstein HJ, Kritchevsky S, Harris T, Yaffe K, Satterfield S, Studenski S, Rosano C.. Neurology. 2017;89(4):336-342.

Transcriptomic profiles of aging in naive and memory CD4+ cells from mice. Taylor J, Reynolds L, Hou L, Lohman K, Cui W, Kritchevsky S, McCall C, Liu Y.. Immun Ageing. 2017;2017(14):15.

The Short Physical Performance Battery (SPPB) score predicts survival among older adults with acute myeloid leukemia (AML) who have achieved remission [abstract]. Saad MH, Tooze JA, Pardee TS, Williamson J, Kritchevsky S, Ellis LR, Powell BL, Klepin HD.. J Am Geriatr Soc. 2017;65(Suppl 1):S131.

Poor appetite and dietary intake in community-dwelling older adults. van der Meij BS, Wijnhoven HAH, Lee JS, Houston DK, Hue T, Harris TB, Kritchevsky SB, Newman AB, Visser M.. J Am Geriatr Soc. 2017;65(10):2190-2197.

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Akesson K, Amin N,.. Nat Commun. 2017;8(1):80.

ENabling reduction of low-grade inflammation in SEniors Pilot Study: concept, rationale, and design. Manini TM, Anton SD, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu C, McDermott MM, Miller ME, Tracy RP, Walston JD, Radziszewska B, Lu J, Stowe C, Wu S, Newman AB, Ambrosius WT, Pahor M.. J Am Geriatr Soc. 2017;65(9):1961-1968.

Is there a synergistic role for vitamin K and vitamin D in lower extremity function related to knee osteoarthritis? The Osteoarthritis Initiative and Health, Aging and Body Composition studies [abstract]. Shea M, Loeser RF, Kritchevsky SB, Houston DK, McAlindon TE, Booth SL.. Osteoarthritis Cartilage. 2017;25(Suppl 1):S185-S186.

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