Profile

Gregory L. Kucera, Ph.D.Wake Forest School of Medicine

Gregory L. Kucera, Ph.D.

Associate Core Director,
Professor,


Contact Information

Academic: 336-716-6348 | Department: 336-716-4464

Education & Training

  • B.S., Davidson College, 1982
  • Ph.D., Wake Forest University, 1987
  • Fellowship, University of Vermont, 1990
Gregory L. Kucera, Ph.D.

Gregory L. Kucera, Ph.D.

Associate Core Director, Comprehensive Cancer Center
Professor, Hematology & Oncology
Physiology & Pharmacology
Cancer Biology

Research Interests

Antineoplastic Agents; Platinum; Acridines; Deoxycytidine; DNA
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Contact Information

Academic: 336-716-6348 | Department: 336-716-4464

Recent Publications

Improving nucleoside analogs via lipid conjugation: is fatter any better?. Alexander P, Kucera G, Pardee TS.. Crit Rev Oncol Hematol. 2016;100():46-56.

Synthesis, reactivity, and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors. Yang M, Pickard AJ, Qiao X, Gueble MJ, Day CS, Kucera GL, Bierbach U.. Inorg Chem. 2015;54(7):3316-3324.

Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry. Qiao X, Ding S, Liu F, Kucera GL, Bierbach U.. J Biol Inorg Chem. 2014;19(3):415-426.

Design of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent. Ding S, Pickard AJ, Kucera GL, Bierbach U.. Chemistry. 2014;20(49):16164-73.

Redesigning the DNA-targeted chromophore in platinum-acridine anticancer agents: a structure-activity relationship study. Pickard AJ, Liu F, Bartenstein TF, Haines LG, Levine KE, Kucera GL, Bierbach U.. Chemistry. 2014;20(49):16174-87.

Tuning the subcellular distribution and target selectivity of cytotoxic platinum-intercalator conjugates [abstract]. Pickard AJ, Liu F, Bartenstein TF, Haines LG, Levine KE, West TK, Kucera GL, Bierbach U.. Abstr Pap Am Chem Soc. 2014;247():295-MEDI.

Targeting cancer-related kinases with metal-functionalized inhibitors [abstract]. Yang M, Pickard AJ, Wright MV, Kucera GL, Bierbach U.. Abstr Pap Am Chem Soc. 2014;247():142-MEDI.

Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer. Ding S, Qiao X, Kucera GL, Bierbach U.. Chem Commun (Camb). 2013;49(24):2415-2417.

Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents. Ding S, Qiao X, Suryadi J, Marrs GS, Kucera GL, Bierbach U.. Angew Chem Int Ed Engl. 2013;52(12):3350-3354.

Compositions and methods for double-targeting virus infections and targeting cancer cells. Kucera L, Ishaq KS, Morris-Natschke SL, Fleming RA, Kucera GL, inventors; Wake Forest University Health Sciences, assignee.. Canada patent CA 2,445,565. 2013 July 9. 2013;():.

Novel phospholipid conjugates double-targeted HIV. Morris-Natschke SL, Fleming RA, Kucera GL, inventors; Wake Forest University Health Sciences, assignee.. United States Patent US 8,138,200. 2012 Mar 20. 2012;():.

Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells. Qiao X, Zeitany AE, Wright MW, Essader AS, Levine KE, Kucera GL, Bierbach U.. Metallomics. 2012;4(7):645-652.

Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents. Ding S, Qiao X, Kucera GL, Bierbach U.. J Med Chem. 2012;55(22):10198-203.

Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents. Graham LA, Suryadi J, West TK, Kucera GL, Bierbach U.. J Med Chem. 2012;55(17):7817-7827.

Compositions and methods for double-targeting virus infections and targeting cancer cells. Kucera L, Ishaq KS, Morris-Natschke SL, Fleming RA, Kucera GL, inventors; Wake Forest University Health Sciences, assignee.. Japan patent JP 5031162; 2012 July 6. 2012;():.

Biomedical applications of targeting platinum conjugates to DNA secondary structural motifs [abstract]. Pickard AJ, West TK, Kucera GL, Bierbach U.. Abstr Pap Am Chem Soc. 2011;241():161-INOR.

Inhibition of DNA synthesis by a platinum-acridine hybrid agent leads to potent cell kill in nonsmall cell lung cancer. Smyre CL, Saluta G, Kute TE, Kucera GL, Bierbach U.. ACS Med Chem Lett. 2011;2(11):870-874.

Unusual reactivity of a potent platinum-acridine hybrid antitumor agent. Graham LA, Wilson GM, West TK, Day CS, Kucera GL, Bierbach U.. ACS Med Chem Lett. 2011;2(9):687-691.

Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents. Rao L, West TK, Saluta G, Kucera GL, Bierbach U.. Chem Res Toxicol. 2010;23(7):1148-1150.

Phospholipid/deoxycytidine analogue prodrugs for the treatment of cancer. Pickin KA, Alexander RL, Morrow CS, Morris-Natschke SL, Ishaq KS, Fleming RA, Kucera GL.. J Drug Del Sci Tech. 2009;19(1):31-36.

Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis. Eiter LC, Hall NW, Day CS, Saluta G, Kucera GL, Bierbach U.. J Med Chem. 2009;52(21):6519-6522.

Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups. Kheradi AR, Saluta G, Kucera GL, Day CS, Bierbach U.. Bioorg Med Chem Lett. 2009;19(13):3423-3425.

Compositions and methods for targeting cancer cells. Kucera L, Fleming R, Ishaq K, Kucera G, Morris-Natschke S, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 7,638,528. 2009 Dec 29. 2009;():.

Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups. Choudhury JR, Guddneppanavar R, Saluta G, Kucera GL, Bierbach U.. J Med Chem. 2008;51(11):3069-3072.

Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines. Ma Z, Saluta G, Kucera GL, Bierbach U.. Bioorg Med Chem Lett. 2008;18(13):3799-3801.

A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer. Ma Z, Choudhury JR, Wright MW, Day CS, Saluta G, Kucera GL, Bierbach U.. J Med Chem. 2008;51(23):7574-7580.

Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells. Barnes AP, Miller BE, Kucera GL.. Gynecol Oncol. 2007;104(2):443-450.

Photo-induced cytotoxicity of prodigiosin analogues. Park G, Tomlinson JT, Misenheimer JA, Kucera GL, Manderville RA.. Bull Korean Chem Soc. 2007;28(1):49-52.

Effect of the diamine nonleaving group in platinum--acridinylthiourea conjugates on DNA damage and cytotoxicity. Guddneppanavar R, Choudhury JR, Kheradi AR, Steen BD, Saluta G, Kucera GL, Day CS, Bierbach U.. J Med Chem. 2007;50(9):2259-2263.

Intraperitoneal hyperthermic chemotherapy using carboplatin: a phase I analysis in ovarian carcinoma. Lentz SS, Miller BE, Kucera GL, Levine EA.. Gynecol Oncol. 2007;106(1):207-210.

Compositions and methods for targeting cancer cells. Kucera L, Ishaq K, Morris-Natsche S, Kucera G, Fleming R, inventors; Wake Forest University Health Sciences, assignee.. Unites States patent US 7,309,696. 2007 Dec 18. 2007;():.

Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue. Tomlinson JT, Park G, Misenheimer JA, Kucera GL, Hesp K, Manderville RA.. Org Lett. 2006;8(21):4951-4954.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Gregory L. Kucera, Ph.D.

Gregory L. Kucera, Ph.D.

Associate Core Director, Comprehensive Cancer Center
Professor, Hematology & Oncology
Physiology & Pharmacology
Cancer Biology

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