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Gregory L. Kucera, Ph.D.

Gregory L. Kucera, Ph.D.

Associate Core Director, Comprehensive Cancer Center
Associate Professor, Hematology & Oncology
Comprehensive Cancer Center
Cancer Biology
Physiology & Pharmacology
Contact Information
Appointment:
336-713-5440
Office:
336-716-4464
Fax:
336-716-5687
Email: gkucera@wakehealth.edu
Education & Training
  BS Davidson College 1982
  PhD Wake Forest University 1987
Fellowship University of Vermont 1990
Gregory L. Kucera, Ph.D.

Gregory L. Kucera, Ph.D.

Associate Core Director, Comprehensive Cancer Center
Associate Professor, Hematology & Oncology
Comprehensive Cancer Center
Cancer Biology
Physiology & Pharmacology
Contact Information
Appointment:
336-713-5440
Office:
336-716-4464
Fax:
336-716-5687
Email: gkucera@wakehealth.edu
Recent Publications
Pickard AJ, West TK, Kucera GL, Bierbach U. Biomedical applications of targeting platinum conjugates to DNA secondary structural motifs [abstract]. Abstr Pap Am Chem Soc. 2011; 241():161-INOR.

Smyre CL, Saluta G, Kute TE, Kucera GL, Bierbach U. Inhibition of DNA synthesis by a platinum-acridine hybrid agent leads to potent cell kill in nonsmall cell lung cancer. ACS Med Chem Lett. 2011; 2(11):870-874.

Rao L, West TK, Saluta G, Kucera GL, Bierbach U. Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents. Chem Res Toxicol. 2010; 23(7):1148-1150.

Pickin KA, Alexander RL, Morrow CS, Morris-Natschke SL, Ishaq KS, Fleming RA, Kucera GL. Phospholipid/deoxycytidine analogue prodrugs for the treatment of cancer. J Drug Del Sci Tech. 2009; 19(1):31-36.

Eiter LC, Hall NW, Day CS, Saluta G, Kucera GL, Bierbach U. Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis. J Med Chem. 2009; 52(21):6519-6522.

Kheradi AR, Saluta G, Kucera GL, Day CS, Bierbach U. Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups. Bioorg Med Chem Lett. 2009; 19(13):3423-3425.

Kucera L, Fleming R, Ishaq K, Kucera G, Morris-Natschke S, inventors; Wake Forest University Health Sciences, assignee. Compositions and methods for targeting cancer cells. United States patent US 7,638,528. 2009 Dec 29. 2009; ():.

Choudhury JR, Guddneppanavar R, Saluta G, Kucera GL, Bierbach U. Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups. J Med Chem. 2008; 51(11):3069-3072.

Ma Z, Saluta G, Kucera GL, Bierbach U. Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines. Bioorg Med Chem Lett. 2008; 18(13):3799-3801.

Ma Z, Choudhury JR, Wright MW, Day CS, Saluta G, Kucera GL, Bierbach U. A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer. J Med Chem. 2008; 51(23):7574-7580.

Barnes AP, Miller BE, Kucera GL. Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells. Gynecol Oncol. 2007; 104(2):443-450.

Park G, Tomlinson JT, Misenheimer JA, Kucera GL, Manderville RA. Photo-induced cytotoxicity of prodigiosin analogues. Bull Korean Chem Soc. 2007; 28(1):49-52.

Guddneppanavar R, Choudhury JR, Kheradi AR, Steen BD, Saluta G, Kucera GL, Day CS, Bierbach U. Effect of the diamine nonleaving group in platinum--acridinylthiourea conjugates on DNA damage and cytotoxicity. J Med Chem. 2007; 50(9):2259-2263.

Lentz SS, Miller BE, Kucera GL, Levine EA. Intraperitoneal hyperthermic chemotherapy using carboplatin: a phase I analysis in ovarian carcinoma. Gynecol Oncol. 2007; 106(1):207-210.

Kucera L, Ishaq K, Morris-Natsche S, Kucera G, Fleming R, inventors; Wake Forest University Health Sciences, assignee. Compositions and methods for targeting cancer cells. Unites States patent US 7,309,696. 2007 Dec 18. 2007; ():.

Tomlinson JT, Park G, Misenheimer JA, Kucera GL, Hesp K, Manderville RA. Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue. Org Lett. 2006; 8(21):4951-4954.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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Last Updated 2/23/2012
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