Profile

George Kulik, D.V.M., Ph.D.Wake Forest School of Medicine

George Kulik, D.V.M., Ph.D.

Associate Professor,

Clinical Interests

Prostate Cancer

Contact Information

Academic: 336-713-7650 | Department: 336-713-7650

Email: gkulik@wakehealth.edu

Additional Languages

Russian, Spanish, Ukrainian

Education & Training

  • D.V.M., Ukraine, 1986
  • Ph.D., Ukraine, 1991
  • Fellowship, Free Standing Institution-Unit, 1994
George Kulik, D.V.M., Ph.D.

George Kulik, D.V.M., Ph.D.

Associate Professor, Cancer Biology
Urology

Research Interests

Prostatic Neoplasms; bcl-Associated Death Protein; Apoptosis; Signal Transduction; Gene Expression Regulation, Neoplastic
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Contact Information

Academic: 336-713-7650 | Department: 336-713-7650

Email: gkulik@wakehealth.edu

Recent Publications

Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. Zhang Q, Wan M, Shi J, Horita DA, Miller LD, Kute TE, Kridel SJ, Kulik G, Sui G.. J Mol Cell Biol. 2016;8(3):232-243.

Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network. Kulik G.. Asian J Androl. 2015;17(3):471-474.

A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies. Hassan S, Karpova Y, Flores A, D'Agostino R Jr, Danhauer SC, Hemal A, Kulik G.. Int Urol Nephrol. 2014;46(3):505-510.

Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells. Sastry KS, Al-Muftah MA, Li P, Al-Kowari MK, Wang E, Ismail Chouchane A, Kizhakayil D, Kulik G, Marincola FM, Haoudi A, Chouchane L.. Cell Death Differ. 2014;21(12):1936-1949.

Behavioral stress accelerates prostate cancer development in mice. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G.. J Clin Invest. 2013;123(2):874-886.

Targeting psychoemotional stress to treat prostate cancer. Kulik G.. Asian J Androl. 2013;15(3):362-363.

Dimeric DNA aptamer complexes for high-capacity-targeted drug delivery using pH-sensitive covalent linkages. Boyacioglu O, Stuart CH, Kulik G, Gmeiner WH.. Mol Ther Nucleic Acids. 2013;2():e107.

BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells. Yancey D, Nelson KC, Baiz D, Hassan S, Flores A, Pullikuth A, Karpova Y, Axanova L, Moore V, Sui G, Kulik G.. PLoS One. 2013;8(9):e74561.

Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer. Baiz D, Hassan S, Choi YA, Flores A, Karpova Y, Yancey D, Pullikuth A, Sui G, Sadelain M, Debinski W, Kulik G.. Neoplasia. 2013;15(10):1172-1183.

Surgical stress delays prostate involution in mice. Hassan S, Karpova Y, Flores A, D'Agostino R Jr, Kulik G.. PLoS One. 2013;8(11):e78175.

Systems modeling of anti-apoptotic pathways in prostate cancer: psychological stress triggers a synergism pattern switch in drug combination therapy. Sun X, Bao J, Nelson KC, Li KC, Kulik G, Zhou X.. PLoS Comput Biol. 2013;9(12):e1003358.

Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer. Zhu S, Mott RT, Fry EA, Taneja P, Kulik G, Sui G, Inoue K.. Am J Pathol. 2013;183(4):1339-1350.

Synthesis and characterization of a novel prostate cancer-targeted phosphatidylinositol-3-kinase inhibitor prodrug. Baiz D, Pinder TA, Hassan S, Karpova Y, Salsbury F, Welker ME, Kulik G.. J Med Chem. 2012;55(18):8038-8046.

Expression of the Bcl-2 protein BAD promotes prostate cancer growth. Smith AJ, Karpova Y, D'Agostino R Jr, Willingham M, Kulik G.. PLoS ONE. 2009;4(7):e6224.

Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. Sastry KSR, Karpova Y, Prokopovich S, Smith AJ, Essau B, Gersappe A, Carson JP, Weber MJ, Register TC, Chen YQ, Penn RB, Kulik G, et al.. J Biol Chem. 2007;282(19):14094-100.

Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Edwards IJ, D'Agostino R Jr, Chen YQ, et al.. J Clin Invest. 2007;117(7):1866-1875.

Epidermal growth factor protects prostate cancer cells from apoptosis by inducing BAD phosphorylation via redundant signaling pathways. Sastry KSR, Karpova Y, Kulik G.. J Biol Chem. 2006;281(37):27367-77.

Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD. Sastry KSR, Smith AJ, Karpova Y, Datta SR, Kulik G.. J Biol Chem. 2006;281(30):20891-901.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Cancer Biology

Clinical Interests

Prostate Cancer
George Kulik, D.V.M., Ph.D.

George Kulik, D.V.M., Ph.D.

Associate Professor, Cancer Biology
Urology

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