Profile

George Kulik, D.V.M., Ph.D.Wake Forest School of Medicine

George Kulik, D.V.M., Ph.D.

Associate Professor,

Clinical Interests

Prostate Cancer

Contact Information

Academic: 336-713-7650 | Department: 336-713-7650

Email: gkulik@wakehealth.edu

Additional Languages

Russian, Spanish, Ukrainian

Education & Training

  • D.V.M., Ukraine, 1986
  • Ph.D., Ukraine, 1991
  • Fellowship, Free Standing Institution-Unit, 1994
George Kulik, D.V.M., Ph.D.

George Kulik, D.V.M., Ph.D.

Associate Professor, Cancer Biology
Urology

Research Interests

cancer/oncogenesis, cell growth, differentiation,d

Contact Information

Academic: 336-713-7650 | Department: 336-713-7650

Email: gkulik@wakehealth.edu

Recent Publications

Zhang Q, Wan M, Shi J, Horita DA, Miller LD, Kute TE, Kridel SJ, Kulik G, Sui G. Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. J Mol Cell Biol. 2016;():.

Kulik G. Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network. Asian J Androl. 2015;17(3):471-474.

Hassan S, Karpova Y, Flores A, D'Agostino R Jr, Danhauer SC, Hemal A, Kulik G. A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies. Int Urol Nephrol. 2014;46(3):505-510.

Sastry KS, Al-Muftah MA, Li P, Al-Kowari MK, Wang E, Ismail Chouchane A, Kizhakayil D, Kulik G, Marincola FM, Haoudi A, Chouchane L. Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells. Cell Death Differ. 2014;21(12):1936-1949.

Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013;123(2):874-886.

Kulik G. Targeting psychoemotional stress to treat prostate cancer. Asian J Androl. 2013;15(3):362-363.

Boyacioglu O, Stuart CH, Kulik G, Gmeiner WH. Dimeric DNA aptamer complexes for high-capacity-targeted drug delivery using pH-sensitive covalent linkages. Mol Ther Nucleic Acids. 2013;2():e107.

Yancey D, Nelson KC, Baiz D, Hassan S, Flores A, Pullikuth A, Karpova Y, Axanova L, Moore V, Sui G, Kulik G. BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells. PLoS One. 2013;8(9):e74561.

Baiz D, Hassan S, Choi YA, Flores A, Karpova Y, Yancey D, Pullikuth A, Sui G, Sadelain M, Debinski W, Kulik G. Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer. Neoplasia. 2013;15(10):1172-1183.

Hassan S, Karpova Y, Flores A, D'Agostino R Jr, Kulik G. Surgical stress delays prostate involution in mice. PLoS One. 2013;8(11):e78175.

Sun X, Bao J, Nelson KC, Li KC, Kulik G, Zhou X. Systems modeling of anti-apoptotic pathways in prostate cancer: psychological stress triggers a synergism pattern switch in drug combination therapy. PLoS Comput Biol. 2013;9(12):e1003358.

Zhu S, Mott RT, Fry EA, Taneja P, Kulik G, Sui G, Inoue K. Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer. Am J Pathol. 2013;183(4):1339-1350.

Baiz D, Pinder TA, Hassan S, Karpova Y, Salsbury F, Welker ME, Kulik G. Synthesis and characterization of a novel prostate cancer-targeted phosphatidylinositol-3-kinase inhibitor prodrug. J Med Chem. 2012;55(18):8038-8046.

Smith AJ, Karpova Y, D'Agostino R Jr, Willingham M, Kulik G. Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE. 2009;4(7):e6224.

Sastry KSR, Karpova Y, Prokopovich S, Smith AJ, Essau B, Gersappe A, Carson JP, Weber MJ, Register TC, Chen YQ, Penn RB, Kulik G, et al. Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem. 2007;282(19):14094-100.

Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Edwards IJ, D'Agostino R Jr, Chen YQ, et al. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007;117(7):1866-1875.

Sastry KSR, Karpova Y, Kulik G. Epidermal growth factor protects prostate cancer cells from apoptosis by inducing BAD phosphorylation via redundant signaling pathways. J Biol Chem. 2006;281(37):27367-77.

Sastry KSR, Smith AJ, Karpova Y, Datta SR, Kulik G. Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD. J Biol Chem. 2006;281(30):20891-901.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Cancer Biology

Clinical Interests

Prostate Cancer
George Kulik, D.V.M., Ph.D.

George Kulik, D.V.M., Ph.D.

Associate Professor, Cancer Biology
Urology

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