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Carl D. Langefeld, Ph.D.Wake Forest School of Medicine

Carl D. Langefeld, Ph.D.

Section Head,
Professor,




Contact Information

Academic: 336-713-0013 | Department: 336-716-2011

Email: clangefe@wakehealth.edu

Education & Training

  • Ph.D., University of Michigan/Ann Arbor, 1999

Memberships

  • Am Diabetes Assn
  • Am Soc of Human Genetics
  • Biometric Society
  • Int'L Genetic Epidemiology Soc
Carl D. Langefeld, Ph.D.

Carl D. Langefeld, Ph.D.

Section Head, Biostatistical Sciences
Professor, Biostatistical Sciences
Center for Comparative Medicine Research
Center for Diabetes Research
Center for Public Health Genomics
Sticht Center on Aging

Research Interests

arthritis, atherosclerosis/thrombosis, diabetes, epidemiology, genetics/genome, genomics and proteomics, immunology/allergy/inflammatio, minority health issues, neurosciences/behavior, obesity, statistics/mathematics

Contact Information

Academic: 336-713-0013 | Department: 336-716-2011

Email: clangefe@wakehealth.edu

Recent Publications

Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS,. Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis. 2016;75(1):242-252.

Hwang DY, Dell CA, Sparks MJ, Watson TD, Langefeld CD, Comeau ME, Rosand J, Battey TW, Koch S, Perez ML, James ML, McFarlin J, Osborne JL, Woo D, Kittner SJ, Sheth KN. Clinician judgment vs formal scales for predicting intracerebral hemorrhage outcomes. Neurology. 2016;86(2):126-133.

Freedman BI, Pastan SO, Israni AK, Schladt D, Julian BA, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Bowden DW, Hicks PJ, Palmer ND,. APOL1 genotype and kidney transplantation outcomes from deceased African American donors. Transplantation. 2016;100(1):194-202.

Langefeld CD, Divers J, Pajewski NM, Hawfield AT, Reboussin DM, Bild DE, Kaysen GA, Kimmel PL, Raj DS, Ricardo AC, Wright JT Jr, Sedor JR, Rocco MV, Freedman BI. Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. Kidney Int. 2015;87(1):169-175.

Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J. APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Kidney Int. 2015;87(1):176-181.

Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, Hirschfield GM, Xie G, Coltescu C, Amos C, Li H, Ice JA, Nath SK, Mariette X, Bowman S,. The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet. 2015;24(2):582-596.

Palmer ND, Ng MC, Langefeld CD, Divers J, Lea JP, Okusa MD, Kimberly RP, Bowden DW, Freedman BI. Lack of association of the APOL1 G3 haplotype in African Americans with ESRD. J Am Soc Nephrol. 2015;26(5):1021-1025.

Kariuki SN, Ghodke-Puranik Y, Dorschner JM, Chrabot BS, Kelly JA, Tsao BP, Kimberly RP, Alarcon-Riquelme ME, Jacob CO, Criswell LA, Sivils KL, Langefeld CD, Harley JB, Skol AD, Niewold TB. Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. Genes Immun. 2015;16(1):15-23.

Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW. Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hum Genet. 2015;134(2):203-213.

Palmer ND, Goodarzi MO, Langefeld CD, Wang N, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH , Haritunians T, Ziegler JT, Williams AH, Stefansovski D, Cui J, Mackay AW, Henkin LF, Bergman RN, Gao X, Gauderman J, Varma R, Hanis CL,. Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes. 2015;64(5):1853-1866.

Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW. Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Neurobiol Aging. 2015;36(3):1602.e7-15.

Martins M, Williams AH, Comeau M, Marion M, Ziegler JT, Freedman BI, Merrill JT, Glenn SB, Kelly JA, Sivils KM, James JA, Guthridge JM, Alarcon-Riquelme ME, Bae SC, Kim JH, Kim D, Anaya JM, Boackle SA, Criswell LA, Kimberly RP, Alarcon GS, Brown EE,. Genetic association of CD247 (CD3zeta) with SLE in a large-scale multiethnic study. Genes Immun. 2015;16(2):142-150.

Vaughn SE, Foley C, Lu X, Patel ZH, Zoller EE, Magnusen AF, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath S, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcon GS,. Lupus risk variants in the PXK locus alter B-cell receptor internalization. Front Genet. 2015;5():450.

Raffield LM, Cox AJ, Carr JJ, Freedman BI, Hicks PJ, Langefeld CD, Hsu FC, Bowden DW. Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study. Acta Diabetol. 2015;52(4):743-751.

Freedman BI, Julian BA, Pastan SO, Israni AK, Schladt D, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Hicks PJ, Palmer ND, Adams PL,. Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure. Am J Transplant. 2015;15(6):1615-1622.

Lu X, Zoller EE, Weirauch MT, Wu Z, Namjou B, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath SK, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcon GS, Reveille JD,. Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression. Am J Hum Genet. 2015;96(5):731-739.

Rannikmae K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, Traylor M, Anderson CD, Battey TW, Radmanesh F, Deka R, Woo JG, Martin LJ, Jimenez-Conde J, Selim M, Brown DL, Silliman SL, Kidwell CS, Montaner J, Langefeld CD,. Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology. 2015;84(9):918-926.

Ma J, Divers J, Palmer ND, Julian BA, Israni AK, Schladt D, Pastan SO, Chattrabhuti K, Gautreaux MD, Hauptfeld V, Bray RA, Kirk AD, Brown WM, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Guan M, Palanisamy A, Reeves-Daniel AM, Bowden DW,. Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. Kidney Int. 2015;88(3):584-592.

Freitag DF, Butterworth AS, Willeit P, Howson JM, Burgess S, Kaptoge S, Young R, Ho WK, Wood AM, Sweeting M, Spackman S, Staley JR, Ramond A, Harshfield E, Nielsen SF, Grande P, Lange LA, Bown MJ, Jones GT, Scott RA, Bevan S, Porcu E,. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2015;3(4):243-253.

Sajuthi S, Sharma N, McWilliams D, Chou J, Comeau M, Palmer ND, Ma L, Calles J, Demons J, Rogers S, Beal J, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. eQTL analysis of adipose and muscle in African Americans identifies genetic regulators for type 2 diabetes and obesity-associated genes [abstract]. Diabetes. 2015;64(Suppl 1):A82.

Sharma NK, Sajuthi S, Chou J, Ma L, Calles J, Demons J, Rogers S, McWilliams D, Beal J, Comeau M, Palmer ND, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. Transcriptional profiles of adipose and muscle tissue are associated with insulin sensitivity and influenced by genetic variation in African Americans [abstract]. Diabetes. 2015;64(Suppl 1):A456.

Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA. IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L129-L138.

Sharma PR, Mackey AJ, Dejene EA, Ramadan JW, Langefeld CD, Palmer ND, Taylor KD, Wagenknecht LE, Watanabe RM, Rich SS, Nunemaker CS. An islet-targeted genome-wide association scan identifies novel genes implicated in cytokine-mediated islet stress in type 2 diabetes. Endocrinology. 2015;156(9):3147-3156.

Carty CL, Keene KL, Cheng YC, Meschia JF, Chen WM, Nalls M, Bis JC, Kittner SJ, Rich SS, Tajuddin S, Zonderman AB, Evans MK, Langefeld CD, Gottesman R, Mosley TH, Shahar E, Woo D, Yaffe K, Liu Y, Sale MM, Dichgans M, Malik R,. Meta-analysis of genome-wide association studies identifies genetic risk factors for stroke in African Americans. Stroke. 2015;46(8):2063-2068.

Radmanesh F, Falcone GJ, Anderson CD, McWilliams D, Devan WJ, Brown WM, Battey TW, Ayres AM, Raffeld MR, Schwab K, Sun G, Deka R, Viswanathan A, Goldstein JN, Greenberg SM, Tirschwell DL, Silliman SL, Selim M, Meschia JF, Brown DL,. Rare coding variation and risk of intracerebral hemorrhage. Stroke. 2015;46(8):2299-2301.

Walsh KB, Sekar P, Langefeld CD, Moomaw CJ, Elkind MS, Boehme AK, James ML, Osborne J, Sheth KN, Woo D, Adeoye O. Monocyte count and 30-day case fatality in intracerebral hemorrhage. Stroke. 2015;46(8):2302-2304.

Ramos PS, Shedlock AM, Langefeld CD. Genetics of autoimmune diseases: insights from population genetics. J Hum Genet. 2015;60(11):657-664.

Coull B, Kidwell C, Norato G, Dixon S, Osborne J, Rosand J, Vashkevich A, Mehndiratta P, Martini SR, Worrall BB, Sheth KN, James ML, Elkind MS, Miller T, Kittner S, Barton L, Clapham R, Moomaw CJ, Langefeld CD, Woo D. An analysis of cerebral amyloid angiopathy by the Boston Criteria in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) cohort [abstract]. Int J Stroke. 2015;10(Suppl 2):290-291.

Iyengar SK, Sedor JR, Freedman BI, Kao WH, Kretzler M, Keller BJ, Abboud HE, Adler SG, Best LG, Bowden DW, Burlock A, Chen YD, Cole SA, Comeau ME, Curtis JM, Divers J, Drechsler C, Duggirala R, Elston RC, Guo X, Huang H, Hoffmann MM,. Genome-wide association and trans-ethnic meta-analysis for advanced diabetic kidney disease: Family Investigation of Nephropathy and Diabetes (FIND). PLoS Genet. 2015;11(8):e1005352.

Urbanic JJ, Case D, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Naughton M, Weaver KE, Baglan K, Bryant D, Langefeld C, Lad TE, Lee L, Rine G, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Hu JJ,. A prospective evaluation of radiotherapy (RT) related skin reactions in a multi-racial/ethnic population of women with newly diagnosed breast cancer (BC) [abstract]. J Clin Oncol. 2015;33(15 Suppl):6593.

Hawkins GA, Friedman DJ, Lu L, McWilliams DR, Chou JW, Sajuthi S, Divers J, Parekh RS, Li M, Genovese G, Pollack MR, Hicks PJ, Bowden DW, Ma L, Freedman BI, Langefeld CD. Re-sequencing of the APOL1-APOL4 and MYH9 gene regions in African Americans does not identify additional risks for CKD progression. Am J Nephrol. 2015;42(2):99-106.

Kelly JA, Sivils KL, Nath SK, Langefeld CD, Wakeland EK, Gaffney PM. Utilization of a combined family-based/case-control cohort for the ImmunoChip identifies SLE loci not previously seen in standard case-control studies [abstract]. Clin Exp Rheumatol. 2015;33(3 Suppl 90):S21.

Lessard CJ, Sajuthi S, Zhao J, Kim K, Harley JB, Vyse TJ, Sivils KL, Langefeld CD, Bae S, Tsao BP. Identification of a systemic lupus erythematosus risk locus spanning the genes ATG16L2, FCHSD2, and p2RY2 in Koreans [abstract]. Clin Exp Rheumatol. 2015;33(3 Suppl 90):S74.

Zhao J, Wu H, Langefeld CD, Kaufman KM, Kelly JA, Bae SC, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Criswell LA, Freedman B, Kamen DL, Gilkeson GS, Jacob CO, James JA, Merrill JT, Gaffney PM, Sivils KM, Niewold TB, Petri MA, Song ST,. Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clin Immunol. 2015;161(2):157-162.

Sheth KN, Martini SR, Moomaw CJ, Koch S, Elkind MS, Sung G, Kittner SJ, Frankel M, Rosand J, Langefeld CD, Comeau ME, Waddy SP, Osborne J, Woo D. Prophylactic antiepileptic drug use and outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage study. Stroke. 2015;46(12):3532-3535.

Homburger JR, Moreno-Estrada A, Gignoux CR, Nelson D, Sanchez E, Ortiz-Tello P, Pons-Estel BA, Acevedo-Vasquez E, Miranda P, Langefeld CD, Gravel S, Alarcon-Riquelme ME, Bustamante CD. Genomic insights into the ancestry and demographic history of South America. PLoS Genet. 2015;11(12):e1005602.

Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC. Plasma FGF23 and calcified atherosclerotic plaque in African Americans with type 2 diabetes mellitus. Am J Nephrol. 2015;42(6):391-401.

Liu K, Kurien BT, Zimmerman SL, Kaufman KM, Taft DH, Kottyan LC, Lazaro S, Weaver CA, Ice JA, Adler AJ, Chodosh J, Radfar L, Rasmussen A, Stone DU, Lewis DM, Li S, Koelsch KA, Igoe A, Talsania M, Kumar J, Maier-Moore JS, Harris VM,. X chromosome dose and sex bias in autoimmune diseases: increased 47,XXX in systemic lupus erythematosus and Sjogren's syndrome. Arthritis Rheumatol. 2015;():.

Cobb J, Hinks A, Marion MC, Sudman M, Bowes J, Bohnsack J, Wedderburn LR, Haas JP, Langefeld CD, Prahalad S, Thompson SD, Thomson W. Chromatin marks mapping to juvenile idiopathic arthritis associated genomic regions identify CD4 and regulatory T cells as critical cell types in JIA [abstract]. Rheumatology. 2015;54(Suppl 1):148.

Alarcon-Riquelme ME, Ziegler JT, Molineros J, Howard TD, Moreno-Estrada A, Sanchez-Rodriguez E, Ainsworth HC, Ortiz-Tello P, Comeau ME, Rasmussen A, Kelly JA, Adler A, Acevedo-Vazquez E, Cucho JM, la Torre IG, Cardiel MH, Miranda P, Catoggio L,. GWAS in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture. Arthritis Rheumatol. 2015;():.

Gao C, Wang N, Guo X, Ziegler JT, Taylor KD, Xiang AH, Hai Y, Kridel SJ, Nadler JL, Kandeel F, Raffel LJ, Chen YD, Norris JM, Rotter JI, Watanabe RM, Wagenknecht LE, Bowden DW, Speliotes EK, Goodarzi MO, Langefeld CD, Palmer ND. A comprehensive analysis of common and rare variants to identify adiposity loci in Hispanic Americans: the IRAS Family Study (IRASFS). PLoS One. 2015;10(11):e0134649.

Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas JP, Martini A, Gattorno M, Ozen S, Prahalad S, Zeft AS, Bohnsack JF, Mellins ED, Ilowite NT, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg A, Wedderburn LR, Anton J,. HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. Proc Natl Acad Sci U S A. 2015;112(52):.

Hellwege JN, Palmer ND, Ziegler JT, Langefeld CD, Lorenzo C, Norris JM, Takamura T, Bowden DW. Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics. Gene. 2014;534(1):33-39.

Palmer ND, Ng MC, Hicks PJ, Mudgal P, Langefeld CD, Freedman BI, Bowden DW. Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease. PLoS One. 2014;9(2):e88273.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-321.

Divers J, Palmer ND, Lu L, Langefeld CD, Rocco MV, Hicks PJ, Murea M, Ma L, Bowden DW, Freedman BI. Gene-gene interactions in APOL1-associated nephropathy. Nephrol Dial Transplant. 2014;29(3):587-594.

Freedman BI, Langefeld CD, Andringa KK, Croker JA, Williams AH, Garner NE, Birmingham DJ, Hebert LA, Hicks PJ, Segal MS, Edberg JC, Brown EE, Alarcon GS, Costenbader KH, Comeau ME, Criswell LA, Harley JB, James JA, Kamen DL,. End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheum. 2014;66(2):390-396.

Cox AJ, Hsu FC, Ng MC, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study. Diabetes Care. 2014;37(4):1157-1164.

Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA,. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet. 2014;94(4):586-598.

Woo D, Falcone GJ, Devan WJ, Brown WM, Biffi A, Howard TD, Anderson CD, Brouwers HB, Valant V, Battey TW, Radmanesh F, Raffeld MR, Baedorf-Kassis S, Deka R, Woo JG, Martin LJ, Haverbusch M, Moomaw CJ, Sun G, Broderick JP, Flaherty ML,. Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. Am J Hum Genet. 2014;94(4):511-521.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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