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Carl D. Langefeld, Ph.D.Wake Forest School of Medicine

Carl D. Langefeld, Ph.D.

Section Head,
Professor,

Contact Information

Academic: 336-713-0013 | Department: 336-716-2011

Email: clangefe@wakehealth.edu

Education & Training

  • Ph.D., University of Michigan/Ann Arbor, 1999

Memberships

  • Am Diabetes Assn
  • Am Soc of Human Genetics
  • Biometric Society
  • Int'L Genetic Epidemiology Soc
Carl D. Langefeld, Ph.D.

Carl D. Langefeld, Ph.D.

Section Head, Biostatistical Sciences
Professor, Biostatistical Sciences

Research Interests

Genetic Predisposition to Disease; Polymorphism, Single Nucleotide; Lupus Erythematosus, Systemic; Diabetes Mellitus, Type 2; African Americans
More »

Contact Information

Academic: 336-713-0013 | Department: 336-716-2011

Email: clangefe@wakehealth.edu

Recent Publications

Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. J Hum Genet. 2017;62(2):175-184.

Genome-wide association of CKD progression: the chronic renal insufficiency cohort study. Parsa A, Kanetsky PA, Xiao R, Gupta J, Mitra N, Limou S, Xie D, Xu H, Anderson AH, Ojo A, Kusek JW, Lora CM, Hamm LL, He J, Sandholm N, Jeff J, Raj DE, Boger CA, Bottinger E, Salimi S, Parekh RS, Adler SG, Langefeld CD, Bowden DW, Groop PH,.. J Am Soc Nephrol. 2017;28(3):923-934.

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW Jr, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM,.. Nat Genet. 2017;49(1):125-130.

Ischemic lesions, blood pressure dysregulation, and poor outcomes in intracerebral hemorrhage. Kidwell CS, Rosand J, Norato G, Dixon S, Worrall BB, James ML, Elkind MS, Flaherty ML, Osborne J, Vashkevich A, Langefeld CD, Moomaw CJ, Woo D.. Neurology. 2017;88(8):782-788.

Analysis of whole exome sequencing with cardiometabolic traits using family-based linkage and association in the IRAS Family Study. Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW.. Ann Hum Genet. 2017;81(2):49-58.

Bladder capacity is a biomarker for a bladder-centric versus systemic manifestation in interstitial cystitis/bladder pain syndrome. Walker SJ, Zambon J, Andersson KE, Langefeld C, Matthews CA, Badlani G, Bowman H, Evans RJ.. J Urol. 2017;():.

Rare and low-frequency coding variants alter human adult height. Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rueger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NG,.. Nature. 2017;542(7640):186-190.

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS,.. Ann Rheum Dis. 2016;75(1):242-252.

Clinician judgment vs formal scales for predicting intracerebral hemorrhage outcomes. Hwang DY, Dell CA, Sparks MJ, Watson TD, Langefeld CD, Comeau ME, Rosand J, Battey TW, Koch S, Perez ML, James ML, McFarlin J, Osborne JL, Woo D, Kittner SJ, Sheth KN.. Neurology. 2016;86(2):126-133.

X chromosome dose and sex bias in autoimmune diseases: increased prevalence of 47,XXX in systemic lupus erythematosus and Sjogren's syndrome. Liu K, Kurien BT, Zimmerman SL, Kaufman KM, Taft DH, Kottyan LC, Lazaro S, Weaver CA, Ice JA, Adler AJ, Chodosh J, Radfar L, Rasmussen A, Stone DU, Lewis DM, Li S, Koelsch KA, Igoe A, Talsania M, Kumar J, Maier-Moore JS, Harris VM,.. Arthritis Rheumatol. 2016;68(5):1290-1300.

Genome-wide association study in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture. Alarcon-Riquelme ME, Ziegler JT, Molineros J, Howard TD, Moreno-Estrada A, Sanchez-Rodriguez E, Ainsworth HC, Ortiz-Tello P, Comeau ME, Rasmussen A, Kelly JA, Adler A, Acevedo-Vazquez E, Cucho JM, la Torre IG, Cardiel MH, Miranda P, Catoggio L,.. Arthritis Rheumatol. 2016;68(4):932-943.

APOL1 genotype and kidney transplantation outcomes from deceased African American donors. Freedman BI, Pastan SO, Israni AK, Schladt D, Julian BA, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Bowden DW, Hicks PJ, Palmer ND,.. Transplantation. 2016;100(1):194-202.

Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Deng Y, Zhao J, Sakurai D, Sestak AL, Osadchiy V, Langefeld CD, Kaufman KM, Kelly JA, James JA, Petri MA, Bae SC, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Criswell LA, Freedman BI, Kamen DL, Gilkeson GS, Jacob CO, Merrill JT, Gaffney PM, Sivils KM,.. Ann Rheum Dis. 2016;75(11):2007-2013.

Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

Analysis of advanced glycation end products in the DHS Mind Study. Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW.. J Diabetes Complications. 2016;30(2):262-268.

Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage. Woo D, Kruger AJ, Sekar P, Haverbusch M, Osborne J, Moomaw CJ, Martini S, Hosseini SM, Ferioli S, Worrall BB, Elkind MS, Sung G, James ML, Testai FD, Langefeld CD, Broderick JP, Koch S, Flaherty ML.. Neurology. 2016;86(10):905-911.

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A,.. Nat Commun. 2016;7():10023.

Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry. Prahalad S, McCracken CE, Ponder LA, Angeles-Han ST, Rouster Stevens KA, Vogler LB, Langefeld CD, Thompson SD.. Pediatr Rheumatol Online J. 2016;14(1):14.

Genetic analysis of advanced glycation end products in the DHS MIND study. Adams JN, Raffield LM, Martelle SE, Freedman BI, Langefeld CD, Carr JJ, Cox AJ, Bowden DW.. Gene. 2016;584(2):173-179.

Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility. Finkel TH, Li J, Wei Z, Wang W, Zhang H, Behrens EM, Reuschel EL, Limou S, Wise C, Punaro M, Becker ML, Munro JE, Flato B, Forre O, Thompson SD, Langefeld CD, Glass DN, Glessner JT, Kim CE, Frackelton E, Shivers DK, Thomas KA, Chiavacci RM,.. BMC Med Genet. 2016;17(1):24.

Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI.. Bone. 2016;87():71-77.

APOL1 renal-risk genotypes associate with longer hemodialysis survival in prevalent nondiabetic African American patients with end-stage renal disease. Ma L, Langefeld CD, Comeau ME, Bonomo JA, Rocco MV, Burkart JM, Divers J, Palmer ND, Hicks PJ, Bowden DW, Lea JP, Krisher JO, Clay MJ, Freedman BI.. Kidney Int. 2016;90(2):389-395.

Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). Williams RC, Elston RC, Kumar P, Knowler WC, Abboud HE, Adler S, Bowden DW, Divers J, Freedman BI, Igo RP Jr, Ipp E, Iyengar SK, Kimmel PL, Klag MJ, Kohn O, Langefeld CD, Leehey DJ, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Rotter JI, Schelling JR,.. BMC Genomics. 2016;17(1):325.

Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM,.. Hum Genet. 2016;135(8):869-880.

Trans-ethnic meta-analysis and functional annotation illuminates the genetic architecture of fasting glucose and insulin. Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen WM, Dauriz M,.. Am J Hum Genet. 2016;99(1):56-75.

Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes. Yuan M, Hsu FC, Bowden DW, Xu J, Carrie Smith S, Wagenknecht LE, Comeau ME, Divers J, Register TC, Jeffrey Carr J, Langefeld CD, Freedman BI.. Obesity (Silver Spring). 2016;24(8):1810-1818.

Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch DA, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS,.. BMC Genet. 2016;17(1):74.

Identification of a systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. Lessard CJ, Sajuthi S, Zhao J, Kim K, Ice JA, Li H, Ainsworth H, Rasmussen A, Kelly JA, Marion M, Bang SY, Bin Joo Y, Choi J, Lee HS, Mo Kang Y, Suh CH, Tae Chung W, Lee SK, Choe JY, Cheol Shim S, Hee Oh J, Jin Kim Y, Han BG, Shen N, Siew Howe H,.. Arthritis Rheumatol. 2016;68(5):1197-1209.

Improved performance of dynamic measures of insulin response over surrogate indices to identify genetic contributors of type 2 diabetes: the GUARDIAN Consortium. Palmer ND, Wagenknecht LE, Langefeld CD, Wang N, Buchanan TA, Xiang AH, Allayee H, Bergman RN, Raffel LJ, Chen YD, Haritunians T, Fingerlin T, Goodarzi MO, Taylor KD, Rotter JI, Watanabe RM, Bowden DW.. Diabetes. 2016;65(7):2072-2080.

APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume. Freedman BI, Gadegbeku CA, Bryan RN, Palmer ND, Hicks PJ, Ma L, Rocco MV, Smith SC, Xu J, Whitlow CT, Wagner BC, Langefeld CD, Hawfield AT, Bates JT, Lerner AJ, Raj DS, Sadaghiani MS, Toto RD, Wright JT Jr, Bowden DW, Williamson JD, Sink KM,.. Kidney Int. 2016;90(2):440-449.

Racial-ethnic disparities in acute blood pressure after intracerebral hemorrhage. Koch S, Elkind MS, Testai FD, Brown WM, Martini S, Sheth KN, Chong JY, Osborne J, Moomaw CJ, Langefeld CD, Sacco RL, Woo D.. Neurology. 2016;87(8):786-791.

Novel genetic variants associated with increased vertebral volumetric BMD, reduced vertebral fracture risk, and increased expression of SLC1A3 and EPHB2. Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P,.. J Bone Miner Res. 2016;31(12):2085-2097.

Bone mineral density and progression of subclinical atherosclerosis in African Americans with type 2 diabetes. Wagenknecht LE, Divers J, Register TC, Russell GB, Bowden DW, Xu J, Langefeld CD, Lenchik L, Hruska KA, Carr JJ, Freedman BI.. J Clin Endocrinol Metab. 2016;101(11):4135-4141.

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes. Hsu FC, Yuan M, Bowden DW, Xu J, Smith SC, Wagenknecht LE, Langefeld CD, Divers J, Register TC, Carr JJ, Williamson JD, Sink KM, Maldjian JA, Freedman BI.. J Diabetes Complications. 2016;30(8):1506-1512.

Omics analysis of adiponectin in African Americans to elucidate the biology underlying metabolic disease [abstract]. Palmer ND, Sajuthi S, Sharma N, Chou J, Bowden DW, Freedman BI, Langefeld CD, Das SK.. In: Abstracts of the 2016 Annual Meeting of the American Diabetes Association; 2016 June 10-14; New Orleans (LA). 2016;():2461.

Genetic variants in CETP increase risk of intracerebral hemorrhage. Anderson CD, Falcone GJ, Phuah CL, Radmanesh F, Brouwers HB, Battey TW, Biffi A, Peloso GM, Liu DJ, Ayres AM, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Flaherty ML, Kraft P,.. Ann Neurol. 2016;80(5):730-740.

Untreated hypertension: a powerful risk factor for lobar and nonlobar intracerebral hemorrhage in whites, blacks, and hispanics. Walsh KB, Woo D, Sekar P, Osborne J, Moomaw CJ, Langefeld CD, Adeoye O.. Circulation. 2016;134(19):1444-1452.

APOL1 renal-risk variants induce mitochondrial dysfunction. Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI.. J Am Soc Nephrol. 2016;():.

In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells. Rodman C, Almeida-Porada G, George SK, Moon J, Soker S, Pardee T, Beaty M, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD.. Leukemia. 2016;():.

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications. Ombrello MJ, Arthur VL, Remmers EF, Hinks A, Tachmazidou I, Grom AA, Foell D, Martini A, Gattorno M, Ozen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg AM, Wedderburn LR,.. Ann Rheum Dis. 2016;():.

Genetic variation at 16q24.2 is associated with small vessel stroke. Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT Jr, Ikram MA, Launer LJ, Seshadri S,.. Ann Neurol. 2016;():.

Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases. Hinks A, Bowes J, Cobb J, Ainsworth HC, Marion MC, Comeau ME, Sudman M, Han B, Becker ML, Bohnsack JF, de Bakker P, Haas JP, Hazen M, Lovell DJ, Nigrovic PA, Nordal E, Punnaro M, Rosenberg AM, Rygg M, Smith SL, Wise CA, Videm V,.. Ann Rheum Dis. 2016;76(4):765-772.

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. Langefeld CD, Divers J, Pajewski NM, Hawfield AT, Reboussin DM, Bild DE, Kaysen GA, Kimmel PL, Raj DS, Ricardo AC, Wright JT Jr, Sedor JR, Rocco MV, Freedman BI.. Kidney Int. 2015;87(1):169-175.

APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J.. Kidney Int. 2015;87(1):176-181.

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, Hirschfield GM, Xie G, Coltescu C, Amos C, Li H, Ice JA, Nath SK, Mariette X, Bowman S,.. Hum Mol Genet. 2015;24(2):582-596.

Lack of association of the APOL1 G3 haplotype in African Americans with ESRD. Palmer ND, Ng MC, Langefeld CD, Divers J, Lea JP, Okusa MD, Kimberly RP, Bowden DW, Freedman BI.. J Am Soc Nephrol. 2015;26(5):1021-1025.

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. Kariuki SN, Ghodke-Puranik Y, Dorschner JM, Chrabot BS, Kelly JA, Tsao BP, Kimberly RP, Alarcon-Riquelme ME, Jacob CO, Criswell LA, Sivils KL, Langefeld CD, Harley JB, Skol AD, Niewold TB.. Genes Immun. 2015;16(1):15-23.

Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW.. Hum Genet. 2015;134(2):203-213.

Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Palmer ND, Goodarzi MO, Langefeld CD, Wang N, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH , Haritunians T, Ziegler JT, Williams AH, Stefansovski D, Cui J, Mackay AW, Henkin LF, Bergman RN, Gao X, Gauderman J, Varma R, Hanis CL,.. Diabetes. 2015;64(5):1853-1866.

Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW.. Neurobiol Aging. 2015;36(3):1602.e7-15.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Carl D. Langefeld, Ph.D.

Carl D. Langefeld, Ph.D.

Section Head, Biostatistical Sciences
Professor, Biostatistical Sciences

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