Paul J. Laurienti, M.D., Ph.D.Wake Forest School of Medicine

Paul J. Laurienti, M.D., Ph.D.


Contact Information

Academic: 336-716-3261 | Department: 336-760-3261


Education & Training

  • B.S., University of Houston, 1991
  • Ph.D., University of Texas Medical School-Galveston, 1995
  • M.D., University of Texas Medical School-Galveston, 1999
  • Fellowship, University of Texas Medical Sc, 1995
  • Residency, Radiology, North Carolina Baptist Hospita, 1999
  • Fellowship, WFU School of Medicine, 2000


  • Sigma Xi Society
  • Soc Of Neuroscience
  • Western Nc Chpt Soc For Neuros
Paul J. Laurienti, M.D., Ph.D.

Paul J. Laurienti, M.D., Ph.D.

Professor, Radiology
Sticht Center on Aging
Center for Diabetes Research
Center for Integrative Medicine
Translational Science Institute

Research Interests

aging, alternative medicine, cognition/learning, cross(mult/tnslat/inter)discip, degenerative disorders, fitness/physical, mental disorders/psychiatry/ps, neurosciences/behavior, nutrition, radiology imaging/nuclear medi, substance abuse

Contact Information

Academic: 336-716-3261 | Department: 336-760-3261


Recent Publications

Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ. Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Front Aging Neurosci. 2015;6():341.

Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, Kim-Shapiro DB. Mechanisms of human erythrocytic bioactivation of nitrite. J Biol Chem. 2015;290(2):1281-1294.

Simpson SL, Laurienti PJ. A two-part mixed-effects modeling framework for analyzing whole-brain network data. Neuroimage. 2015;113():310-319.

Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ. Changes in brain network efficiency and working memory performance in aging. PLoS One. 2015;10(4):e0123950.

Telesford QK, Laurienti PJ, Davenport AT, Friedman DP, Kraft RA, Daunais JB. The effects of chronic alcohol self-administration in nonhuman primate brain networks. Alcohol Clin Exp Res. 2015;39(4):659-671.

Paolini BM, Laurienti PJ, Simpson SL, Burdette JH, Lyday RG, Rejeski WJ. Global integration of the hot-state brain network of appetite predicts short term weight loss in older adult. Front Aging Neurosci. 2015;7():70.

Moussa MN, Wesley MJ, Porrino LJ, Hayasaka S, Bechara A, Burdette JH, Laurienti PJ. Age-related differences in advantageous decision making are associated with distinct differences in functional community structure. Brain Connect. 2014;4(3):193-202.

Paolini BM, Laurienti PJ, Norris J, Rejeski WJ. Meal replacement: calming the hot-state brain network of appetite. Front Psychol. 2014;5():249.

Paolini B, Rejeski J, Laurienti P. The role of meal replacements in regulating the hedonic brain network of appetite [abstract]. J Altern Complement Med. 2014;20(5):A31.

Hugenschmidt CE, Burdette JH, Morgan AR, Williamson JD, Kritchevsky SB, Laurienti PJ. Graph theory analysis of functional brain networks and mobility disability in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(11):1399-1406.

Laurienti PJ. Neural murmurations: comment on "understanding brain networks and brain organization" by Luiz Pessoa [editorial]. Phys Life Rev. 2014;11(3):452-454.

Marsh AP, Klebous CL, Laurienti PJ, Kim-Shapiro DB, Rejeski WJ, Robertson TP, Redman H. Daily beet root juice supplement and exercise training in older hypertensive adults [abstract]. Med Sci Sports Exerc. 2014;46(5 Suppl 1):665.

Wilkins RW, Hodges DA, Laurienti PJ, Steen M, Burdette JH. Network science and the effects of music preference on functional brain connectivity: from Beethoven to Eminem. Sci Rep. 2014;4():6130.

Stanley ML, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ. Changes in global and regional modularity associated with increasing working memory load. Front Hum Neurosci. 2014;8():954.

Shaltout HA, Marsh AP, Laurienti P, Basu S, Klebous CC, Kus N, Morgan A, DosSantos PC, Norris JL, Miller G, Rejeski J, Hawfield AT, Diz DI, Kim-Shapiro DB. Effect of adding beet root juice to exercise on physical performance and cardiovascular measures in old hypertensive subjects [abstract]. Hypertension. 2014;64(Suppl 1):A462.

Joyce KE, Hayasaka S, Laurienti PJ. The human functional brain network demonstrates structural and dynamical resilience to targeted attack. PLoS Comput Biol. 2013;9(1):e1002885.

Telesford QK, Burdette JH, Laurienti PJ. An exploration of graph metric reproducibility in complex brain networks. Front Neurosci. 2013;7():67.

Rzucidlo JK, Roseman PL, Laurienti PJ, Dagenbach D. Stability of whole brain and regional network topology within and between resting and cognitive states. PLoS One. 2013;8(8):e70275.

Simpson SL, Bowman FD, Laurienti PJ. Analyzing complex functional brain networks: fusing statistics and network science to understand the brain. Stat Surv. 2013;7():1-36.

Simpson SL, Lyday RG, Hayasaka S, Marsh AP, Laurienti PJ. A permutation testing framework to compare groups of brain networks. Front Comput Neurosci. 2013;7():171.

Telesford QK, Laurienti PJ, Friedman DP, Kraft RA, Daunais JB. The effects of alcohol on the nonhuman primate brain: a network science approach to neuroimaging. Alcohol Clin Exp Res. 2013;37(11):1891-1900.

Voss MW, Wong CN, Baniqued PL, Burdette JH, Erickson KI, Prakash RS, McAuley E, Laurienti PJ, Kramer AF. Aging brain from a network science perspective: something to be positive about?. PLoS One. 2013;8(11):e78345.

Bullins J, Laurienti PJ, Morgan AR, Norris J, Paolini BM, Rejeski WJ. Drive for consumption, craving, and connectivity in the visual cortex during the imagery of desired food. Front Aging Neurosci. 2013;5():77.

Stanley ML, Moussa MN, Paolini BM, Lyday RG, Burdette JH, Laurienti PJ. Defining nodes in complex brain networks. Front Comput Neurosci. 2013;7():169.

Simpson SL, Moussa MN, Laurienti PJ. An exponential random graph modeling approach to creating group-based representative whole-brain connectivity networks. Neuroimage. 2012;60(2):1117-1126.

Li XX, Long XJ, Laurienti P, Wyatt C. Registration of images with varying topology using embedded maps. IEEE Trans Med Imaging. 2012;31(3):749-765.

Addicott MA, Peiffer AM, Laurienti PJ. The effects of dietary caffeine use and abstention on blood oxygen level-dependent activation and cerebral blood flow. J Caffeine Res. 2012;2(1):15-22.

Rejeski WJ, Burdette J, Burns M, Morgan AR, Hayasaka S, Norris J, Williamson DA, Laurienti PJ. Power of food moderates food craving, perceived control, and brain networks following a short-term post-absorptive state in older adults. Appetite. 2012;58(3):806-813.

Laurienti PJ. Commentary: from neuron to brain: relating neurophysiological principles of multisensory integration to the human brain In: Stein BE, ed. The new handbook of multisensory processing. Cambridge (MA): MIT Press;2012: 171-178.

Paolini B, Burdette JH, Laurienti PJ, Morgan AR, Williamson DA, Rejeski WJ. Coping with brief periods of food restriction: mindfulness matters. Front Aging Neurosci. 2012;4():article 13.

Joyce KE, Laurienti PJ, Hayasaka S. Complexity in a brain-inspired agent-based model. Neural Netw. 2012;33():275-290.

Telesford QK, Davenport AT, Kraft RA, Laurienti PJ, Daunais JB. Dynamic changes in the brain due to acute ethanol exposure in non-human primate brain networks [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):268A.

Joyce KE, Hayaska S, Laurienti PJ. A genetic algorithm for controlling an agent-based model of the functional human brain. Biomed Sci Instrum. 2012;48():210-217.

Moussa MN, Steen MR, Laurienti PJ, Hayasaka S. Consistency of network modules in resting-state FMRI connectome data. PLoS One. 2012;7(8):e44428.

Wilkins RW, Hodges DA, Laurienti PJ, Steen MR, Burdette JH. Network science: a new method for investigating the complexity of musical experiences in the brain. Leonardo. 2012;45(3):282-283.

Presley TD, Morgan AR, Bechtold E, Clodfelter W, Dove RW, Jennings JM, Kraft RA, King SB, Laurienti PJ, Rejeski WJ, Burdette JH, Kim-Shapiro DB, Miller GD. Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide. 2011;24(1):34-42.

Simpson SL, Hayasaka S, Laurienti PJ. Exponential random graph modeling for complex brain networks. PLoS ONE. 2011;6(5):e20039.

Hayasaka S, Hugenschmidt CE, Laurienti PJ. A network of genes, genetic disorders, and brain areas. PLoS ONE. 2011;6(6):e20907.

Hanlon CA, Wesley MJ, Stapleton JR, Laurienti PJ, Porrino LJ. The association between frontal-striatal connectivity and sensorimotor control in cocaine users. Drug Alcohol Depend. 2011;115(3):240-243.

Peiffer AM, Hugenschmidt CE, Laurienti PJ. Ethics in 15 min per week. Sci Eng Ethics. 2011;17(2):289-297.

Miller G, Tennille P, Morgan A, Rejeski WJ, King SB, Jennings J, Kraft R, Laurienti P, Burdette J, Kim-Shapiro D. Acute effect of a high nitrate diet on brain perfusion in older adults [abstract]. Nitric Oxide. 2011;24(Suppl):S28.

Mozolic JL, Long AB, Morgan AR, Rawley-Payne M, Laurienti PJ. A cognitive training intervention improves modality-specific attention in a randomized controlled trial of healthy older adults. Neurobiol Aging. 2011;32(4):655-668.

Laurienti PJ, Joyce KE, Telesford QK, Burdette JH, Hayasaka S. Universal fractal scaling of self-organized networks. Physica A. 2011;390(20):3608-3613.

Steen M, Hayasaka S, Joyce K, Laurienti P. Assessing the consistency of community structure in complex networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2011;84(1 Pt 2):016111.

Moussa MN, Vechlekar CD, Burdette JH, Steen MR, Hugenschmidt CE, Laurienti PJ. Changes in cognitive state alter human functional brain networks. Front Hum Neurosci. 2011;5():article 83.

Telesford QK, Simpson SL, Burdette JH, Hayasaka S, Laurienti PJ. The brain as a complex system: using network science as a tool for understanding the brain. Brain Connect. 2011;1(4):295-308.

Telesford QK, Wyatt CL, Kraft RA, Friedman DP, Laurienti PJ, Daunais JB. The effects of acute and chronic ethanol exposure in nonhuman primate brain networks [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):126A.

Mozolic JL, Hugenschmidt CE, Peiffer AM, Laurienti PJ. Multisensory integration and aging In: Murray MM, Wallace MT, eds. The neural basis of multisensory processes. Boca Raton (FL): CRC Press;2011: 381-395.

Steen M, Hayasaka S, Lobanov O, Laurienti P, Coghill R. Individual differences in brain networks during pain processing: a method for assessing modularity [abstract]. In: Human Brain Mapping 17th Annual Meeting Abstracts; 2011 June 26-30; Quebec City (Canada). 2011;():774.

Telesford QK, Joyce KE, Hayasaka S, Burdette JH, Laurienti PJ. The ubiquity of small-world networks. Brain Connect. 2011;1(5):367-375.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Radiology

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