Paul J. Laurienti, M.D., Ph.D.Wake Forest School of Medicine

Paul J. Laurienti, M.D., Ph.D.


Contact Information

Academic: 336-716-3261 | Department: 336-760-1286


Education & Training

  • B.S., University of Houston, 1991
  • Ph.D., University of Texas Medical School-Galveston, 1995
  • M.D., University of Texas Medical School-Galveston, 1999
  • Fellowship, University of Texas Medical Sc, 1995
  • Residency, Radiology, North Carolina Baptist Hospita, 1999
  • Fellowship, WFU School of Medicine, 2000


  • Sigma Xi Society
  • Soc Of Neuroscience
  • Western Nc Chpt Soc For Neuros
Paul J. Laurienti, M.D., Ph.D.

Paul J. Laurienti, M.D., Ph.D.

Professor, Radiology
Sticht Center on Aging
Center for Diabetes Research
Center for Integrative Medicine
Translational Science Institute

Research Interests

aging, alternative medicine, cognition/learning, cross(mult/tnslat/inter)discip, degenerative disorders, fitness/physical, mental disorders/psychiatry/ps, neurosciences/behavior, nutrition, substance abuse

Contact Information

Academic: 336-716-3261 | Department: 336-760-1286


Recent Publications

Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ. Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Front Aging Neurosci. 2015;6():341.

Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, Kim-Shapiro DB. Mechanisms of human erythrocytic bioactivation of nitrite. J Biol Chem. 2015;290(2):1281-1294.

Simpson SL, Laurienti PJ. A two-part mixed-effects modeling framework for analyzing whole-brain network data. Neuroimage. 2015;113():310-319.

Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ. Changes in brain network efficiency and working memory performance in aging. PLoS One. 2015;10(4):e0123950.

Telesford QK, Laurienti PJ, Davenport AT, Friedman DP, Kraft RA, Daunais JB. The effects of chronic alcohol self-administration in nonhuman primate brain networks. Alcohol Clin Exp Res. 2015;39(4):659-671.

Moussa MN, Wesley MJ, Porrino LJ, Hayasaka S, Bechara A, Burdette JH, Laurienti PJ. Age-related differences in advantageous decision making are associated with distinct differences in functional community structure. Brain Connect. 2014;4(3):193-202.

Paolini BM, Laurienti PJ, Norris J, Rejeski WJ. Meal replacement: calming the hot-state brain network of appetite. Front Psychol. 2014;5():249.

Paolini B, Rejeski J, Laurienti P. The role of meal replacements in regulating the hedonic brain network of appetite [abstract]. J Altern Complement Med. 2014;20(5):A31.

Hugenschmidt CE, Burdette JH, Morgan AR, Williamson JD, Kritchevsky SB, Laurienti PJ. Graph theory analysis of functional brain networks and mobility disability in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(11):1399-1406.

Marsh AP, Klebous CL, Laurienti PJ, Kim-Shapiro DB, Rejeski WJ, Robertson TP, Redman H. Daily beet root juice supplement and exercise training in older hypertensive adults [abstract]. Med Sci Sports Exerc. 2014;46(5 Suppl 1):665.

Wilkins RW, Hodges DA, Laurienti PJ, Steen M, Burdette JH. Network science and the effects of music preference on functional brain connectivity: from Beethoven to Eminem. Sci Rep. 2014;4():6130.

Stanley ML, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ. Changes in global and regional modularity associated with increasing working memory load. Front Hum Neurosci. 2014;8():954.

Joyce KE, Hayasaka S, Laurienti PJ. The human functional brain network demonstrates structural and dynamical resilience to targeted attack. PLoS Comput Biol. 2013;9(1):e1002885.

Telesford QK, Burdette JH, Laurienti PJ. An exploration of graph metric reproducibility in complex brain networks. Front Neurosci. 2013;7():67.

Rzucidlo JK, Roseman PL, Laurienti PJ, Dagenbach D. Stability of whole brain and regional network topology within and between resting and cognitive states. PLoS One. 2013;8(8):e70275.

Simpson SL, Lyday RG, Hayasaka S, Marsh AP, Laurienti PJ. A permutation testing framework to compare groups of brain networks. Front Comput Neurosci. 2013;7():171.

Telesford QK, Laurienti PJ, Friedman DP, Kraft RA, Daunais JB. The effects of alcohol on the nonhuman primate brain: a network science approach to neuroimaging. Alcohol Clin Exp Res. 2013;37(11):1891-1900.

Voss MW, Wong CN, Baniqued PL, Burdette JH, Erickson KI, Prakash RS, McAuley E, Laurienti PJ, Kramer AF. Aging brain from a network science perspective: something to be positive about?. PLoS One. 2013;8(11):e78345.

Bullins J, Laurienti PJ, Morgan AR, Norris J, Paolini BM, Rejeski WJ. Drive for consumption, craving, and connectivity in the visual cortex during the imagery of desired food. Front Aging Neurosci. 2013;5():77.

Stanley ML, Moussa MN, Paolini BM, Lyday RG, Burdette JH, Laurienti PJ. Defining nodes in complex brain networks. Front Comput Neurosci. 2013;7():169.

Li XX, Long XJ, Laurienti P, Wyatt C. Registration of images with varying topology using embedded maps. IEEE Trans Med Imaging. 2012;31(3):749-765.

Addicott MA, Peiffer AM, Laurienti PJ. The effects of dietary caffeine use and abstention on blood oxygen level-dependent activation and cerebral blood flow. J Caffeine Res. 2012;2(1):15-22.

Rejeski WJ, Burdette J, Burns M, Morgan AR, Hayasaka S, Norris J, Williamson DA, Laurienti PJ. Power of food moderates food craving, perceived control, and brain networks following a short-term post-absorptive state in older adults. Appetite. 2012;58(3):806-813.

Laurienti PJ. Commentary: from neuron to brain: relating neurophysiological principles of multisensory integration to the human brain In: Stein BE, ed. The new handbook of multisensory processing. Cambridge (MA): MIT Press;2012: 171-178.

Paolini B, Burdette JH, Laurienti PJ, Morgan AR, Williamson DA, Rejeski WJ. Coping with brief periods of food restriction: mindfulness matters. Front Aging Neurosci. 2012;4():article 13.

Joyce KE, Laurienti PJ, Hayasaka S. Complexity in a brain-inspired agent-based model. Neural Netw. 2012;33():275-290.

Telesford QK, Davenport AT, Kraft RA, Laurienti PJ, Daunais JB. Dynamic changes in the brain due to acute ethanol exposure in non-human primate brain networks [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):268A.

Joyce KE, Hayaska S, Laurienti PJ. A genetic algorithm for controlling an agent-based model of the functional human brain. Biomed Sci Instrum. 2012;48():210-217.

Moussa MN, Steen MR, Laurienti PJ, Hayasaka S. Consistency of network modules in resting-state FMRI connectome data. PLoS One. 2012;7(8):e44428.

Wilkins RW, Hodges DA, Laurienti PJ, Steen MR, Burdette JH. Network science: a new method for investigating the complexity of musical experiences in the brain. Leonardo. 2012;45(3):282-283.

Presley TD, Morgan AR, Bechtold E, Clodfelter W, Dove RW, Jennings JM, Kraft RA, King SB, Laurienti PJ, Rejeski WJ, Burdette JH, Kim-Shapiro DB, Miller GD. Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide. 2011;24(1):34-42.

Simpson SL, Hayasaka S, Laurienti PJ. Exponential random graph modeling for complex brain networks. PLoS ONE. 2011;6(5):e20039.

Hayasaka S, Hugenschmidt CE, Laurienti PJ. A network of genes, genetic disorders, and brain areas. PLoS ONE. 2011;6(6):e20907.

Hanlon CA, Wesley MJ, Stapleton JR, Laurienti PJ, Porrino LJ. The association between frontal-striatal connectivity and sensorimotor control in cocaine users. Drug Alcohol Depend. 2011;115(3):240-243.

Peiffer AM, Hugenschmidt CE, Laurienti PJ. Ethics in 15 min per week. Sci Eng Ethics. 2011;17(2):289-297.

Miller G, Tennille P, Morgan A, Rejeski WJ, King SB, Jennings J, Kraft R, Laurienti P, Burdette J, Kim-Shapiro D. Acute effect of a high nitrate diet on brain perfusion in older adults [abstract]. Nitric Oxide. 2011;24(Suppl):S28.

Mozolic JL, Long AB, Morgan AR, Rawley-Payne M, Laurienti PJ. A cognitive training intervention improves modality-specific attention in a randomized controlled trial of healthy older adults. Neurobiol Aging. 2011;32(4):655-668.

Laurienti PJ, Joyce KE, Telesford QK, Burdette JH, Hayasaka S. Universal fractal scaling of self-organized networks. Physica A. 2011;390(20):3608-3613.

Steen M, Hayasaka S, Joyce K, Laurienti P. Assessing the consistency of community structure in complex networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2011;84(1 Pt 2):016111.

Moussa MN, Vechlekar CD, Burdette JH, Steen MR, Hugenschmidt CE, Laurienti PJ. Changes in cognitive state alter human functional brain networks. Front Hum Neurosci. 2011;5():article 83.

Telesford QK, Simpson SL, Burdette JH, Hayasaka S, Laurienti PJ. The brain as a complex system: using network science as a tool for understanding the brain. Brain Connect. 2011;1(4):295-308.

Telesford QK, Wyatt CL, Kraft RA, Friedman DP, Laurienti PJ, Daunais JB. The effects of acute and chronic ethanol exposure in nonhuman primate brain networks [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):126A.

Mozolic JL, Hugenschmidt CE, Peiffer AM, Laurienti PJ. Multisensory integration and aging In: Murray MM, Wallace MT, eds. The neural basis of multisensory processes. Boca Raton (FL): CRC Press;2011: 381-395.

Steen M, Hayasaka S, Lobanov O, Laurienti P, Coghill R. Individual differences in brain networks during pain processing: a method for assessing modularity [abstract]. In: Human Brain Mapping 17th Annual Meeting Abstracts; 2011 June 26-30; Quebec City (Canada). 2011;():774.

Telesford QK, Joyce KE, Hayasaka S, Burdette JH, Laurienti PJ. The ubiquity of small-world networks. Brain Connect. 2011;1(5):367-375.

Hugenschmidt CE, Hayasaka S, Peiffer AM, Laurienti PJ. Applying capacity analyses to psychophysical evaluation of multisensory interactions. Inf Fusion. 2010;11(1 Special Issue):12-20.

Mozolic JL, Hayasaka S, Laurienti PJ. A cognitive training intervention increases resting cerebral blood flow in healthy older adults. Front Hum Neurosci. 2010;4():article 16.

Burdette JH, Laurienti PJ, Espeland MA, Morgan A, Telesford Q, Vechlekar CD, Hayasaka S, Jennings JM, Katula JA, Kraft RA, Rejeski WJ. Using network science to evaluate exercise-associated brain changes in older adults. Front Aging Neurosci. 2010;2():article 23.

Stein BE, Burr D, Constantinidis C, Laurienti PJ, Meredith MA, Perrault TJ Jr, Ramachandran R, Roder B, Rowland BA, Stanford TR, et al. Semantic confusion regarding the development of multisensory integration: a practical solution. Eur J Neurosci. 2010;31(10):1713-1720.

Joyce KE, Laurienti PJ, Burdette JH, Hayasaka S. A new measure of centrality for brain networks. PLoS ONE. 2010;5(8):e12200.

Telesford QK, Morgan AR, Hayasaka S, Simpson SL, Barret W, Kraft RA, Mozolic JL, Laurienti PJ. Reproducibility of graph metrics in fMRI networks. Front Neuroinform. 2010;4():117.

Presley TD, Morgan A, Bechtold E, Clodfelter W, Dove RW, Jennings JM, Kraft RA, King SB, Laurenti PJ[sic] [Laurienti PJ], Rejeski WJ, Burdette JH, Kim-Shapiro DB, Miller GD. Acute effect of a high nitrate diet on brain perfusion in older adults [abstract]. Free Radic Biol Med. 2010;49(Suppl 1):S119-S120.

Peiffer AM, Hugenschmidt CE, Maldjian JA, Casavona R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ. Aging and the interaction of sensory cortical function and structure. Hum Brain Mapp. 2009;30(1):228-240.

Maldjian JA, Baer AH, Kraft RA, Laurienti PJ, Burdette JH. Fully automated processing of fMRI data in SPM: from MRI scanner to PACS. Neuroinformatics. 2009;7(1):57-72.

Hugenschmidt CE, Mozolic JL, Laurienti PJ. Suppression of multisensory integration by modality-specific attention in aging. Neuroreport. 2009;20(4):349-353.

Addicott MA, Yang LL, Peiffer AM, Laurienti PJ. Methodological considerations for the quantification of self-reported caffeine use. Psychopharmacology (Berl). 2009;203(3):571-578.

Stein BE, Rowland B, Laurienti P, Stanford TR. Multisensory convergence and integration In: Squire LR, ed. Encyclopedia of neuroscience, vol 5. Berlin: Elsevier/Academic Press;2009: 1119-1124.

Hugenschmidt CE, Mozolic JL, Tan H, Kraft RA, Laurienti PJ. Age-related increase in cross-sensory noise in resting and steady-state cerebral perfusion. Brain Topogr. 2009;21(3-4):241-251.

Addicott MA, Yang LL, Peiffer AM, Burnett LR, Burdette JH, Chen MY, Hayasaka S, Kraft RA, Maldjian JA, Laurienti PJ. The effect of daily caffeine use on cerebral blood flow: how much caffeine can we tolerate?. Hum Brain Mapp. 2009;30(10):3102-3114.

Hugenschmidt CE, Peiffer AM, McCoy TP, Hayasaka S, Laurienti PJ. Preservation of crossmodal selective attention in healthy aging. Exp Brain Res. 2009;198(2-3):273-285.

Addicott MA, Laurienti PJ. A comparison of the effects of caffeine following abstinence and normal caffeine use. Psychopharmacology (Berl). 2009;207(3):423-431.

Peiffer AM, Hugenschmidt CE, Mozolic J, Laurienti PJ. Do structural MRI analyses show evidence for cognitive reserve in the healthy aging brain? [abstract]. Gerontologist. 2009;49(Suppl 2):306.

Mozolic JL, Hugenschmidt CE, Peiffer AM, Laurienti PJ. Modality-specific selective attention attenuates multisensory integration. Exp Brain Res. 2008;184(1):39-52.

Hugenschmidt CE, Peiffer AM, Kraft RA, Casanova R, Deibler AR, Burdette JH, Maldjian JA, Laurienti PJ. Relating imaging indices of white matter integrity and volume in healthy older adults. Cereb Cortex. 2008;18(2):433-442.

Peiffer AM, Maldjian JA, Laurienti PJ. Resurrecting Brinley plots for a novel use: meta-analyses of functional brain imaging data in older adults. Int J Biomed Imaging. 2008;2008():.

Casanova R, Ryali S, Serences J, Yang L, Kraft R, Laurienti PJ, Maldjian JA. The impact of temporal regularization on estimates of the BOLD hemodynamic response function: a comparative analysis. Neuroimage. 2008;40(4):1606-1618.

Maldjian JA, Laurienti PJ, Burdette JH, Kraft RA. Clinical implementation of spin-tag perfusion magnetic resonance imaging. J Comput Assist Tomogr. 2008;32(3):403-406.

Mozolic JL, Joyner D, Hugenschmidt CE, Peiffer AM, Kraft RA, Maldjian JA, Laurienti PJ. Cross-modal deactivations during modality-specific selective attention. BMC Neurol. 2008;8():article 35.

Peiffer AM, Laurienti PJ, Hugenschmidt CE. Fostering a culture of responsible lab conduct [letter]. Science. 2008;322(5905):1186.

Mozolic J, Morgan A, Laurienti P. Cognitive training impacts brain structure and function of healthy older adults in a randomized controlled trial [abstract]. Gerontologist. 2008;48(Special Issue 3):492.

Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, Flowers L, Wood F, Maldjian JA. Biological parametric mapping: a statistical toolbox for multimodality brain image analysis. Neuroimage. 2007;34(1):137-143.

Peiffer AM, Mozolic JL, Hugenschmidt CE, Laurienti PJ. Age-related multisensory enhancement in a simple audiovisual detection task. Neuroreport. 2007;18(10):1077-1081.

Hayasaka S, Peiffer AM, Hugenschmidt CE, Laurienti PJ. Power and sample size calculation for neuroimaging studies by non-central random field theory. Neuroimage. 2007;37(3):721-730.

Laurienti PJ, Burdette JH, Maldjian JA, Wallace MT. Enhanced multisensory integration in older adults. Neurobiol Aging. 2006;27(8):1155-1163.

Srikanth R, Casanova R, Laurienti PJ, Peiffer AM, Maldjian JA. Estimation of false discovery rates for wavelet-denoised statistical parametric maps. Neuroimage. 2006;33(1):72-84.

Wyatt CL, Laurienti PJ. Nonrigid registration of images with different topologies using embedded maps. Conf Proc IEEE Eng Med Biol Soc. 2006;1():4823-4827.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Radiology

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