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Profile

Profile
Research

Cynthia J. Lees, D.V.M., Ph.D.

Assistant Professor, Pathology-Comparative Medicine
Translational Science Institute
WFU Primate Center
Translational Science Institute
Orthopaedics

Contact Information

Academic: 336-716-1590 | Department: 336-716-1590

Email: clees@wakehealth.edu

Education & Training

Ph.D., WFU School of Medicine , 1997
B.S., Penn State University , 1979
D.V.M., North Carolina State University , 1988
Fellowship, WFU School of Medicine, 1994

Memberships

Am Soc Of Bone & Mineral Resea
Endocrine Society

Cynthia J. Lees, D.V.M., Ph.D.

Assistant Professor, Pathology-Comparative Medicine Translational Science Institute
WFU Primate Center
Translational Science Institute
Orthopaedics

Contact Information

Academic: 336-716-1590 | Department: 336-716-1590

Email: clees@wakehealth.edu

Recent Publications

Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res. 2012;72(11):2833-2843.

Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat. 2012;133(2):617-634.

Zhou X, Zhu D, Qi X-L, Palaninathan K, Lees CJ, Bennett AJ, Salinas E, Stanford TR, Constantinidis C. Antisaccade performance and neural activity in the prefrontal cortex of juvenile monkeys [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Lees CJ, Temel RE, et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature. 2011;478(7369):404-407.

Temel RE, Rayner KJ, Esau CC, McDaniel AL, Marshall SM, Lees CJ, van Gils JM, Fernandez-Hernando C, Fisher EA, Moore KJ. Inhibition of miR-33a and b in non-human primates raises plasma HDL cholesterol and reduces VLDL triglycerides [abstract]. Circulation. 2011;124(21 Suppl):A13280.

Kaplan JR, Chen H, Appt SE, Lees CJ, Franke AA, Berga SL, Wilson ME, Manuck SB, Clarkson TB. Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet. Hum Reprod. 2010;25(12):3083-3094.

Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol. 2009;16(1):21-28.

Wood CE, Lees CJ, Cline JM. Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone. Menopause. 2009;16(3):466-476.

Wagner JD, Jorgensen MJ, Cline JM, Lees CJ, Franke AA, Zhang L, Ayers MR, Schultz C, Kaplan JR. Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring. Am J Primatol. 2009;71(9):802-811.

Bennett A, Pierre PJ, Lees CJ, Hopkins WD, Corcoran CA. Translational study of the consequences of early life impoverishment on health across the lifespan [abstract]. Gerontologist. 2009;49(Suppl 2):66.

Barclay WW, Axanova LS, Chen W, Romero L, Maund SL, Soker S, Lees CJ, Cramer SD. Characterization of adult prostatic progenitor/stem cells exhibiting self-renewal and multilineage differentiation. Stem Cells. 2008;26(3):600-610.

Pierre PJ, Hopkins WD, Taglialatela JP, Lees CJ, Bennett AJ. Age-related neuroanatomical differences from the juvenile period to adulthood in mother-reared macaques (Macaca radiata). Brain Res. 2008;1226():56-60.

Cline JM, Botts S, Lees CJ, Brommage R. Effects of lasofoxifene on the uterus, vagina, and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis). Am J Obstet Gynecol. 2008;199(2):158.e1-e8.

Lees CJ, Cline M. Effects of diet and menstrual cyclicity on bone mass accumulation in pubertal monkeys [abstract]. J Bone Miner Res. 2008;23(Suppl):S502.

Ivester P, Roberts LJ II, Young T, Vivian J, Lees C, Young J, Daunais J, Friedman D, Grant KA, Cunningham C, et al. Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. Alcohol Clin Exp Res. 2007;31(1):144-155.

Lees C, Shen V, Brommage R. Effects of lasofoxifene on bone in surgically postmenopausal cynomolgus monkeys. Menopause. 2007;14(1):97-105.

Sikoski P, Register TC, Lees CJ, Lundeen S, Hutchison J, Brown KH, Cline JM. Effects of two novel selective estrogen receptor modulators, raloxifene, tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis). Am J Obstet Gynecol. 2007;196(1):75.e1-7.

Wood CE, Register TC, Lees CJ, Chen H, Kimrey S, Cline JM. Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys. Breast Cancer Res Treat. 2007;101(2):125-134.

Lees CJ, Kaplan JR, Chen H, Jerome CP, Register TC, Franke AA. Bone mass and soy isoflavones in socially housed, premenopausal macaques. Am J Clin Nutr. 2007;86(1):245-250.

Wood CE, Sitruk-Ware RL, Tsong Y-Y, Register TC, Lees CJ, Cline JM. Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model. Menopause. 2007;14(4):639-647.

Shively CA, Wood CE, Register TC, Willard SL, Lees CJ, Chen H, Sitruk-Ware RL, Tsong Y-Y, Cline JM. Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys. Psychoneuroendocrinology. 2007;32(8-10):981-990.

Lees CJ, Chen H, Kaplan JR. Does pre- or post-menopausal soy consumption affect postmenopausal bone loss? [abstract]. J Bone Miner Res. 2007;22(Suppl 1):S431.

Stute P, Wood CE, Register TC, Lees CJ, Kiesel L, Sieberns K, Cline MJ [sic] [Cline JM]. Life stage differences in mammary gland gene expression profile [abstract]. Menopause. 2007;14(6):1081.

Wood CE, Lees CJ, Cline M. Effects of testosterone therapy in combination with oral estradiol and progesterone on breast proliferation and serum lipids in a postmenopausal primate model [abstract]. Menopause. 2007;14(6):1108.

Appt SE, Clarkson TB, Lees CJ, Anthony MS. Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys. Maturitas. 2006;55(2):187-194.

Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, Cline JM. Effects of high-dose soy lsoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod. 2006;75(3):477-486.