Xiaoyan Iris Leng, M.D., Ph.D.Wake Forest School of Medicine

Xiaoyan Iris Leng, M.D., Ph.D.

Associate Professor,

Clinical Interests

Clinical Trials

Contact Information

Academic: 336-716-4564 | Department: 336-716-2011


Additional Languages


Education & Training

  • M.D., Beijing Medical University-China, 1995
  • M.S., Beijing Medical University-China, 1998
  • M.S., University of California-Davis, 2001
  • Ph.D., University of California-Davis, 2004


  • Am Statistical Assoc
  • Institute Of Mathematical Stat
Xiaoyan Iris Leng, M.D., Ph.D.

Xiaoyan Iris Leng, M.D., Ph.D.

Associate Professor, Biostatistical Sciences
Center for Comparative Medicine Research
Sticht Center on Aging

Contact Information

Academic: 336-716-4564 | Department: 336-716-2011


Recent Publications

Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB. A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory study. Obesity (Silver Spring). 2015;23(1):77-84.

Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ. Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc. 2015;63(3):462-469.

Beavers DP, Pettinger M, Espeland MA, Snively BM, Leng X, Hunt JR, Tindle HA, Shumaker SA. The evolution of the WHI 80+ cohort. J Gerontol A Biol Sci Med Sci. 2015;():.

Chen JC, Espeland MA, Brunner RL, Lovato LC, Wallace RB, Leng X, Phillips LS, Robinson JG, Kotchen JM, Johnson KC, Manson JE, Stefanick ML, Sarto GE, Mysiw WJ. Sleep duration, cognitive decline, and dementia risk in older women. Alzheimers Dement. 2015;():.

Butler SG, Clark H, Baginski SG, Todd JT, Lintzenich C, Leng X. Computed tomography pulmonary findings in healthy older adult aspirators versus nonaspirators. Laryngoscope. 2014;124(2):494-497.

Bracey DN, Seyler TM, Shields JS, Leng X, Jinnah RH, Lang JE. A comparison of acetate and digital templating for hip resurfacing. Am J Orthop (Belle Mead NJ). 2014;43(1):E19-E24.

Nicklas BJ, Gaukstern JE, Beavers KM, Newman JC, Leng X, Rejeski WJ. Self-monitoring of spontaneous physical activity and sedentary behavior to prevent weight regain in older adults. Obesity (Silver Spring). 2014;22(6):1406-1412.

Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Int J Obes (Lond). 2014;38(11):1397-1402.

Liu CK, Leng X, Hsu FC, Kritchevsky SB, Ding J, Earnest CP, Ferrucci L, Goodpaster BH, Guralnik JM, Lenchik L, Pahor M, Fielding RA. The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). J Nutr Health Aging. 2014;18(1):59-64.

Sawaki L, Butler AJ, Leng X, Wassenaar PA, Mohammad YM, Blanton S, Sathian K, Nichols-Larsen DS, Wolf SL, Good DC, Wittenberg GF. Differential patterns of cortical reorganization following constraint-induced movement therapy during early and late period after stroke: a preliminary study. NeuroRehabilitation. 2014;35(3):415-426.

Lang R, Liu G, Shi Y, Bharadwaj S, Leng X, Zhou X, Liu H, Atala A, Zhang Y. Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS One. 2013;8(1):e53980.

Arcury TA, Chen H, Savoca MR, Anderson AM, Leng X, Bell RA, Quandt SA. Ethnic variation in oral health and social integration among older rural adults. J Appl Gerontol. 2013;32(3):302-323.

Whitt-Glover MC, Hunter JC, Foy CG, Quandt SA, Vitolins MZ, Leng I, Hornbuckle LM, Sanya KA, Bertoni AG. Translating the Dietary Approaches to Stop Hypertension (DASH) diet for use in underresourced, urban African American communities, 2010. Prev Chronic Dis. 2013;10():120088.

Espeland MA, Shumaker SA, Leng I, Manson JE, Brown CM, LeBlanc ES, Vaughan L, Robinson J, Rapp SR, Goveas JS, Wactawski-Wende J, Stefanick ML, Li W, Resnick SM. Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med. 2013;173(15):1429-1436.

Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA. Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Curr Gerontol Geriatr Res. 2013;():495793.

Houston DK, Bray GA, Hill JO, Jakicic JM Johnson KC, Leng X, Rejeski W, Kritchevsky SB. Impact of a long-term intensive lifestyle intervention on physical function: the action for health and memory study in diabetes movement [abstract]. Gerontologist. 2013;53(Suppl 1):389.

Ip EH, Zhang Q, Schwartz R, Tooze J, Leng X, Han H, Williamson DA. Multi-profile hidden Markov model for mood, dietary intake, and physical activity in an intervention study of childhood obesity. Stat Med. 2013;32(19):3314-3331.

Haring B, Leng X, Robinson J, Johnson KC, Jackson RD, Beyth R, Wactawski-Wende J, von Ballmoos MW, Goveas JS, Kuller LH, Wassertheil-Smoller S. Cardiovascular disease and cognitive decline in postmenopausal women: results from the Women's Health Initiative Memory Study. J Am Heart Assoc. 2013;2(6):e000369.

Haring B, Leng I, Robinson J, Johnson KC, Jacksons R, Beyth R, Wactawski-Wende J, von Ballmoos MW, Goveas J, Kuller LH, Wassertheil-Smoller S. Coronary heart disease is associated with cognitive decline in postmenopausal women: results from the Women's Health Initiative Memory Study [abstract]. Circulation. 2013;127(12 Suppl):AMP25.

Nicklas BJ, Gaukstern JE, Legault C, Leng I, Rejeski WJ. Intervening on spontaneous physical activity to prevent weight regain in older adults: design of a randomized, clinical trial. Contemp Clin Trials. 2012;33(2):450-455.

Nekl CG, Lintzenich CR, Leng X, Lever T, Butler SG. Effects of effortful swallow on esophageal function in healthy adults. Neurogastroenterol Motil. 2012;24(3):252-e108.

Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, Chou J, Leng X, Fetrow JS. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum. 2012;64(3):705-717.

Chapman DB, French CC, Leng X, Browne JD, Waltonen JD, Sullivan CA. Parathyroid hormone early percent change: an individualized approach to predict postthyroidectomy hypocalcemia. Am J Otolaryngol. 2012;33(2):216-220.

Butler SG, Lintzenich CR, Leng X, Stuart A, Feng X, Carr JJ, Kritchevsky SB. Tongue adiposity and strength in healthy older adults. Laryngoscope. 2012;122(7):1600-1604.

Arcury TA, Savoca MR, Anderson AM, Chen H, Gilbert GH, Bell RA, Leng X, Reynolds T, Quandt SA. Dental care utilization among North Carolina rural older adults. J Public Health Dent. 2012;72(3):190-197.

Stehle JR Jr, Leng X, Kitzman DW, Nicklas BJ, Kritchevsky SB, High KP. Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. J Gerontol A Biol Sci Med Sci. 2012;67(11):1212-1218.

Feng X, Xu Z, Butler SG, Leng I, Zhang T, Kritchevsky SB. Effects of aging and levodopa on the laryngeal adductor reflex in rats. Exp Gerontol. 2012;47(12):900-907.

Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Gilbert GH, Quandt SA. Impact of denture usage patterns on dietary quality and food avoidance among older adults. J Nutr Gerontol Geriatr. 2011;30(1):86-102.

Quandt SA, Savoca MR, Leng X, Chen H, Bell RA, Gilbert GH, Anderson AM, Kohrman T, Arcury TA. Dry mouth and dietary quality in older adults in North Carolina. J Am Geriatr Soc. 2011;59(3):439-445.

Darcy JM, Grzywacz JG, Stephens RL, Leng I, Clinch CR, Arcury TA. Maternal depressive symptomatology: 16-month follow-up of infant and maternal health-related quality of life. J Am Board Fam Med. 2011;24(3):249-257.

Liu C, Leng I, Kritchevsky S, Ding J, Earnest C, Ferrucci L, Goodpaster B, Guralnik J, Hsu F, Lenchik L, et al. The impact of sarcopenia on the response to a physical activity intervention in older adults [abstract]. J Am Geriatr Soc. 2011;59(Suppl 1):S63.

Maslan J, Leng X, Rees C, Blalock D, Butler SG. Maximum phonation time in healthy older adults. J Voice. 2011;25(6):709-713.

Butler SG, Maslan J, Stuart A, Leng X, Wilhelm E, Lintzenich CR, Williamson J, Kritchevsky SB. Factors influencing bolus dwell times in healthy older adults assessed endoscopically. Laryngoscope. 2011;121(12):2526-2534.

Stehle JR, Nicklas B, Kritchevsky SB, Kitzman DW, Leng X, High K. Association between microbial translocation and adiposity in healthy elderly adults [abstract]. Gerontologist. 2011;51(Suppl 2):490.

Quandt SA, Chen H, Bell RA, Savoca MR, Anderson AM, Leng X, Kohrman T, Gilbert GH, Arcury TA. Food avoidance and food modification practices of older rural adults: association with oral health status and implications for service provision. Gerontologist. 2010;50(1):100-111.

Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Frazier RJ, Gilbert GH, Quandt SA. Severe tooth loss in older adults as a key indicator of compromised dietary quality. Public Health Nutr. 2010;13(4):466-474.

Butler SG, Stuart A, Leng X, Rees C, Williamson J, Kritchevsky SB. The association between aspiration status and tongue and handgrip strength in healthy older adults [abstract]. J Am Geriatr Soc. 2010;58(Suppl 1):132.

Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Gilbert GH, Quandt SA. Association between dietary quality of rural older adults and self-reported food avoidance and food modification due to oral health problems. J Am Geriatr Soc. 2010;58(7):1225-1232.

Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic biostatistics: the statistical challenges of clinical research with older study participants. J Am Geriatr Soc. 2010;58(7):1386-1392.

Helderman JB, Welch CD, Leng X, O'Shea TM. Sepsis-associated electroencephalographic changes in extremely low gestational age neonates. Early Hum Dev. 2010;86(8):509-513.

Olex AL, Hiltbold EM, Leng X, Fetrow JS. Dynamics of dendritic cell maturation are identified through a novel filtering strategy applied to biological time-course microarray replicates. BMC Immunol. 2010;11():article 41.

Butler SG, Stuart A, Leng X, Rees C, Williamson J, Kritchevsky SB. Factors influencing aspiration during swallowing in healthy older adults. Laryngoscope. 2010;120(11):2147-2152.

Tucker JN, Grzywacz JG, Leng I, Clinch CR, Arcury TA. Return to work, economic hardship, and women's postpartum health. Women Health. 2010;50(7):618-638.

Butler SG, Stuart A, Leng I, Rees C, Williamson J, Kritchevsky S. The effect of aspiration status on tongue and handgrip strength in healthy older adults [abstract]. Dysphagia. 2010;25(4):360.

Butler SG, Stuart A, Leng I, Rees C, Williamson J, Kritchevsky S. Benchmark data for flexible endoscopic evaluation of swallowing [abstract]. Dysphagia. 2010;25(4):373.

Shumaker SA, Espeland MA, Leng X, Limacher M, Manson JE, Stefanick ML. Cognitive function and cognitive change on incident CCD: the WHI Memory Study (WHIMS) [abstract]. Gerontologist. 2010;50(Suppl 1):309.

Brinkley TE, Leng X, Miller ME, Kitzman DW, Pahor M, Berry MJ, Marsh AP, Kritchevsky SB, Nicklas BJ. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009;64(4):455-461.

Hartmann EL, Kitzman D, Rocco M, Leng X, Klepin H, Gordon M, Rejeski J, Berry M, Kritchevsky S. Physical function in older candidates for renal transplantation: an impaired population. Clin J Am Soc Nephrol. 2009;4(3):588-594.

Sink KM, Leng X, Williamson J, Kritchevsky SB, Yaffe K, Kuller L, Yasar S, Atkinson H, Robbins M, Goff DC Jr, et al. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study. Arch Intern Med. 2009;169(13):1195-1202.

Puntawagkoon C, Kitzman DW, Kritchevsky SB, Hamilton CA, Nicklas B, Leng X, Brubaker PH, Hundley WG. Exercise limb blood flow is reduced despite adequate cardiac output in elderly patients with heart failure [abstract]. J Card Fail. 2009;15(6 Suppl 1):S69.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Biostatistical Sciences

Clinical Interests

Clinical Trials

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