Research ›

Profile

Profile
Research

Xiaoyan Iris Leng, M.D., Ph.D.

Associate Professor, Department of Biostatistics
Sticht Center on Aging
WFU Primate Center

Clinical Specialties

Clinical Trials

Contact Information

Academic: 336-716-4564 | Department: 336-716-2011

Email: ileng@wakehealth.edu

Additional Languages

Chinese-Mandarin

Education & Training

M.D., Beijing Medical University-China , 1995
Ph.D., University of California-Davis , 2004
M.S., Beijing Medical University-China , 1998
M.S., University of California-Davis , 2001

Memberships

Am Statistical Assoc
Institute Of Mathematical Stat

Xiaoyan Iris Leng, M.D., Ph.D.

Associate Professor, Department of Biostatistics Sticht Center on Aging
WFU Primate Center

Contact Information

Academic: 336-716-4564 | Department: 336-716-2011

Email: ileng@wakehealth.edu

Recent Publications

Lang R, Liu G, Shi Y, Bharadwaj S, Leng X, Zhou X, Liu H, Atala A, Zhang Y. Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS One. 2013;8(1):e53980.

Arcury TA, Chen H, Savoca MR, Anderson AM, Leng X, Bell RA, Quandt SA. Ethnic variation in oral health and social integration among older rural adults. J Appl Gerontol. 2013;32(3):302-323.

Nicklas BJ, Gaukstern JE, Legault C, Leng I, Rejeski WJ. Intervening on spontaneous physical activity to prevent weight regain in older adults: design of a randomized, clinical trial. Contemp Clin Trials. 2012;33(2):450-455.

Nekl CG, Lintzenich CR, Leng X, Lever T, Butler SG. Effects of effortful swallow on esophageal function in healthy adults. Neurogastroenterol Motil. 2012;24(3):252-e108.

Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, Chou J, Leng X, Fetrow JS. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum. 2012;64(3):705-717.

Chapman DB, French CC, Leng X, Browne JD, Waltonen JD, Sullivan CA. Parathyroid hormone early percent change: an individualized approach to predict postthyroidectomy hypocalcemia. Am J Otolaryngol. 2012;33(2):216-220.

Butler SG, Lintzenich CR, Leng X, Stuart A, Feng X, Carr JJ, Kritchevsky SB. Tongue adiposity and strength in healthy older adults. Laryngoscope. 2012;122(7):1600-1604.

Arcury TA, Savoca MR, Anderson AM, Chen H, Gilbert GH, Bell RA, Leng X, Reynolds T, Quandt SA. Dental care utilization among North Carolina rural older adults. J Public Health Dent. 2012;72(3):190-197.

Stehle JR Jr, Leng X, Kitzman DW, Nicklas BJ, Kritchevsky SB, High KP. Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. J Gerontol A Biol Sci Med Sci. 2012;67(11):1212-1218.

Feng X, Xu Z, Butler SG, Leng I, Zhang T, Kritchevsky SB. Effects of aging and levodopa on the laryngeal adductor reflex in rats. Exp Gerontol. 2012;47(12):900-907.

Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Gilbert GH, Quandt SA. Impact of denture usage patterns on dietary quality and food avoidance among older adults. J Nutr Gerontol Geriatr. 2011;30(1):86-102.

Quandt SA, Savoca MR, Leng X, Chen H, Bell RA, Gilbert GH, Anderson AM, Kohrman T, Arcury TA. Dry mouth and dietary quality in older adults in North Carolina. J Am Geriatr Soc. 2011;59(3):439-445.

Darcy JM, Grzywacz JG, Stephens RL, Leng I, Clinch CR, Arcury TA. Maternal depressive symptomatology: 16-month follow-up of infant and maternal health-related quality of life. J Am Board Fam Med. 2011;24(3):249-257.

Liu C, Leng I, Kritchevsky S, Ding J, Earnest C, Ferrucci L, Goodpaster B, Guralnik J, Hsu F, Lenchik L, et al. The impact of sarcopenia on the response to a physical activity intervention in older adults [abstract]. J Am Geriatr Soc. 2011;59(Suppl 1):S63.

Maslan J, Leng X, Rees C, Blalock D, Butler SG. Maximum phonation time in healthy older adults. J Voice. 2011;25(6):709-713.

Butler SG, Maslan J, Stuart A, Leng X, Wilhelm E, Lintzenich CR, Williamson J, Kritchevsky SB. Factors influencing bolus dwell times in healthy older adults assessed endoscopically. Laryngoscope. 2011;121(12):2526-2534.

Stehle JR, Nicklas B, Kritchevsky SB, Kitzman DW, Leng X, High K. Association between microbial translocation and adiposity in healthy elderly adults [abstract]. Gerontologist. 2011;51(Suppl 2):490.

Quandt SA, Chen H, Bell RA, Savoca MR, Anderson AM, Leng X, Kohrman T, Gilbert GH, Arcury TA. Food avoidance and food modification practices of older rural adults: association with oral health status and implications for service provision. Gerontologist. 2010;50(1):100-111.

Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Frazier RJ, Gilbert GH, Quandt SA. Severe tooth loss in older adults as a key indicator of compromised dietary quality. Public Health Nutr. 2010;13(4):466-474.

Butler SG, Stuart A, Leng X, Rees C, Williamson J, Kritchevsky SB. The association between aspiration status and tongue and handgrip strength in healthy older adults [abstract]. J Am Geriatr Soc. 2010;58(Suppl 1):132.

Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Gilbert GH, Quandt SA. Association between dietary quality of rural older adults and self-reported food avoidance and food modification due to oral health problems. J Am Geriatr Soc. 2010;58(7):1225-1232.

Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic biostatistics: the statistical challenges of clinical research with older study participants. J Am Geriatr Soc. 2010;58(7):1386-1392.

Helderman JB, Welch CD, Leng X, O'Shea TM. Sepsis-associated electroencephalographic changes in extremely low gestational age neonates. Early Hum Dev. 2010;86(8):509-513.

Olex AL, Hiltbold EM, Leng X, Fetrow JS. Dynamics of dendritic cell maturation are identified through a novel filtering strategy applied to biological time-course microarray replicates. BMC Immunol. 2010;11():article 41.

Butler SG, Stuart A, Leng X, Rees C, Williamson J, Kritchevsky SB. Factors influencing aspiration during swallowing in healthy older adults. Laryngoscope. 2010;120(11):2147-2152.

Tucker JN, Grzywacz JG, Leng I, Clinch CR, Arcury TA. Return to work, economic hardship, and women's postpartum health. Women Health. 2010;50(7):618-638.

Butler SG, Stuart A, Leng I, Rees C, Williamson J, Kritchevsky S. The effect of aspiration status on tongue and handgrip strength in healthy older adults [abstract]. Dysphagia. 2010;25(4):360.

Butler SG, Stuart A, Leng I, Rees C, Williamson J, Kritchevsky S. Benchmark data for flexible endoscopic evaluation of swallowing [abstract]. Dysphagia. 2010;25(4):373.

Shumaker SA, Espeland MA, Leng X, Limacher M, Manson JE, Stefanick ML. Cognitive function and cognitive change on incident CCD: the WHI Memory Study (WHIMS) [abstract]. Gerontologist. 2010;50(Suppl 1):309.

Brinkley TE, Leng X, Miller ME, Kitzman DW, Pahor M, Berry MJ, Marsh AP, Kritchevsky SB, Nicklas BJ. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009;64(4):455-461.

Hartmann EL, Kitzman D, Rocco M, Leng X, Klepin H, Gordon M, Rejeski J, Berry M, Kritchevsky S. Physical function in older candidates for renal transplantation: an impaired population. Clin J Am Soc Nephrol. 2009;4(3):588-594.

Sink KM, Leng X, Williamson J, Kritchevsky SB, Yaffe K, Kuller L, Yasar S, Atkinson H, Robbins M, Goff DC Jr, et al. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study. Arch Intern Med. 2009;169(13):1195-1202.

Puntawagkoon C, Kitzman DW, Kritchevsky SB, Hamilton CA, Nicklas B, Leng X, Brubaker PH, Hundley WG. Exercise limb blood flow is reduced despite adequate cardiac output in elderly patients with heart failure [abstract]. J Card Fail. 2009;15(6 Suppl 1):S69.

Savoca MR, Arcury TA, Leng X, Bell RA, Chen H, Anderson A, Kohrman T, Quandt SA. The diet quality of rural older adults in the South as measured by healthy eating index-2005 varies by ethnicity. J Am Diet Assoc. 2009;109(12):2063-2067.

Puntawangkoon C, Kitzman DW, Kritchevsky SB, Hamilton CA, Nicklas B, Leng X, Brubaker PH, Hundley WG. Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure. J Cardiovasc Magn Reson. 2009;11(1):article 48.

Quandt SA, Savoca MR, Leng X, Chen H, Bell RA, Anderson AM, Gilbert GH, Arcury TA. Food avoidance and modification influence dietary quality among multi-ethnic older rural adults [abstract]. Gerontologist. 2009;49(Suppl 2):512.

Arcury TA, Savoca M, Anderson A, Chen H, Leng X, Bell R, Quandt SA. Social isolation, oral health, and health related quality of life in a multi-ethnic sample of older rural adults [abstract]. Gerontologist. 2009;49(Suppl 2):34.

Leng X. Some consideration on multiple outcomes in aging research clinical trial design [abstract]. Gerontologist. 2009;49(Suppl 2):247.

Muller H-G, Chiou J-M, Leng X. Inferring gene expression dynamics via functional regression analysis. BMC Bioinformatics. 2008;9():article 60.

Hall P, Leng X, Muller H-G. Weighted-bootstrap alignment of explanatory variables. J Stat Plan Inference. 2008;138(6):1817-1827.

Grant KA, Leng X, Green HL, Szeliga KT, Rogers LSM, Gonzales SW. Drinking typography established by scheduled induction predicts chronic heavy drinking in a monkey model of ethanol self-administration. Alcohol Clin Exp Res. 2008;32(10):1824-1838.

Sawaki L, Butler AJ, Leng X, Wassenaar PA, Mohammad YM, Blanton S, Sathian K, Good DC, Wittenberg GF, et al. Constraint-induced movement therapy results in increased motor map area in subjects 3 to 9 months after stroke. Neurorehabil Neural Repair. 2008;22(5):505-513.

Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008;20(4):302-309.

Nicklas BJ, Brinkley T, Leng X, Miller M, Kitzrnan D [sic] [Kitzman D], Berry M, Marsh A, Pahor M, Kritchevsky S. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities [abstract]. Gerontologist. 2008;48(Special Issue 3):491-492.

Kritchevsky SB, Nicklas BJ, Lyles MF, Marsh AP, Miller GD, Miller ME, Leng X. Effect of PPAR gamma use during a hypocaloric diet for weight loss on reductions in total and visceral fat in older men and women [abstract]. Diabetes. 2008;57(Suppl 1):A482.

Sawaki L, Leng X, Butler AJ, Wassenaar PA, Mohammad Y, Blanton S, Sathian K, Nichols-Larsen DS, Wolf SL, Wittenberg GF, et al. Motor map plasticity in subacute and chronic patients receiving constraint-induced therapy after stroke [abstract]. Stroke. 2007;38(2):519.

Kritchevsky SB, Lenchik L, Leng X, Ding J, Guralnik J, Ferrucci L, Pahor M, Earnest C, Hsu F, Goodpaster G. Body composition and physical function in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study [abstract]. J Am Geriatr Soc. 2007;55(4 Suppl):S67.

Sink KM, Leng X, Williamson J, Kritchevsky S, Yaffe K, Psaty B, Kuller L, Yasar S, Atkinson H, Robbins M, Goff D. Centrally active ACE inhibitors may slow cognitive decline: the Cardiovascular Health Study [abstract]. J Am Geriatr Soc. 2007;55(4 Suppl 1):S14.

Leng X, Muller H-G. Time ordering of gene coexpression. Biostatistics. 2006;7(4):569-584.

Grant KA, Leng IY, Gonzales SW. Prediction of ethanol self-administration in cynomolgus monkeys [abstract]. Am J Primatol. 2006;68(Suppl 1):127.