Profile

Glenn J. Lesser, M.D.Wake Forest Baptist Health

Doctor Rating

4.7 out of 5

158 Ratings
18 Comments

Glenn J. Lesser, M.D.

Professor,




Clinical Interests

Neuro-oncology, Cancer Pain Control, Cancer Symptom Management, Brain Tumors

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-713-5440
Department: 336-713-5440

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Education & Training

  • B.A., Duke University, 1983
  • M.D., Penn State University College of Medicine, 1987
  • Residency, Internal Medicine, North Carolina Baptist Hospita, 1991
  • Fellowship, Johns Hopkins University Schoo, 1994
  • Internship, Internal Medicine, North Carolina Baptist Hospita, 1998

Memberships

  • North Carolina Medical Assn
  • Society of Neuro-Oncology
  • Southern Assn For Oncology
  • Southern Medical Association
  • Am Coll of Physicians Fellow
  • Am Medical Assn
  • Am Soc of Clinical Oncology

NPI Number

  • 1205810660
Glenn J. Lesser, M.D.

Doctor Rating

4.7 out of 5

158 Ratings
18 Comments

Glenn J. Lesser, M.D.

Professor, Hematology & Oncology
Comprehensive Cancer Center
Brain Tumor Center of Excellence
Anesthesiology
Neurosurgery

Research Interests

alternative medicine, cancer/oncogenesis, drugs/therapeutic agents pharm, molecular biology/molecular me, rare diseases, vaccines

Contact Information

Academic: 336-716-9527 | Department: 336-713-5440

Media Medical Expert »

Recent Publications

Lewis JA, Petty WJ, Harmon M, Peacock JE, Valente K, Owen J, Pirmohamed M, Lesser GJ. Hemolytic anemia in two patients with glioblastoma multiforme: a possible interaction between vorinostat and dapsone. J Oncol Pharm Pract. 2015;21(3):220-223.

Fisher BJ, Hu C, Macdonald DR, Lesser GJ, Coons SW, Brachman DG, Ryu S, Werner-Wasik M, Bahary JP, Liu J, Chakravarti A, Mehta M. Phase 2 study of temozolomide-based chemoradiation therapy for high-risk low-grade gliomas: preliminary results of radiation therapy oncology group 0424. Int J Radiat Oncol Biol Phys. 2015;91(3):497-504.

Mirlohi S, Duncan SE, Harmon M, Case D, Lesser G, Dietrich AM. Analysis of salivary fluid and chemosensory functions in patients treated for primary malignant brain tumors. Clin Oral Investig. 2015;19(1):127-137.

Norden AD, Schiff D, Ahluwalia MS, Lesser GJ, Nayak L, Lee EQ, Rinne ML, Muzikansky A, Dietrich J, Purow B, Doherty LM, LaFrankie DC, Pulverenti JR, Rifenburg JA, Ruland SF, Smith KH, Gaffey SC, McCluskey C, Ligon KL, Reardon DA, Wen PY. Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas. J Neurooncol. 2015;121(2):297-302.

Lucas JT Jr, Huang AJ, Mott RT, Lesser GJ, Tatter SB, Chan MD. Anaplastic ganglioglioma: a report of three cases and review of the literature. J Neurooncol. 2015;123(1):171-177.

Page BR, Shaw EG, Lu L, Bryant D, Grisell D, Lesser GJ, Monitto DC, Naughton MJ, Rapp SR, Savona SR, Shah S, Case D, Chan MD. Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue. Neuro Oncol. 2015;():.

Lawrence JA, Griffin L, Balcueva EP, Groteluschen DL, Samuel TA, Lesser GJ, Naughton MJ, Case LD, Shaw EG, Rapp SR. A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy. J Cancer Surviv. 2015;():.

Renfrow JJ, Mitchell JW, Goodman M, Mellen LA, Wilson JA, Mott RT, Lesser GJ. Relapsing intracranial plasma cell granuloma: a case report. Oncol Lett. 2014;7(2):531-533.

Paulsson AK, McMullen KP, Peiffer AM, Hinson WH, Kearns WT, Johnson AJ, Lesser GJ, Ellis TL, Tatter SB, Debinski W, Shaw EG, Chan MD. Limited margins using modern radiotherapy techniques does not increase marginal failure rate of glioblastoma. Am J Clin Oncol. 2014;37(2):177-181.

Strowd RE, Swett K, Harmon M, Carter AF, Pop-Vicas A, Chan M, Tatter SB, Ellis T [deceased], Blevins M, High K, Lesser GJ. Influenza vaccine immunogenicity in patients with primary central nervous system malignancy. Neuro Oncol. 2014;16(12):1639-1644.

Leyrer CM, Chan MD, Peiffer AM, Horne E, Harmon M, Carter AF, Hinson WH, Mirlohi S, Duncan SE, Dietrich AM, Lesser GJ. Taste and smell disturbances after brain irradiation: a dose-volume histogram analysis of a prospective observational study. Pract Radiat Oncol. 2014;4(2):130-135.

Paulsson AK, Holmes JA, Peiffer AM, Miller LD, Liu W, Xu J, Hinson WH, Lesser GJ, Laxton AW, Tatter SB, Debinski W, Chan MD. Comparison of clinical outcomes and genomic characteristics of single focus and multifocal glioblastoma. J Neurooncol. 2014;119(2):429-435.

Huang AJ, Huang KE, Page BR, Ayala-Peacock DN, Lucas JT Jr, Lesser GJ, Laxton AW, Tatter SB, Chan MD. Risk factors for leptomeningeal carcinomatosis in patients with brain metastases who have previously undergone stereotactic radiosurgery. J Neurooncol. 2014;120(1):163-169.

Shaw E, McKee N, Case D, Lawrence J, Lesser G, Naughton M, Peiffer A, Loghin M, Giguere J, Stieber V, Rapp S. Incidence of mild cognitive impairment in irradiated brain tumor survivors [abstract]. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S162-S163.

Urbanic JJ, Case D, Lesser G, Enevold G, Naughton M, Danhauer S, Rapp S, Vitolins M, Johnson S, McCollough M, Duncan D, Papagikos M, Shaw EG. L-arginine - based nutritional supplement did not improve erectile function or quality of life in prostate cancer survivors previously treated with radiation therapy: results of CCOP research base protocol 98110-A randomized phase 2 dose. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S86-S87.

Holmes JA, Paulsson A, Peiffer AM, Miller LD, Xu J, Hinson WH, Lesser GJ, Tatter SB, Debinski W, Chan MD. Genomic predictors of infield and marginal failure for glioblastoma treated with concurrent radiation therapy and temozolomide: a step towards personalized radiation fields? [abstract]. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S291-S292.

Lesser G, Harmon M, Khan I, Whitlow C, Brown W. Cellular microparticles as blood-borne endothelial biomarkers in patients with malignant gliomas [abstract]. Neuro Oncol. 2014;16(Suppl 5):v27.

Strowd R, Russell G, Harmon M, Carter A, Chan M, Tatter S, Laxton A, High K, Lesser G. A pilot study of high-dose influenza vaccine immunogenicity in patients with primary central nervous system malignancy [abstract]. Neuro Oncol. 2014;16(Suppl 5):v207.

Wen P, Reardon D, Phuphanich S, Aiken R, Landolfi J, Curry W, Zhu JJ, Glantz M, Peereboom D, Markert J, Larocca R, O'Rourke D, Fink K, Kim L, Gruber M, Lesser G, Pan E, Kesari S, Yu J. A randomized double blind placebo-controlled phase 2 trial of dendritic cell (DC) vaccine ICT-107 following standard treatment in newly diagnosed patients with GBM [abstract]. Neuro Oncol. 2014;16(Suppl 5):v22.

Vincent A, Lesser G, Brown D, Vern-Gross T, Metheny-Barlow L, Lawrence J, Chan M. Prolonged regression of metastatic leptomeningeal breast cancer that has failed conventional therapy: a case report and review of the literature. J Breast Cancer. 2013;16(1):122-126.

Lesser GJ, Case D, Stark N, Williford S, Giguere J, Garino LA, Naughton MJ, Vitolins MZ, Lively MO, Shaw EG. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. J Support Oncol. 2013;11(1):31-42.

Norden AD, Lesser GJ, Drappatz J, Ligon KL, Hammond SN, Lee EQ, Reardon DR, Fadul CE, Plotkin SR, Batchelor TT, Zhu JJ, Beroukhim R, Muzikansky A, Doherty L, Lafrankie D, Smith K, Tafoya V, Lis R, Stack EC, Rosenfeld MR, Wen PY. Phase 2 study of dose-intense temozolomide in recurrent glioblastoma. Neuro Oncol. 2013;15(7):930-935.

Kota G, Gupta P, Lesser GJ, Wilson JA, Mintz A. Somatostatin receptor molecular imaging for metastatic intracranial hemangiopericytoma. Clin Nucl Med. 2013;38(12):984-987.

Somasundaram A, Lesser GJ, Mott RT, Hsu W. Malignant transformation of an intramedullary epidermoid cyst in the thoracic region of the spinal cord: case report. J Neurosurg Spine. 2013;19(5):591-594.

Strowd RE, Blackwood R, Brown M, Harmon M, Lovato J, Yalcinkaya T, Lesser G. Impact of temozolomide on gonadal function in patients with primary malignant brain tumors. J Oncol Pharm Pract. 2013;19(4):321-327.

Renfrow JJ, Lesser GJ. Molecular subtyping of brain metastases and implications for therapy. Curr Treat Options Oncol. 2013;14(4):514-527.

Morrell RM, Tooze JA, Harmon MS, Carter AF, DeTroye AT, Lesser GJ. An automated system for detecting nonadherence in laboratory testing and monitoring for myelosuppression in patients receiving self-administered oral chemotherapy. J Oncol Pract. 2013;9(5):E268-E271.

Vitolins MZ, Griffin L, Tomlinson WV, Vuky J, Adams PT, Moose D, Frizzell B, Lesser GJ, Naughton M, Radford JE Jr, Shaw EG. Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer. J Clin Oncol. 2013;31(32):4092-4098.

Norden A, Schiff D, Ahluwalia M, Lesser G, Nayak L, Lee E, Muzikansky A, Dietrich J, Smith K, Gaffey S, McCluskey C, Ligon K, Reardon D, Wen P. Phase II trial of triple receptor tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas [abstract]. Neuro Oncol. 2013;15(Suppl 3):123-124.

Norden A, Hammond S, Drappatz J, Phuphanich S, Reardon D, Wong E, Plotkin S, Lesser G, Raizer J, Batchelor T, Lee E, Kaley T, Muzikansky A, Doherty L, LaFrankie D, Ruland S, Smith K, Gerard M, McCluskey C, Wen P. Phase II study of monthly pasireotide lar (Som230C) for recurrent or progressive meningioma: final results [abstract]. Neuro Oncol. 2013;15(Suppl 3):123.

Shaw EG, Case D, Bryant D, Grisell D, Lesser G, Monitto DC, Naughton MJ, Rapp SR, Sovano SR, Shah S, Chan MD. Phase II double-blind placebo-controlled study of armodafinil for brain radiation induced fatigue [abstract]. J Clin Oncol. 2013;31(15 Suppl):9505.

Urbanic JJ, Case D, Naughton MJ, Hu JJ, Enevold G, Beech B, Weaver KE, Danhauer S, Rapp SR, Sheidler V, Vitolins M, Lesser G, Shaw EG. Minority accrual on a prospective study targeting a diverse US breast cancer population: an analysis of Wake Forest CCOP research base protocol 97609 [abstract]. J Clin Oncol. 2013;31(15 Suppl):6564.

Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG. A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2012;82(2):743-748.

Ruiz J, Case D, Enevold G, Rosdhal R, Tatter SB, Ellis TL, McQuellon RP, McMullen KP, Stieber VW, Shaw EG, Lesser GJ. A phase II trial of thalidomide and procarbazine in adult patients with recurrent or progressive malignant gliomas. J Neurooncol. 2012;106(3):611-617.

Geer CP, Simonds J, Anvery A, Chen MY, Burdette JH, Zapadka ME, Ellis TL, Tatter SB, Lesser GJ, Chan MD, McMullen KP, Johnson AJ. Does MR perfusion imaging impact management decisions for patients with brain tumors? A prospective study. AJNR Am J Neuroradiol. 2012;33(3):556-562.

Renfrow JJ, DeTroye A, Chan M, Tatter S, Ellis T, McMullen K, Johnson A, Mott R, Lesser GJ. Initial experience with bendamustine in patients with recurrent primary central nervous system lymphoma: a case report. J Neurooncol. 2012;107(3):659-663.

Garcia-Espinosa MA, Lesser GJ, Debinski W, Tallant EA, Gallagher PE. Angiotensin-(1-7), a peptide hormone with therapeutic potential for the treatment of glioblastomas [abstract]. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 1938.

Hawkins ES, Aiken R, Chandler J, Fink KL, Glantz MJ, Grewal J, Gruber ML, Kesari S, Landolfi JC, LaRocca RV, Lesser GJ, Markert J, Mayer TM, O'Rourke D, Peereboom DM, Phuphanich S, Schiff D, Sloan AE, Stea B, Zhu J-J. A randomized, double-blind, controlled phase IIb study of the safety and efficacy of ICT-107 in newly diagnosed patients with glioblastoma multiforme following resection and chemoradiation [abstract]. J Clin Oncol. 2012;30(15 Suppl):TPS2107.

Sams K, Case LD, Lesser GJ, Naughton MJ, Williford SK, Giguere JK, Garino A, Vitolins M, Shaw EG. Comparing three validated methods of patient self-reported fatigue in a prospective randomized clinical trial [abstract]. J Clin Oncol. 2012;30(15 Suppl):Abstr 9108.

Attia A, Rapp SR, Case LD, D'Agostino R, Lesser G, Naughton M, McMullen K, Rosdhal R, Shaw EG. Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood. J Neurooncol. 2012;109(2):357-363.

High KP, Case D, Hurd D, Powell B, Lesser G, Falsey AR, Siegel R, Metzner-Sadurski J, Krauss JC, Chinnasami B, Sanders G, Rousey S, Shaw EG. A randomized, controlled trial of Panax quinquefolius extract (CVT-E002) to reduce respiratory infection in patients with chronic lymphocytic leukemia. J Support Oncol. 2012;10(5):195-201.

Nabors LB, Mikkelsen T, Hegi ME, Ye X, Batchelor T, Lesser G, Peereboom D, Rosenfeld MR, Olsen J, Brem S, Fisher JD, Grossman SA. A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306). Cancer. 2012;118(22):5601-5607.

Leyrer M, Chan MD, Peiffer AM, Horne E, Harmon M, Carter AF, Hinson WH, Duncan SE, Dietrich AM, Lesser GJ. Radiation-induced taste and smell toxicity: a dose-volume histogram analysis of a prospective observational study [abstract]. Int J Radiat Oncol Biol Phys. 2012;84(3 Suppl):S302.

Paulsson A, Peiffer AM, McMullen KP, Hinson WH, Lesser GJ, Ellis TL [deceased], Tatter SB, Shaw EG, Chan MD. Comparison of clinical outcomes for single focus and multifocal glioblastoma [abstract]. Int J Radiat Oncol Biol Phys. 2012;84(3 Suppl):S274.

Strowd RE, Swett K, Harmon M, Pop-Vicas A, Chan M, Tatter SB, Ellis TL [deceased], Blevins M, High K, Lesser GJ. A pilot study of influenza vaccine immunogenicity in patients with malignant central nervous system (CNS) tumors [abstract]. Neuro Oncol. 2012;14(Suppl 6):154.

Strowd RE III, Knovich MA, Lesser GJ. The therapeutic management of bleeding and thrombotic disorders complicating CNS malignancies. Curr Treat Options Oncol. 2012;13(4):451-464.

Batchelor TT, Grossman SA, Mikkelsen T, Ye X, Desideri S, Lesser GJ. Rituximab monotherapy for patients with recurrent primary CNS lymphoma [editorial]. Neurology. 2011;76(10):929-930.

Kota G, Gupta P, Wilson J, Lesser G, Mintz A. Metastatic intracranial hemangiopericytoma: the role of octreotide and PET imaging in diagnosis, pre-treatment and follow-up evaluation [abstract]. J Nucl Med. 2011;52(Suppl 1):abstr 1065.

Chan MD, Attia A, Tatter SB, Lesser G, Zapadka ME, Mott RT, Carter A, McMullen KP, Shaw EG, Ellis TE [sic ] [Ellis TL]. Radiation-induced adult medulloblastoma: a two-case report and review of the literature. J Neurooncol. 2011;103(3):745-749.

Lamar Z, Lesser GJ. Management of meningeal neoplasms: meningiomas and hemangiopericytomas. Curr Treat Options Oncol. 2011;12(3):230-239.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hematology & Oncology

Clinical Interests

Neuro-oncology, Cancer Pain Control, Cancer Symptom Management, Brain Tumors
Glenn J. Lesser, M.D.

Glenn J. Lesser, M.D.

Professor, Hematology & Oncology
Comprehensive Cancer Center
Brain Tumor Center of Excellence
Anesthesiology
Neurosurgery

Doctor Rating

4.7 out of 5

Glenn J. Lesser, M.D.158 Ratings
18 Comments

Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
4.8
CP efforts to include in decisions
4.8
CP explanations of prob/condition
4.8
CP spoke using clear language
4.8
Friendliness/courtesy of CP
4.9
Likelihood of recommending CP
4.9
Patients' confidence in CP
4.9
Time CP spent with patient
4.8
Wait time at clinic
4



Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.

7/7/2015

My doctors at Wake have always been great! Made hard experiences better!

6/16/2015

They have always done a great job and have been respectful to us!

6/16/2015

I would not have stayed with this doctor for 11 years if I was not confident in his care and treatment> Survey a waste of time for me and I will not do any more!

3/17/2015

*Dr. Glenn Lesser is one of the most outstanding doctors, men, gentlemen - MALE I've ever had the privilege to meet.

3/11/2015

*Dr. Lesser is the best!

3/1/2015

Everyone was thorough, professional and courteous

2/24/2015

My health has improved under *Dr. Lesser's care.

2/24/2015

Dr. Lesser is a very good provider ( Physician).

2/23/2015

Great experience. Highly recommend Dr. Lesser.

2/11/2015

Excellent doctor & staff.

2/3/2015

Best experience with *Dr. Lesser - very caring & compassionate doctor.

1/21/2015

The best.

1/20/2015

*Dr. Lesser is a wonderful doctor.

1/6/2015

Very good experience.

12/31/2014

very qualified

11/11/2014

*Dr. Lesser has been the greatest doctor from 2006 when he became my doctor, & I was in one of his trials. I am a brain cancer survivor b/c of him.

9/3/2014

I had a list of questions for *Dr. Lesser, and he took the time to answer me fully.

9/3/2014

Dr. Lesser & his staff are just like family to me. Couldn't ask for any better!!

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