Nicole Hope Levi, Ph.D.Wake Forest School of Medicine

Nicole Hope Levi, Ph.D.

Associate Professor,

Clinical Interests

Emergence-based Drug Delivery, Wound Healing Problems, Breast Cancer

Contact Information

Academic: 336-713-8052 | Department: 336-716-4171


Education & Training

  • M.S., Clemson University, 2002
  • Ph.D., WFU Sch of Med/Va Tech Biomedical Engineering & Sc, 2007


  • Biomedical Engineering Society
Nicole Hope Levi, Ph.D.

Nicole Hope Levi, Ph.D.

Associate Professor, Plastic & Reconstructive Surgery

Research Interests

biotechnology, cancer/oncogenesis, drugs/therapeutic agents pharm, medical technology/devices

Contact Information

Academic: 336-713-8052 | Department: 336-716-4171


Recent Publications

Wailes EM, Levi-Polyachenko NH. Multi-walled nanotubes for cellular reprogramming of cancer. Nanomedicine. 2016;12(4):955-963.

Wailes EM, MacNeill CM, McCabe E, Levi-Polyachenko NH. Shaping PEDOT nanoparticles for use in 3D tissue phantoms. J Appl Polym Sci. 2016;133(18):43378.

Graham EG, Wailes EM, Levi-Polyachenko NH. Multi-walled carbon nanotubes inhibit breast cancer cell migration. J Biomed Nanotechnol. 2016;12(2):308-319.

Levi-Polyachenko N, Jacob R, Day C, Kuthirummal N. Chitosan wound dressing with hexagonal silver nanoparticles for hyperthermia and enhanced delivery of small molecules. Colloids Surf B Biointerfaces. 2016;142():315-324.

Levi-Polyachenko N, Rosenbalm T, Kuthirummal N, Shelton J, Hardin W, Teruel M, Hobley E, Wang R, Day C, Narayanan V, David L, Wagner WD. Development and characterization of elastic nanocomposites for craniofacial contraction osteogenesis. J Biomed Mater Res B Appl Biomater. 2015;103(2):407-416.

Wang R, Levi-Polyanchenko N, Morykwas M, Argenta L, Wagner WD. Novel nanofiber-based material for endovascular scaffolds. J Biomed Mater Res A. 2015;103(3):1150-1158.

Rosenbalm TN, Teruel M, Day CS, Donati GL, Morykwas M, Argenta L, Kuthirummal N, Levi-Polyachenko N. Structural and mechanical characterization of bioresorbable, elastomeric nanocomposites from poly(glycerol sebacate)/nanohydroxyapatite for tissue transport applications. J Biomed Mater Res B Appl Biomater. 2015;():.

MacNeill CM, Graham EG, Levi-Polyachenko NH. Soft template synthesis of donor-acceptor conjugated polymer nanoparticles: structural effects, stability, and photothermal studies. J Polym Sci A1. 2014;52(11):1622-1632.

Thompson EA, Graham E, MacNeill CM, Young M, Donati G, Wailes EM, Jones BT, Levi-Polyachenko NH. Differential response of MCF7, MDA-MB-231, and MCF 10A cells to hyperthermia, silver nanoparticles and silver nanoparticle-induced photothermal therapy. Int J Hyperthermia. 2014;30(5):312-323.

Levi-Polyachenko N, Young C, MacNeill C, Braden A, Argenta L, Reid S. Eradicating group A streptococcus bacteria and biofilms using functionalised multi-wall carbon nanotubes. Int J Hyperthermia. 2014;30(7):490-501.

Wailes E, Levi-Polyachendo N. MWNTs inhibit breast cancer migration [abstract]. FASEB J. 2014;28(1 Suppl):1048.5.

MacNeill CM, Coffin RC, Carroll DL, Levi-Polyachenko NH. Low band gap donor-acceptor conjugated polymer nanoparticles and their NIR-mediated thermal ablation of cancer cells. Macromol Biosci. 2013;13(1):28-34.

Graham EG, MacNeill CM, Levi-Polyachenko NH. Quantifying folic acid-functionalized multi-walled carbon nanotubes bound to colorectal cancer cells for improved photothermal ablation. J Nanopart Res. 2013;15(5):1649.

MacNeill CM, Wailes EM, Levi-Polyachenko NH. A comparative study of the photothermal efficiency of electrically conducting poly(3,4-ethylenedioxythiophene)-based nanomaterials with cancer cells. J Nanosci Nanotechnol. 2013;13(6):3784-3791.

Wagner WD, Wang R, Levi-Polyachenko N. Heart valve substitute fabricated from silk protein, collagen, and poly-glycerol sebacate has enhanced endothelial cell growth and reduced thrombogenicity [abstract]. FASEB J. 2013;27():527.4.

Carroll DL, Stewart JH IV, Levi-Polyachenko NH, inventors; Wake Forest University Health Sciences, assignee. Compositions and methods for treating cancer. United States patent US 8,501,233. 2013 Aug 6. 2013;():.

Wagner WD, Argenta LC, Morykwas MJ, Levi-Polyachenko N. Production of a biodegradable electrospun biomaterial with tensile strength and elasticity [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):905.2.

Argenta LC, Carroll DL, Levi NH, Liu J, Morykwas MJ, Tatter S, Wagner WD, inventors; Wake Forest University Health Sciences and Wake Forest University, assignees. Device and method for treating central nervous system pathology. United States patent 8,267,960. 2012 Sept 8. 2012;():.

Ringwood AH, McCarthy M, Levi-Polyachenko N, Carroll DL. Nanoparticles in natural aquatic systems and cellular toxicity [abstract]. Comp Biochem Physiol A Mol Integr Physiol. 2010;157(1 Suppl):S53.

Coldren FM, Palavecino EL, Levi-Polyachenko NH, Wagner WD, Smith TL, Smith BP, Webb LX, Carroll DL. Encapsulated Staphylococcus aureus strains vary in adhesiveness assessed by atomic force microscopy. J Biomed Mater Res A. 2009;89(2):402-410.

McGee MP, Morykwas M, Levi-Polyachenko N, Argenta L. Swelling and pressure-volume relationships in the dermis measured by osmotic-stress technique. Am J Physiol Regul Integr Comp Physiol. 2009;296(6):R1907-1913.

Levi-Polyachenko NH, Merkel EJ, Jones BT, Carroll DL, Stewart JH. Rapid photothermal intracellular drug delivery using multiwalled carbon nanotubes. Mol Pharm. 2009;6(4):1092-1099.

Ringwood AH, Levi-Polyachenko N, Carroll DL. Fullerene exposures with oysters: embryonic, adult, and cellular responses. Environ Sci Technol. 2009;43(18):7136-7141.

Burke A, Singh R, Kraft RA, Levi-Polyachenko N, Hatcher HC, D'Agostino R Jr, Kock ND, Carroll DL, Akman S, Torti FM, Torti SV, et al. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc Natl Acad Sci U S A. 2009;106(31):12897-902.

Levi-Polyachenko NH, Carroll DL, Stewart JH IV. Applications of carbon-based nanomaterials for drug delivery in oncology In: Cataldo F, Da Ros T, eds. Medicinal chemistry and pharmacological potential of fullerenes and carbon nanotubes. Berlin: Springer;2008: 223-266.

Stewart JH IV, Tran T-L, Levi N, Tsai WS, Schrump DS, Nguyen DM. The essential role of the mitochondria and reactive oxygen species in cisplatin-mediated enhancement of Fas ligand-induced apoptosis in malignant pleural mesothelioma. J Surg Res. 2007;141(1):120-131.

Levi N, Hantgan RR, Lively MO, Carroll DL, Prasad GL. C60-Fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects. J Nanobiotechnol. 2006;4():article 14.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Plastic & Reconstructive Surgery

Clinical Interests

Emergence-based Drug Delivery, Wound Healing Problems, Breast Cancer
Nicole Hope Levi, Ph.D.

Nicole Hope Levi, Ph.D.

Associate Professor, Plastic & Reconstructive Surgery

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