Profile

Edward A. Levine, M.D.Wake Forest Baptist Health

Doctor Rating

4.7 out of 5

192 Ratings
3 Comments

Edward A. Levine, M.D.

Chief, Surgical Sciences-Oncology
Director-At-Large,
Core Director,
Professor, Surgical Sciences-Oncology


Clinical Specialties

Sarcoma, Gastrointestinal Tumors, Esophageal Cancer, Mesothelioma, Peritoneal Carcinomatosis, Esophageal Tumors, Melanoma, Breast Cancer

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-4276
Department: 336-716-0545

Email: elevine@wakehealth.edu

Insurance Accepted »

Media Medical Expert »

Education & Training

  • B.S., Northern Illinois University , 1981
  • M.D., Finch University of Health Sci/Chicago Med School , 1985
  • Residency, Surgery, Michael Reese Hosp/Med Ctr, 1990
  • Residency, Oncology, U Illinois Hospital, 1992

Memberships

  • North Carolina Medical Society
  • Southern Assn For Oncology
  • Southern Medical Association
  • Southern Surgical Assn
  • Southern Surgical Congress
  • Winston-Salem Surgical Society
  • Am Hepato-Pancreato-Biliary
  • Am Coll Of Surgeons
  • Connective Tissue Oncology Soc

NPI Number

  • 1275518334
Edward A. Levine, M.D.

Doctor Rating

4.7 out of 5

192 Ratings
3 Comments

Edward A. Levine, M.D.

Chief, Surgical Sciences-Oncology
Director-At-Large, Comprehensive Cancer Center
Core Director, Comprehensive Cancer Center
Professor, Surgical Sciences-Oncology
Comprehensive Cancer Center
Office of Women in Medicine and Science

Research Interests

cancer/oncogenesis

Contact Information

Academic: 336-716-0545 | Department: 336-716-0545

Email: elevine@wakehealth.edu

Media Medical Expert »

Recent Publications

Levine EA, Stewart JH IV, Shen P, Russell GB, Loggie BL, Votanopoulos KI. Intraperitoneal chemotherapy for peritoneal surface malignancy: experience with 1,000 patients. J Am Coll Surg. 2014;218(4):573-585.

Votanopoulos KI, Randle RW, Craven B, Swett KR, Levine EA, Shen P, Stewart JH, Mirzazadeh M. Significance of urinary tract involvement in patients treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Ann Surg Oncol. 2014;21(3):868-874.

Randle RW, Swett KR, Swords DS, Shen P, Stewart JH, Levine EA, Votanopoulos KI. Efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in the management of malignant ascites. Ann Surg Oncol. 2014;21(5):1474-1479.

Blackham AU, Swett K, Eng C, Sirintrapun J, Bergman S, Geisinger KR, Votanopoulos K, Stewart JH, Shen P, Levine EA. Perioperative systemic chemotherapy for appendiceal mucinous carcinoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Surg Oncol. 2014;109(7):740-745.

Ahmed S, Levine EA, Swett KR, Randle RW, Shen PW, Stewart JH, Votanopoulos KI. Significance of diaphragmatic resections and thoracic chemoperfusion on outcomes of peritoneal surface disease treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) [abstract]. Ann Surg Oncol. 2014;21(Suppl 1):S135.

Bryan M, D'Agostino R, Brown D, Levine E, Howard-McNatt M. Is postmastectomy radiation therapy indicated in patients with close or positive margins? [abstract]. Ann Surg Oncol. 2014;21(Suppl 2):33.

Votanopoulos KI, Russell G, Randle RW, Shen PW, Stewart JH, Levine EA. Peritoneal surface disease (PSD) from appendiceal cancer treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): overview of 481 cases [abstract]. Ann Surg Oncol. 2014;21(Suppl 1):S128-S129.

Randle RW, Swett KR, Stewart JH, Shen P, Levine EA, Votanopoulos KI. Morbidity and mortality following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in patients with diabetes [abstract]. Ann Surg Oncol. 2014;21(Suppl 1):S87.

Jin LX, Squires MH, Poultsides G, Votanopoulos KI, Weber SM, Bloomston M, Pawlik T, Hawkins WG, Linehan D, Strasberg SM, Archer AW, Cardona K, Cho C, Kooby DA, Levine EA, Winslow E, Saunders ND, Spolverato G, Maithel SK, Fields RC. Factors associated with recurrence in lymph node-negative gastric adenocarcinoma: results from the US Gastric Cancer Collaborative [abstract]. Ann Surg Oncol. 2014;21(Suppl 1):S173.

Salazar R, Capdevila J. Rosenberg R, de Waard JW, Glimelius B, Bibeau F, Klaase J, Van der Hoeven JJM, Midgley RA, Chang GJ, Bachleitner-Hofmann T, Asano M, Ziebermayr R, Levine EA, Deck KB, Sington J, Law WL, Shbeeb I, Stork L, Marshall J. Comparison of ColoPrint risk classification with clinical risk in the prospective PARSC trial [abstract]. J Clin Oncol. 2014;32(3 Suppl):465.

Turaga K, Levine E, Barone R, Sticca R, Petrelli N, Lambert L, Nash G, Morse M, Adbel-Misih R, Alexander HR, Attiyeh F, Bartlett D, Bastidas A, Blazer T, Chu Q, Chung K, Dominguez-Parra L, Espat NJ, Foster J, Fournier K, Garcia R, Goodman M,. Consensus guidelines from The American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States. Ann Surg Oncol. 2014;21(5):1501-1505.

Sirintrapun SJ, Blackham AU, Russell G, Votanopoulos K, Stewart JH, Shen P, Levine EA, Geisinger KR, Bergman S. Significance of signet ring cells in high-grade mucinous adenocarcinoma of the peritoneum from appendiceal origin. Hum Pathol. 2014;():.

Blackham AU, Russell GB, Stewart JH IV, Votanopoulos K, Levine EA, Shen P. Metastatic colorectal cancer: survival comparison of hepatic resection versus cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2014;():.



Votanopoulos K, Ihemelandu C, Shen P, Stewart J, Russell G, Levine EA. A comparison of hematologic toxicity profiles after heated intraperitoneal chemotherapy with oxaliplatin and mitomycin C. J Surg Res. 2013;179(1):e133-e139.

Addington E, Russell G, Tedeschi R, Levine E, Shen P, Stewart J, Danhauer S, Duckworth K, McQuellon R. Post-traumatic growth is sustained two years after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy [abstract]. Psychooncology. 2013;22(Suppl 2):54.

Sirintrapun J, Blackham A, Russell G, Stewart J, Shen P, Levine E, Geisinger K, Bergman S, Cimic A. Significance of signet-ring cells in extracellular mucin pools versus tissue in high-grade mucinous carcinoma peritonei [abstract]. Lab Invest. 2013;93(Suppl 1):180A.

Votanopoulos KI, Swett K, Blackham AU, Ihemelandu C, Shen P, Stewart JH, Levine EA. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from rectal cancer. Ann Surg Oncol. 2013;20(4):1088-1092.

Ihemelandu C, Levine EA, Aklilu M, Yacoub G, Howerton R, Bolemon B, Graham M, Russell G, Shen P. Optimal timing of systemic therapy in resectable colorectal liver metastases. Am Surg. 2013;79(4):414-421.


Duckworth K, McQuellon R, Russell G, Campbell C, Shen P, Stewart J IV, Levine E. Patient preparedness and treatment satisfaction following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS+HIPEC) [abstract]. Psychooncology. 2013;22(Suppl 2):54-55.

Howard-McNatt M, Lawrence J, Melin SA, Levine EA, Shen P, Stewart JH IV. Race and recurrence in women who undergo neoadjuvant chemotherapy for breast cancer. Am J Surg. 2013;205(4):397-401.

O'Flaherty JT, Wooten RE, Samuel MP, Thomas MJ, Levine EA, Case LD, Akman SA, Edwards IJ. Fatty acid metabolites in rapidly proliferating breast cancer. PLoS One. 2013;8(5):e63076.

Blackham A, Swett K, Eng C, Sirintrapun J, Bergman S, Geisinger K, Votanopoulos KI, Stewart JH, Shen P, Levine E. Perioperative systemic chemotherapy for metastatic appendiceal cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy [abstract]. Ann Surg Oncol. 2013;20(Suppl 1):S13.

Kusamura S, Deraco M, Baratti D, Moran B, Sugarbaker PH, Levine E, Dominique E, Morris D, Chua T, Sardi A, Glehen O, Gilly F, Barrios P, Portilla AG, de Hingh IHJT, Ceelan WP, Pelz JW, Pompiliu P, Gonzalez-Moreno S,. Learning curve and surgical performance of cytoreductive surgery and intraperitoneal chemotherapy for pseudomyxoma peritonei: a PSOGI multicentric study [abstract]. Ann Surg Oncol. 2013;20(Suppl 1):S13.

Newman NA, Lucas JT, Peacock DA, Trottman PA, Wentworth SS, Winters SM, Levine E, Shen P. Predictors for readmission after pancreatic resection for malignancy [abstract]. Ann Surg Oncol. 2013;20(Suppl 1):S140.

Randle RW, Swett KR, Shen P, Stewart JH, Levine EA, Votanopoulos KI. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in peritoneal sarcomatosis. Am Surg. 2013;79(6):620-624.

Sun Y, Shen P, Stewart JH, Russell GB, Levine EA. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. Am Surg. 2013;79(6):644-648.

Votanopoulos KI, Swett K, Swords DS, Shen P, Stewart JH, Levine E. Obesity and peritoneal surface disease outcomes following cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) [abstract]. Ann Surg Oncol. 2013;20(Suppl 1):S113.

Swain SM, Tang G, Geyer CE Jr, Rastogi P, Atkins JN, Donnellan PP, Fehrenbacher L, Azar CA, Robidoux A, Polikoff JA, Brufsky AM, Biggs DD, Levine EA, Zapas JL, Provencher L, Northfelt DW, Paik S, Costantino JP, Mamounas EP, Wolmark N. Definitive results of a phase III adjuvant trial comparing three chemotherapy regimens in women with operable, node-positive breast cancer: the NSABP B-38 trial. J Clin Oncol. 2013;31(26):3197-3204.


Votanopoulos KI, Newman NA, Russell G, Ihemelandu C, Shen P, Stewart JH, Levine EA. Outcomes of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients older than 70 years; survival benefit at considerable morbidity and mortality. Ann Surg Oncol. 2013;20(11):3497-3503.

Votanopoulos KI, Swords DS, Swett KR, Randle RW, Shen P, Stewart JH, Levine EA. Obesity and peritoneal surface disease: outcomes after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for appendiceal and colon primary tumors. Ann Surg Oncol. 2013;20(12):3899-3904.

Hu JJ, Lee EM, Allen GO, Levine EA. Combined genetic and nutritional risk models of triple negative breast cancer [abstract]. Cancer Res. 2013;73(8 Suppl 1):A1284.


Mann GN, Mann LV, Levine EA, Shen P. Primary leiomyosarcoma of the inferior vena cava: a 2-institution analysis of outcomes. Surgery. 2012;151(2):261-267.

Howard-McNatt M, Geisinger KR, Stewart JH IV, Shen P, Levine EA. Is intraoperative imprint cytology evaluation still feasible for the evaluation of sentinel lymph nodes for lobular carcinoma of the breast?. Ann Surg Oncol. 2012;19(3):929-934.

Brucher BLDM, Piso P, Verwaal V, Esquivel J, Derraco M, Yonemura Y, Gonzalez-Moreno S, Pelz J, Konigsrainer A, Strohlein M, Levine EA, Morris D, Bartlett D, Glehen O, Garofalo A, Nissan A. Peritoneal carcinomatosis: cytoreductive surgery and HIPEC--overview and basics. Cancer Invest. 2012;30(3):209-224.

Craven B, Shen P, Levine E, Votanopoulos K, Stewart J, Mirzazadeh M. Urologic recostructive [sic] procedures in cytoreductive surgery (CRS) and intraperitoneal hyperthermic chemotherapy (HIPEC) for peritoneal surface malignancy in 934 consecutive procedures [abstract]. Neurourol Urodyn. 2012;31(2):287.

McQuellon R, Duckworth K, Russell G, Shen P, Stewart J, Votanopoulos K, Levine E. After screening for depression in a high risk medical population: then what? [abstract]. Psychooncology. 2012;21(Suppl 1):126-127.

Cao C, Yan TD, Morris DL, van der Speeten K, Laurberg S, Glehen O, Link K, Piso P, Tentes AAK, Deraco M, Larsen SG, Kecmanovic D, Bayon LG, Melero JT, Gonzalez-Moreno S, Mahteme H, Gertsch P, Moran B, Esquivel J, Alexander R, Levine EA,. Prospective registry on mesothelioma peritonei treatment (PROMPT): study design and rationale. Tumori. 2012;98(1):166-171.

Kelly DA, Wood BC, Knoll GM, Chang SC, Crantford JC, Bharti GD, Levine EA, Thompson JT. Outcome analysis of 541 women undergoing breast conservation therapy. Ann Plast Surg. 2012;68(5):435-437.

Levine EA, Blazer DG III, Kim MK, Shen P, Stewart JH IV, Guy C, Hsu DS. Gene expression profiling of peritoneal metastases from appendiceal and colon cancer demonstrates unique biologic signatures and predicts patient outcomes. J Am Coll Surg. 2012;214(4):599-607.

Anderson RT, Kimmick GG, McCoy TP, Hopkins J, Levine E, Miller G, Ribisl P, Mihalko SL. A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial. J Cancer Surviv. 2012;6(2):172-181.

Cao C, Yan TD, Deraco M, Elias D, Glehen O, Levine EA, Moran BJ, Morris DL, Chua TC, Piso P, Sugarbaker PH, Baratti D, Kusamura S, Gilly FN, Shen P, Mohamed F. Importance of gender in diffuse malignant peritoneal mesothelioma. Ann Oncol. 2012;23(6):1494-1498.

Chua TC, Moran BJ, Sugarbaker PH, Levine EA, Glehen O, Gilly FN, Baratti D, Deraco M, Elias D, Sardi A, Liauw W, Yan TD, Barrios P, Gomez Portilla A, de Hingh IHJT, Ceelen WP, Pelz JO, Piso P, Gonzalez-Moreno S, Van Der Speeten K, Morris DL. Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol. 2012;30(20):2449-2456.

Duckworth KE, McQuellon RP, Russell GB, Cashwell CS, Shen P, Stewart JH IV, Levine EA. Patient rated outcomes and survivorship following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS + HIPEC). J Surg Oncol. 2012;106(4):376-380.

Newman NA, Votanopoulos KL, Stewart JH, Shen P, Levine EA. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer. Minerva Chir. 2012;67(4):309-318.

Votanopoulos KI, Shen P, Stewart JH IV, Levine EA. Current status and future directions in appendiceal cancer with peritoneal dissemination. Surg Oncol Clin N Am. 2012;21(4):599-609.

Votanopoulos KI, Ihemelandu C, Shen P, Stewart JH, Russell GB, Levine EA. Outcomes of repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal surface malignancy. J Am Coll Surg. 2012;215(3):412-417.

Baker JJ, Newman NA, Levine EA, Deal AM, Frank JS, Stewart JH, Shen P, Meyers MO. Utility of routine PET/CT for initial staging of patients with sentinel lymph node positive melanoma [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S127.

Blackham A, Russell GB, Stewart JH, Votanopoulos K, Levine EA, Shen P. Decreased survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy compared to hepatic resection for metastatic colorectal cancer [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S95-S96.

Dougherty S, Urbanic J, Stewart J, Levine E, Howard-McNatt M. Is radiation indicated in patients with T1-T2 breast cancer with close or positive margins after mastectomy? [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S86-S87.

Griffith KF, Levine EA, Shen P, Stewart JH, Votanopoulas KI [sic] [Votanopoulos KI], Russell GB, Geisinger K. Appendiceal neuroendocrine tumors with peritoneal surface dissemination treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S109.

Ihemelandu CU, Shen P, Stewart JH, Votanopoulos K, McQuellon R, Russell G, Levine EA. Predicting postoperative morbidity following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CS plus HIPEC) with preoperative FACT - C (Functional Assessment of Cancer Therapy) and patient rated performance status [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S16.

Ihemelandu CU, Russell G, Shen P, Stewart JH, Votanopoulos K, Levine EA. Impact of lymph node metastasis on survival outcome for patients diagnosed with mucinous carcinoma of the appendix: the role of right hemicolectomy [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S98.

Shen P, Gahagan J, Stewart JH, Votanopoulus K [sic] [Votanopoulos K], Swett K, Levine EA. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis: analysis of postoperative morbidity and mortality from a high volume center [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S141.

Votanopoulos KI, Shen P, Stewart JH, Russell G, Levine EA, Newman NA. Cytoreductive surgery (CS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in the elderly [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S100-S101.

Swain SM, Tang G, Geyer CE, RStogi P, Atkins JN, Donnellan PP, Fehrenbacher L, Azar CA, Robidoux A, Polikoff J, Brufsky A, Biggs DD, Levine EA, Zapas JL, Provencher L, Perez EA, Paik S, Costantino JP, Mamounas EP, Wolmark N. NSABP B-38: Definitive analysis of a randomized adjuvant trial comparing dose-dense (DD) AC -> paclitaxel (P) plus gemcitabine (G) with DD AC -> P and with docetaxel, doxorubicin,. J Clin Oncol. 2012;30(18 Suppl):LBA1000.

Cooper JM, Levine E. Total gastrectomy and pancreaticoduodenectomy for gastric polyposis and duodenal ampullary adenoma in a patient with attenuated familial adenomatous polyposis. Am Surg. 2011;77(3):378-380.

Yan TD, Deraco M, Elias D, Glehen O, Levine EA, Moran BJ, Morris DL, Chua TC, Piso P, Shen P, et al. A novel tumor-node-metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi-institutional database. Cancer. 2011;117(9):1855-1863.


Feldman S, Krishnamurthy S, Gillanders W, Gittleman M, Beitsch PD, Young PR, Streck CJ, Whitworth PW, Levine EA, Boolbol S, et al. A novel automated assay for the rapid identification of metastatic breast carcinoma in sentinel lymph nodes. Cancer. 2011;117(12):2599-2607.

Becher RD, Shen P, Stewart JH, Russell G, Bradley JF, Levine EA. Splenectomy ameliorates hematologic toxicity of hyperthermic intraperitoneal chemotherapy. J Gastrointest Oncol. 2011;2(2):70-76.

Duckworth K, McQuellon R, Russell G, Levine E, Shen P, Stewart J, Cromer M, Cashwell C. Quality of life and sleep quality of long-term survivors of cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy [abstract]. Psychooncology. 2011;20(Suppl 1):79-80.

Mihalko SL, Davenport A, McCoy T, Levine EA, Vitolins M, Brubaker P, Anderson R. Weight gain negatively impacts health-related quality of life: implications for physical activity in breast cancer survivors [abstract]. Ann Behav Med. 2011;41(Suppl 1):S161.

Ihemelandu CU, Shen P, Stewart JH, Votanopoulos K, Levine EA. Management of peritoneal carcinomatosis from colorectal cancer. Semin Oncol. 2011;38(4):568-575.

Ortega-Deballon P, Glehen O, Levine E, Piso P, Sugarbaker PH, Hayes-Jordan A, Facy A, Bakrin N, Rat P. Childbearing after hyperthermic intraperitoneal chemotherapy: results from an international survey. Ann Surg Oncol. 2011;18(8):2297-2301.

Howard-McNatt M, Schroll RW, Hurt GJ, Levine EA. Contralateral prophylactic mastectomy in breast cancer patients who test negative for BRCA mutations. Am J Surg. 2011;202(3):298-302.

Smith TR, Liu-Mares W, Van Emburgh BO, Levine EA, Allen GO, Hill JW, Reis IM, Kresty LA, Pegram MD, Miller MS, et al. Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer. Carcinogenesis. 2011;32(9):1354-1360.

Parson EN, Lentz S, Russell G, Shen P, Levine EA, Stewart JH IV. Outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface dissemination from ovarian neoplasms. Am J Surg. 2011;202(4):481-486.

Hill AR, McQuellon RP, Russell GB, Shen P, Stewart JH IV, Levine EA. Survival and quality of life following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis of colonic origin. Ann Surg Oncol. 2011;18(13):3673-3679.

Stewart JH IV, Levine EA. Role of bacillus Calmette-Guerin in the treatment of advanced melanoma. Expert Rev Anticancer Ther. 2011;11(11):1671-1676.

Howard-McNatt M, Forsberg C, Levine EA, DeFranzo A, Marks M, David L. Breast cancer reconstruction in the elderly. Am Surg. 2011;77(12):1640-1643.

Esquivel J, Stojadinovic A, Levine EA. The American Society of Peritoneal Surface Malignancies (ASPSM) [letter]. Ann Surg Oncol. 2011;18(Suppl 3):S218-S219.

Helm CW, Richard SD, Pan J, Bartlett D, Goodman MD, Hoefer R, Lentz SS, Levine EA, Loggie BW, Miller B, et al. Hyperthermic intraperitoneal chemotherapy in ovarian cancer: first report of the HYPER-O Registry. Int J Gynecol Cancer. 2010;20(1):61-69.

Becher RD, Shen P, Stewart JH, Russell G, Bradley T, Levine EA. Splenectomy ameliorates hematologic toxicity of intraperitoneal hyperthermic chemotherapy [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S83-S84.

Helm C, Richard SD, Pan J, Bartlett D, Goodman MD, Hoefer R, Lentz SS, Levine EA, Loggie BW, Miller B, et al. Hyperthermic chemotherapy for ovarian cancer--report of the HYPERO Registry [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S88.

Hill AR, McQuellon RP, Russell GB, Shen P, Stewart JH, Levine EA. Survival and health-related quality of life following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for disseminated peritoneal cancer of colonic origin [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S9.

Howard-McNatt M, Schroll R, Hurt G, Levine E. Contralateral prophylatic mastectomy in breast cancer patients who test negative for BRCA mutations [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S60.

Kaminski JP, Case D, Howard-McNatt M, Geisinger KR, Levine EA. Intraoperative imprint cytology of sentinel nodes in patients with breast cancer--costly or cost effective? [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S49.

Parson N, Shen P, Russell GB, Lentz SS, Levine EA, Stewart JH. Outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface dissemination from ovarian neoplasms [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S120.

Votanopoulos KI, Shen P, Stewart JH, Russell G, Levine EA. A comparison of hematologic toxicity profiles after heated intraperitoneal chemotherapy with oxaliplatin and mitomycin-C [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S85.

Lata AL, Oaks T, Levine EA. Initial institutional experience with thoracoscopic assisted esophagectomy. Am Surg. 2010;76(7):735-740.

Beard HR, Cantrell EF, Russell GB, Howard-McNatt M, Shen P, Levine EA. Outcome after mastectomy for ipsilateral breast tumor recurrence after breast conserving surgery. Am Surg. 2010;76(8):829-834.

Yan TD, Sugarbaker PH, Elias D, Glehen O, Levine EA, Moran BJ, Deraco M, Morris DL, Piso P. Continued uncertainty regarding hyperthermic intraperitoneal chemotherapy in malignant peritoneal mesothelioma [reply to letter]. J Clin Oncol. 2010;28(24):E419.

Monjazeb AM, Riedlinger G, Aklilu M, Geisinger KR, Mishra G, Isom S, Clark P, Levine EA, Blackstock AW. Outcomes of patients with esophageal cancer staged with [18F] fluorodeoxyglucose positron emission tomography (FDG-PET): can postchemoradiotherapy FDG-PET predict the utility of resection?. J Clin Oncol. 2010;28(31):4714-4721.

Blackham AU, Shen P, Stewart JH, Russell GB, Levine EA. Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for malignant peritoneal mesothelioma: mitomycin versus cisplatin. Ann Surg Oncol. 2010;17(10):2720-2727.

Kaminski JP, Case D, Howard-McNatt M, Geisinger KR, Levine EA. Sentinel lymph node intraoperative imprint cytology in patients with breast cancer--costly or cost effective?. Ann Surg Oncol. 2010;17(11):2920-2925.

Monjazeb AM, Riedlinger G, Isom S, Aklilu M, Geisinger KR, Mishra G, Levine EA, Blackstock AW. Radiotherapy for esophageal cancer: does dose affect outcomes? [abstract]. Int J Radiat Oncol Biol Phys. 2010;78(3 Suppl):S307.

Esquivel J, Chua TC, Stojadinovic A, Melero JT, Levine EA, Gutman M, Howard R, Piso P, Shen P, Stewart JH, et al. Accuracy and clinical relevance of computed tomography scan interpretation of peritoneal cancer index in colorectal cancer peritoneal carcinomatosis: a multi-institutional study. J Surg Oncol. 2010;102(6):565-570.

Rohani P, Scotti SD, Shen P, Stewart JH, Russell GB, Cromer M, Levine EA. Use of FDG-PET imaging for patients with disseminated cancer of the appendix. Am Surg. 2010;76(12):1338-1344.

Levine E, Krishnamurthy S, Gittleman M, Young P, Streck C, Boolbol S, Meric-Bernstam F, Hermann R, Han L, Cohen J-M, et al. Prospective comparison of the OSNA Breast Cancer System to imprint cytology for the intraoperative analysis of sentinel lymph nodes from cancer of the breast [abstract]. Ann Surg Oncol. 2010;17(2 Suppl 2):S180.


Danhauer SC, Mihalko SL, Russell GB, Campbell CR, Felder L, Daley K, Levine EA. Restorative yoga for women with breast cancer: findings from a randomized pilot study. Psychooncology. 2009;18(4):360-368.

Blackstock AW, Aklilu M, Lovato J, Degrass L, Sommer J, Howerton R, Mishra G, Levine E, McQuellon R. Aprepitant/5HT-3 antagonist (EMEND) for the prevention of chemoradiation-induced nausea and vomiting (CRINV) in patients receiving gemcitabine/5-FU-based chemoradiation and concurrent upper abdominal radiation for pancreatic cancer [abstract]. J Clin Oncol. 2009;27(Suppl):e20661.

McQuellon R, Russell G, Campbell C, Duckworth K, Shen P, Stewart J, Fenstermaker J, Pruitt L, Cromer M, Levine E, et al. Assessing depressive symptoms with the Center for Epidemiologic Studies Depression Scale prior to cytoreductive surgery + intraperitoneal hyperthermic chemotherapy [abstract]. Psychooncology. 2009;18(Suppl 1):S42-S43.

Moore P, Hundley J, Hundley J, Levine EA, Williford P, Sangueza O, McCoy T, Shen P. Does shave biopsy accurately predict the final Breslow depth of primary cutaneous melanoma?. Am Surg. 2009;75(5):369-373.

Trivedi AN, Levine EA, Mishra G. Adenocarcinoma of the appendix is rarely detected by colonoscopy. J Gastrointest Surg. 2009;13(4):668-675.


Wood BC, David LR, Defranzo AJ, Stewart JH, Shen P, Geisinger KR, Marks MW, Levine EA. Impact of sentinel lymph node biopsy on immediate breast reconstruction after mastectomy. Am Surg. 2009;75(7):551-556.

Godat LN, Horton JK, Shen P, Stewart JH, Wentworth S, Levine EA. Recurrence after mastectomy for ductal carcinoma in situ. Am Surg. 2009;75(7):592-597.

Wong SL, Young YD, Geisinger KR, Shen P, Stewart JH, Sangueza O, Pichardo-Geisinger R, Levine EA. Intraoperative imprint cytology for evaluation of sentinel lymph nodes from Merkel cell carcinoma. Am Surg. 2009;75(7):615-619.

Becher RD, Shen P, Stewart JH, Geisinger KR, McCarthy LR, Levine EA. Sentinel lymph node mapping for gastric adenocarcinoma. Am Surg. 2009;75(8):710-714.




Stewart JH IV, Shen P, Levine EA. Translation considerations for hyperthermic intraperitoneal chemotherapy. Curr Probl Cancer. 2009;33(3):194-202.

Stewart JH IV, Levine EA, Shen P. The current role of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of appendiceal tumors. Curr Probl Cancer. 2009;33(3):142-153.

Yan TD, Deraco M, Baratti D, Kusamura S, Elias D, Glehen O, Gilly FN, Levine EA, Shen P, Mohamed F, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience. J Clin Oncol. 2009;27(36):6237-6242.

Stewart JH IV, Levine EA. Oncology In: O'Leary JP, Tabuenca A, Capote LR, eds. The physiologic basis of surgery. 4th ed. Philadelphia: Lippincott Williams & Wilkins;2008: 188-217.

Jackson LC, Camacho F, Levine EA, Anderson RT, Stewart JH IV. Patterns of care analysis among women with ductal carcinoma in situ in North Carolina. Am J Surg. 2008;195(2):164-169.

Van Emburgh BO, Hu JJ, Levine EA, Mosley LJ, Case LD, Lin H-Y, Knight SN, Perrier ND, Willingham MC, Miller MS, et al. Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer. Mol Carcinog. 2008;47(2):88-99.

McQuellon RP, Russell GB, Shen P, Stewart JH IV, Saunders W, Levine EA. Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. Ann Surg Oncol. 2008;15(1):125-133.

Jakub JW, Levine EA, Paramo J, Shivers S, Russell G, Reintgen DS. Can colon cancer patients adequately staged as T3N0 be cured with surgery alone [abstract]. Ann Surg Oncol. 2008;15(Suppl 2):49.

Shen P, Thai K, Stewart JH, Howerton R, Loggie BW, Russell G, Levine EA. Isolated metastases of colorectal cancer to the liver or peritoneum: outcomes associated with optimal surgical treatment [abstract]. Ann Surg Oncol. 2008;15(Suppl 2):6.

Van Emburgh BO, Hu JJ, Levine EA, Mosley LJ, Perrier ND, Freimanis RI, Allen GO, Rubin P, Carey LA, Miller MS, et al. Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer. Oncol Rep. 2008;19(5):1311-1321.

Geisinger KR, Levine EA. Sentinel lymph nodes: an introduction [editorial]. Pathol Case Rev. 2008;13(3):85-86.

Young YD, Parsons AC, Levine EA, Geisinger KR. Intraoperative imprint cytology for sentinel lymph node evaluation of Merkel cell carcinoma: a case report. Pathol Case Rev. 2008;13(3):109-113.


Stewart JH IV, Shen P, Russell G, Fenstermaker J, McWilliams L, Coldrun FM, Levine KE, Jones BT, Levine EA. A phase I trial of oxaliplatin for intraperitoneal hyperthermic chemoperfusion for the treatment of peritoneal surface dissemination from colorectal and appendiceal cancers. Ann Surg Oncol. 2008;15(8):2137-2145.

McQuellon R, Gavazzi C, Piso P, Swain D, Levine E. Quality of life and nutritional assessment in peritoneal surface malignancy (PSM): recommendations for care. J Surg Oncol. 2008;98(4):300-305.

Danhauer SC, Russell G, Campbell CR, Daley KL, McQuellon RP, Levine E. Restorative yoga for women with breast cancer: findings from a randomized pilot study [abstract]. Ann Behav Med. 2008;35(Suppl 1):S103.

Anderson RT, Kimmick GG, Camacho F, Whitmire JT, Dickinson C, Levine EA, Torit FM, Balkrishnan R. Health system correlates of receipt of radiation therapy after breast-conserving surgery: a study of low-income Medicaid-enrolled women. Am J Manag Care. 2008;14(10):644-652.

Shen P, Stewart JH, Levine EA. Metastases of colorectal cancer to the liver and peritoneum: comparison of surgical paradigms. Expert Rev Anticancer Ther. 2008;8(11):1797-1808.

Stewart JH IV, Shen P, Levine EA. Intraperitoneal hyperthermic chemotherapy: an evolving paradigm for the treatment of peritoneal surface malignancies. Expert Rev Anticancer Ther. 2008;8(11):1809-1818.

Smith TR, Levine EA, Freimanis RI, Akman SA, Allen GO, Hoang KN, Liu-Mares W, Hu JJ. Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis. 2008;29(11):2132-2138.

Levine EA, Edwards M, Wood BC. Treatment of in-transit metastases from Merkel cell carcinoma with isolated hyperthermic limb infusion [reply to letter]. Am Surg. 2008;74(12):1223.

Shen P, Thai K, Stewart JH, Howerton R, Loggie BW, Russell GB, Levine EA. Peritoneal surface disease from colorectal cancer: comparison with the hepatic metastases surgical paradigm in optimally resected patients. Ann Surg Oncol. 2008;15(12):3422-3432.

Howard-McNatt M, Levine EA. Sentinel node mapping: status in 2008. Pathol Case Rev. 2008;13(3):87-94.

Shen P, Jackson L, Carter JE, Levine EA. Surgical therapy for metastatic carcinomas of unknown origin In: Wick MR, ed. Metastatic carcinomas of unknown origin. New York: Demos Medical Publishing;2008: 225-240.

Mondi MM, Cuenca RE, Ollila DW, Stewart JH, Levine EA. Sentinel lymph node biopsy during pregnancy: initial clinical experience. Ann Surg Oncol. 2007;14(1):218-221.

Geisinger KR, Levine EA, Shen P, Bradley RF. Pleuropulmonary involvement in pseudomyxoma peritonei: morphologic assessment and literature review. Am J Clin Pathol. 2007;127(1):135-143.

Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, Baratti D, Bartlett D, Barone R, Barrios P, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Ann Surg Oncol. 2007;14(1):128-133.

Foley KL, Kimmick G, Camacho F, Levine EA, Balkrishnan R, Anderson R. Survival disadvantage among Medicaid-insured breast cancer patients treated with breast conserving surgery without radiation therapy. Breast Cancer Res Treat. 2007;101(2):207-214.

McQuellon RP, Danhauer SC, Russell GB, Shen P, Fenstermaker J, Stewart JH, Levine EA. Monitoring health outcomes following cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis. Ann Surg Oncol. 2007;14(3):1105-1113.

McQuellon RP, Russell GB, Shen P, Stewart JH, Saunders WW, Levine EA. Survival and quality of life (QOL) after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy (IPHC) for disseminated peritoneal cancer (PC) of appendiceal origin [abstract]. Ann Surg Oncol. 2007;14(2 Suppl):30-31.

Shen P, Geisinger KR, Zagoria R, Levine EA. Pathologic correlation study of microwave coagulation therapy for hepatic malignancies using a three-ring probe. J Gastrointest Surg. 2007;11(5):603-611.

Soo V, Bradley T, Shen P, Stewart JH, Russell GB, Levine EA. Splenectomy ameliorates hematologic toxicity of intraperitoneal hyperthermic chemotherapy [abstract]. Ann Surg Oncol. 2007;14(2 Suppl):116.

Stewart JH, Bertoni AE, Staten J, Shen P, Levine EA, Gross CP. Participation in surgical oncology clinical trials: gender, race/ethnicity and age-based disparities [abstract]. Ann Surg Oncol. 2007;14(2 Suppl):29.

Levine EA, Stewart JH IV, Russell GB, Geisinger KR, Loggie BL, Shen P. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy: experience with 501 procedures. J Am Coll Surg. 2007;204(5):943-955.

Easler J, Fennimore B, Farmer M, Yacoub J, Geisinger K, Aklilu M, Blackstock W, Case D, Levine E, Mishra G. Molecular profiling with MIB-1 correlates with microscopic evidence of residual disease in patients undergoing neoadjuvant therapy for esophageal cancer (EC) [abstract]. Gastroenterology. 2007;132(4 Suppl 2):A854.

Kuebler JP, Wieand HS, O'Connell MJ, Smith RE, Colangelo LH, Yothers G, Petrelli NJ, Findlay MP, Seay TE, Levine EA, et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol. 2007;25(16):2198-2204.

Soo V, Shen P, Pichardo R, Azzazy H, Stewart JH, Geisinger KR, Levine EA. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Ann Surg Oncol. 2007;14(5):1612-1617.

Stewart JH, Shen P, Levine EA. Patient selection for cytoreduction and hyperthermic intraperitoneal chemoperfusion In: Ceelen WP, ed. Peritoneal carcinomatosis: a multidisciplinary approach. New York: Springer;2007: 215-225.

Stewart JH, Shen P, Levine EA. Patient selection for cytoreduction and hyperthermic intraperitoneal chemoperfusion. Cancer Treat Res. 2007;134():215-229.

Lentz SS, Miller BE, Kucera GL, Levine EA. Intraperitoneal hyperthermic chemotherapy using carboplatin: a phase I analysis in ovarian carcinoma. Gynecol Oncol. 2007;106(1):207-210.

Yacoub J, Richardson C, Farmer M, Lee WR, Clark PE, Hurt G, Levine EA. Male breast cancer during treatment with leuprolide for prostate cancer. Clin Adv Hematol Oncol. 2007;5(7):555-556.



Kilpatrick LA, Shen P, Stewart JH, Levine EA. Use of sentinel lymph node biopsy for melanoma of the head and neck. Am Surg. 2007;73(8):754-758.

Stewart JH IV, Bertoni AG, Staten JL, Levine EA, Gross CP. Participation in surgical oncology clinical trials: gender-, race/ethnicity-, and age-based disparities. J Surg Oncol. 2007;14(12):3328-3334.

Wood BC, Kleinpeter KP, Levine EA. Treatment of in-transit metastases from Merkel cell carcinoma with isolated hyperthermic limb perfusion [letter]. Am Surg. 2007;73(12):1291-1292.

Kim C, Farmer MR, Yacoub J, Monjazeb A, Levine EA, Aklilu M, Geinsinger [sic] KR [Geisinger KR], Mishra G, Melin S, Blackstock AW. Tri-modality therapy for esophageal cancer: mucinous histology is associated with decreased pathologic response rates to neoadjuvant chemoradiation therapy [abstract]. Int J Radiat Oncol Biol Phys. 2007;69(3 Suppl):S267.

Monjazeb AM, Farmer MR, Mattern M, Mebea A, Levine EA, Geisinger KR, Mishra G, Melin S, Blackstock AW. Patterns of failure for esophageal cancer patients optimally staged with 18-F-FDG-PET and observed after chemo-radiotherapy [abstract]. Int J Radiat Oncol Biol Phys. 2007;69(3 Suppl):S274.

Chmelo E, Kolakowski E, Mihalko SL, Levine E, Ribisl P. Physical activity and function: the value of assessment prior to surgical intervention for breast cancer [abstract]. Ann Behav Med. 2007;33(Suppl 1):S148.

Mihalko SL, Anderson RT, McCoy T, Chmelo EA, Kolakowski E, Rogers SD, Ribisl PM, Levine E. Research on optimal recovery practices in breast cancer: the Restore Trial [abstract]. Ann Behav Med. 2007;33(Suppl 1):S55.

Stoeckel WT, David L, Levine EA, Argenta AE, Perrier ND. Vacuum-assisted closure for the treatment of complex breast wounds. Breast. 2006;15(5):610-613.

Berg WA, Weinberg IN, Narayanan D, Lobrano ME, Ross E, Amodei L, Tafra L, Adler LP, Uddo J, Levine EA, et al. High-resolution fluorodeoxyglucose positron emission tomography with compression ('positron emission mammography') is highly accurate in depicting primary breast cancer. Breast J. 2006;12(4):309-323.

Rao PN, Crippin J, Levine E, Hunt J, Baliga S, Balart L, Anthony L, Mulekar M, Raj MHG. Elevation of serum riboflavin carrier protein in hepatocellular carcinoma. Hepatol Res. 2006;35(2):83-87.

Thomas KA, Lechner J, Shen P, Waters GS, Geisinger KR, Levine EA. Use of sentinel node mapping for cancer of the colon: 'to map or not to map'. Am Surg. 2006;72(7):606-611.

Blackstock AW, Mornex F, Partensky C, Descos L, Case LD, Melin SA, Levine EA, Mishra G, Limentani SA, Kachnic LA, et al. Adjuvant gemcitabine and concurrent radiation for patients with resected pancreatic cancer: a phase II study. Br J Cancer. 2006;95(3):260-265.

Foley KL, Camacho F, Levine EA, Kimmick G, Balkrishnan R, Anderson R. The influence of radiation therapy on survival among Medicaid-enrolled breast cancer patients treated with breast conserving surgery [abstract]. J Clin Oncol. 2006;24(18 Suppl Pt I):30s.

Blackstock AW, Aklilu M, Lovato J, Farmer MR, Mishra G, Melin SA, Oaks T, Geisinger K, Levine EA. Pathologic complete response may not represent the optimal surrogate for survival after preoperative therapy for esophageal cancer. Int J Gastrointest Cancer. 2006;37(1):7-14.

Farmer MR, Yacoub J, Aklilu M, Levine EA, Geisinger K, Mishra G, Melin S, Blackstock AW. Tri-modality therapy for esophageal cancer: hemoglobin levels are prognostic for survival but do not predict response to radiochemotherapy [abstract]. Int J Radiat Oncol Biol Phys. 2006;66(3 Suppl):S269.

Kimmick G, Camacho F, Foley KL, Levine EA, Balkrishnan R, Anderson R. Racial differences in patterns of care among Medicaid-enrolled patients with breast cancer. J Oncol Pract. 2006;2(5):205-213.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Surgical Sciences-Oncology

Clinical Specialties

Sarcoma, Gastrointestinal Tumors, Esophageal Cancer, Mesothelioma, Peritoneal Carcinomatosis, Esophageal Tumors, Melanoma, Breast Cancer
Edward A. Levine, M.D.

Edward A. Levine, M.D.

Chief, Surgical Sciences-Oncology
Director-At-Large, Comprehensive Cancer Center
Core Director, Comprehensive Cancer Center
Professor, Surgical Sciences-Oncology
Comprehensive Cancer Center
Office of Women in Medicine and Science

Doctor Rating

4.7 out of 5

Edward A. Levine, M.D.192 Ratings
3 Comments

Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
4.7
CP efforts to include in decisions
4.7
CP explanations of prob/condition
4.8
CP spoke using clear language
4.8
Friendliness/courtesy of CP
4.8
Likelihood of recommending CP
4.8
Patients' confidence in CP
4.8
Time CP spent with patient
4.6
Wait time at clinic
3.8



Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.

7/7/2014

Dr. Levine was assuring and comforting during the visit. I was impressed with his knowledge and have complete confidence in his skill for my upcoming surgery.

6/2/2014

I trust him with my life, I'm very confident in his abilities, I do feel rushed when he is in the room, I'm sure he stays very busy.

4/14/2014

I recommend *Dr. Levine to all my friends & family.

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