Profile

Xingnan Li, Ph.D.Wake Forest School of Medicine

Xingnan Li, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-7514 | Department: 336-716-2011

Email: xinli@wakehealth.edu

Education & Training

  • B.S., Peking University, 1997
  • Ph.D., Michigan State University, 2004
  • M.S., Michigan State University, 2005
Xingnan Li, Ph.D.

Xingnan Li, Ph.D.

Assistant Professor, Center for Genomics and Personalized Medicine Research

Research Interests

Asthma; Genome-Wide Association Study; Polymorphism, Single Nucleotide; Lung; Forced Expiratory Volume
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Contact Information

Academic: 336-713-7514 | Department: 336-716-2011

Email: xinli@wakehealth.edu

Recent Publications

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.. J Asthma. 2016;():.

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Allergy. 2015;70(10):1309-1318.

Factor analysis of Chronic Obstructive Pulmonary Disease (COPD) related phenotypes in the subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Li X, Li H, Ampleford J, Dransfield MT, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2439.

Evaluation of genetic variants in Il6 and Il6r in the Nhlbi subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Hawkins GA, Ampleford EJ, Ortega VE, Li X, Peters SP, Barr RG, Couper D, Han MK, Kanner R, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A4693.

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2014;133(6):1557-1563.

Genetics and asthma. Slager RE, Li X, Meyers DA, Bleecker ER. In: Bernstein JA, Levy ML, eds. Clinical asthma: theory and practice. Boca Raton: CRC Press;2014: 21-28.

Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2014;189(Meeting Abstracts):A1001.

Predictors of response to bronchodilators in children with severe asthma [abstract]. Coverstone AM, Zheng J, Bacharier LB, Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Gaston BM, Bleecker ER, Moore WC, Castro M.. Am J Respir Crit Care Med. 2014;189():A3839.

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, Eng CS, Pino-Yanes M, Padhukasahasram B, Yang JJ, Mathias RA, Beaty TH, Li X, Graves P, Romieu I, Navarro Bdel R, Salam MT,.. BMC Med Genomics. 2014;7():48.

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(2):313-320.

Clinical heterogeneity in the severe asthma research program. Moore WC, Fitzpatrick AM, Li X, Hastie AT, Li H, Meyers DA, Bleecker ER.. Ann Am Thorac Soc. 2013;10(Suppl):S118-S124.

Phenotypic/genetic characteristics of atopic/non-atopic early/late onset asthma [abstract]. Li X, Moore WC, Ampleford EJ, Li H, Hawkins G, Hastie AT, Boushey HA, Busse WW, Castro M, Erzurum SC, Israel E, Lemanske RF, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2395.

Cluster analysis of asthma phenotypes in children ages 6 to 18 years from the EVE Consortium [abstract]. Gower WA, Li X, Li H, Ampleford EJ, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A3803.

Elderly subjects with asthma are less responsive to albuterol and ipratropium bromide when compared to younger subjects, but have similar responses to the two drugs [abstract]. Moore WC, Smith R, Krings J, Li X, Li H, Peters SP, Wenzel SE, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A4215.

The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients [letter]. Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA.. J Allergy Clin Immunol. 2012;129(2):575-578.

Phenotype determinants for asthma severity clusters and genetic association for cluster-based asthma severity in Severe Asthma Research Program (SARP) [abstract]. Li X, Moore WC, Li H, Ampleford EJ, Busse WW, Erzurum SC, Wenzel SE, Howard TD, Hawkins GA, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2501.

Exome sequencing of asthma candidate genes in chromosome 2q11-12 and 2q33 [abstract]. Hawkins G, Li X, Slager R, Moore WC, Peters SP, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4904.

The addition of sputum inflammatory cell counts to the SARP cluster analysis results in similar clinical asthma phenotypes with biologic heterogeneity [abstract]. Moore WC, Hastie AT, Li H, Li X, Busse WW, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3625.

The IL6R variation Asp358 Ala is a potential modifier of lung function in subjects with asthma. Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2012;130(2):510-515.

Genetics of asthma susceptibility and severity. Slager RE, Hawkins GA, Li X, Postma DS, Meyers DA, Bleecker ER.. Clin Chest Med. 2012;33(3):431-443.

Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Rodriguez-Santana JR,.. J Allergy Clin Immunol. 2012;130(3):622-629.

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA.. J Allergy Clin Immunol. 2012;130(4):861-868.

Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Bleecker ER, Moore WC, et al.. J Allergy Clin Immunol. 2011;127(2):382-389.

Recent developments in the genetics of asthma susceptibility and severity. Slager RE, Li X, Meyers DA, Bleecker ER. In: Chung KF, Bel EH, Wenzel SE, eds. Difficult-to-treat severe asthma. Sheffield: European Respiratory Society Journals;2011: 82-96.

Importance of hedgehog interacting protein and other lung function genes in asthma. Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Peters SP, Hawkins GA, Bleecker ER, Meyers DA, et al.. J Allergy Clin Immunol. 2011;127(6):1457-1465.

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Li X, Bleecker ER, Meyers DA, et al.. Nat Genet. 2011;43(9):887-892.

Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2010;125(2):328-335.

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Peters SP, Bleecker ER, et al.. Am J Respir Crit Care Med. 2010;181(4):315-323.

Genome-wide association study of asthma severity using proportional odds model identifies TMEM154 [abstract]. Li X, Howard TD, Ampleford EJ, Peters SP, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A3728.

DNA copy number alterations in prostate cancers: a combined analysis of published CGH studies. Sun J, Liu W, Adams TS, Sun J, Li X, Turner AR, Chang B, Kim JW, Zheng SL, Xu J, et al.. Prostate. 2007;67(7):692-700.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Xingnan Li, Ph.D.

Xingnan Li, Ph.D.

Assistant Professor, Center for Genomics and Personalized Medicine Research

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