Profile

Tie Fu Liu, M.D., Ph.D.Wake Forest School of Medicine

Tie Fu Liu, M.D., Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-8607 | Department: 336-716-8607

Email: tliu@wakehealth.edu

Additional Languages

Chinese-Mandarin

Education & Training

  • M.D., Hengyang Medical College, 1983
  • M.Med., China Medical University, 1990
  • Ph.D., Univ Hong Kong Faculty of Medicine-Hong Kong, 1998
Tie Fu Liu, M.D., Ph.D.

Tie Fu Liu, M.D., Ph.D.

Assistant Professor, Molecular Medicine

Research Interests

Epigenesis, Genetic; Endotoxins; Drug Resistance; Sirtuin 1; Sepsis
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Contact Information

Academic: 336-716-8607 | Department: 336-716-8607

Email: tliu@wakehealth.edu

Recent Publications

Sirtuins link inflammation and metabolism. Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE.. J Immunol Res. 2016;2016():8167273.

Rescuing immunosuppressed septic mice from death by reducing the mitochondrial block in glucose oxidation [abstract]. Liu T, Vachharajani V, Martin A, McCall C.. Shock. 2016;45(6 Suppl 1):130.

Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE.. J Biol Chem. 2015;290(1):396-408.

Transcriptomic profiles of aging in purified human immune cells. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,.. BMC Genomics. 2015;16(1):333.

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE.. J Leukoc Biol. 2014;96(5):785-796.

Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Vachharajani V, Liu T, McCall CE.. Expert Rev Clin Immunol. 2014;10(9):1141-1150.

Deacetylation by SIRT1 reprograms inflammation and cancer. Liu TF, McCall CE.. Genes Cancer. 2013;4(3-4):135-147.

NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. Liu TF, Vachharajani VT, Yoza BK, McCall CE.. J Biol Chem. 2012;287(31):25758-69.

Fueling the flame: bioenergy couples metabolism and inflammation. Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE.. J Leukoc Biol. 2012;92(3):499-507.

NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE.. J Biol Chem. 2011;286(11):9856-9864.

MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-alpha during TLR4-induced gene reprogramming. El Gazzar M, Church A, Liu T, McCall CE.. J Leukoc Biol. 2011;90(3):509-519.

Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B.. J Leukoc Biol. 2011;90(3):439-446.

Dynamic and selective nucleosome repositioning during endotoxin tolerance. El Gazzar M, Liu T, Yoza BK, McCall CE.. J Biol Chem. 2010;285(2):1259-1271.

Gene-specific epigenetic regulation in serious infections with systemic inflammation. McCall CE, Yoza B, Liu T, El Gazzar M.. J Innate Immun. 2010;2(5):395-405.

Reoxygenation of hypoxic glioblastoma multiforme cells potentiates the killing effect of an interleukin-13-based cytotoxin. Liu TF, Cai J, Gibo DM, Debinski W.. Clin Cancer Res. 2009;15(1):160-168.

Re-oxygenation of hypoxic glioblastoma multiforme cells potentiates killing effect of interleukin 13-based cytotoxins through re-establishment and further up-regulation of IL13 receptor alpha2 [abstract]. Liu T, Cai J, Gibo D, Debinski W.. Neuro Oncol. 2007;9(4):494.

Variant IL-13-directed diphtheria toxin fusion recombinant cytotoxin for the treatment of malignant gliomas [abstract]. Liu T, Cai J, Gibo D, Debinski W.. Neuro Oncol. 2006;8(4):429.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Molecular Medicine

Tie Fu Liu, M.D., Ph.D.

Tie Fu Liu, M.D., Ph.D.

Assistant Professor, Molecular Medicine

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