Research Interests
aging
,
cognition/learning
,
diabetes
,
genetics/genome
Recent Publications
Mitchell GF, Verwoert GC, Tarasov KV, Isaacs A, Smith AV, Liu Y, Andrews JS, Howard TD, Herrington DM, Ding J, et al.
Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. Circ Cardiovasc Genet.
2012;
5(1):81-90.
Qayyum R, Snively BM, Ziv E, Nalls MA, Liu Y, Tang W, Yanek LR, Lange L, Evans MK, Ganesh S, Austin MA, Lettre G, Becker DM, Zonderman AB, Singleton AB, Harris TB, Mohler ER, Logsdon BA, Kooperberg C, Folsom AR, Wilson JG, Becker LC, Reiner AP.
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in African Americans. PLoS Genet.
2012;
8(3):e1002491.
Manning AK, LaValley M, Liu C-T, Rice K, An P, Liu Y, Miljikovic I, Rasmussen-Torvik L, Harris TB, Province MA, et al.
Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP ? environment regression coefficients. Genet Epidemiol.
2011;
35(1):11-18.
Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Rudock ME, Liu Y, et al.
Meta-analysis of genome-wide association studies in greater than 80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation.
2011;
123(7):731-738.
Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bowden DW, Kritchevsky SB, Rudock ME, Liu Y, et al.
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet.
2011;
7(2):e1001300.
Smith JG, Magnani JW, Palmer C, Meng YA, Soliman EZ, Musani SK, Kerr KF, Schnabel RB, Lubitz SA, Liu Y, et al.
Genome-wide association studies of the PR interval in African Americans. PLoS Genet.
2011;
7(2):e1001304.
Boger CA, Chen M-H, Tin A, Olden M, Kottgen A, de Boer IH, Fuchsberger C, O'Seaghdha CM, Lohman K, Liu Y, et al.
CUBN is a gene locus for albuminuria. J Am Soc Nephrol.
2011;
22(3):555-570.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Annemarie K, Petersen AK, Eriksson J, Lehtimaki T, Liu Y, et al.
Genetic determinants of serum testosterone concentrations in men [abstract]. Clin Chem Lab Med.
2011;
49(Suppl 1):S424.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bandinelli S, Bell JT, Liu Y, et al.
Eight common genetic variants associated with serum DHEAS levels suggests a key role in ageing mechanisms [abstract]. Clin Chem Lab Med.
2011;
49(Suppl 1):S425.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Liu Y, et al.
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet.
2011;
7(4):e1002025.
Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen M-H, Smith AV, Toniolo D, Zakai NA, Yang Q, Liu Y, et al.
Multiple loci are associated with white blood cell phenotypes. PLoS Genet.
2011;
7(6):e1002113.
Kilpelainen TO, Zillikens MC, Stancakova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Liu Y, et al.
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet.
2011;
43(8):753-760.
Hsu F-C, Sides EG, Mychaleckyj JC, Worrall BB, Elias GA, Liu Y, Chen W-M, Coull BM, Toole JF, Rich SS, et al.
Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk. Neurology.
2011;
77(16):1543-1550.
Kanoni S, Nettleton JA, Hivert M-F, Ye Z, van Rooij FJA, Anderson JS, Saylor G, Houston DK, Liu Y, Kritchevsky SB, et al.
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes.
2011;
60(9):2407-2416.
Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M, Lunetta KL, Milaneschi Y, Lohman KK, Liu Y, et al.
A genome-wide association study of aging. Neurobiol Aging.
2011;
32(11):e15-e28.
Reiner AP, Lettre G, Nalls MA, Ganesh SK, Mathias R, Austin MA, Lohman K, Yang L, Liu Y, Snively BM, et al.
Genome-wide association study of white blood cell count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT). PLoS Genet.
2011;
7(6):e1002108.
Ehret GB, Munroe PB, Rice KM, Liu Y, Palmer ND, Lohman KK, Rudock ME, Langefeld CD, Prokopenko I, Wagenknecht LE, et al.
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature.
2011;
478(7367):103-109.
Liu C-T, Garnaas MK, Tin A, Kottgen A, Franceschini N, Peralta CA, de Boer IH, Lu X, Ding J, Liu Y, et al.
Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet.
2011;
7(9):e1002264.
Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Kritchevsky SB, Liu Y, Lohman K, et al.
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet.
2011;
43(11):1082-1090.
N'Diaye A, Chen GK, Palmer CD, Ge B, Tayo B, Mathias RA, Ding J, Nalls MA, Kritchevsky SB, Lohman K, Liu Y, et al.
Identification, replication, and fine-mapping of loci associated with adult height in individuals of African ancestry. PLoS Genet.
2011;
7(10):e1002298.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Koster A, Petersen A-K, Eriksson J, Lehtimaki T, Liu Y, et al.
Genetic determinants of serum testosterone concentrations in men. PLoS Genet.
2011;
7(10):e1002313.
Tranah GJ, Manini TM, Lohman KK, Nalls MA, Kritchevsky S, Newman AB, Harris TB, Miljkovic I, Biffi A, Cummings SR, Liu Y.
Mitochondrial DNA variation in human metabolic rate and energy expenditure. Mitochondrion.
2011;
11(6):855-861.
van den Borst B, Koster A, Yu B, Gosker HR, Meibohm B, Bauer DC, Kritchevsky SB, Liu Y, Newman AB, Harris TB, Schols AMWJ.
Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?. Thorax.
2011;
66(11):961-969.
O'Donnell CJ, Kavousi M, Smith AV, Kardia SLR, Feitosa MF, Hwang S-J, Sun YV, Herrington DM, Howard TD, Liu Y, et al.
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation.
2011;
124(25):2855-2864.
Burdon KP, Rudock ME, Lehtinen AB, Langefeld CD, Bowden DW, Register TC, Liu Y, Freedman BI, Carr JJ, Hedrick CC, et al.
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the Diabetes Heart Study. Mediators Inflamm.
2010;
2010():170153.
Kottgen A, Pattaro C, Boger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Lohman K, Liu Y, et al.
New loci associated with kidney function and chronic kidney disease. Nat Genet.
2010;
42(5):376-384.
Kalogeroupoulos A, Georgiopoulou V, Psaty BM, Rodondi N, Smith AL, Harrison DG, Liu Y, Hoffmann U, Bauer DC, Kritchevsky SB, et al.
Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. J Am Coll Cardiol.
2010;
55(19):2129-2137.
Kestenbaum B, Glazer NL, Kottgen A, Felix JF, Hwang S-J, Liu Y, Lohman K, Kritchevsky SB, Hausman DB, Petersen A-K, et al.
Common genetic variants associate with serum phosphorus concentration. J Am Soc Nephrol.
2010;
21(7):1223-1232.
Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Houston DK, Burke GL, Liu YM, Kritchevsky SB, et al.
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet.
2010;
376(9736):180-188.
O'Seaghdha CM, Yang Q, Glazer NL, Leak TS, Dehghan A, Smith AV, Kao WHL, Lohman K, Hwang S-J, Liu YM, et al.
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. Hum Mol Genet.
2010;
19(21):4296-4303.
Tranah GJ, Manini TM, Lohman KK, Nalls MA, Kritchevsky S, Newman AB, Harris TB, Biffi A, Cummings SR, Liu YM.
Mitochondrial DNA variation in human metabolic rate, energy expenditure and mortality: the Health, Aging and Body Composition Study [abstract]. Genet Epidemiol.
2010;
34(8):972-973.
Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert M-F, Anderson JS, Houston DK, Kritchevsky SB, Liu Y, Saylor G, et al.
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care.
2010;
33(12):2684-2691.
Freedman BI, Hicks PJ, Bostrom MA, Cunningham ME, Liu Y, Divers J, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al.
Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int.
2009;
75(7):736-745.
Hsu F-C, Kritchevsky SB, Liu Y, Kanaya A, Newman AB, Perry SE, Visser M, Pahor M, Harris TB, Nicklas BJ.
Association between inflammatory components and physical function in the Health, Aging, and Body Composition Study: a principal component analysis approach. J Gerontol A Biol Sci Med Sci.
2009;
64(5):581-589.
Bielinski SJ, Pankow JS, Post W, Liu Y, Folsome AR, Hedrick CC.
MCP-1 polymorphisms, subclinical atherosclerosis, and incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA) [abstract]. Circulation.
2009;
119(10):e329-e330.
Ding J, Hsu F-C, Harris TB, Liu Y, Kritchevsky SB, Szklo M, Ouyang P, Espeland MA, Lohman KK, Carr JJ, et al.
The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr.
2009;
90(3):499-504.
McGeachie M, Ramoni RLB, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, et al.
Integrative predictive model of coronary artery calcification in atherosclerosis. Circulation.
2009;
120(24):2448-2454.
Sale MM, Furie KL, Hsu F-C, Mychaleckyj JC, Sides EG, Howard TD, Worrall BB, Liu Y, Coull BM, Toole JF, et al.
Multiple variants in the transcobalamin 2 and cystathionine beta-synthase genes are associated with homocysteine levels in subjects from the Vitamin Intervention for Stroke Prevention (VISP) trial [abstract]. Stroke.
2008;
39(2):630.
Liu Y, Freedman BI, Burdon KP, Langefeld CD, Howard T, Herrington D, Goff DC Jr, Bowden DW, Wagenknecht LE, Rich SS, et al.
Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Am J Kidney Dis.
2008;
52(2):242-250.
Bielinski SJ, Pankow JS, Foster CL, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, et al.
Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination. Atherosclerosis.
2008;
199(1):172-178.
Howard TD, Liu Y, Saylor G, Giles WH, Wozniak MA, Gallagher M, Steinberg KK, Macko RF, Cole JW, Kittner SJ.
Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke in a replication population of young African-American women [abstract]. Stroke.
2007;
38(2):528.
Zhang L, Kao WHL, Bertheir-Schaad Y, Liu Y, Plantiga L, Jaar BG, Fink N, Powe N, Klag MJ, Smith MW, et al.
Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients. J Am Soc Nephrol.
2006;
17(8):2285-2292.
Rich SS, Burdon KP, Langefeld CD, Liu Y, Freedman BI, Carr JJ, Hedrick CC, Bowden DW.
Human lipoxygenase gene variation in subclinical atherosclerosis: the Diabetes Heart Study [abstract]. Atheroscler Suppl.
2006;
7(3):335.
Lange LA, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman BI, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW.
Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet.
2006;
70(Pt 6):717-725.
All Publications
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.
For a list of earlier publications, visit the Carpenter Library Publication Search.