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Mark O. Lively, Ph.D.

Mark O. Lively, Ph.D.

Professor, Biochemistry
Translational Science Institute
Translational Science Institute
Institute for Regenerative Medicine

Contact Information

Academic: 336-716-2969 | Department: 336-716-2969

Email: mlively@wakehealth.edu

Education & Training

  • Ph.D., Georgia Institute of Technology , 1978
  • B.S., Georgia Institute of Technology , 1975
  • Fellowship, Georgia Institute of Technology, 1979
  • Fellowship, University of Washington, 1982

Memberships

  • Protein Society
  • Am Soc Of Biochem & Mol Biolog
  • Am Soc Of Mass Spectrometry
  • Assn of Biomolecular Resource
Mark O. Lively, Ph.D.

Mark O. Lively, Ph.D.

Professor, Biochemistry Translational Science Institute
Translational Science Institute
Institute for Regenerative Medicine

Research Interests

cancer/oncogenesis

Contact Information

Academic: 336-716-2969 | Department: 336-716-2969

Email: mlively@wakehealth.edu

Recent Publications

Beauchamp A, Lively MO, Mintz A, Gibo D, Wykosky J, Debinski W. EphrinA1 is released in three forms from cancer cells by matrix metalloproteases. Mol Cell Biol. 2012;32(16):3253-3264.

Bourne HR, Lively MO. Iceberg alert for NIH [editorial]. Science. 2012;337(6093):390.

Govan JM, Uprety R, Hemphill J, Lively MO, Deiters A. Regulation of transcription through light-activation and light-deactivation of triplex-forming oligonucleotides in mammalian cells. ACS Chem Biol. 2012;7(7):1247-1256.

Okada H, Butterfield LH, Hamilton RL, Lively MO, Chan MD, Salazar AM, Potter DM, Shaw EG, Lieberman FS. A BI-institutional pilot study of peptide-based vaccines in combination with poly ICLC in patients with WHO grade 2 low-grade glioma [abstract]. J Immunother. 2012;35(9):743.

Okada H, Butterfield LH, Hamilton RH, Mintz AH, Engh JA, Drappatz J, Lively MO, Chan MD, Salazar AM, Potter DM, Shaw EG, Liebeman FS. A BI-institutional pilot study of peptide-based vaccines in combination with poly ICLC in patients with WHO grade 2 low-grade glioma [abstract]. Neuro Oncol. 2012;14(Suppl 6):44.

Govan JM, Lively MO, Deiters A. Photochemical control of DNA decoy function enables precise regulation of nuclear factor kappaB activity. J Am Chem Soc. 2011;133(33):13176-82.

Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Lively M, Ferrario CM. Localization and metabolism of angiotensin-(1-12) in human atrial tissue [abstract]. Hypertension. 2011;58(5):e50.

Fortunato JE, Lopez HN, Lively MO. Pepsin in saliva as a biomarker for esophageal reflux compared with 24-hour esophageal impedance/PH monitoring in pediatric patients [abstract]. J Pediatr Gastroenterol Nutr. 2011;53(Suppl 1):E77.

Lesser GJ, Case LD, Stark N, Williford SK, Giguere JK, Garino A, Naughton MJ, Vitolins M, Lively M, Shaw EG. A randomized double-blind placebo-controlled study of oral coenzyme Q10 to relieve self-reported cancer-treatment-related fatigue in newly diagnosed breast cancer patients [abstract]. J Clin Oncol. 2010;28(15 Suppl):9006.

Vitolins M, Lesser GJ, Case LD, Williford SK, Giguere JK, Garino A, Naughton MJ, Lively M, Melin SA, Shaw EG. Self-reported compliance compared to biomarker levels of vitamin E in breast cancer patients participating in a CoQ10 clinical trial [abstract]. J Clin Oncol. 2010;28(15 Suppl):e19524.



Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol. 2009;16(1):21-28.


Reading BJ, Hiramatsu N, Sawaguchi S, Matsubara T, Hara A, Lively MO, Sullivan CV. Conserved and variant molecular and functional features of multiple egg yolk precursor proteins (vitellogenins) in white perch (Morone americana) and other teleosts. Mar Biotechnol (NY). 2009;11(2):169-187.

Young DD, Govan JM, Lively MO, Deiters A. Photochemical regulation of restriction endonuclease activity. Chembiochem. 2009;10(10):1612-1616.

Young DD, Edwards WF, Lusic H, Lively MO, Deiters A. Light-triggered polymerase chain reaction. Chem Commun. 2008;4():462-464.

Coffman LG, Brown JC, Johnson DA, Parthasarathy N, D'Agostino RB Jr, Lively MO, Hua X, Willingham MC, Torti FM, Torti SV, et al. Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin. Am J Physiol Lung Cell Mol Physiol. 2008;294(3):L505-L515.

Lusic H, Lively MO, Deiters A. Light-activated deoxyguanosine: photochemical regulation of peroxidase activity. Mol Biosyst. 2008;4(6):508-511.

Young DD, Lusic H, Lively MO, Yoder JA, Deiters A. Gene silencing in mammalian cells with light-activated antisense agents. Chembiochem. 2008;9(18):2937-2940.

Ekici OD, Karla A, Paetzel M, Lively MO, Pei D, Dalbey RE. Altered-3 substrate specificity of Escherichia coli signal peptidase 1 mutants as revealed by screening a combinatorial peptide library. J Biol Chem. 2007;282(1):417-425.

Lin Z, Johnson LC, Weissbach H, Brot N, Lively MO, Lowther WT. Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function. Proc Natl Acad Sci U S A. 2007;104(23):9597-9602.

Lusic H, Young DD, Lively MO, Deiters A. Photochemical DNA activation. Org Lett. 2007;9(10):1903-1906.

Newbern J, Taylor A, Robinson M, Lively MO, Milligan CE. c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Neuroscience. 2007;147(3):680-692.

Patel VB, Spencer CH, Young TA, Lively MO, Cunningham CC. Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase. Free Radic Biol Med. 2007;43(11):1499-1507.

Ho M, Onda M, Wang Q-c, Hassan R, Pastan I, Lively MO. Mesothelin is shed from tumor cells [letter]. Cancer Epidemiol Biomarkers Prev. 2006;15(9):1751.

Levi N, Hantgan RR, Lively MO, Carroll DL, Prasad GL. C60-Fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects. J Nanobiotechnol. 2006;4():article 14.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Biochemistry

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