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Hui-Wen Lo, Ph.D.Wake Forest School of Medicine

Hui-Wen Lo, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-0695 | Department: 336-716-0695

Email: hlo@wakehealth.edu

Education & Training

  • B.S., Chung Shan Med University, Taichung, Taiwan, 1986
  • M.A., University of Texas-Austin, 1990
  • M.S., Univ of Texas Health Science Center At Houston, 1994
  • Ph.D., Univ of Texas Health Science Center At Houston, 2002
Hui-Wen Lo, Ph.D.

Hui-Wen Lo, Ph.D.

Associate Professor, Cancer Biology
Brain Tumor Center of Excellence

Research Interests

Receptor, Epidermal Growth Factor; Glioblastoma; Brain Neoplasms; Transcription Factors; Receptor, erbB-2
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Contact Information

Academic: 336-716-0695 | Department: 336-716-0695

Email: hlo@wakehealth.edu

Recent Publications

Repeat stereotactic radiosurgery as salvage therapy for locally recurrent brain metastases previously treated with radiosurgery. McKay WH, McTyre ER, Okoukoni C, Alphonse-Sullivan NK, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Laxton AW, Tatter SB, Watabe K, Chan MD.. J Neurosurg. 2017;127(1):148-156.

Outcomes for anaplastic glioma treated with radiation therapy with or without concurrent temozolomide. McTyre E, Lucas JT, Helis C, Farris M, Soike M, Mott R, Laxton AW, Tatter SB, Lesser GJ, Strowd RE, Lo HW, Debinski W, Chan MD.. Am J Clin Oncol. 2017;():.

Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR.. J Clin Neurosci. 2017;43():6-10.

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW.. Oncotarget. 2017;():.

Biology and treatment of metastasis of sarcoma to the brain. Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S.. Front Biosci (Elite Ed). 2016;8():233-244.

EGFR and HER2 signaling in breast cancer brain metastasis. Sirkisoon SR, Carpenter RL, Rimkus T, Miller L, Metheny-Barlow L, Lo HW.. Front Biosci (Elite Ed). 2016;8():245-263.

Targeting the sonic hedgehog signaling pathway: review of smoothened and GLI inhibitors. Rimkus TK, Carpenter RL, Qasem S, Chan M, Lo HW.. Cancers (Basel). 2016;8(2):E22.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

Genomic predictors of imaging response and survival in glioblastoma [abstract]. Soike M, McTyre E, Holmes JA, Paulsson AK, Miller L, Lesser GJ, Strowd RE, Johnson A, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E121-E122.

Impact of timing of radiotherapy in patients with newly diagnosed glioblastoma. Randolph DM II, McTyre ER, Paulsson AK, Holmes JA, Hinson WH, Lesser GJ, Strowd R, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD.. Clin Neurol Neurosurg. 2016;151():73-78.

miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-alpha. Xing F, Sharma S, Liu Y, Mo YY, Wu K, Zhang YY, Pochampally R, Martinez LA, Lo HW, Watabe K.. Oncogene. 2015;34(37):4890-4900.

Mechanisms regulating glioma invasion. Paw I, Carpenter RC [sic] [Carpenter RL], Watabe K, Debinski W, Lo HW.. Cancer Lett. 2015;362(1):1-7.

Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. Carpenter RL, Paw I, Dewhirst MW, Lo HW.. Oncogene. 2015;34(5):546-557.

The gain-of-function truncated GLI1 (TGLI1) promotes glioblastoma angiogenesis by direct upregulation of VEGF-C and TEM7 expression [abstract]. Carpenter RL, Paw I, Sirkisoon S, Xing F, Gibo D, Watabe K, Debinski W, Lo HW.. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research (AACR); 2015 Apr 18-22; Philadelphia (PA). 2015;():A4165.

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Carpenter RL, Paw I, Zhu H, Sirkisoon S, Xing F, Watabe K, Debinski W, Lo HW.. Oncotarget. 2015;6(26):22653-65.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Cancer Biology

Hui-Wen Lo, Ph.D.

Hui-Wen Lo, Ph.D.

Associate Professor, Cancer Biology
Brain Tumor Center of Excellence

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