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Profile

Profile
Research

Richard F. Loeser Jr, M.D.

Program Director, Sticht Center on Aging
Program Director, Translational Science Institute
Professor, Molecular Medicine
Translational Science Institute
WFU Primate Center
Center for Biomolecular Imaging
Sticht Center on Aging
Orthopaedics

Clinical Specialties

Rheumatology

Contact Information

Academic: 336-716-8701 | Department: 336-716-4322

Education & Training

M.D., West Virginia University School of Medicine , 1984
Internship, Medicine, North Carolina Baptist Hospital, 1985
Residency, Internal Medicine, North Carolina Baptist Hospital, 1987
Fellowship, North Carolina Baptist Hospital, 1989

Memberships

Am Assn for the Adv of Science
Orthopaedic Research Society
Osteoarthritis Res Soc Intl
Am Coll Of Rheumatology

NPI Number

1609851732

Richard F. Loeser Jr, M.D.

Program Director, Sticht Center on Aging
Program Director, Translational Science Institute
Professor, Molecular Medicine Translational Science Institute
WFU Primate Center
Center for Biomolecular Imaging
Sticht Center on Aging
Orthopaedics

Research Interests

aging, arthritis, hormones/cytokines/signalling, molecular biology/molecular me

Contact Information

Academic: 336-716-8701 | Department: 336-716-4322

Recent Publications

Loeser RF. Aging processes and the development of osteoarthritis. Curr Opin Rheumatol. 2013;25(1):108-113.

Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan M, Ferguson C, Fetrow JS. Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis. PLoS One. 2013;8(1):e54633.

Loeser RF. Connective tissue structure and function In: Goldman L, Schafer AI, eds. Goldman's Cecil medicine, vol 2. 24th ed. Philadelphia: Elsevier/Saunders;2012: 1659-1662.

Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, Chou J, Leng X, Fetrow JS. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum. 2012;64(3):705-717.

Yammani RR, Loeser RF. Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Arthritis Res Ther. 2012;14(1):R23.

Loeser RF Jr, Olex AL, McNulty M, Carlson CS, Callahan M, Ferguson C, Fetrow JS. Transcriptional regulation during the development of surgically-induced OA in mice [abstract]. Osteoarthritis Cartilage. 2012;20(Suppl 1):S50.

Messier SP, DeVita P, Nicklas BJ, Beavers D, Mihalko S, Miller GD, Lyles M, Hunter DJ, Eckstein F, Legault C, Williamson JD, Carr JJ, Loeser RF. The Intensive Diet and Exercise for Arthritis Trial (IDEA): effects on knee joint loading and inflammation [abstract]. Osteoarthritis Cartilage. 2012;20(Suppl 1):S28.

Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64(6):1697-1707.

Lotz M, Loeser RF. Effects of aging on articular cartilage homeostasis. Bone. 2012;51(2):241-248.

McNulty MA, Loeser RF, Davey C, Callahan MF, Ferguson CM, Carlson CS. Histopathology of naturally occurring and surgically induced osteoarthritis in mice. Osteoarthritis Cartilage. 2012;20(8):949-956.

Hunter DJ, Beavers D, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko S, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP. The Intensive Diet and Exercise for Arthritis Trial (IDEA): 18-month radiographic and MRI outcomes [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S1070.

Loeser RF, Greene M. Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S3-S4.

Loeser RF, Olex AL, Westwood B, McNutlty MA, Carlson CS, Callahan M, Ferguson C, Fetrow JS. A systems biology approach to elucidating pathways active during the development of osteoarthritis [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S314.

Walton NR, Loeser RF, Beavers D, Nicklas BJ, Lyles M, Messier SP. The effects of intensive diet and exercise on bone density in older adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S1070-71.

Loeser RF. The effects of aging on the development of osteoarthritis. HSS J. 2012;8(1):18-19.

Messier SP, Legault C, Loeser RF, Van Arsdale SJ, Davis C, Ettinger WH, DeVita P. Does high weight loss in older adults with knee osteoarthritis affect bone-on-bone joint loads and muscle forces during walking?. Osteoarthritis Cartilage. 2011;19(3):272-280.

Houston DK, Davis C, Legault C, Hausman DB, Nicklas BJ, Loeser RF, Kritchevsky SB, Messier SP. Serum 25-hydroxyvitamin D and physical function in older adults with knee osteoarthritis [abstract]. FASEB J. 2011;25(Meeting Abstracts):abstr 97.6.

Ruiz J, Wallace EL, Miller DP, Loeser RF, Miles M, DuBose TD, Lichstein PR. A comprehensive 3-year internal medicine residency research curriculum. Am J Med. 2011;124(5):469-473.

Chubinskaya S, Otten L, Soeder S, Borgia JA, Aigner T, Rueger DC, Loeser RF. Regulation of chondrocyte gene expression by osteogenic protein-1. Arthritis Res Ther. 2011;13(2):R55.

Loeser RF. Aging and osteoarthritis. Curr Opin Rheumatol. 2011;23(5):492-496.

Loeser RF, Erickson EA, Long DA [sic] [Long DL]. Rac1 and NADPH oxidase regulate NF kappa B activity and MMP-13 expression in chondrocytes in response to integrin activation [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S702.

Messier SP, Nicklas BJ, Legault C, Mihalko S, Miller GD, DeVita P, Lyles M, Hunter DJ, Eckstein F, Williamson JD, Carr JJ, Loeser RF. The Intensive Diet and Exercise for Arthritis Trial: 18-month clinical outcomes [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S281.

Anderson AS, Loeser RF. Why is osteoarthritis an age-related disease?. Best Pract Res Clin Rheumatol. 2010;24(1):15-26.

Loeser RF, Olex A, Chou J, McNulty MA, Carlson CS, Callahan M, Ferguson C, Fetrow JS. The effects of age on disease severity and gene expression in the destabilized medial meniscus (DMM) model of OA in mice [abstract]. In: Transactions of the 56th Annual Meeting of the Orthopaedic Research Society; 2010 Mar 6-9; New Orleans (LA). 2010;():Abstr 345.

Beier F, Loeser RF. Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes. J Cell Biochem. 2010;110(3):573-580.

Loeser RF. Age-related changes in the musculoskeletal system and the development of osteoarthritis. Clin Geriatr Med. 2010;26(3):371-386.

Wallin R, Schurgers LJ, Loeser RF. Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2010;18(8):1096-1103.

Long DL, Loeser RF. p38gamma mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation. Osteoarthritis Cartilage. 2010;18(9):1203-1210.

Miranda KJ, Loeser RF, Yammani RR. Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem. 2010;285(41):31517-24.

Miranda KJ, Loeser RF, Yammani RR. Response to Berge et al.: comment on the importance of S100A4 in regulation of MMP-13 [letter]. J Biol Chem. 2010;285(53):Ie24.

Olex A, Loeser R, Chou J, Callahan M, Ferguson C, Fetrow JS. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice [abstract]. Genome Biol. 2010;11(Suppl 1):P29.

Loeser R, Fetrow J, Chou J, Nicklas B, Kritchevsky SB. Using gene microarrays to discover skeletal muscle mechanisms underlying clinical responses to diet and exercise interventions [abstract]. Gerontologist. 2010;50(Suppl 1):80.

Cravero JD, Carlson CS, Im H-J, Yammani RR, Long D, Loeser RF. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum. 2009;60(2):492-500.

Yammani RR, Long D, Loeser RF. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum. 2009;60(3):792-800.

Loeser RF Jr, Delbono O. Aging of the muscles and joints In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, Hazzard WR, Wollard NF, eds. Hazzard's geriatric medicine and gerontology. 6th ed. New York: McGraw Hill Medical;2009: 1355-1368.

Loeser RF, Im H-J, Richardson B, Lu Q, Chubinskaya S. Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage. Osteoarthritis Cartilage. 2009;17(4):513-517.

Sevick MA, Miller GD, Loeser RF, Williamson JD, Messier SP. Cost-effectiveness of exercise and diet in overweight and obese adults with knee osteoarthritis. Med Sci Sports Exerc. 2009;41(6):1167-1174.

Loeser RF. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage. 2009;17(8):971-979.

Loeser RF. Articular cartilage nuclear receptors: an emerging target for treatment of osteoarthritis [editorial]. Osteoarthritis Cartilage. 2009;17(7):829-831.

Yin W, Park J-I, Loeser RF. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem. 2009;284(46):31972-81.

Messier SP, Legault C, Mihalko S, Miller GD, Loeser RF, DeVita P, Lyles M, Eckstein F, Williamson JD, Nicklas BJ, et al. The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale. BMC Musculoskelet Disord. 2009;10():article 93.

Loeser RF, McNulty MA, TReuting PM, Carlson CS. Reduction in articular cartilage lesions in older adult mice overexpressing catalase targeted to mitochondria [abstract]. Osteoarthritis Cartilage. 2009;17(Suppl 1):S27.

Loeser RF, Yin W. Reactive oxygen species contribute to IGF-I resistance in osteoarthritic chondrocytes through inhibition of the IRS-I-PI3 kinase-Akt signaling pathway [abstract]. Arthritis Rheum. 2009;60(Suppl 10):1911.

Loeser RF, Yin W. Reactive oxygen species inhibit IGF-I induction of chondrocyte porteoglycan synthesis through differential regulation of PI-3 kinase-AKT and MEK-ERK MAPK signaling pathways [abstract]. Osteoarthritis Cartilage. 2009;17(Suppl 1):S36-S37.

Loeser RF. Connective tissue structure and function In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia: Saunders Elsevier;2008: 1975-1981.

Long D, Blake S, Song X-Y, Lark M, Loeser RF. Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther. 2008;10(1):art. R23.

Miller GD, Nicklas BJ, Loeser RF. Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy. J Am Geriatr Soc. 2008;56(4):644-651.

Del Carlo M Jr, Loeser RF. Cell death in osteoarthritis. Curr Rheumatol Rep. 2008;10(1):37-42.

Loeser RF, Erickson EA, Long DL. Mitogen-activated protein kinases as therapeutic targets in osteoarthritis. Curr Opin Rheumatol. 2008;20(5):581-586.

Chua SD Jr, Messier SP, Legault C, Lenz ME, Thonar EJ-MA, Loeser RF. Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee. Osteoarthritis Cartilage. 2008;16(9):1047-1053.

Atif U, Philip A, Aponte J, Woldu EM, Brady S, Kraus VB, Jordan JM, Doherty M, Wilson AG, Loeser R, et al. Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians. Osteoarthritis Cartilage. 2008;16(10):1174-1177.

Anderson AS, Loeser R, Carr J, Claudine L [sic] [Legault C], Nicklas B, Stephen M [sic] [Messier S]. Quadriceps muscle quality correlates with physical performance in obese and overweight adults with knee osteoarthritis: preliminary data from the IDEA study [abstract]. Arthritis Rheum. 2008;58(12):3992.

Loeser RF. Molecular mechanisms of cartilage destruction in osteoarthritis. J Musculoskelet Neuronal Interact. 2008;8(4):303-306.

Loeser RF. Translational research in osteoarthritis--from molecules to animals to humans. J Musculoskelet Neuronal Interact. 2008;8(4):301-302.

Del Carlo M, Schwartz D, Erickson EA, Loeser RF. Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. Free Radic Biol Med. 2007;42(9):1350-1358.

Gilchrist CL, Chen J, Richardson WJ, Loeser RF, Setton LA. Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. J Orthop Res. 2007;25(6):829-840.

Im H-J, Muddasani P, Natarajan V, Schmid TM, Block JA, Davis F, van Wijnen AJ, Loeser RF. Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem. 2007;282(15):11110-21.

Allen EE, Diao L, Fetrow JS, John DJ, Loeser RF, Poole LB.The shuffle index and evaluation of models of signal transduction pathways

Chubinskaya S, Hakimiyan A, Pacione C, Yanke A, Rappoport L, Aigner T, Rueger DC, Loeser RF. Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads. Osteoarthritis Cartilage. 2007;15(4):421-430.

Kraus VB, Jordan JM, Doherty M, Wilson AG, Moskowitz R, Hochberg M, Loeser R, Hooper M, Renner JB, Crane MM, et al. The genetics of generalized osteoarthitis (GOGO) study: study design and evaluation of osteoarthritis phenotypes. Osteoarthritis Cartilage. 2007;15(2):120-127.

Carnagey KM, Miller GD, Nicklas BJ, Loeser RF. Inflammatory biomarkers and physical function in older obese adults with knee osteoarthritis following intensive weight loss therapy [abstract]. FASEB J. 2007;21(6):A1072.

Messier SP, Mihalko S, Loeser RF, Legault C, Jolla J, Pfruender J, Prosser B, Adrian A, Williamson JD. Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study. Osteoarthritis Cartilage. 2007;15(11):1256-1266.

Ramsay O, Loeser R, Nicklas B, Legault C, Messier S. Physical function status is related to body fat mass, but not lean mass, in older adults with knee osteoarthritis [abstract]. Arthritis Rheum. 2007;56(12):4262.

Miller GD, Nicklas BJ, Davis C, Loeser RF, Lenchik L, Messier SP. Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity. 2006;14(7):1219-1230.

Yammani RR, Carlson CS, Bresnick AR, Loeser RF. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: role of the receptor for advanced glycation end products. Arthritis Rheum. 2006;54(9):2901-2911.

Loeser RF, Yammani R, Erickson E, King B, Poole L. Chondrocyte MMP-13 expression in response to alpha 5 beta 1 integrin stimulation requires protein sulfenic acids as signaling intermediates [abstract]. Arthritis Rheum. 2006;54(9 Suppl):S318.

Ekenstedt KJ, Sonntag WE, Loeser RF, Lindgren BR, Carlson CS. Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Arthritis Rheum. 2006;54(12):3850-3858.

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For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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Professor, Molecular Medicine

Clinical Specialties

Rheumatology

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