Douglas S. Lyles, Ph.D.Wake Forest School of Medicine

Douglas S. Lyles, Ph.D.

Program Director,

Contact Information

Department: 336-716-4237


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Education & Training

  • B.A., University of Pennsylvania, 1972
  • Ph.D., University of Mississippi School of Medicine, 1975
  • Fellowship, Rockefeller University, 1978


  • Am Soc Of Biochem & Mol Biolog
  • Am Soc of Microbiology
  • Am Soc Of Virology
Douglas S. Lyles, Ph.D.

Douglas S. Lyles, Ph.D.

Chair, Biochemistry
Program Director, Comprehensive Cancer Center
Professor, Biochemistry
Comprehensive Cancer Center
Center for Comparative Medicine Research

Research Interests

cancer/oncogenesis, cell growth, differentiation,d, genetics/genome, immunology/allergy/inflammatio, infectious diseases, molecular biology/molecular me, structural biology, vaccines

Contact Information

Department: 336-716-4237


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Recent Publications

Yu N, Puckett S, Antinozzi PA, Cramer SD, Lyles DS. Changes in susceptibility to oncolytic vesicular stomatitis virus during progression of prostate cancer. J Virol. 2015;89(10):5250-5263.

Blackham AU, Northrup SA, Willingham M, Sirintrapun J, Russell GB, Lyles DS, Stewart JH IV. Molecular determinants of susceptibility to oncolytic vesicular stomatitis virus in pancreatic adenocarcinoma. J Surg Res. 2014;187(2):412-426.

Blackham AU, Northrup SA, Willingham M, D'Agostino RB Jr, Lyles DS, Stewart JH IV. Variation in susceptibility of human malignant melanomas to oncolytic vesicular stomatitis virus. Surgery. 2013;153(3):333-343.

Lyles DS. Assembly and budding of negative-strand RNA viruses. Adv Virus Res. 2013;85():57-90.

Lawrence TM, Wanjalla CN, Gomme EA, Wirblich C, Gatt A, Carnero E, Garcia-Sastre A, Lyles DS, McGettigan JP, Schnell MJ. Comparison of heterologous prime-boost strategies against human immunodeficiency virus type 1 Gag using negative stranded RNA viruses. PLoS One. 2013;8(6):e67123.

Randle RW, Northrup SA, Sirintrapun SJ, Lyles DS, Stewart JH. Oncolytic vesicular stomatitis virus as a treatment for neuroendocrine tumors. Surgery. 2013;154(6):1323-1330.

Rajani KR, Pettit Kneller EL, McKenzie MO, Horita DA, Chou JW, Lyles DS. Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription. PLoS Pathog. 2012;8(9):e1002929.

Johnson JB, Douglas LS [sic] [Lyles DS], Martha AMA [sic] [Alexander-Miller MA], Griffith DG [sic] [Parks GD]. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and VSV to neutralization [abstract]. Immunobiology. 2012;217(11):1215-1216.

Gerlier D, Lyles DS. Interplay between innate immunity and negative-strand RNA viruses: towards a rational model. Microbiol Mol Biol Rev. 2011;75(3):468-490.

Stewart JH IV, Ahmed M, Northrup SA, Willingham M, Lyles DS. Vesicular stomatitis virus as a treatment for colorectal cancer. Cancer Gene Ther. 2011;18(12):837-849.

Johnson JB, Lyles DS, Parks GD. Complement evasion by vesicular stomatitis virus involves recruitment of host complement regulatory proteins [abstract]. Mol Immunol. 2010;47(13):2239.

Porosnicu M, Liu J, Lyles D. Susceptibility of head and neck cancer to an attenuated model of the oncolytic vesicular stomatitis virus expressing suicide genes [abstract]. J Clin Oncol. 2010;27(15 Suppl):e14604.

Ahmed M, Puckett S, Arimilli S, Braxton CL, Mizel SB, Lyles DS. Stimulation of human dendritic cells by wild-type and M protein mutant vesicular stomatitis viruses engineered to express bacterial flagellin. J Virol. 2010;84(22):12093-98.

Dancho B, McKenzie MO, Connor JH, Lyles DS. Vesicular stomatitis virus matrix protein mutations that affect association with host membranes and viral nucleocapsids. J Biol Chem. 2009;284(7):4500-4509.

Kneller ELP, Connor JH, Lyles DS. hnRNPs relocalize to the cytoplasm following infection with vesicular stomatitis virus. J Virol. 2009;83(2):770-780.

Agnihothram SS, Dancho B, Grant KW, Grimes ML, Lyles DS, Nunberg JH. Assembly of arenavirus envelope glycoprotein GPC in detergent-soluble membrane microdomains. J Virol. 2009;83(19):9890-9900.

Faul EJ, Lyles DS, Schnell MJ. Interferon response and viral evasion by members of the family Rhabdoviridae. Viruses. 2009;1(3):832-851.

Whitlow ZW, Connor JH, Lyles DS. New mRNAs are preferentially translated during vesicular stomatitis virus infection. J Virol. 2008;82(5):2286-2294.

Ahmed M, Marino TR, Puckett S, Kock ND, Lyles DS. Immune response in the absence of neurovirulence in mice infected with m protein mutant vesicular stomatitis virus. J Virol. 2008;82(18):9273-9277.

Lyles DS, Rupprecht CE. Rhabdoviridae In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Straus SE, Martin MA, Roizman B, eds. Fields virology. 5th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins;2007: 1363-1408.

Connor JH, McKenzie MO, Parks GD, Lyles DS. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007;362(1):109-119.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Biochemistry

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