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Research

Mary F. Lyles, M.D.

Associate Professor, Gerontology and Geriatric Medicine
Sticht Center on Aging

Clinical Specialties

Obesity Treatment, Body Composition, Geriatrics, Osteoporosis, Geriatric Medicine and Assessment

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-713-8250
Department: 336-713-8116

Insurance Accepted »

Education & Training

B.A., Saint Louis University , 1971
M.D., University of Mississippi School of Medicine , 1975
Internship, Internal Medicine, Misericordia Hosp Med Ctr, 1976
Residency, Internal Medicine, Misericordia Hosp Med Ctr, 1978
Fellowship, SUNY-Stony Brook, 1985

Board Certifications

American Board of Internal Medicine, Internal Medicine
American Board of Internal Medicine, Internal Medicine, Geriatric Medicine

Memberships

Soc Of General Internal Medici
Am Coll of Physicians Fellow
Am Geriatrics Society

NPI Number

1861477804

Mary F. Lyles, M.D.

Associate Professor, Gerontology and Geriatric Medicine Sticht Center on Aging

Contact Information

Academic: 336-713-8116 | Department: 336-713-8116

Recent Publications

Lyles MF, Demons JL, Murphy KM, Nicklas BJ. Skeletal muscle sampling in elderly research participants with chronic disease [abstract]. J Am Geriatr Soc. 2012;60(Suppl 4):S197.

Messier SP, DeVita P, Nicklas BJ, Beavers D, Mihalko S, Miller GD, Lyles M, Hunter DJ, Eckstein F, Legault C, Williamson JD, Carr JJ, Loeser RF. The Intensive Diet and Exercise for Arthritis Trial (IDEA): effects on knee joint loading and inflammation [abstract]. Osteoarthritis Cartilage. 2012;20(Suppl 1):S28.

Walker FO, Lyles MF, Li Z. Sheet fitting palsy. J Clin Neuromuscul Dis. 2012;14(1):48-50.

Hunter DJ, Beavers D, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko S, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP. The Intensive Diet and Exercise for Arthritis Trial (IDEA): 18-month radiographic and MRI outcomes [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S1070.

Walton NR, Loeser RF, Beavers D, Nicklas BJ, Lyles M, Messier SP. The effects of intensive diet and exercise on bone density in older adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S1070-71.

Beavers KM, Beavers DP, Lyles MF, Nicklas B. Body composition and cardiometabolic risk factor changes with intentional weight loss and subsequent weight regain [abstract]. Gerontologist. 2012;52(Suppl 1):701.

Shea MK, Nicklas BJ, Marsh AP, Houston DK, Miller GD, Isom S, Miller ME, Carr JJ, Lyles MF, Kritchevsky SB, et al. The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss. Obesity (Silver Spring). 2011;19(8):1636-1646.

Beavers KM, Lyles MF, Davis CC, Wang X, Beavers DP, Nicklas BJ. Is lost lean mass from intentional weight loss recovered during weight regain in postmenopausal women?. Am J Clin Nutr. 2011;94(3):767-774.

Messier SP, Nicklas BJ, Legault C, Mihalko S, Miller GD, DeVita P, Lyles M, Hunter DJ, Eckstein F, Williamson JD, Carr JJ, Loeser RF. The Intensive Diet and Exercise for Arthritis Trial: 18-month clinical outcomes [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S281.

Wang XW, You TJ, Yang RZ, Lyles MF, Demons J, Gong DW, Nicklas BJ. Muscle strength is associated with adipose tissue gene expression of inflammatory adipokines in postmenopausal women [research letter]. Age Ageing. 2010;39(5):656-659.

Welmerink DB, Longstreth WT Jr, Lyles MF, Fitzpatrick AL. Cognition and the risk of hospitalization for serious falls in the elderly: results from the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2010;65(11):1242-1249.

Lyles MF, Murphy K, Nicklas B, Hafer-Macko C, Ryan A. Feasibility, efficacy and safety of skeletal muscle acquisition in frail elderly with comorbidities [abstract]. Gerontologist. 2010;50(Suuppl 1):80.

Easter L, Nicklas BJ, Lyles MF, Gordon M. Optimizing Weight for Life in Seniors: a unique clinic to improve physical function and mobility in the elderly through weight management [abstract]. J Am Diet Assoc. 2010;110(9 Suppl 2):A-14.

Nicklas BJ, Wang X, You T, Lyles MF, Demons J, Easter L, Berry MJ, Lenchik L, Carr JJ. Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial. Am J Clin Nutr. 2009;89(4):1043-1052.

Lyles MF, Wang X, Demons J, Nicklas B. Functional consequences of weight regain 12 months after a successful weight loss intervention [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S160.

Messier SP, Legault C, Mihalko S, Miller GD, Loeser RF, DeVita P, Lyles M, Eckstein F, Williamson JD, Nicklas BJ, et al. The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale. BMC Musculoskelet Disord. 2009;10():article 93.

Kritchevsky SB, Nicklas B, Denise H [sic] [Houston D], Melanie B [sic] [Bopp M], Anthony MP [sic] [Marsh AP], Gary MD [sic] [Miller GD], Lyles MF, Michael ME [sic] [Miller ME], Carr J. Evaluating strategies to optimize the body composition of older adults during voluntary weight loss [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl 1):S162.

Lyles MF, Wang X, Demons JL, Nicklas BJ. Functional consequences of weight regain: changes 6 months after a successful weight loss intervention [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl):S20.

Wang X, Lyles MF, You T, Berry MJ, Rejeski WJ, Nicklas BJ. Weight regain is related to decreases in physical activity during weight loss. Med Sci Sports Exerc. 2008;40(10):1781-1788.

Gordon MM, Czerwinski MJ, Bopp G, Easter L, Miller GD, Lyles MF, Houston DK, Nicklas BJ, Kritchevsky SB. Effects of dietary protein on the composition of weight loss in post-menopausal women. J Nutr Health Aging. 2008;12(8):505-509.

Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008;20(4):302-309.

Lyles M, Wang X, Nicklas B. Changes in weight and body composition 12 months following completion of a weight loss intervention [abstract]. Obesity (Silver Spring). 2008;16(Suppl 1):S207.

Nicklas BJ, Wang XW, You TJ, Lyles MF, Demons J. Effect of aerobic exercise intensity on loss of visceral fat and metabolic risk factors in women [abstract]. Diabetes. 2008;57(Suppl 1):A93.

Kritchevsky SB, Nicklas BJ, Lyles MF, Marsh AP, Miller GD, Miller ME, Leng X. Effect of PPAR gamma use during a hypocaloric diet for weight loss on reductions in total and visceral fat in older men and women [abstract]. Diabetes. 2008;57(Suppl 1):A482.

Lyles MF, Wang X, You T, Lenchik L, Demons JL, Nicklas BJ. Changes in weight and body composition 12 months following completion of a weight loss intervention [abstract]. J Am Geriatr Soc. 2007;55(4 Suppl):S165-S166.

Demons JL, Wang X, Lyles MF, Kritchevsky SB, Nicklas BJ. Effects of weight loss on physical performance in obese postmenopausal women [abstract]. J Am Geriatr Soc. 2007;55(4 Suppl):S164.

Wang X, You T, Lyles M, Demons J, Nicklas BJ. Adipose tissue production of inflammatory mediators is related to aerobic fitness and muscle strength in obese postmenopausal women [abstract]. Med Sci Sports Exerc. 2007;39(5 Suppl):S68.

You T, Wang X, Lyles M, Demons J, Nicklas B. Inflammatory proteins released by abdominal and gluteal subcutaneous adipose tissue: regional differences and relationships with metabolic risk factors [abstract]. Obesity. 2007;15(Suppl 1):A80-A81.

Lyles M, Demons J, Murphy K. Fat biopsy: a safe and acceptable procedure in overweight older women [abstract]. Obesity. 2007;15(Program Abstr Suppl):A188.

Lyles M, Demons J, Marsh A, O'Rourke K, Murphy K. Muscle biopsy in older adults: a safe and acceptable research procedure [abstract]. Obesity. 2007;15(Program Abstr Suppl):A187.

You T, Murphy KM, Lyles MF, Demons JL, Lenchik L, Nicklas BJ. Addition of aerobic exercise to dietary weight loss preferentially reduces abdominal adipocyte size. Int J Obes. 2006;30(8):1211-1216.

Nicklas B, You T, Lyles M, Demons J, Wang X. Weight loss via caloric restriction and aerobic exercise reduces prevalence of metabolic syndrome in older, obese women. Gerontologist. 2006;46(Special Issue 1):550.