Mary F. Lyles, M.D.
Associate Professor, Gerontology and Geriatric Medicine
Weight Loss; Obesity; Resistance Training; Body Composition; Osteoarthritis, Knee
Academic: 336-713-8116 | Department: 336-713-8570
Gait speed response to aerobic versus resistance exercise training in older adults. Henderson RM, Leng XI, Chmelo EA, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ.. Aging Clin Exp Res. 2017;29(5):969-976.
Effect of resistance training and caloric restriction on the metabolic syndrome. Normandin E, Chmelo E, Lyles MF, Marsh AP, Nicklas BJ.. Med Sci Sports Exerc. 2017;49(3):413-419.
Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial. Messier SP, Callahan LF, Beavers DP, Queen K, Mihalko SL, Miller GD, Losina E, Katz JN, Loeser RF, Quandt SA, DeVita P, Hunter DJ, Lyles MF, Newman J, Hackney B, Jordan JM.. BMC Musculoskelet Disord. 2017;18(1):91.
Change in bone mineral density during weight loss with resistance versus aerobic exercise training in older adults. Beavers KM, Beavers DP, Martin SB, Marsh AP, Lyles MF, Lenchik L, Shapses SA, Nicklas BJ.. J Gerontol A Biol Sci Med Sci. 2017;72(11):1582-1585.
Long-term effects of telephone-delivered psychotherapy for late-life GAD [abstract]. Brenes G, Danhauer S, Lyles MF, Anderson A, Miller M.. Am J Geriatr Psychiatry. 2017;25(3 Suppl 1):S130-S131.
Alterations in quadriceps muscle physiology as the result of knee osteoarthritis [abstract]. Noehren B, Kosmac K, Walton RG, Lyles MF, Loeser RF, Messier SP, Peterson CA.. Osteoarthritis Cartilage. 2017;25(Suppl 1):S280-S281.
Effect of intensive blood-pressure treatment on patient-reported outcomes. Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J, Rocco M,.. N Engl J Med. 2017;377(8):733-744.
Intramyocellular lipid and impaired myofiber contraction in normal weight and obese older adults. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O.. J Gerontol A Biol Sci Med Sci. 2016;71(4):557-564.
Legacy effects of short-term intentional weight loss on total body and thigh composition in overweight and obese older adults. Chmelo EA, Beavers DP, Lyles MF, Marsh AP, Nicklas BJ, Beavers KM.. Nutr Diabetes. 2016;6():e203.
Does long-term intensive diet and exercise reduce the biomechanical burden in overweight and obese adults with knee osteoarthritis? The Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Messier SP, Beavers D, Mihalko SL, Miller GD, Nicklas BJ, Lyles M, Hunter DJ, Carr JJ, Eckstein F, Guermazi A, Loeser RF, DeVita P.. Osteoarthritis Cartilage. 2016;24(Suppl):S47-S48.
Skeletal muscle mitochondrial content, oxidative capacity, and Mfn2 expression are reduced in older patients with heart failure and preserved ejection fraction and are related to exercise intolerance. Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW.. JACC Heart Fail. 2016;4(8):636-645.
Insulin resistance correlations with executive functioning in sedentary older adults: the INFINITE study [abstract]. Dougherty A, Brinkley TE, Lyles MF, Nicklas BJ, Williams JA, Hugenschmidt CE.. J Am Geriatr Soc. 2016;64(Suppl 1):S262-S263.
Caloric restriction during aerobic training enhances cardiorespiratory fitness in obese, older adults: a randomized controlled trial: 1529 Board #182 June 2, 9: 00 AM - 10: 30 AM [abstract]. Nicklas BJ, Crotts C, Chmelo EA, Yow D, Gordon M, Lyles MF, Beavers KM, Houston DK, Hugenschmidt C, Leng I, Brinkley TE.. Med Sci Sports Exerc. 2016;48(5 Suppl 1):416-417.
The association of lean and fat mass with all-cause mortality in older adults: the Cardiovascular Health Study. Spahillari A, Mukamal KJ, DeFilippi C, Kizer JR, Gottdiener JS, Djousse L, Lyles MF, Bartz TM, Murthy VL, Shah RV.. Nutr Metab Cardiovasc Dis. 2016;26(11):1039-1047.
Effects of telephone-delivered cognitive-behavioral therapy and nondirective supportive therapy on sleep, health-related quality of life, and disability. Brenes GA, Danhauer SC, Lyles MF, Anderson A, Miller ME.. Am J Geriatr Psychiatry. 2016;24(10):846-854.
Research muscle biopsy tissue yields in older adults: associations with participant characteristics [abstract]. Lyles MF, Demons JL, Murphy KM, Gregory H, Stone J, Nicklas B.. Gerontologist. 2016;56(Suppl 3):350.
Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis. Beavers KM, Beavers DP, Newman JJ, Anderson AM, Loeser RF Jr, Nicklas BJ, Lyles MF, Miller GD, Mihalko SL, Messier SP.. Osteoarthritis Cartilage. 2015;23(2):249-256.
Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. Corrales-Medina VF, Alvarez KN, Weissfeld LA, Angus DC, Chirinos JA, Chang CC, Newman A, Loehr L, Folsom AR, Elkind MS, Lyles MF, Kronmal RA, Yende S.. JAMA. 2015;313(3):264-274.
Heterogeneity of physical function responses to exercise training in older adults. Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ.. J Am Geriatr Soc. 2015;63(3):462-469.
Preparation and respirometric assessment of mitochondria isolated from skeletal muscle tissue obtained by percutaneous needle biopsy [video article]. Bharadwaj MS, Tyrrell DJ, Lyles MF, Demons JL, Rogers GW, Molina AJ.. J Vis Exp. 2015;(96):e52350.
Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP.. Am J Clin Nutr. 2015;101(5):991-999.
Addition of exercise increases plasma adiponectin and release from adipose tissue. Wang X, You T, Murphy K, Lyles MF, Nicklas BJ.. Med Sci Sports Exerc. 2015;47(11):2450-2455.
The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP.. Osteoarthritis Cartilage. 2015;23(7):1090-1098.
The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ.. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.
Barriers to mental health treatment in rural older adults. Brenes GA, Danhauer SC, Lyles MF, Hogan PE, Miller ME.. Am J Geriatr Psychiatry. 2015;23(11):1172-1178.
Telephone-delivered cognitive behavioral therapy and telephone-delivered nondirective supportive therapy for rural older adults with generalized anxiety disorder: a randomized clinical trial. Brenes GA, Danhauer SC, Lyles MF, Hogan PE, Miller ME.. JAMA Psychiatry. 2015;72(10):1012-1020.
Intermediate and long-term risk of new-onset heart failure after hospitalization for pneumonia in elderly adults. Corrales-Medina VF, Taljaard M, Yende S, Kronmal R, Dwivedi G, Newman AB, Elkind MS, Lyles MF, Chirinos JA.. Am Heart J. 2015;170(2):306-312.e6.
Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ.. BMC Obes. 2015;2():40.
Telephone-delivered psychotherapy for rural-dwelling older adults with generalized anxiety disorder: study protocol of a randomized controlled trial. Brenes GA, Danhauer SC, Lyles MF, Miller ME.. BMC Psychiatry. 2014;14():34.
Comparison of aerobic versus resistance training for improving gait speed in older adults [abstract]. Henderson R, Leng I, Chmelo E, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ.. J Am Geriatr Soc. 2014;62(Suppl 1):S154.
Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M.. Am J Physiol Heart Circ Physiol. 2014;306(9):H1364-1370.
The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese older adults with osteoarthritis. Beavers DP, Beavers KM, Loeser RF, Walton NR, Lyles MF, Nicklas BJ, Shapses SA, Newman JJ, Messier SP.. Osteoarthritis Cartilage. 2014;22(6):726-733.
Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women. You T, Wang X, Murphy KM, Lyles MF, Demons JL, Yang R, Gong DW, Nicklas BJ.. Obesity (Silver Spring). 2014;22(7):1679-1684.
Aerobic exercise training and self-reported fatigue in older, obese adults [abstract]. Gordon MM, Chmelo E, Crotts C, Lyles M, Brinkley T, Newman J, Rejeski WJ, Nicklas B.. Med Sci Sports Exerc. 2014;46(5):224.
Predictors of attendance to intensive diet and exercise interventions among older overweight and obese adults with knee osteoarthritis: results from the intensive diet and exercise for arthritis (IDEA) Trial [abstract]. Mihalko SL, Beavers D, Miller G, Lyles M, Commander S, Carpenter M, Cook L, Messier S.. Ann Behav Med. 2014;47(Suppl 1):S120.
Skeletal muscle ultrasound as a tool to assess muscle function [abstract]. Dhar S, Nicklas B, Lyles M, Morris P, Delbono O, Files DC.. Crit Care Med. 2014;42(12 Suppl 1):A1528.
Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women. Beavers DP, Beavers KM, Lyles MF, Nicklas BJ.. J Gerontol A Biol Sci Med Sci. 2013;68(6):691-698.
Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults. Marsh AP, Shea MK, Vance Locke RM, Miller ME, Isom S, Miller GD, Nicklas BJ, Lyles MF, Carr JJ, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2013;68(7):828-836.
Strength Training for Arthritis Trial (START): design and rationale. Messier SP, Mihalko SL, Beavers DP, Nicklas BJ, Devita P, Carr JJ, Hunter DJ, Williamson JD, Bennell KL, Guermazi A, Lyles M, Loeser RF.. BMC Musculoskelet Disord. 2013;14():208.
Teaching medical student geriatrics competencies in 1 week: an efficient model to teach and document selected competencies using clinical and community resources. Atkinson HH, Lambros A, Davis BR, Lawlor JS, Lovato J, Sink KM, Demons JL, Lyles MF, Watkins FS, Callahan KE, Williamson JD.. J Am Geriatr Soc. 2013;61(7):1182-1187.
Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF.. JAMA. 2013;310(12):1263-1273.
Aortic stiffness predicts blood pressure responses to exercise in obese older adults [abstract]. Brinkley TE, Gordon MM, Chmelo EA, Jefferson M, Lyles MF, Hundley WG, Gregory HW, Nicklas BJ.. Med Sci Sports Exerc. 2013;45(5 Suppl 1):11.
Does 400 meter walk time predict Vo(2) peak in obese, older adults? [abstract]. Chmelo E, Gordon M, Crotts C, Lyles MF, Brinkley T, Blocker J, Nicklas BJ.. Med Sci Sports Exerc. 2013;45(5 Suppl 1):573.
Heart rate recovery is associated with central adiposity in obese older adults [abstract]. Jefferson ME, Gordon MM, Chmelo EA, Lyles MF, Nicklas BJ, Brinkley TE.. Med Sci Sports Exerc. 2013;45(5 Suppl 1):11.
Is gait speed associated with strength, power, and lower extremity function in older, overweight and obese men and women? [abstract]. Sorensen JA, Crotts C, Chmelo E, Lyles MF, Marsh AP, Nicklas BJ.. Med Sci Sports Exerc. 2013;45(5 Suppl 1):644.
Effects of weight loss on subcutaneous adipose tissue hormone/cytokine production: depot comparisons [abstract]. You TJ, Wang XW, Yang RZ, Gong D, Lyles M, Nicklas B.. Med Sci Sports Exerc. 2013;45(5 Suppl 1):418-419.
Addiction of aerobic exercise to caloric restriction increases adiponectin circulating concentrations and release from abdominal and gluteal adipose tissue in obese/overweight postmenopausal women [abstract]. Wang X, You T, Lyles MF, Murphy KM, Nicklas BJ.. In: Obesityweek 2013 November 11-16; Atlanta (GA). 2013;():S76.
Skeletal muscle sampling in elderly research participants with chronic disease [abstract]. Lyles MF, Demons JL, Murphy KM, Nicklas BJ.. J Am Geriatr Soc. 2012;60(Suppl 4):S197.
The Intensive Diet and Exercise for Arthritis Trial (IDEA): effects on knee joint loading and inflammation [abstract]. Messier SP, DeVita P, Nicklas BJ, Beavers D, Mihalko S, Miller GD, Lyles M, Hunter DJ, Eckstein F, Legault C, Williamson JD, Carr JJ, Loeser RF.. Osteoarthritis Cartilage. 2012;20(Suppl 1):S28.
Sheet fitting palsy. Walker FO, Lyles MF, Li Z.. J Clin Neuromuscul Dis. 2012;14(1):48-50.
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.
For a list of earlier publications, visit the Carpenter Library Publication Search.