Profile

Lijun Ma, Ph.D., M.D.Wake Forest School of Medicine

Lijun Ma, Ph.D., M.D.

Assistant Professor,

Contact Information

Academic: 336-716-2209 | Department: 336-716-4650

Education & Training

  • M.D., Nanjing Medical University-China, 1991
  • Ph.D., Nanjing Medical University-China, 1999
  • Residency, Nanjing Univ of Sci & Tech Med, 1994
  • Fellowship, National Institues of Health, 2004
  • Fellowship, National Institues of Health, 2009
  • Fellowship, WFU School of Medicine, 2011
Lijun Ma, Ph.D., M.D.

Lijun Ma, Ph.D., M.D.

Assistant Professor, Nephrology

Research Interests

Acetyl-CoA Carboxylase; Polymorphism, Single Nucleotide; Diabetic Nephropathies; Gene Expression Regulation, Enzymologic; Genetic Predisposition to Disease
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Contact Information

Academic: 336-716-2209 | Department: 336-716-4650

Recent Publications

Characterization of circulating APOL1 protein complexes in African Americans. Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L.. J Lipid Res. 2016;57(1):120-130.

Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

APOL1 renal-risk genotypes associate with longer hemodialysis survival in prevalent nondiabetic African American patients with end-stage renal disease. Ma L, Langefeld CD, Comeau ME, Bonomo JA, Rocco MV, Burkart JM, Divers J, Palmer ND, Hicks PJ, Bowden DW, Lea JP, Krisher JO, Clay MJ, Freedman BI.. Kidney Int. 2016;90(2):389-395.

Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM,.. Hum Genet. 2016;135(8):869-880.

APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume. Freedman BI, Gadegbeku CA, Bryan RN, Palmer ND, Hicks PJ, Ma L, Rocco MV, Smith SC, Xu J, Whitlow CT, Wagner BC, Langefeld CD, Hawfield AT, Bates JT, Lerner AJ, Raj DS, Sadaghiani MS, Toto RD, Wright JT Jr, Bowden DW, Williamson JD, Sink KM,.. Kidney Int. 2016;90(2):440-449.

Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. Ma L, Shelness GS, Snipes JA, Murea M, Antinozzi PA, Cheng D, Saleem MA, Satchell SC, Banas B, Mathieson PW, Kretzler M, Hemal AK, Rudel LL, Petrovic S, Weckerle A, Pollak MR, Ross MD, Parks JS, Freedman BI.. J Am Soc Nephrol. 2015;26(2):339-348.

Adipose tissue gene expression and metabolic health of obese adults. Das SK, Ma L, Sharma NK.. Int J Obes (Lond). 2015;39(5):869-873.

Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure. Freedman BI, Julian BA, Pastan SO, Israni AK, Schladt D, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Hicks PJ, Palmer ND, Adams PL,.. Am J Transplant. 2015;15(6):1615-1622.

Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. Ma J, Divers J, Palmer ND, Julian BA, Israni AK, Schladt D, Pastan SO, Chattrabhuti K, Gautreaux MD, Hauptfeld V, Bray RA, Kirk AD, Brown WM, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Guan M, Palanisamy A, Reeves-Daniel AM, Bowden DW,.. Kidney Int. 2015;88(3):584-592.

eQTL analysis of adipose and muscle in African Americans identifies genetic regulators for type 2 diabetes and obesity-associated genes [abstract]. Sajuthi S, Sharma N, McWilliams D, Chou J, Comeau M, Palmer ND, Ma L, Calles J, Demons J, Rogers S, Beal J, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. Diabetes. 2015;64(Suppl 1):A82.

Transcriptional profiles of adipose and muscle tissue are associated with insulin sensitivity and influenced by genetic variation in African Americans [abstract]. Sharma NK, Sajuthi S, Chou J, Ma L, Calles J, Demons J, Rogers S, McWilliams D, Beal J, Comeau M, Palmer ND, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. Diabetes. 2015;64(Suppl 1):A456.

Biogenesis and cytotoxicity of APOL1 renal-risk variant proteins in hepatocytes and hepatoma cells. Cheng D, Weckerle A, Yu Y, Ma L, Zhu X, Murea M, Freedman BI, Parks JS, Shelness GS.. J Lipid Res. 2015;56(8):1583-1593.

Re-sequencing of the APOL1-APOL4 and MYH9 gene regions in African Americans does not identify additional risks for CKD progression. Hawkins GA, Friedman DJ, Lu L, McWilliams DR, Chou JW, Sajuthi S, Divers J, Parekh RS, Li M, Genovese G, Pollack MR, Hicks PJ, Bowden DW, Ma L, Freedman BI, Langefeld CD.. Am J Nephrol. 2015;42(2):99-106.

Obesity associated modulation of miRNA and co-regulated target transcripts in human adipose tissue of non-diabetic subjects. Sharma NK, Varma V, Ma L, Hasstedt SJ, Das SK.. Microrna. 2015;4(3):194-204.

Characterization of circulating APOL1 complexes and their kidney distribution in African Americans [abstract]. Ma L, Weckerle A, Snipes JA, Cheng D, Gebre AK, Murea M, Hawkins GA, Parks JS, Freedman BI.. J Am Soc Nephrol. 2015;26(Abstract Suppl):708A.

Gene-gene interactions in APOL1-associated nephropathy. Divers J, Palmer ND, Lu L, Langefeld CD, Rocco MV, Hicks PJ, Murea M, Ma L, Bowden DW, Freedman BI.. Nephrol Dial Transplant. 2014;29(3):587-594.

Variation in the multidrug resistance protein 1 gene (ABCB1) in African American deceased organ donors is associated with renal allograft failure [abstract]. Ma J, Divers J, Palmer ND, Julian BA, Pastan SO, Israni AK, Gaston RS, Ma L, Stratta RJ, Palanisamy A, Reeves-Daniel AM, Freedman BI.. J Am Soc Nephrol. 2014;25(Abstract Suppl):40A.

An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. Ma L, Murea M, Snipes JA, Marinelarena A, Kruger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA,.. PLoS One. 2013;8(2):e56193.

ApoL1 protein in non-diseased human podocytes: endogenous synthesis versus uptake? [abstract]. Ma L, Snipes JA, Murea M, Antinozzi PA, Shelness GS, Saleem M, Satchell SC, Banas B, Mathieson PW, Kretzler M, Petrovic S, Ross MD, Pollak MR, Rudel L, Parks JS, Freedman BI.. J Am Soc Nephrol. 2013;24(Abstract Suppl):557A.

JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Divers J, Nunez M, High KP, Murea M, Rocco MV, Ma L, Bowden DW, Hicks PJ, Spainhour M, Ornelles DA, Kleiboeker SB, Duncan K, Langefeld CD, Turner J, Freedman BI.. Kidney Int. 2013;84(6):1207-1213.

Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study. Langberg KA, Ma L, Sharma NK, Hanis CL, Elbein SC [deceased], Hasstedt SJ, Das SK.. J Hum Genet. 2012;57(1):57-61.

Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. Murea M, Ma L, Freedman BI.. Rev Diabet Stud. 2012;9(1):6-22.

Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians. Traurig MT, Perez JM, Ma L, Bian L, Kobes S, Hanson RL, Knowler WC, Krakoff JA, Bogardus C, Baier LJ.. Obesity (Silver Spring). 2012;20(12):2426-2430.

Dose-dependent expression of ApoL1 protein sensitizes cell death pathways [abstract]. Chen Z, Freedman BI, Graham WD, Ross NA, Pollak MR, Ross MD, Murea M, Ma L, Antinozzi PA.. J Am Soc Nephrol. 2012;23():136A.

JC polyoma virus interacts with apolipoprotein L1 genetic risk in African Americans with non-diabetic nephropathy [abstract]. Freedman BI, Murea M, Rocco MV, Ma L, Bowden DW, Ornelles DA, Kleiboeker S, Langefeld CD, Turner J, Divers J.. J Am Soc Nephrol. 2012;23():178A.

Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. Murea M, Lu L, Ma L, Hicks PJ, Divers J, McDonough CW, Langefeld CD, Bowden DW, Freedman BI.. Am J Nephrol. 2011;33(6):502-509.

An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects. Das SK, Sharma NK, Hasstedt SJ, Mondal AK, Ma L, Langberg KA, Elbein SC [deceased].. J Clin Endocrinol Metab. 2011;96(8):E1308-1313.

The effect of ACACB cis-variants on gene expression and metabolic traits. Ma L, Mondal AK, Murea M, Sharma NK, Langberg KA, Das SK, Antinozzi PA, Parks JS, Elbein SC [deceased], Freedman BI, et al.. PLoS ONE. 2011;6(8):e23860.

Apolipoprotein L1 (APOL1) nephropathy risk variants associate with HDL subfraction concentration in African Americans [abstract]. Freedman BI, Langefeld CD, Murea M, Ma L, Otvos JD, Turner J, Antinozzi PA, Rocco MV, Parks JS.. J Am Soc Nephrol. 2011;22(Abstract Suppl):178A.

Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans. Freedman BI, Langefeld CD, Murea M, Ma L, Otvos JD, Turner J, Antinozzi PA, Divers J, Hicks PJ, Bowden DW, Rocco MV, Parks JS.. Nephrol Dial Transplant. 2011;26(11):3805-3810.

Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation. Murea M, Freedman BI, Parks JS, Antinozzi PA, Elbein SC [deceased], Ma L.. Clin J Am Soc Nephrol. 2010;5(12):2373-2379.

The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes. Tang SCW, Leung VTM, Chan LYY, Ma L, Elbein SC [deceased], Bowden DW, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI, et al.. Nephrol Dial Transplant. 2010;25(12):3931-3934.

Digital deconstruction of heterogeneous renal cell preparations with high-content imaging and cell specific biomarkers [abstract]. Antinozzi PA, Barnes BC, Deegan D, Ma L, Freedman BI, Murea M.. J Am Soc Nephrol. 2010;21(Suppl):409A.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Nephrology

Lijun Ma, Ph.D., M.D.

Lijun Ma, Ph.D., M.D.

Assistant Professor, Nephrology

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