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Research

Joseph A. Maldjian, M.D.

Professor, Radiology
Sticht Center on Aging
Center for Diabetes Research

Clinical Specialties

Neuroradiology, Radiology, Advanced MRI Methods

Contact Information

Department: 336-716-1286

Email: maldjian@wakehealth.edu

Education & Training

B.A., Princeton University , 1984
M.D., Robert Wood Johnson Medical School , 1988
Internship, St Barnabas Med Ctr, 1989
Residency, Mount Sinai Hosp, 1993

Board Certifications

American Board of Radiology, Radiology

Memberships

Int'L Soc.Of Magnetic Resonanc
North Am Radiologic Society
Roentgen Ray Society
Am Board Of Radiology
Am Coll Of Radiology
Am Soc Of Neuroradiology

NPI Number

1649255878

Joseph A. Maldjian, M.D.

Professor, Radiology Sticht Center on Aging
Center for Diabetes Research

Research Interests

biotechnology, drugs/therapeutic agents pharm, engineering/bioengineering, radiology/imaging

Contact Information

Academic: 336-716-2815 | Department: 336-716-1286

Email: maldjian@wakehealth.edu

Recent Publications

Casanova R, Whitlow CT, Wagner B, Espeland MA, Maldjian JA. Combining graph and machine learning methods to analyze differences in functional connectivity across sex. Open Neuroimag J. 2012;6():1-9.

Urban JE, Maldjian JA, Whitlow CT, Stitzel JD. A method to investigate the size and shape variation of the lateral ventricles with age. Biomed Sci Instrum. 2012;48():447-453.

Maldjian JA, Whitlow CT. Whither the hippocampus? FDG-PET hippocampal hypometabolism in Alzheimer disease revisited. AJNR Am J Neuroradiol. 2012;33(10):1975-1982.

McGehee BE, Pollock JM, Maldjian JA. Brain perfusion imaging: how does it work and what should I use?. J Magn Reson Imaging. 2012;36(6):1257-1272.

Urban JE, Whitlow CT, Edgerton CA, Powers AK, Maldjian JA, Stitzel JD. Motor vehicle crash-related subdural hematoma from real-world head impact data. J Neurotrauma. 2012;29(18):2774-2781.

Pollock JM, Whitlow CT, Simonds J, Stevens EA, Kraft RA, Burdette JH, Maldjian JA. Response of arteriovenous malformations to gamma knife therapy evaluated with pulsed arterial spin-labeling MRI perfusion. AJR Am J Roentgenol. 2011;196(1):15-22.

Whitlow CT, Casanova R, Maldjian JA. Effect of resting-state functional MR imaging duration on stability of graph theory metrics of brain network connectivity. Radiology. 2011;259(2):516-524.

Casanova R, Espeland MA, Goveas JS, Davatzikos C, Gaussoin SA, Maldjian JA, Brunner RL, Kuller LH, Johnson KC, Wagner B, et al. Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes. Magn Reson Imaging. 2011;29(4):546-553.

Casanova R, Whitlow CT, Wagner B, Williamson J, Shumaker SA, Maldjian JA, Espeland MA. High dimensional classification of structural MRI Alzheimer's disease data based on large scale regularization. Front Neuroinform. 2011;5():article 22.

Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein H, Ding J, Lovato LC, Lovato J, Coker L, Maldjian J, et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 2011;10(11):969-977.

Casanova R, Maldjian JA, Espeland MA. Evaluating the impact of different factors on Voxel-based classification methods of ADNI structural MRI brain images. Int J Biomed Data Mining. 2011;1():B110102.

Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE [sic] [Hugenschmidt CE], Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC-Y, Hsu F-C, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010;7(3):188-201.

Casanova R, Espeland MA, Goveas J, Davatzikos C, Gaussoin SA, Wagner B, Maldjian JA, Resnick SM. Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes [abstract]. Gerontologist. 2010;50(Suppl 1):308-309.

Peiffer AM, Hugenschmidt CE, Maldjian JA, Casavona R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ. Aging and the interaction of sensory cortical function and structure. Hum Brain Mapp. 2009;30(1):228-240.

Pollock JM, Deibler AR, Whitlow CT, Tan H, Kraft RA, Burdette JH, Maldjian JA. Hypercapnia-induced cerebral hyperperfusion: an underrecognized clinical entity. AJNR Am J Neuroradiol. 2009;30(2):378-385.

Maldjian JA, Baer AH, Kraft RA, Laurienti PJ, Burdette JH. Fully automated processing of fMRI data in SPM: from MRI scanner to PACS. Neuroinformatics. 2009;7(1):57-72.

Hairston WD, Maldjian JA. An adaptive staircase procedure for the E-Prime programming environment. Comput Methods Programs Biomed. 2009;93(1):104-108.

Rumboldt Z, Rowley HA, Steinberg F, Maldjian JA, Ruscalleda J, Gustafsson L, Bastianello S. Multicenter, double-blind, randomized, intra-individual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine in MRI of brain tumors at 3 Tesla. J Magn Reson Imaging. 2009;29(4):760-767.

Tan H, Maldjian JA, Pollock JM, Burdette JH, Yang LY, Deibler AR, Kraft RA. A fast, effective filtering method for improving clinical pulsed arterial spin labeling MRI. J Magn Reson Imaging. 2009;29(5):1134-1139.

Pollock JM, Tan H, Kraft RA, Whitlow CT, Burdette JH, Maldjian JA. Arterial spin-labeled MR perfusion imaging: clinical applications. Magn Reson Imaging Clin N Am. 2009;17(2):315-338.

Pollock JM, Whitlow CT, Tan H, Kraft RA, Burdette JH, Maldjian JA. Pulsed arterial spin-labeled MR imaging evaluation of tuberous sclerosis. AJNR Am J Neuroradiol. 2009;30(4):815-820.

Casanova R, Yang L, Hairston WD, Laurienti PJ, Maldjian JA. Evaluating the impact of spatio-temporal smoothness constraints on the BOLD hemodynamic response function estimation: an analysis based on Tikhonov regularization. Physiol Meas. 2009;30(5):N37-N51.

Addicott MA, Yang LL, Peiffer AM, Burnett LR, Burdette JH, Chen MY, Hayasaka S, Kraft RA, Maldjian JA, Laurienti PJ. The effect of daily caffeine use on cerebral blood flow: how much caffeine can we tolerate?. Hum Brain Mapp. 2009;30(10):3102-3114.

Espeland MA, Tindle HA, Bushnell CA, Jaramillo SA, Kuller LH, Margolis KL, Mysiw WJ, Maldjian JA, Melhem ER, Resnick SM. Brain volumes, cognitive impairment, and conjugated equine estrogens. J Gerontol A Biol Sci Med Sci. 2009;64(12):1243-1250.

Hairston WD, Hodges DA, Casanova R, Hayasaka S, Kraft R, Maldjian JA, Burdette JH. Closing the mind's eye: deactivation of visual cortex related to auditory task difficulty. Neuroreport. 2008;19(2):151-154.

Hugenschmidt CE, Peiffer AM, Kraft RA, Casanova R, Deibler AR, Burdette JH, Maldjian JA, Laurienti PJ. Relating imaging indices of white matter integrity and volume in healthy older adults. Cereb Cortex. 2008;18(2):433-442.

Peiffer AM, Maldjian JA, Laurienti PJ. Resurrecting Brinley plots for a novel use: meta-analyses of functional brain imaging data in older adults. Int J Biomed Imaging. 2008;2008():.

Pollock JM, Deibler AR, West TG, Burdette JH, Kraft RA, Maldjian JA. Arterial spin-labeled magnetic resonance imaging in hyperperfused seizure focus: a case report. J Comput Assist Tomogr. 2008;32(2):291-292.

Casanova R, Ryali S, Serences J, Yang L, Kraft R, Laurienti PJ, Maldjian JA. The impact of temporal regularization on estimates of the BOLD hemodynamic response function: a comparative analysis. Neuroimage. 2008;40(4):1606-1618.

Maldjian JA, Laurienti PJ, Burdette JH, Kraft RA. Clinical implementation of spin-tag perfusion magnetic resonance imaging. J Comput Assist Tomogr. 2008;32(3):403-406.

Underhill HR, Yuan C, Terry JG, Chen H, Espeland MA, Kraft R, Carr JJ, Maldjian J, Tang R, Crouse JR III, et al. Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2008;10(1):article 31.

Deibler AR, Pollock JM, Kraft RA, Tan H, Burdette JH, Maldjian JA. Arterial spin-labeling in routine clinical practice, part 2: hypoperfusion patterns. AJNR Am J Neuroradiol. 2008;29(7):1235-1241.

Deibler AR, Pollock JM, Kraft RA, Tan H, Burdette JH, Maldjian JA. Arterial spin-labeling in routine clinical practice, part 1: technique and artifacts. AJNR Am J Neuroradiol. 2008;29(7):1228-1234.

Pollock JM, Whitlow CT, Deibler AR, Tan H, Burdette JH, Kraft RA, Maldjian JA. Anoxic injury-associated cerebral hyperperfusion identified with arterial spin-labeled MR imaging. AJNR Am J Neuroradiol. 2008;29(7):1302-1307.

Pollock JM, Deibler AR, Burdette JH, Kraft RA, Tan H, Evans AB, Maldjian JA. Migraine associated cerebral hyperperfusion with arterial spin-labeled MR imaging. AJNR Am J Neuroradiol. 2008;29(8):1494-1497.

Deibler AR, Pollock JM, Kraft RA, Tan H, Burdette JH, Maldjian JA. Arterial spin-labeling in routine clinical practice, part 3: hyperperfusion patterns. AJNR Am J Neuroradiol. 2008;29(8):1428-1435.

Mozolic JL, Joyner D, Hugenschmidt CE, Peiffer AM, Kraft RA, Maldjian JA, Laurienti PJ. Cross-modal deactivations during modality-specific selective attention. BMC Neurol. 2008;8():article 35.

Rowley HA, Scialfa G, Gao P-y, Maldjian JA, Hassell D, Kuhn MJ, Wippold FJ II, Gallucci M, Bowen BC, Schmalfuss IM, et al. Contrast-enhanced MR imaging of brain lesions: a large-scale intraindividual crossover comparison of gadobenate dimeglumine versus gadodiamide. AJNR Am J Neuroradiol. 2008;29(9):1684-1691.

Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, Flowers L, Wood F, Maldjian JA. Biological parametric mapping: a statistical toolbox for multimodality brain image analysis. Neuroimage. 2007;34(1):137-143.

Kuhn MJ, Picozzi P, Maldjian JA, Schmalfuss IM, Maravilla KR, Bowen BC, Wippold FJ II, Runge VM, Knopp MV, Wolansky LJ, et al. Evaluation of intraaxial enhancing brain tumors on magnetic resonance imaging: intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for visualization and assessment, and implications for surgical intervention. J Neurosurg. 2007;106(4):557-566.

Maravilla KR, Maldjian JA, Schmalfuss IM, Kuhn MJ, Bowen BC, Wippold FJ II, Runge VM, Knopp MV, Kremer S, Wolansky LJ, et al. Contrast enhancement of central nervous system lesions: multicenter intraindividual crossover comparative study of two MR contrast agents. Radiology. 2006;240(2):389-400.

Laurienti PJ, Burdette JH, Maldjian JA, Wallace MT. Enhanced multisensory integration in older adults. Neurobiol Aging. 2006;27(8):1155-1163.

Srikanth R, Casanova R, Laurienti PJ, Peiffer AM, Maldjian JA. Estimation of false discovery rates for wavelet-denoised statistical parametric maps. Neuroimage. 2006;33(1):72-84.

McMullen KP, Papagikos MA, Glazier SS, McLean TW, Maldjian JA, Shaw EG. Pseudo-progression based on MRI changes following radiation therapy for pilocytic astrocytoma [abstract]. Int J Radiat Oncol Biol Phys. 2006;66(3 Suppl):S243-S244.

Papagikos MA, McMullen KP, Glazier SS, McLean TW, Maldjian JA, Shaw EG. MRI pseudo-progression following radiation therapy for pilocytic astroctyoma [abstract]. Neuro Oncol. 2006;8(4):487-488.