Frank C. Marini, Ph.D.Wake Forest School of Medicine

Frank C. Marini, Ph.D.


Contact Information

Academic: 336-713-1471 | Department: 336-716-2011


Education & Training

  • Ph.D., Univ Texas M D Anderson Hosp, 1998
Frank C. Marini, Ph.D.

Frank C. Marini, Ph.D.

Professor, Institute for Regenerative Medicine
Comprehensive Cancer Center
Cancer Biology

Research Interests

biotechnology, cancer/oncogenesis, cell growth, differentiation,d, health services, research/outc, immunology/allergy/inflammatio

Contact Information

Academic: 336-713-1471 | Department: 336-716-2011


Recent Publications

Cortes-Santiago N, Hossain MB, Gabrusiewicz K, Fan X, Gumin J, Marini FC, Alonso MM, Lang F, Yung WK, Fueyo J, Gomez-Manzano C. Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas. Oncotarget. 2016;():.

Kelkar SS, Hill TK, Marini FC, Mohs AM. Near infrared fluorescent nanoparticles based on hyaluronic acid: self-assembly, optical properties, and cell interaction. Acta Biomater. 2016;36():112-121.

Hill TK, Abdulahad A, Kelkar SS, Marini FC, Long TE, Provenzale JM, Mohs AM. Indocyanine green-loaded nanoparticles for image-guided tumor surgery. Bioconjug Chem. 2015;26(2):294-303.

Bussard KM, Marini FC. Breast cancer cell quiescence in bone is orchestrated by osteoblasts transitioned into tumor-associated fibroblasts via exosomal miRs [abstract]. Clin Exp Metastasis. 2015;32(3):195-196.

Gabrusiewicz K, Hossain MB, Cortes-Santiago N, Fan X, Kaminska B, Marini FC, Fueyo J, Gomez-Manzano C. Macrophage ablation reduces M2-like populations and jeopardizes tumor growth in a MAFIA-based glioma model. Neoplasia. 2015;17(4):374-384.

Hossain A, Gumin J, Gao F, Figueroa J, Shinojima N, Takezaki T, Priebe W, Villarreal D, Kang SG, Joyce C, Sulman E, Wang Q, Marini FC, Andreeff M, Colman H, Lang FF. Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6/gp130/STAT3 pathway. Stem Cells. 2015;33(8):2400-2415.

Bussard KM, Marini FC. Breast cancer cell quiescence in bone is modulated by Osteo-TAFs [abstract]. Cancer Res. 2015;75(15 Suppl):3205.

Zarifpour M, Sandberg J, Abolbashari M, Vadhavkar M, Kelkar S, Mohs A, Marini F, Andersson KE, Christ G. Characterization of functional bladder regeneration in mice [abstract]. Neurourol Urodyn. 2014;33(2):186.

Abraham J, Nunez-Alvarez Y, Hettmer S, Carrio E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA,. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014;28(14):1578-1591.

Gabrusiewicz K, Liu D, Cortes-Santiago N, Hossain MB, Conrad CA, Aldape KD, Fuller GN, Marini FC, Alonso MM, Idoate MA, Gilbert MR, Fueyo J, Gomez-Manzano C. Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes. Oncotarget. 2014;5(8):2208-2220.

Katsivalis K, Reid T, Marini FC, Atala A, Sadri-Ardekani H. Eliminating leukemia cells from human testicular cell cultures prior to spermatogonial stem cell autotransplantation to restore fertility [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S136.

Sapoznik E, Niu G, Lu P, Zhou Y, Criswell T, Marini F, Xu Y, Soker S. Fiber-based imaging on electrospun scaffold [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S61.

Bussard KM, Marini FC. Metastatic breast cancer cells induce an osteoblast-TAF-like phenotype and communicate with osteoblasts via gap junctions and exosomal crosstalk to facilitate breast cancer cell quiescence in bone [abstract]. Cancer Res. 2014;74(19 Suppl):A4804.

Dembinski JL, Wilson SM, Spaeth EL, Studeny M, Zompetta C, Samudio I, Roby K, Andreeff M, Marini FC. Tumor stroma engraftment of gene-modified mesenchymal stem cells as anti-tumor therapy against ovarian cancer. Cytotherapy. 2013;15(1):20-32.

Orlando G, Booth C, Wang Z, Totonelli G, Ross CL, Moran E, Salvatori M, Maghsoudlou P, Turmaine M, Delario G, Al-Shraideh Y, Farooq U, Farney AC, Rogers J, Iskandar SS, Burns A, Marini FC, De Coppi P, Stratta RJ, Soker S. Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies. Biomaterials. 2013;34(24):5915-5925.

Spaeth EL, Labaff AM, Toole BP, Klopp A, Andreeff M, Marini FC. Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment. Cancer Res. 2013;73(17):5347-5359.

Gabrusiewicz K, Cortes-Santiago N, Fan XJ, Hossain MB, Kaminska B, Heimberger A, Rao G, Yung WKA, Marini F, Fueyo J, Gomez-Manzano C. Modeling tumor microenvironment in vivo: impact of conditional macrophage ablation in glioma progression [abstract]. Neuro Oncol. 2013;15(Suppl 3):236.

Nowicka A, Marini FC, Solley TN, Elizondo PB, Zhang Y, Sharp HJ, Broaddus R, Kolonin M, Mok SC, Thompson MS, Woodward WA, Lu K, Salimian B, Nagrath D, Klopp AH. Human omental-derived adipose stem cells increase ovarian cancer proliferation, migration, and chemoresistance. PLoS One. 2013;8(12):e81859.

Bussard KM, Marini FC. Crosstalk between breast cancer and stromal cells occurs via exosomes and gap junctions in bone metastatic breast cancer [abstract]. Cancer Res. 2013;73(8 Suppl 1):A1625.

Ko SY, Barengo N, Ladanyi A, Lee J-S, Marini F, Lengyel E, Naora H. The developmental patterning gene HOXA9 promotes ovarian cancer growth via paracrine effects on mesenchymal stem cells and peritoneal fibroblasts [abstract]. Cancer Res. 2013;73(8 Suppl 1):A2611.

Orlando G, Wang Z, Booth C, Ross C, Totonelli G, De Coppi P, Marini F, Atala A, Stratta RJ, Soker S. Production and characterization of human renal and ileal ECM scaffols: the ideal platform for renal and intestinal bioengineering investigations [abstract]. J Tissue Eng Regen Med. 2012;6(Suppl 1):127-128.

Ko SY, Barengo N, Ladanyi A, Lee JS, Marini F, Lengyel E, Naora H. HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. J Clin Invest. 2012;122(10):3603-3617.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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