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Thomas J. Martin, Ph.D.Wake Forest School of Medicine

Thomas J. Martin, Ph.D.

Substance Addiction& Abuse Ctr

Contact Information

Academic: 336-716-8554


Education & Training

  • B.S., University of North Carolina-Chapel Hill, 1984
  • Ph.D., Virginia Commonwealth University, 1989
  • Fellowship, WFU School of Medicine, 1994

Board Certifications

  • American Board of Internal Medicine, Internal Medicine


  • Soc Of Neuroscience
  • Am Pain Society
  • Coll on Probs of Drug Dependen

NPI Number

  • 1245410653
Thomas J. Martin, Ph.D.

Thomas J. Martin, Ph.D.

Professor, Anesthesiology
Substance Addiction& Abuse Ctr

Research Interests

Analgesics, Opioid; Reinforcement (Psychology); Conditioning, Operant; Heroin; Rats, Inbred F344
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Contact Information

Academic: 336-716-8554


Recent Publications

Chronic delta9-THC in rhesus monkeys: effects on cognitive performance and dopamine D2/D3 receptor availability. John WS, Martin TJ, Solingapuram Sai KK, Nader SH, Gage HD, Mintz A, Nader MA.. J Pharmacol Exp Ther. 2018;364(2):300-310.

High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Chen R, McIntosh S, Hemby SE, Sun H, Sexton T, Martin T, Childers SR.. Neurosci Lett. 2018;671():133-139.

Psychosocial stress delays recovery of postoperative pain following incisional surgery in the rat. Arora V, Martin TJ, Aschenbrenner CA, Hayashida K, Kim SA, Parker RA, Eisenach JC, Peters CM.. Neuroscience. 2018;382():35-47.

Behavioral determinants of cannabinoid self-administration in Old World monkeys. John WS, Martin TJ, Nader MA.. Neuropsychopharmacology. 2017;42(7):1522-1530.

Audiovisual distraction increases prefrontal cortical neuronal activity and impairs attentional performance in the rat. Ririe DG, Danilo Boada M, Schmidt BS, Martin SJ, Kim SA, Martin TJ.. J Exp Neurosci. 2017;11():.

Assessment of behavioral disruption in rats with abdominal inflammation using visual cue titration and the five-choice serial-reaction time task. Martin TJ, Strassburg TJ, Grigg AL, Kim SA, Ririe DG, Eisenach JC.. Anesthesiology. 2017;127(2):372-381.

A G protein-biased ligand of the kappa opioid receptor is antinociceptive and antipruritic but does not cause sedation or dysphoria [abstract]. Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aube J, Jones SR, Martin TJ, Bohn LM.. FASEB J. 2017;31(Suppl 1):992.4.

Incisional surgery at a critical period of development reduces impulse control in adult rats [abstract]. Ririe DG, MacGregor M, Martin TJ.. In: Abstracts of the 2017 Annual Meeting of the American Society of Anesthesiologists (ASA); 2017 Oct 21-25; Boston (MA). 2017;():A5012.

Disruption of spinal noradrenergic activation delays recovery of acute incision-induced hypersensitivity and increases spinal glial activation in the rat. Arora V, Morado-Urbina CE, Aschenbrenner CA, Hayashida KI, Wang F, Martin TJ, Eisenach JC, Peters CM.. J Pain. 2016;17(2):190-202.

A novel G-protein biased kappa opioid that displays analgesic but not dysphoric actions in the rat [abstract]. Martin T, Kim S, Rose J, Jones S, Aube J, Bohn L.. J Pain. 2016;17(4 Suppl 1):S65.

Nerve injury induced activation of fast-conducting high threshold mechanoreceptors predicts non-reflexive pain related behavior. Boada MD, Martin TJ, Ririe DG.. Neurosci Lett. 2016;632():44-49.

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aube J, Jones SR, Martin TJ, Bohn LM.. Sci Signal. 2016;9(456):ra117.

Reduced PFC activity may underlie reduced attentional performance from incisional pain [abstract]. Ririe D, Boada D, Martin T.. Soc Neurosci Abstr. 2016;2016(Neuroscience Meeting Planner):.

Inflammatory abdominal pain disrupts performance in a visual attention task in rats [abstract]. Martin TJ, Strassburg TJ, Kim SA, Ririe DG, Eisenach JC.. Soc Neurosci Abstr. 2016;2016(Neuroscience Meeting Planner):.

Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task. Martin TJ, Grigg A, Kim SA, Ririe DG, Eisenach JC.. J Neurosci Methods. 2015;241():37-43.

Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Peters CM, Hayashida KI, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC.. Anesthesiology. 2015;122(4):895-907.

Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats. Czoty PW, Tran P, Thomas LN, Martin TJ, Grigg A, Blough BE, Beveridge TJ.. Psychopharmacology (Berl). 2015;232(13):2405-2414.

Surgical incision impairs attentional performance postoperatively in the rat; implications for the prolonged 'foggy' feeling after anesthesia and surgery [abstract]. Ririe DG, Harris M, Grigg A, Kim S, Martin TJ.. In: Abstracts of the 2015 Annual Meeting of the American Society of Anesthesiologists (ASA); 2015 Oct 24-28; San Diego (CA). 2015;():A4011.

Regional differences in mu and kappa opioid receptor G-protein activation in brain in male and female prairie voles. Martin TJ, Sexton T, Kim SA, Severino AL, Peters CM, Young LJ, Childers SR.. Neuroscience. 2015;311():422-429.

Differential suppression of intracranial self-stimulation, food-maintained operant responding, and open field activity by paw incision and spinal nerve ligation in rats. Ewan EE, Martin TJ.. Anesth Analg. 2014;118(4):854-862.

Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Danilo Boada M, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG.. Pain. 2014;155(12):2646-2655.

. Fairbanks CA, Martin TJ, eds.. In: Neurobiological studies of addiction in chronic pain states. New York: Springer;2014: .

Opioid self-administration in the presence of chronic pain: analgesia or addiction?. Ewan EE, Martin TJ. In: Fairbanks CA, Martin TJ, eds. Neurobiological studies of addiction in chronic pain states. New York: Springer;2014: 17-30.

Analgesics as reinforcers with chronic pain: evidence from operant studies. Ewan EE, Martin TJ.. Neurosci Lett. 2013;557(Pt A):60-64.

Intracranial self-stimulation of the paraventricular nucleus of the hypothalamus: increased faciliation by morphine compared to cocaine. Ewan EE, Martin TJ.. Anesthesiology. 2012;116(5):1116-1123.

Opioid facilitation of rewarding electrical brain stimulation is suppressed in rats with neuropathic pain. Ewan EE, Martin TJ.. Anesthesiology. 2011;114(3):624-632.

Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury. Martin TJ, Buechler NL, Kim SA, Ewan EE, Xiao R, Childers SR.. Anesthesiology. 2011;114(3):633-642.

Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids. Ewan EE, Martin TJ.. Anesthesiology. 2011;115(6):1271-1280.

Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR.. J Neuroimmunol. 2011;239(1-2):53-60.

Optical inhibition of neurons in whole rat dorsal root ganglion after in vivo intrathecal viral vector induced expression of the optically active proton pump Arch-T [abstract]. Ririe DG, Boada DM, Martin TJ, Boyden ES, Eisenach JC.. In: Abstracts of the 2011 Annual Meeting of the American Society of Anesthesiologists (ASA); 2011 Oct 15-19; Chicago (IL). 2011;():A391.

Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. Hains LE, Loram LC, Weiseler JL, Frank MG, Bloss EB, Sholar P, Taylor FR, Harrison JA, Martin TJ, Eisenach JC, et al.. J Pain. 2010;11(10):1004-1014.

Maybe anesthesia is NOT the whole story: long-term effects of incision in early development in rat [abstract]. Ririe DG, Martin TJ.. In: Abstracts of the 2009 Annual Meeting of the American Society of Anesthesiologists (ASA); 2009 Oct 17-21; New Orleans (LA). 2009;():A688.

Mu-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats. Martin TJ, Coller M, Co C, Smith JE.. Neuropsychopharmacology. 2008;33(5):1171-1178.

In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain. Murthy V, Martin TJ, Kim S, Davies HML, Childers SR.. J Pharmacol Exp Ther. 2008;326(2):587-595.

Chronic pain alters drug self-administration: implications for addiction and pain mechanisms. Martin TJ, Ewan E.. Exp Clin Psychopharmacol. 2008;16(5):357-366.

Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain. Martin TJ, Kahn WR, Xiao R, Childers SR.. Synapse. 2007;61(3):176-184.

Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC.. Anesthesiology. 2007;106(2):312-322.

Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion. Martin TJ, McIntosh S, Smith JE.. Synapse. 2006;60(5):384-391.

Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Martin TJ, Beuchler NL, Eisenach JC.. Anesth Analg. 2006;103(3):690-695.

Chronic activation of spinal adenosine A1 receptors results in hypersensitivity. Martin TJ, Eisenach JC, Misler J, Childers SR.. Neuroreport. 2006;17(15):1619-1622.

Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation. Martin TJ, Kim SA, Eisenach JC.. Pain. 2006;125(3):257-263.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Anesthesiology

Thomas J. Martin, Ph.D.

Thomas J. Martin, Ph.D.

Professor, Anesthesiology
Substance Addiction& Abuse Ctr

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