Profile

Charles E. McCall, M.D.Wake Forest School of Medicine

Charles E. McCall, M.D.

Professor,







Clinical Specialties

Infectious Diseases, Immune Compromise, Sepsis, Immunology

Contact Information

Academic: 336-716-4322 | Department: 336-716-2691

Media Medical Expert »

Education & Training

  • B.S., Wake Forest University , 1957
  • M.D., WFU School of Medicine , 1961
  • Internship, Boston Med Ctr, 1962
  • Residency, Boston Med Ctr, 1963
  • Residency, Boston Med Ctr, 1966
  • Fellowship, Harvard Medical School, 1968

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Assn Of Immunologists
  • Am Assn Of University Professo
  • Am Coll Of Physicians
  • Am Federation Of Clinical Rese
  • Am Soc Of Clinical Investigati
  • Assn Of American Physicians
  • Infectious Disease Society Of

NPI Number

  • 1497730402
Charles E. McCall, M.D.

Charles E. McCall, M.D.

Professor, Molecular Medicine
Translational Science Institute
Office of Women in Medicine and Science
Sticht Center on Aging
WFU Primate Center
Microbiology & Immunology

Research Interests

critical/intensive care medici, genetics/genome, hormones/cytokines/signalling, immunology/allergy/inflammatio, infectious diseases, molecular biology/molecular me

Contact Information

Academic: 336-716-4322 | Department: 336-716-2691

Media Medical Expert »

Recent Publications

Hoth JJ, Wells JD, Jones SE, Yoza BK, McCall CE. Complement mediates a primed inflammatory response after traumatic lung injury. J Trauma Acute Care Surg. 2014;76(3):601-609.

Liu TF, McCall CE. Deacetylation by SIRT1 reprograms inflammation and cancer. Genes Cancer. 2013;4(3-4):135-147.

Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes. Clin Vaccine Immunol. 2013;20(9):1396-1404.


Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,. Methylomics of gene expression in human monocytes. Hum Mol Genet. 2013;22(24):5065-5074.

Millet P, McCall C, Yoza B. RelB: an outlier in leukocyte biology. J Leukoc Biol. 2013;94(5):941-951.

Brudecki L, Ferguson DA, Yin D, Lesage GD, McCall CE, El Gazzar M. Hematopoietic stem-progenitor cells restore immunoreactivity and improve survival in late sepsis. Infect Immun. 2012;80(2):602-611.


Vachharajani V, Cunningham C, Yoza B, Carson J Jr, Vachharajani TJ, McCall C. Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Obesity (Silver Spring). 2012;20(3):498-504.

Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Infect Immun. 2012;80(6):2026-2034.



Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.

Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol. 2012;92(3):499-507.

Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Adoptive transfer of CD34+ cells during murine sepsis rebalances macrophage lipopolysaccharide responses. Immunol Cell Biol. 2012;90(10):925-934.


Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem. 2011;286(11):9856-9864.

Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock. 2011;35(6):604-609.


McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011;90(3):439-446.

McCall C, Bowes RC, McCall W. Objective vs. subjective measurements of sleep in depressed insomniacs: first night effect or reverse first night effect? [abstract]. Sleep. 2011;34(Suppl):A255-A256.

El Gazzar M, Liu T, Yoza BK, McCall CE. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J Biol Chem. 2010;285(2):1259-1271.

El Gazzar M, McCall CE. MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem. 2010;285(27):20940-51.

Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010;17(6):407-416.

McCall CE, Yoza B, Liu T, El Gazzar M. Gene-specific epigenetic regulation in serious infections with systemic inflammation. J Innate Immun. 2010;2(5):395-405.

Hoth JJ, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary parenchymal cells mediate toll-like receptor dependent responses after traumatic lung injury. J Am Coll Surg. 2010;211(3 Suppl):S51.

Chen X, Yoza BK, El Gazzar M, Hu JYQ, Cousart SL, McCall CE. RelB sustains IkappaBalpha expression during endotoxin tolerance. Clin Vaccine Immunol. 2009;16(1):104-110.

El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE. Chromatin-specific remodeling by HMGB1 and linker histone H1 silence proinflammatory genes during endotoxin tolerance. Mol Cell Biol. 2009;29(7):1959-1971.

Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK. Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009;31(4):376-381.


Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary contusion primes systemic innate immunity responses. J Trauma. 2009;67(1):14-21.

El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE. G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem. 2008;283(47):32198-208.

McCall CE, Yoza BK. Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med. 2007;175(8):763-767.

El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007;111(1):36-44.

El Gazzar M, Yoza BK, Hu JY-Q, Cousart SL, McCall CE. Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance. J Biol Chem. 2007;282(37):26857-64.

Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007;28(4):447-452.

Loza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang B-L. Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS ONE. 2007;2(10):e1035.

Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM. The pathogenesis of pulmonary contusion: an open chest model in the rat. J Trauma. 2006;61(1):32-45.

Yoza BK, Hu JY-Q, Cousart SL, Forrest LM, McCall CE. Induction of RelB participates in endotoxin tolerance. J Immunol. 2006;177(6):4080-4085.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Molecular Medicine
Translational Science Institute

Clinical Specialties

Infectious Diseases, Immune Compromise, Sepsis, Immunology

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.