Profile

Charles E. McCall, M.D.

Charles E. McCall, M.D.

Director, Translational Science Institute
Professor, Molecular Medicine
Sticht Center on Aging
Translational Science Institute
WFU Primate Center
Microbiology & Immunology
Infectious Diseases
Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Contact Information
Office:
336-716-4322
Clinical Specialties
Infectious Diseases, Immune Compromise, Sepsis, Immunology
Education & Training
  BSWake Forest University1957
  MDWFU School of Medicine1961
ResidencyBoston Med Ctr1963
  Boston Med Ctr1966
InternshipBoston Med Ctr1962
FellowshipHarvard Medical School1968
Memberships
American Association of Advancement of Science
American Association of Immunologists
American Association of University Professors
American Coll of Physicians
American Federation of Clinical Research
American Society of Clinical Investigation
Association of American Physicians
Infectious Disease Society of Am.
NPI Number
1497730402
Charles E. McCall, M.D.

Charles E. McCall, M.D.

Director, Translational Science Institute
Professor, Molecular Medicine
Sticht Center on Aging
Translational Science Institute
WFU Primate Center
Microbiology & Immunology
Infectious Diseases
Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Contact Information
Office:
336-716-4322
Research Interests
immunology/allergy/inflammatio , infectious diseases , metabolism , molecular biology/molecular me
Recent Publications
Yoza BK, McCall CE. Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis. Cytokine. 2011; 53(2):145-152.


Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem. 2011; 286(11):9856-9864.


Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock. 2011; 35(6):604-609.


El Gazzar M, Church A, Liu T, McCall CE. MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-alpha during TLR4-induced gene reprogramming. J Leukoc Biol. 2011; 90(3):509-519.


McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011; 90(3):439-446.


El Gazzar M, Liu T, Yoza BK, McCall CE. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J Biol Chem. 2010; 285(2):1259-1271.


El Gazzar M, McCall CE. MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem. 2010; 285(27):20940-51.


Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010; 17(6):407-416.


McCall CE, Yoza B, Liu T, El Gazzar M. Gene-specific epigenetic regulation in serious infections with systemic inflammation. J Innate Immun. 2010; 2(5):395-405.


Hoth JJ, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary parenchymal cells mediate toll-like receptor dependent responses after traumatic lung injury. J Am Coll Surg. 2010; 211(3 Suppl):S51.


Chen X, Yoza BK, El Gazzar M, Hu JYQ, Cousart SL, McCall CE. RelB sustains IkappaBalpha expression during endotoxin tolerance. Clin Vaccine Immunol. 2009; 16(1):104-110.


El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE. Chromatin-specific remodeling by HMGB1 and linker histone H1 silence proinflammatory genes during endotoxin tolerance. Mol Cell Biol. 2009; 29(7):1959-1971.


Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK. Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009; 31(4):376-381.


Chen X, El Gazzar M, Yoza BK, McCall CE. The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. J Biol Chem. 2009; 284(41):27857-65.


Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary contusion primes systemic innate immunity responses. J Trauma. 2009; 67(1):14-21.


El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE. G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem. 2008; 283(47):32198-208.


McCall CE, Yoza BK. Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med. 2007; 175(8):763-767.


El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007; 111(1):36-44.


El Gazzar M, Yoza BK, Hu JY-Q, Cousart SL, McCall CE. Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance. J Biol Chem. 2007; 282(37):26857-64.


Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007; 28(4):447-452.


Loza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang B-L. Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS ONE. 2007; 2(10):e1035.


Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM. The pathogenesis of pulmonary contusion: an open chest model in the rat. J Trauma. 2006; 61(1):32-45.


Yoza BK, Hu JY-Q, Cousart SL, Forrest LM, McCall CE. Induction of RelB participates in endotoxin tolerance. J Immunol. 2006; 177(6):4080-4085.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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Last Updated 2/7/2012
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