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Charles E. McCall, M.D.Wake Forest School of Medicine

Charles E. McCall, M.D.

Professor,



Redox Biology & Medicine Ctr

Clinical Interests

Infectious Diseases, Immune Compromise, Sepsis, Immunology

Contact Information

Academic: 336-716-2691 | Department: 336-713-4259

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Education & Training

  • B.S., Wake Forest University, 1957
  • M.D., WFU School of Medicine, 1961
  • Internship, Boston Med Ctr, 1962
  • Residency, Boston Med Ctr, 1963
  • Residency, Boston Med Ctr, 1966
  • Fellowship, Harvard Medical School, 1968

Board Certifications

  • American Board of Allergy and Immunology, Infectious Disease
  • American Board of Internal Medicine, Infectious Disease

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Assn Of Immunologists
  • Am Assn Of University Professo
  • Am Coll Of Physicians
  • Am Federation Of Clinical Rese
  • Am Soc Of Clinical Investigati
  • Assn Of American Physicians
  • Infectious Disease Soc of Amer

NPI Number

  • 1497730402
Charles E. McCall, M.D.

Charles E. McCall, M.D.

Professor, Translational Science Institute
Molecular Medicine
Office of Women in Medicine and Science
Center on Diabetes, Obesity, and Metabolism
Redox Biology & Medicine Ctr
Microbiology & Immunology

Research Interests

Sepsis; Inflammation; Endotoxins; Sirtuin 1; Gene Silencing
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Contact Information

Academic: 336-716-2691 | Department: 336-713-4259

Media Medical Expert »

Recent Publications

Stat3 and C/EBPbeta synergize to induce miR-21 and miR-181b expression during sepsis. McClure C, McPeak MB, Youssef D, Yao ZQ, McCall CE, El Gazzar M.. Immunol Cell Biol. 2017;95(1):42-55.

Myeloid cell-specific knockout of NFI-A improves sepsis survival. McPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar M.. Infect Immun. 2017;85(4):e00066-17.

Sirtuin 2 regulates microvascular inflammation during sepsis. Buechler N, Wang X, Yoza BK, McCall CE, Vachharajani V.. J Immunol Res. 2017;2017():2648946.

Frontline science: myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice. McPeak MB, Youssef D, Williams DA, Pritchett CL, Yao ZQ, McCall CE, El Gazzar M.. J Leukoc Biol. 2017;102(2):191-200.

Transcriptomic profiles of aging in naive and memory CD4+ cells from mice. Taylor J, Reynolds L, Hou L, Lohman K, Cui W, Kritchevsky S, McCall C, Liu Y.. Immun Ageing. 2017;2017(14):15.

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR Jr, Post W, Hoeschele I, Bell DA, Herrington D,.. Nat Commun. 2017;8(1):393.

Expression of C/EBPbeta in myeloid progenitors during sepsis promotes immunosuppression. Dai J, Kumbhare A, Youssef D, Yao ZQ, McCall CE, El Gazzar M.. Mol Immunol. 2017;91():165-172.

The oxidative state of cysteine thiol 144 regulates the SIRT6 glucose homeostat. Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE.. Sci Rep. 2017;7(1):11005.

NFI-A disrupts myeloid cell differentiation and maturation in septic mice. McClure C, Ali E, Youssef D, Yao ZQ, McCall CE, El Gazzar M.. J Leukoc Biol. 2016;99(1):201-211.

GAPDH binding to TNF-alpha mRNA contributes to posttranscriptional repression in monocytes: a novel mechanism of communication between inflammation and metabolism. Millet P, Vachharajani V, McPhail L, Yoza B, McCall CE.. J Immunol. 2016;196(6):2541-2551.

Sirtuins link inflammation and metabolism. Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE.. J Immunol Res. 2016;2016():8167273.

Pulmonary contusion decreases SIRT1 and primes the lung for a second hit [abstract]. Hoth JJ, Furdui CM, Wells JD, Yoza B, McCall C.. Shock. 2016;45(6 Suppl 1):85.

Rescuing immunosuppressed septic mice from death by reducing the mitochondrial block in glucose oxidation [abstract]. Liu T, Vachharajani V, Martin A, McCall C.. Shock. 2016;45(6 Suppl 1):130.

Sirtuin-2 regulates sepsis inflammation in ob/ob mice. Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V.. PLoS One. 2016;11(8):e0160431.

Precision immunometabolic checkpoint treatment of lethal murine sepsis: targeting the NAD plus and sirtuin 1-dependent homeostasis network [abstract]. Liu T, Vachharajani V, Zhang X, Xu J, McCall C.. Eur J Immunol. 2016;46(Suppl 1):1046.

Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice. Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani V.. J Inflamm Res. 2016;9():167-174.

Inflammation associated epigenetics and metabolism novel treatment targets [abstract]. McCall CE.. Shock. 2016;46(4 Suppl 2):13.

Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Chi GC, Liu Y, MacDonald JW, Barr RG, Donohue KM, Hensley MD, Hou L, McCall CE, Reynolds LM, Siscovick DS, Kaufman JD.. Environ Health. 2016;15(1):119.

Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE.. J Biol Chem. 2015;290(1):396-408.

Transcriptomic profiles of aging in purified human immune cells. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,.. BMC Genomics. 2015;16(1):333.

Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-induced modulation of adhesion molecules in ob/ob mice. Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VT.. Obesity (Silver Spring). 2015;23(6):1209-1217.

SIRT1 mediates a primed response to immune challenge after traumatic lung injury. Smith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJ.. J Trauma Acute Care Surg. 2015;78(5):1034-1038.

Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,.. Diabetes. 2015;64(10):3464-3474.

Processing body formation limits proinflammatory cytokine synthesis in endotoxin-tolerant monocytes and murine septic macrophages. McClure C, Brudecki L, Yao ZQ, McCall CE, El Gazzar M.. J Innate Immun. 2015;7(6):572-583.

Transcriptomic profiles of aging in naive and memory CD4+T cells from mice [abstract]. Taylor JR, Reynolds LM, Hou L, Lohman K, Kritchevsky SB, McCall C, Liu YM.. Gerontologist. 2015;55(Suppl 2):341.

Complement mediates a primed inflammatory response after traumatic lung injury. Hoth JJ, Wells JD, Jones SE, Yoza BK, McCall CE.. J Trauma Acute Care Surg. 2014;76(3):601-609.

MicroRNA 21 (miR-21) and miR-181b couple with NFI-A to generate myeloid-derived suppressor cells and promote immunosuppression in late sepsis. McClure C, Brudecki L, Ferguson DA, Yao ZQ, Moorman JP, McCall CE, El Gazzar M.. Infect Immun. 2014;82(9):3816-3825.

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE.. J Leukoc Biol. 2014;96(5):785-796.

Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Vachharajani V, Liu T, McCall CE.. Expert Rev Clin Immunol. 2014;10(9):1141-1150.

Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Reynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington DM, Tracy RP, Liu Y.. Nat Commun. 2014;5():5366.

Deacetylation by SIRT1 reprograms inflammation and cancer. Liu TF, McCall CE.. Genes Cancer. 2013;4(3-4):135-147.

Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes. Brudecki L, Ferguson DA, McCall CE, El Gazzar M.. Clin Vaccine Immunol. 2013;20(9):1396-1404.

MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes. Brudecki L, Ferguson DA, McCall CE, El Gazzar M.. Immunol Cell Biol. 2013;91(8):532-540.

Methylomics of gene expression in human monocytes. Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,.. Hum Mol Genet. 2013;22(24):5065-5074.

RelB: an outlier in leukocyte biology. Millet P, McCall C, Yoza B.. J Leukoc Biol. 2013;94(5):941-951.

Hematopoietic stem-progenitor cells restore immunoreactivity and improve survival in late sepsis. Brudecki L, Ferguson DA, Yin D, Lesage GD, McCall CE, El Gazzar M.. Infect Immun. 2012;80(2):602-611.

Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses. Hoth JJ, Wells JD, Yoza BK, McCall CE.. Shock. 2012;37(4):385-391.

Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Vachharajani V, Cunningham C, Yoza B, Carson J Jr, Vachharajani TJ, McCall C.. Obesity (Silver Spring). 2012;20(3):498-504.

Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Brudecki L, Ferguson DA, McCall CE, El Gazzar M.. Infect Immun. 2012;80(6):2026-2034.

NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. Liu TF, Vachharajani VT, Yoza BK, McCall CE.. J Biol Chem. 2012;287(31):25758-69.

MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators. El Gazzar M, McCall CE.. Immunol Cell Biol. 2012;90(6):587-593.

Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.

Fueling the flame: bioenergy couples metabolism and inflammation. Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE.. J Leukoc Biol. 2012;92(3):499-507.

Adoptive transfer of CD34+ cells during murine sepsis rebalances macrophage lipopolysaccharide responses. Brudecki L, Ferguson DA, McCall CE, El Gazzar M.. Immunol Cell Biol. 2012;90(10):925-934.

Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis. Yoza BK, McCall CE.. Cytokine. 2011;53(2):145-152.

NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE.. J Biol Chem. 2011;286(11):9856-9864.

Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK.. Shock. 2011;35(6):604-609.

MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-alpha during TLR4-induced gene reprogramming. El Gazzar M, Church A, Liu T, McCall CE.. J Leukoc Biol. 2011;90(3):509-519.

Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B.. J Leukoc Biol. 2011;90(3):439-446.

Objective vs. subjective measurements of sleep in depressed insomniacs: first night effect or reverse first night effect? [abstract]. McCall C, Bowes RC, McCall W.. Sleep. 2011;34(Suppl):A255-A256.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Translational Science Institute
Molecular Medicine

Clinical Interests

Infectious Diseases, Immune Compromise, Sepsis, Immunology

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