Profile

Brian A. McCool, Ph.D.Wake Forest School of Medicine

Brian A. McCool, Ph.D.

Professor,

Clinical Interests

Substance Abuse, Anxiety

Contact Information

Academic: 336-716-8608 | Department: 336-716-8608

Email: bmccool@wakehealth.edu

Related Links

Education & Training

  • B.S., University of Texas-Austin, 1988
  • Ph.D., Vanderbilt University, 1993
  • Fellowship, Vanderbilt Univ Medical School, 1996

Memberships

  • Am Assn Of Advancement Of Scie
  • Research Society On Alcoholism
  • Society for Neuroscience
  • Am Soc for Pharm & Exper Ther
Brian A. McCool, Ph.D.

Brian A. McCool, Ph.D.

Professor, Physiology & Pharmacology

Research Interests

Ethanol; Amygdala; Alcohol Drinking; Central Nervous System Depressants; Substance Withdrawal Syndrome
More »

Contact Information

Academic: 336-716-8608 | Department: 336-716-8608

Email: bmccool@wakehealth.edu

Related Links

Recent Publications

Strain-dependent effects of acute alcohol on synaptic vesicle recycling and post-tetanic potentiation in medial glutamate inputs to the mouse basolateral amygdala. Gioia DA, McCool BA.. Alcohol Clin Exp Res. 2017;():.

Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala. Robinson SL, Alexander NJ, Bluett RJ, Patel S, McCool BA.. Neuropharmacology. 2016;108():474-484.

Supersensitive kappa opioid receptors promotes ethanol withdrawal-related behaviors and reduce dopamine signaling in the nucleus accumbens. Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR.. Int J Neuropsychopharmacol. 2016;19(5):.

Strain specific effects of acute ethanol on glutamatergic synapse short term plasticity and vesicle recycling role of MUNC13 [abstract]. Gioia DA, Alexander NJ, McCool BA.. Alcohol Clin Exp Res. 2016;40(Suppl 1):144A.

RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R.. Neuropharmacology. 2016;110(Pt A):297-307.

Effects of repeated chronic intermittent ethanol exposure on glutamatergic signaling at two afferent projections into the rat lateral/basolateral amygdala [abstract]. McGinnis MM, Morales M, Alexander NJ, McCool BA.. Alcohol Clin Exp Res. 2016;40(Suppl 1):200A.

Repeated binge-like ethanol vapor exposures sensitize glutamate release onto rat lateral/basolateral amygdala neurons [abstract]. Morales M, McGinnis MM, Gioia DA, McCool BA.. Alcohol Clin Exp Res. 2016;40(Suppl 1):199A.

Differential expression of Munc13-2 produces unique synaptic phenotypes in the basolateral amygdala of C57BL/6J and DBA/2J mice. Gioia DA, Alexander NJ, McCool BA.. J Neurosci. 2016;36(43):10964-977.

Chronic intermittent ethanol inhalation increases ethanol self-administration in both C57BL/6J and DBA/2J mice. McCool BA, Chappell AM.. Alcohol. 2015;49(2):111-120.

Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell. Peterson VL, McCool BA, Hamilton DA.. Brain Res. 2015;1594():125-135.

Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR.. Synapse. 2015;69(8):385-395.

Microstructural analysis of rat ethanol and water drinking patterns using a modified operant self-administration model. Robinson SL, McCool BA.. Physiol Behav. 2015;149():119-130.

Ethanol gated disruption of glutamatergic vesicle pool dynamics in Dba/2j and C57bl/6j mice [abstract]. Gioia D, McCool B.. Alcohol Clin Exp Res. 2015;39(Suppl 1):115A.

Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long-Evans rats. Morales M, McGinnis MM, McCool BA.. Pharmacol Biochem Behav. 2015;139(Pt A):67-76.

Withdrawal from intermittent ethanol exposure modulates glutamatergic synaptic function in the rat lateral/basolateral amygdala: a time-course study [abstract]. Morales M, Robinson SL, McCool BA.. Alcohol Clin Exp Res. 2015;39(Suppl 1):115A.

Increased excitability of Bla pyramidal cells may contribute to the phenotype associated with a rodent model of alcohol addiction vulnerability [abstract]. Rau AR, Ariwodola OJ, Butler TR, McCool BA, Weiner JL.. Alcohol Clin Exp Res. 2015;39(Suppl 1):297A.

Effects of ethanol dependence on subsequent voluntary home cage intake in adult male and female long-evans rats [abstract]. Morales M, McGinnis MM, McCool BA.. Alcohol Clin Exp Res. 2015;39(Suppl 1):109A.

Lateral/basolateral amygdala serotonin type-2 receptors modulate operant self-administration of a sweetened ethanol solution via inhibition of principal neuron activity. McCool BA, Christian DT, Fetzer JA, Chappell AM.. Front Integr Neurosci. 2014;8():5.

Persistent enhancement of ethanol drinking following a monosodium glutamate-substitution procedure in C57BL6/J and DBA/2J mice. McCool BA, Chappell AM.. Alcohol. 2014;48(1):55-61.

Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J.. Alcohol. 2014;48(2):161.

Differences in presynaptic calciumsensitivty underlie differential glutamatergic function in the basolateral amygdala of DBA/2J and C57BL/6J mice [abstract]. Gioia DA, McCool BA.. Alcohol Clin Exp Res. 2014;38(Suppl 1):89A.

Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Karkhanis AN, McCool BA, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Selective modulation of the rat basolateral amydgala endocannabinoid system by chronic ethanol exposure [abstract]. Robinson SL, McCool BA.. Alcohol Clin Exp Res. 2014;38(Suppl 1):92A.

Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2014;38(11):2770-2779.

Thalamic glutamatergic afferents into the rat basolateral amygdala exhibit increased presynaptic glutamate function following withdrawal from chronic intermittent ethanol. Christian DT, Alexander NJ, Diaz MR, McCool BA.. Neuropharmacology. 2013;65():134-142.

Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Chappell AM, Carter E, McCool BA, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 1):E394-E403.

Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration. Abrahao KP, Ariwodola OJ, Butler TR, Rau AR, Skelly MJ, Carter E, Alexander NP, McCool BA, Souza-Formigoni ML, Weiner JL.. J Neurosci. 2013;33(11):4834-4842.

Behavioral sensitization to ethanol has bidirectional effects on MGLUR1/5 dependent long-term depression in the nucleus accumbens core and shell [abstract]. Abrahao KP, Souza-Formigoni MLO, McCool BA, Camirini R, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 2):120A.

Differential glutamatergic transmission in the basolateral amygdala of C57Bl/6J and Dba/2J mice [abstract]. Gioia DA, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

SR141716 modulation of ethanol-directed appetitive and consummatory behaviors in a rat model of ethanol physical dependence [abstract]. Robinson SL, Chappell AM, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):176A.

Modest intermittent ethanol exposure modulates anxiety-like behaviors and rat lateral/basolateral amygdala glutamatergic synaptic function [abstract]. Robinson SL, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

Adolescent social isolation increases behavioral and neurobiological risk factors of alcoholism in male Long Evans rats [abstract]. Weiner JL, Chappell AM, Carter E, Yorgason J, Jones SR, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):299A.

Using monosodium glutamate to initiate ethanol self-administration in inbred mouse strains. McCool BA, Chappell AM.. Addict Biol. 2012;17(1):121-131.

Chronic intermittent ethanol and withdrawal differentially modulate basolateral amygdala AMPA-type glutamate receptor function and trafficking. Christian DT, Alexander NJ, Diaz MR, Robinson S, McCool BA.. Neuropharmacology. 2012;62(7):2430-2439.

Simultaneous analysis of appetitive and consumatory self-administration behaviors in rats following physical depencence [sic] to ethanol [abstract]. Robinson SL, Chappell AM, McCool BA.. Alcohol Clin Exp Res. 2012;36(Suppl 1):110A.

Juvenile social isolation in rats increases behavioral and neurobiological risk factors of alcoholism [abstract]. Chappell AM, Carter E, Yorgason JT, Jones SR, McCool BA, Weiner JL.. Alcohol Clin Exp Res. 2012;36(Suppl 2):51A.

Ethanol-induced regulation of iGluR and GABAA subunit mRNAs in prefrontal fields of cynomolgus monkey [abstract]. Hemby SE, McCool B, Friedman DP, Helms CM.. Alcohol Clin Exp Res. 2012;36(Suppl 2):39A.

Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses. Diaz MR, Christian DT, Anderson NJ, McCool BA.. J Pharmacol Exp Ther. 2011;337(1):162-170.

Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala. Diaz MR, Chappell AM, Christian DT, Anderson NJ, McCool BA.. Neuropsychopharmacology. 2011;36(5):1090-1103.

Chronic ethanol-induced DIR-mediated potentiation of local, but not LPC GABAergic transmission in the basolateral amygdala [abstract]. Diaz MR, McCool BA.. Alcohol. 2011;45(3):297.

Ethanol modulation of synaptic plasticity. McCool BA.. Neuropharmacology. 2011;61(7):1097-1108.

Input specific alterations of lateral/basolateral amygdala glutamate synaptic transmission following chronic intermittent ethanol and withdrawal [abstract]. Christian DT, Diaz MR, Anderson N, McCool BA.. Alcohol Clin Exp Res. 2011;35(6 Suppl):59A.

A monosodium glutamate-fade increases voluntary ethanol consumption in the ethanol 'non-preferring' DBA/2J mouse line [abstract]. McCool BA, Chappell AM.. Alcohol Clin Exp Res. 2010;34(Suppl 2):84A.

Effects of chronic ethanol and withdrawal on feedforward and feedback GABAergic inhibition in the basolateral amygdala [abstract]. Diaz MR, Christian DT, Anderson NJ, McCool Ba.. Alcohol Clin Exp Res. 2010;34(Suppl 2):198A.

Afferent-specific alteraitons [sic] of amygdala presynaptic glutamatergic function by chronic ethanol and withdrawal [abstract]. Christian DT, Diaz MR, McCool BA.. Alcohol Clin Exp Res. 2010;34(Suppl 2):140A.

Glutamate plasticity in the drunken amygdala: the making of an anxious synapse. McCool BA, Christian DT, Diaz MR, Lack AK.. Int Rev Neurobiol. 2010;91():205-233.

Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration. McCool BA, Chappell AM.. Alcohol Clin Exp Res. 2009;33(2):273-282.

Chronic ethanol and withdrawal effects on kainate receptor-mediated excitatory neurotransmission in the rat basolateral amygdala. Lack AK, Christian DT, Diaz MR, McCool BA.. Alcohol. 2009;43(1):25-33.

Characterization of glutamatergic signaling at two afferent pathways into the basolateral amygdala: effect of chronic ethanol and withdrawal [abstract]. Christian DT, McCool BA.. Alcohol Clin Exp Res. 2009;33(6 Special Issue):208A.

Pre- and post-synaptic effects of chronic ethanol and withdrawal on feedforward and feedback gabaergic interneurons in the basolateral amygdala [abstract]. Diaz MR, Anderson NJ, McCool BA.. Alcohol Clin Exp Res. 2009;33(6 Special Issue):210A.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Physiology & Pharmacology

Clinical Interests

Substance Abuse, Anxiety
Brian A. McCool, Ph.D.

Brian A. McCool, Ph.D.

Professor, Physiology & Pharmacology

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