Profile

Brian A. McCool, Ph.D.Wake Forest School of Medicine

Brian A. McCool, Ph.D.

Professor,

Clinical Specialties

Substance Abuse, Anxiety

Contact Information

Academic: 336-716-8608 | Department: 336-716-8608

Email: bmccool@wakehealth.edu

Education & Training

  • B.S., University of Texas-Austin , 1988
  • Ph.D., Vanderbilt University , 1993
  • Fellowship, Vanderbilt University School o, 1996

Memberships

  • Am Assn Of Advancement Of Scie
  • Research Society On Alcoholism
  • Society for Neuroscience
  • Am Soc Of Pharm & Exper Therap
Brian A. McCool, Ph.D.

Brian A. McCool, Ph.D.

Professor, Physiology & Pharmacology
WFU Primate Center

Research Interests

education/training (all f, t,, neurosciences/behavior, substance abuse

Contact Information

Academic: 336-716-8608 | Department: 336-716-8608

Email: bmccool@wakehealth.edu

Recent Publications



Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J. Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Alcohol. 2014;48(2):161.

Gioia DA, McCool BA. Differences in presynaptic calciumsensitivty underlie differential glutamatergic function in the basolateral amygdala of DBA/2J and C57BL/6J mice [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):89A.

Karkhanis AN, McCool BA, Weiner JL, Jones SR. Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Robinson SL, McCool BA. Selective modulation of the rat basolateral amydgala endocannabinoid system by chronic ethanol exposure [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):92A.


Chappell AM, Carter E, McCool BA, Weiner JL. Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Alcohol Clin Exp Res. 2013;37(Suppl 1):E394-E403.

Abrahao KP, Ariwodola OJ, Butler TR, Rau AR, Skelly MJ, Carter E, Alexander NP, McCool BA, Souza-Formigoni ML, Weiner JL. Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration. J Neurosci. 2013;33(11):4834-4842.

Abrahao KP, Souza-Formigoni MLO, McCool BA, Camirini R, Weiner JL. Behavioral sensitization to ethanol has bidirectional effects on MGLUR1/5 dependent long-term depression in the nucleus accumbens core and shell [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):120A.

Gioia DA, McCool BA. Differential glutamatergic transmission in the basolateral amygdala of C57Bl/6J and Dba/2J mice [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

Robinson SL, Chappell AM, McCool BA. SR141716 modulation of ethanol-directed appetitive and consummatory behaviors in a rat model of ethanol physical dependence [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):176A.

Robinson SL, McCool BA. Modest intermittent ethanol exposure modulates anxiety-like behaviors and rat lateral/basolateral amygdala glutamatergic synaptic function [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

Weiner JL, Chappell AM, Carter E, Yorgason J, Jones SR, McCool BA. Adolescent social isolation increases behavioral and neurobiological risk factors of alcoholism in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):299A.

McCool BA, Chappell AM. Using monosodium glutamate to initiate ethanol self-administration in inbred mouse strains. Addict Biol. 2012;17(1):121-131.

Christian DT, Alexander NJ, Diaz MR, Robinson S, McCool BA. Chronic intermittent ethanol and withdrawal differentially modulate basolateral amygdala AMPA-type glutamate receptor function and trafficking. Neuropharmacology. 2012;62(7):2430-2439.

Robinson SL, Chappell AM, McCool BA. Simultaneous analysis of appetitive and consumatory self-administration behaviors in rats following physical depencence [sic] to ethanol [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):110A.

Chappell AM, Carter E, Yorgason JT, Jones SR, McCool BA, Weiner JL. Juvenile social isolation in rats increases behavioral and neurobiological risk factors of alcoholism [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 2):51A.

Hemby SE, McCool B, Friedman DP, Helms CM. Ethanol-induced regulation of iGluR and GABAA subunit mRNAs in prefrontal fields of cynomolgus monkey [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 2):39A.

Diaz MR, Christian DT, Anderson NJ, McCool BA. Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses. J Pharmacol Exp Ther. 2011;337(1):162-170.

Diaz MR, Chappell AM, Christian DT, Anderson NJ, McCool BA. Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala. Neuropsychopharmacology. 2011;36(5):1090-1103.

Diaz MR, McCool BA. Chronic ethanol-induced DIR-mediated potentiation of local, but not LPC GABAergic transmission in the basolateral amygdala [abstract]. Alcohol. 2011;45(3):297.

McCool BA. Ethanol modulation of synaptic plasticity. Neuropharmacology. 2011;61(7):1097-1108.

Christian DT, Diaz MR, Anderson N, McCool BA. Input specific alterations of lateral/basolateral amygdala glutamate synaptic transmission following chronic intermittent ethanol and withdrawal [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):59A.

McCool BA, Chappell AM. A monosodium glutamate-fade increases voluntary ethanol consumption in the ethanol 'non-preferring' DBA/2J mouse line [abstract]. Alcohol Clin Exp Res. 2010;34(Suppl 2):84A.

Diaz MR, Christian DT, Anderson NJ, McCool Ba. Effects of chronic ethanol and withdrawal on feedforward and feedback GABAergic inhibition in the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2010;34(Suppl 2):198A.

Christian DT, Diaz MR, McCool BA. Afferent-specific alteraitons [sic] of amygdala presynaptic glutamatergic function by chronic ethanol and withdrawal [abstract]. Alcohol Clin Exp Res. 2010;34(Suppl 2):140A.

McCool BA, Christian DT, Diaz MR, Lack AK. Glutamate plasticity in the drunken amygdala: the making of an anxious synapse. Int Rev Neurobiol. 2010;91():205-233.



Christian DT, McCool BA. Characterization of glutamatergic signaling at two afferent pathways into the basolateral amygdala: effect of chronic ethanol and withdrawal [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):208A.

Diaz MR, Anderson NJ, McCool BA. Pre- and post-synaptic effects of chronic ethanol and withdrawal on feedforward and feedback gabaergic interneurons in the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):210A.

McCool BA, Chappell AE [sic] [Chappell AM]. Using monosodium glutamate to initiate voluntary ethanol consumption in 'non-preferring' inbred mouse lines [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):92A.

Spence TE, Christian DT, Diaz MR, McCool BA. Hyperpolarization-activated cation current mediates the facilitatory effects of acute ethanol on gabaergic transmission in the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):149A.

Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, McCool BA, Weiner JL, et al. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol. 2009;43(7):509-519.

Christian DT, McCool BA. 5-HT2 agonist modulation of rat basolateral amygdala field potentials during chronic intermittent ethanol exposure and withdrawal [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):213A.

Diaz MR, McCool BA. Characterization of chronic ethanol and withdrawal on two populations of GABAergic interneurons in the basolateral amygdala [abstract]. Alcohol. 2008;42(4):330.

Diaz MR, McCool BA. Characterization of chronic ethanol and withdrawal on two populations of GABAergic interneurons in the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):27A.

McCool BA, Lack AK, Diaz MR. Glutamate, GABA, and amygdala-dependent anxiety: tipping the balance with chronic ethanol and withdrawal [abstract]. Alcohol. 2008;42(4):315.

McCool BA, Chappell A, Anderson NJ, Lack AK, Diaz MR. Glutamate, GABA, and amygdala-dependent anxiety: tipping the balance with chronic ethanol and withdrawal [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):306A.

Lack AK, Ariwodola OJ, Chappell AM, Weiner JL, McCool BA. Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala. Neuropharmacology. 2008;55(5):661-668.


Anderson NJ, Daunais JB, Friedman DP, Grant KA, McCool BA. Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptors. Alcohol Clin Exp Res. 2007;31(6):1061-1070.

Anderson NJ, Chappell AM, McCool BA. Early social experience modulates genetic responses to ethanol self-administration: a pilot study [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):14A.

Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz M, McCool BA, Jones SR. Terminal effects of chronic alcohol exposure on dopamine dynamics in rat striatum [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):83A.

Chappell AM, McCool BA. Juvenile social isolation enhances ethanol consumption during operant self-administration [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):22A.

McCool BA, Diaz MR, Anderson NJ, Dubois DW, Lack AK. Pre- and post-synaptic adaptations to chronic ethanol and withdrawal at rat basolateral amygdala glutamatergic synapses [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):314A.

Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007;193(4):495-501.

Lack AK, Diaz MR, Chappell A, DuBois DW, McCool BA. Chronic ethanol and withdrawal differentially modulate pre- and postsynaptic function at glutamatergic synapses in rat basolateral amygdala. J Neurophysiol. 2007;98(6):3185-3196.

DuBois DW, Perlegas A, Floyd DW, Weiner JL, McCool BA. Distinct functional characteristics of the lateral/basolateral amygdala GABAergic system in C57BL/6J and DBA/2J mice. J Pharmacol Exp Ther. 2006;318(2):629-640.

Alexander GM, Carden WB, Mu J, Kurukulasuriya NC, McCool BA, Nordskog BK, Friedman DP, Daunais JB, Grant KA, Godwin DW. The native T-type calcium current in relay neurons of the primate thalamus. Neuroscience. 2006;141(1):453-461.

Diaz MR, McCool BA. Dopaminergic modulation of GABAergic synaptic transmission in the rat lateral/basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):17A.

Lack AK, DuBois DW, Diaz MR, Anderson NJ, McCool BA. Chronic ethanol and withdrawal induces glutamatergic synaptic adaptations in the lateral/basolateral amgydala [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):18A.

Hemby SE, O'Connor JA, Acosta G, Floyd D, Anderson N, McCool BA, Friedman D, Grant KA. Ethanol-induced regulation of GABA subunit mRNAs in prefrontal fields of cynomolgus monkeys. Alcohol Clin Exp Res. 2006;30(12):1978-1985.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Physiology & Pharmacology

Clinical Specialties

Substance Abuse, Anxiety
Brian A. McCool, Ph.D.

Brian A. McCool, Ph.D.

Professor, Physiology & Pharmacology
WFU Primate Center

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