Profile

Brian A. McCool, Ph.D.Wake Forest School of Medicine

Brian A. McCool, Ph.D.

Professor,

Clinical Interests

Substance Abuse, Anxiety

Contact Information

Academic: 336-716-8608 | Department: 336-716-8608

Email: bmccool@wakehealth.edu

Related Links

Education & Training

  • B.S., University of Texas-Austin, 1988
  • Ph.D., Vanderbilt University, 1993
  • Fellowship, Vanderbilt Univ Medical School, 1996

Memberships

  • Am Assn Of Advancement Of Scie
  • Research Society On Alcoholism
  • Society for Neuroscience
  • Am Soc for Pharm & Exper Ther
Brian A. McCool, Ph.D.

Brian A. McCool, Ph.D.

Professor, Physiology & Pharmacology

Research Interests

Amygdala; Ethanol; Alcohol Drinking; Substance Withdrawal Syndrome; Central Nervous System Depressants
More »

Contact Information

Academic: 336-716-8608 | Department: 336-716-8608

Email: bmccool@wakehealth.edu

Related Links

Recent Publications

Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala. Robinson SL, Alexander NJ, Bluett RJ, Patel S, McCool BA.. Neuropharmacology. 2016;108():474-484.

Supersensitive kappa opioid receptors promotes ethanol withdrawal-related behaviors and reduce dopamine signaling in the nucleus accumbens. Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR.. Int J Neuropsychopharmacol. 2016;19(5):.

Strain specific effects of acute ethanol on glutamatergic synapse short term plasticity and vesicle recycling role of MUNC13 [abstract]. Gioia DA, Alexander NJ, McCool BA.. Alcohol Clin Exp Res. 2016;40(Suppl 1):144A.

RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R.. Neuropharmacology. 2016;110(Pt A):297-307.

Effects of repeated chronic intermittent ethanol exposure on glutamatergic signaling at two afferent projections into the rat lateral/basolateral amygdala [abstract]. McGinnis MM, Morales M, Alexander NJ, McCool BA.. Alcohol Clin Exp Res. 2016;40(Suppl 1):200A.

Repeated binge-like ethanol vapor exposures sensitize glutamate release onto rat lateral/basolateral amygdala neurons [abstract]. Morales M, McGinnis MM, Gioia DA, McCool BA.. Alcohol Clin Exp Res. 2016;40(Suppl 1):199A.

Differential expression of Munc13-2 produces unique synaptic phenotypes in the basolateral amygdala of C57BL/6J and DBA/2J mice. Gioia DA, Alexander NJ, McCool BA.. J Neurosci. 2016;36(43):10964-977.

Chronic intermittent ethanol inhalation increases ethanol self-administration in both C57BL/6J and DBA/2J mice. McCool BA, Chappell AM.. Alcohol. 2015;49(2):111-120.

Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell. Peterson VL, McCool BA, Hamilton DA.. Brain Res. 2015;1594():125-135.

Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR.. Synapse. 2015;69(8):385-395.

Microstructural analysis of rat ethanol and water drinking patterns using a modified operant self-administration model. Robinson SL, McCool BA.. Physiol Behav. 2015;149():119-130.

Ethanol gated disruption of glutamatergic vesicle pool dynamics in Dba/2j and C57bl/6j mice [abstract]. Gioia D, McCool B.. Alcohol Clin Exp Res. 2015;39(Suppl 1):115A.

Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long-Evans rats. Morales M, McGinnis MM, McCool BA.. Pharmacol Biochem Behav. 2015;139(Pt A):67-76.

Withdrawal from intermittent ethanol exposure modulates glutamatergic synaptic function in the rat lateral/basolateral amygdala: a time-course study [abstract]. Morales M, Robinson SL, McCool BA.. Alcohol Clin Exp Res. 2015;39(Suppl 1):115A.

Increased excitability of Bla pyramidal cells may contribute to the phenotype associated with a rodent model of alcohol addiction vulnerability [abstract]. Rau AR, Ariwodola OJ, Butler TR, McCool BA, Weiner JL.. Alcohol Clin Exp Res. 2015;39(Suppl 1):297A.

Effects of ethanol dependence on subsequent voluntary home cage intake in adult male and female long-evans rats [abstract]. Morales M, McGinnis MM, McCool BA.. Alcohol Clin Exp Res. 2015;39(Suppl 1):109A.

Lateral/basolateral amygdala serotonin type-2 receptors modulate operant self-administration of a sweetened ethanol solution via inhibition of principal neuron activity. McCool BA, Christian DT, Fetzer JA, Chappell AM.. Front Integr Neurosci. 2014;8():5.

Persistent enhancement of ethanol drinking following a monosodium glutamate-substitution procedure in C57BL6/J and DBA/2J mice. McCool BA, Chappell AM.. Alcohol. 2014;48(1):55-61.

Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J.. Alcohol. 2014;48(2):161.

Differences in presynaptic calciumsensitivty underlie differential glutamatergic function in the basolateral amygdala of DBA/2J and C57BL/6J mice [abstract]. Gioia DA, McCool BA.. Alcohol Clin Exp Res. 2014;38(Suppl 1):89A.

Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Karkhanis AN, McCool BA, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Selective modulation of the rat basolateral amydgala endocannabinoid system by chronic ethanol exposure [abstract]. Robinson SL, McCool BA.. Alcohol Clin Exp Res. 2014;38(Suppl 1):92A.

Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2014;38(11):2770-2779.

Thalamic glutamatergic afferents into the rat basolateral amygdala exhibit increased presynaptic glutamate function following withdrawal from chronic intermittent ethanol. Christian DT, Alexander NJ, Diaz MR, McCool BA.. Neuropharmacology. 2013;65():134-142.

Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Chappell AM, Carter E, McCool BA, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 1):E394-E403.

Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration. Abrahao KP, Ariwodola OJ, Butler TR, Rau AR, Skelly MJ, Carter E, Alexander NP, McCool BA, Souza-Formigoni ML, Weiner JL.. J Neurosci. 2013;33(11):4834-4842.

Behavioral sensitization to ethanol has bidirectional effects on MGLUR1/5 dependent long-term depression in the nucleus accumbens core and shell [abstract]. Abrahao KP, Souza-Formigoni MLO, McCool BA, Camirini R, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 2):120A.

Differential glutamatergic transmission in the basolateral amygdala of C57Bl/6J and Dba/2J mice [abstract]. Gioia DA, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

SR141716 modulation of ethanol-directed appetitive and consummatory behaviors in a rat model of ethanol physical dependence [abstract]. Robinson SL, Chappell AM, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):176A.

Modest intermittent ethanol exposure modulates anxiety-like behaviors and rat lateral/basolateral amygdala glutamatergic synaptic function [abstract]. Robinson SL, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

Adolescent social isolation increases behavioral and neurobiological risk factors of alcoholism in male Long Evans rats [abstract]. Weiner JL, Chappell AM, Carter E, Yorgason J, Jones SR, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):299A.

Using monosodium glutamate to initiate ethanol self-administration in inbred mouse strains. McCool BA, Chappell AM.. Addict Biol. 2012;17(1):121-131.

Chronic intermittent ethanol and withdrawal differentially modulate basolateral amygdala AMPA-type glutamate receptor function and trafficking. Christian DT, Alexander NJ, Diaz MR, Robinson S, McCool BA.. Neuropharmacology. 2012;62(7):2430-2439.

Simultaneous analysis of appetitive and consumatory self-administration behaviors in rats following physical depencence [sic] to ethanol [abstract]. Robinson SL, Chappell AM, McCool BA.. Alcohol Clin Exp Res. 2012;36(Suppl 1):110A.

Juvenile social isolation in rats increases behavioral and neurobiological risk factors of alcoholism [abstract]. Chappell AM, Carter E, Yorgason JT, Jones SR, McCool BA, Weiner JL.. Alcohol Clin Exp Res. 2012;36(Suppl 2):51A.

Ethanol-induced regulation of iGluR and GABAA subunit mRNAs in prefrontal fields of cynomolgus monkey [abstract]. Hemby SE, McCool B, Friedman DP, Helms CM.. Alcohol Clin Exp Res. 2012;36(Suppl 2):39A.

Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses. Diaz MR, Christian DT, Anderson NJ, McCool BA.. J Pharmacol Exp Ther. 2011;337(1):162-170.

Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala. Diaz MR, Chappell AM, Christian DT, Anderson NJ, McCool BA.. Neuropsychopharmacology. 2011;36(5):1090-1103.

Chronic ethanol-induced DIR-mediated potentiation of local, but not LPC GABAergic transmission in the basolateral amygdala [abstract]. Diaz MR, McCool BA.. Alcohol. 2011;45(3):297.

Ethanol modulation of synaptic plasticity. McCool BA.. Neuropharmacology. 2011;61(7):1097-1108.

Input specific alterations of lateral/basolateral amygdala glutamate synaptic transmission following chronic intermittent ethanol and withdrawal [abstract]. Christian DT, Diaz MR, Anderson N, McCool BA.. Alcohol Clin Exp Res. 2011;35(6 Suppl):59A.

A monosodium glutamate-fade increases voluntary ethanol consumption in the ethanol 'non-preferring' DBA/2J mouse line [abstract]. McCool BA, Chappell AM.. Alcohol Clin Exp Res. 2010;34(Suppl 2):84A.

Effects of chronic ethanol and withdrawal on feedforward and feedback GABAergic inhibition in the basolateral amygdala [abstract]. Diaz MR, Christian DT, Anderson NJ, McCool Ba.. Alcohol Clin Exp Res. 2010;34(Suppl 2):198A.

Afferent-specific alteraitons [sic] of amygdala presynaptic glutamatergic function by chronic ethanol and withdrawal [abstract]. Christian DT, Diaz MR, McCool BA.. Alcohol Clin Exp Res. 2010;34(Suppl 2):140A.

Glutamate plasticity in the drunken amygdala: the making of an anxious synapse. McCool BA, Christian DT, Diaz MR, Lack AK.. Int Rev Neurobiol. 2010;91():205-233.

Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration. McCool BA, Chappell AM.. Alcohol Clin Exp Res. 2009;33(2):273-282.

Chronic ethanol and withdrawal effects on kainate receptor-mediated excitatory neurotransmission in the rat basolateral amygdala. Lack AK, Christian DT, Diaz MR, McCool BA.. Alcohol. 2009;43(1):25-33.

Characterization of glutamatergic signaling at two afferent pathways into the basolateral amygdala: effect of chronic ethanol and withdrawal [abstract]. Christian DT, McCool BA.. Alcohol Clin Exp Res. 2009;33(6 Special Issue):208A.

Pre- and post-synaptic effects of chronic ethanol and withdrawal on feedforward and feedback gabaergic interneurons in the basolateral amygdala [abstract]. Diaz MR, Anderson NJ, McCool BA.. Alcohol Clin Exp Res. 2009;33(6 Special Issue):210A.

Using monosodium glutamate to initiate voluntary ethanol consumption in 'non-preferring' inbred mouse lines [abstract]. McCool BA, Chappell AE [sic] [Chappell AM].. Alcohol Clin Exp Res. 2009;33(6 Special Issue):92A.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Physiology & Pharmacology

Clinical Interests

Substance Abuse, Anxiety
Brian A. McCool, Ph.D.

Brian A. McCool, Ph.D.

Professor, Physiology & Pharmacology

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