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Profile

Profile
Research

John G. McHaffie, Ph.D.

Professor, Neurobiology & Anatomy

Contact Information

Academic: 336-716-9078 | Department: 336-716-9078

Email: mchaffie@wakehealth.edu

Education & Training

Ph.D., Virginia Commonwealth University , 1984
B.S., Old Dominion University , 1976
Fellowship, Medical College of Virginia, 1986

John G. McHaffie, Ph.D.

Professor, Neurobiology & Anatomy

Contact Information

Academic: 336-716-9078 | Department: 336-716-9078

Email: mchaffie@wakehealth.edu

Recent Publications

McHaffie JG, Fuentes-Santamaria V, Alvarado JC, Fuentes Farias AL, Gutierrez-Ospina G, Stein BE. Anatomical features of the intrinsic circuitry underlying multisensory integration in the superior colliculus In: Stein BE, ed. The new handbook of multisensory processing. Cambridge (MA): MIT Press;2012: 31-47.

Zeidan F, Grant JA, Brown CA, McHaffie JG, Coghill RC. Mindfulness meditation-related pain relief: evidence for unique brain mechanisms in the regulation of pain. Neurosci Lett. 2012;520(2):165-173.

McHaffie JG, Jiang H, Stein BE, Willner W. Amelioration of visual orientation deficits in visual cortex lesioned cats by cross-modal behavioral training [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Jiang H, Stein BE, McHaffie JG. Anterior ectosylvian cortex lesions in the cat disrupt auditory, but not visual, orientation behaviors [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Zeidan F, Martucci KT, Kraft RA, Gordon NS, McHaffie JG, Coghill RC. Brain mechanisms supporting the modulation of pain by mindfulness meditation. J Neurosci. 2011;31(14):5540-5548.

Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, McHaffie JG, Coghill RC. The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain lesions. Brain. 2011;134(Pt 7):1987-2004.

Jiang H, Stein BE, McHaffie JG. Physiological evidence for a trans-basal ganglia pathway linking extrastriate visual cortex and the superior colliculus. J Physiol. 2011;589(Pt 23):5785-5799.

Jiang H, Stein BE, McHaffie JG. Unilateral visual cortex lesions produce an anomalous visual representation of central visual space in the deep layers of the cat superior colliculus [abstract]. Soc Neurosci Abstr. 2011;2011(Neuroscience Meeting Planner):.

Flores-Cano MS, Fuentes-Farias A, McHaffie J, Stein B, Gutierrez-Ospina G. Pyramidal neuron development in anterior ectosylvian sulcus parallels the maturation of multisensory integration in their target superior colliculus [abstract]. Soc Neurosci Abstr. 2011;2011(Neuroscience Meeting Planner):.

Zeidan F, McHaffie J, Kraft R, Martucci K, Coghill R. Brain mechanisms associated with meditation-induced regulation of anxiety [abstract]. In: Human Brain Mapping 17th Annual Meeting Abstracts; 2011 June 26-30; Quebec City (Canada). 2011;():391.

Redgrave P, Coizet V, Comoli E, McHaffie JG, Leriche M, Vautrelle N, Hayes LM, Overton P. Interactions between the midbrain superior colliculus and the basal ganglia. Front Neuroanat. 2010;4():art.132.

Zeidan F, Martucci KT, Kraft RA, McHaffie JG, Gordon NS, Coghill RC. Brain mechanisms associated with meditation related pain relief [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Jiang H, Stein BE, McHaffie JG. A physiological basis for the Sprague Effect? [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

McHaffie JG, Stein BE, Jiang H. Repetitive orienting movements to combined cross-modal cues ameliorate visuomotor deficits in visual cortex lesioned cats [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Zeidan F, Martucci KT, Kraft RA, McHaffie JG, Gordon NS, Coghill RC. Activation of pain modulatory brain regions following brief meditation training [abstract]. In: Abstracts of the 13th World Congress on Pain; 2010 Aug 29 - Sept 2; Montreal, Quebec (Canada). 2010;():abstr 441.

May PJ, McHaffie JG, Stanford TR, Jiang H, Costello MG, Coizet V, Hayes LM, Haber SN, Redgrave P. Tectonigral projections in the primate: a pathway for pre-attentive sensory input to midbrain dopaminergic neurons. Eur J Neurosci. 2009;29(3):575-587.

Coizet V, Graham JH, Moss J, Bolam JP, Savasta M, McHaffie JG, Redgrave P, Overton PG. Short-latency visual input to the subthalamic nucleus is provided by the midbrain superior colliculus. J Neurosci. 2009;29(17):5701-5709.

Jiang H, Stein BE, McHaffie JG. Cortical lesion-induced visual hemineglect is prevented by NMDA antagonist pretreatment. J Neurosci. 2009;29(21):6917-6925.

Hudgins ED, McHaffie JG, Redgrave P, Salinas E, Stanford TR. Putative midbrain dopamine neurons encode sensory salience and reward prediction at different latencies [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

McHaffie JG, Stein BE, Jiang H. Cross-modal rehabilitative training with auditory-visual cues ameliorates visual hemineglect in visual cortex lesioned cats [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Jiang H, Stein BE, McHaffie JG. Neural correlates of cross-modal rehabilitative training in the deep superior colliculus of visual cortex lesioned cats [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Fuentes-Santamaria V, Alvarado JC, McHaffie JG, Stein BE. Axon morphologies and convergence patterns of projections from different sensory-specific cortices of the anterior ectosylvian sulcus onto multisensory neurons in the cat superior colliculus. Cereb Cortex. 2009;19(12):2902-2915.

McHaffie JG. Cross-modal rehabilitative training ameliorates visuomotor deficits produced by visual cortex lesions [abstract]. In: Abstracts of the 10th International Multisensory Research Forum; 2009 June 29 - July 2; New York (NY). 2009;():.

Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting discrimination of sensory features of pain: a new model. J Neurosci. 2009;29(47):14924-1431.

Fuentes-Santamaria V, Alvarado Romero JC, McHaffie JG, Stein BE. Anatomical and physiological evidence for driver and modulator inputs in the anterior ectosylvian sulcus-superior colliculus pathway [abstract]. Histol Histopathol. 2009;24(Suppl 1 Pt 59):S31.

Fuentes-Santamaria V, Alvarado JC, Stein BE, McHaffie JG. Cortex contacts both output neurons and nitrergic interneurons in the superior colliculus: direct and indirect routes for multisensory integration. Cereb Cortex. 2008;18(7):1640-1652.

Fuentes-Santamaria V, McHaffie JG, Stein BE. Maturation of multisensory integration in the superior colliculus: expression of nitric oxide synthase and neurofilament SMI-32. Brain Res. 2008;1242():45-53.

McHaffie JG, Stein BE, Jiang H. Cross-modal rehabiliative training ameliorates visumotor deficits in visual cortex lesioned cats [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Fuentes-Santamaria V, McHaffie JG, Stein BE. Anterior ectosylvian subregions send converging inputs with multiple morphologies to multisensory superior colliculus neurons [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Jiang H, Stein BE, McHaffie JG. Cross-modal rehabiliative training reinstates lost visual responsiveness to deep superior colliculus (SC) neurons [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Hadsel MS, Quevedo A, Oshiro Y, Houle TT, McHaffie JG, Kraft RA, Coghill RC. Precuneus/posterior cingulate cortex activity in experimental pain--a functional magnetic resonance imaging (FMRI) study [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008;():PF 139.

Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting spatial discrimination of pain. J Neurosci. 2007;27(13):3388-3394.

Fathke R Jr, McHaffie J, Henkel C, Gabriele M. Patterns of convergence for multiple afferent projections to the central nucleus of the inferior colliculus prior to the onset of hearing [abstract]. Assoc Res Otolaryngol Abstr. 2007;30():285.

Gabriele ML, Shahmoradian SH, French CC, Henkel CK, McHaffie JG. Early segregation of layered projections from the lateral superior olivary nucleus to the central nucleus of the inferior colliculus in the neonatal cat. Brain Res. 2007;1173():66-77.

Jiang H, Stein BE, McHaffie JG. Deactivation of crossed nigrotectal neurons reinstates visual responsiveness in deep laminae superior colliculus (SC) neurons following large visual cortex lesions [abstract]. Soc Neurosci Abstr. 2007;2007(Abstr Viewer):.

Fuentes-Santamaria V, McHaffie JG, Stein BE. Development of the cortico-collicular circuitry underlying multisensory integration involves nitric oxide containing interneurons [abstract]. Soc Neurosci Abstr. 2007;2007(Abstr Viewer):.

Coizet V, McHaffie J, May P, Stanford T, Jiang H, Costello Grinberg M, Graham J, Overton P, Redgrave P. The tecto-subthalamic projection: a source of short-latency visual input to the subthalamic nucleus [abstract]. Parkinsonism Relat Disord. 2007;13(Suppl 2):S41.

Gabriele ML, Fathke RL, Shahmoradian SH, French CC, Henkel CK, McHaffie JG. Segregation of multiple layered projections to the central nucleus of the inferior colliculus in the neonatal cat [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

McHaffie JG, Jiang H, Stanford TR, Costello MG, Redgrave P, Coizet V, May PJ. The subthalamic nucleus receives afferents from the superior colliculus in cats and macaque monkeys [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

May PJ, McHaffie JG, Jiang H, Stanford TR, Costello MG, Haber SN, Coizet V, Redgrave P. Projections from the superior colliculus to substantai nigra pars compacta in a primate [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Fuentes-Santamaria V, McHaffie JG, Stein BE. Postnatal maturation of converging visual and auditory cortico-collicular inputs onto multisensory superior colliculus neurons [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Jiang H, Stein BE, McHaffie JG. NMDA antagonist pretreatment prevents visual orientation deficits induced by visual cortex lesions and facilitates postlesion acquisition of pattern discrimination [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

McHaffie JG, Jiang H, Stein BE. Superior colliculus mediated visuomotor function depends on coupling global inhibition and focal disinhibition In: Bezard E, ed. Recent breakthroughs in basal ganglia research. New York: Nova Science Publishers;2006: 173-184.

Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting intensity discrimination and memory of pain [abstract]. Neuroimage. 2006;31(Suppl 1):S179.