Linda C. McPhail, Ph.D., Professor Biochemistry - Wake Forest School of Medicine

Linda C. McPhail, Ph.D.

Professor, Biochemistry
Translational Science Institute
Comprehensive Cancer Center
Women's Health Center of Excellence for Research, Leadership, Education
Infectious Diseases
Translational Science Institute

Contact Information

Department: 336-716-2621

Email: lmcphail@wakehealth.edu

Education & Training

Ph.D., Wake Forest University , 1976
B.S., Methodist College , 1970
M.S., Wake Forest University , 1973
Fellowship, Natl Jewish Hosp/Res Ctr, 1980

Memberships

Am Assn for the Adv of Science
Soc for Leukocyte Biology
Am Soc Biochem Molecular Bio
Am Soc for Cell Biology

Linda C. McPhail, Ph.D.

Professor, Biochemistry Translational Science Institute
Comprehensive Cancer Center
Women's Health Center of Excellence for Research, Leadership, Education
Infectious Diseases
Translational Science Institute

Contact Information

Department: 336-716-2621

Email: lmcphail@wakehealth.edu

Recent Publications

Naik S, D'Agostino R Jr, Knovich MA, Grier D, Harrelson R, McPhail L. Impact of iron overload on immune function for patients undergoing allogeneic transplants for hematologic disorders: results of pilot study [abstract]. Biol Blood Marrow Transplant. 2013;19(2 Suppl 2):S300-S301.

Mishra M, Byrd MS, Sergeant S, Azad AK, Parsek MR, McPhail L, Schlesinger LS, Wozniak DJ. Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization. Cell Microbiol. 2012;14(1):95-106.

Davis NY, McPhail LC, Horita DA. The NOXO1beta PX domain preferentially targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3. J Mol Biol. 2012;417(5):440-453.

Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol. 2012;92(3):499-507.

Solomon SB, Bellavia L, Sweeney D, Piknova B, Perlegas A, Helms CC, Ferreyra GA, Bruce King S, Raat NJ, Kern SJ, Sun J, McPhail LC, Schechter AN, Natanson C, Gladwin MT, Kim-Shapiro DB. Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin.. Free Radic Biol Med. 2012;53(12):2229-2239.

Davis NY, McPhail LC, Horita DA. Backbone 1H, 15N, and 13C resonance assignments for the NOXO1 beta PX domain. Biomol NMR Assign. 2011;5(2):139-141.

Lewis EM, Sergeant S, Ledford B, Stull N, Dinauer MC, McPhail LC. Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding. J Biol Chem. 2010;285(5):2959-2967.

McPhail LC. Effect of splice-site mutations in X-linked chronic granulomatous disease [reply to letter]. Clin Immunol. 2009;130(2):234.

Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ. Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic. 2008;9(2):215-229.

Lewis EM, Singla M, Sergeant S, Koty PP, McPhail LC. X-linked chronic granulomatous disease secondary to skewed X chromosome inactivation in a female with a novel CYBB mutation and late presentation. Clin Immunol. 2008;129(2):372-380.

Shen K, Sergeant S, Hantgan RR, McPhail LC, Horita DA. Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation. Biochemistry. 2008;47(34):8855-8865.

Lehman N, Ledford B, Di Fulvio M, Frondorf K, McPhail LC, Gomez-Cambronero J. Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR. FASEB J. 2007;21(4):1075-1087.

Taylor RM, Lord CI, Riesselman MH, Gripentrog JM, Leto TL, McPhail LC, Berdichevsky Y, Pick E, Jesaitis AJ. Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b. Biochemistry. 2007;46(49):14291-304.

Sergeant S, McPhail LC. Measurement of phospholipid metabolism in intact neutrophils. Methods Mol Biol. 2007;412():69-83.