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Giselle C. Melendez ZapataWake Forest School of Medicine

Giselle C. Melendez Zapata

Assistant Professor,

Cardiovascular Sciences Ctr

Clinical Interests

Cardiac Disease, Cardiovascular Disease Preventions and Genetics

Contact Information

Academic: 336-713-7086 | Department: 336-716-6674

Additional Languages


Education & Training

  • B.A., Venezuela, 1995
  • M.D., Central Univ Faculty of Medicine-Venezuela, 2003
  • Fellowship, Cell Biology, University of South Carolina M, 2011


  • American College of Cardiology
  • Am Heart Association
  • Am Physiological Society
Giselle C. Melendez Zapata

Giselle C. Melendez Zapata

Assistant Professor, Cardiology
Comprehensive Cancer Center
Center for Comparative Medicine Research
Office of Women in Medicine and Science
Cardiovascular Sciences Ctr
Pathology-Comparative Medicine

Contact Information

Academic: 336-713-7086 | Department: 336-716-6674

Recent Publications

Frequency of transition from stage A to B or C heart failure after potentially cardiotoxic chemotherapy [abstract]. Jones D, Suerken C, D'Agostino R, Melendez G, Jordan J, Hundley W.. J Am Coll Cardiol. 2017;69(11 Suppl):924.

Decreases in left ventricular mass and not left ventricular ejection fraction are associated with heart failure symptoms in cancer patients six months after potentially cardiotoxic chemotherapy [abstract]. Jordan JH, Melendez G, Suerken C, D'Agostino R, Hundley W.. J Am Coll Cardiol. 2017;69(11 Suppl):1410.

Frequency of left ventricular end-diastolic volume-mediated declines in ejection fraction in patients receiving potentially cardiotoxic cancer treatment. Melendez GC, Sukpraphrute B, D'Agostino RB Jr, Jordan JH, Klepin HD, Ellis L, Lamar Z, Vasu S, Lesser G, Burke GL, Weaver KE, Ntim WO, Hundley WG.. Am J Cardiol. 2017;119(10):1637-1642.

Progressive 3-month increase in LV myocardial ECV after anthracycline-based chemotherapy [letter]. Melendez GC, Jordan JH, D'Agostino RB Jr, Vasu S, Hamilton CA, Hundley WG.. JACC Cardiovasc Imaging. 2017;10(6):708-709.

Early myocardial strain changes during potentially cardiotoxic chemotherapy may occur as a result of reductions in left ventricular end-diastolic volume: the need to interpret left ventricular strain with volumes [research letter]. Jordan JH, Sukpraphrute B, Melendez GC, Jolly MP, D'Agostino RB Jr, Hundley WG.. Circulation. 2017;135(25):2575-2577.

Automated assessments of circumferential strain from cine CMR correlate with LVEF declines in cancer patients early after receipt of cardio-toxic chemotherapy. Jolly MP, Jordan JH, Melendez GC, McNeal GR, D'Agostino RB Jr, Hundley WG.. J Cardiovasc Magn Reson. 2017;19(1):59.

Targeting substance P and relaxin [letter]. Levick SP, Melendez GC.. Int J Cardiol. 2016;204():154-155.

Anthracycline-associated T1 mapping characteristics are elevated independent of the presence of cardiovascular comorbidities in cancer survivors. Jordan JH, Vasu S, Morgan TM, D'Agostino RB Jr, Melendez GC, Hamilton CA, Arai AE, Liu S, Liu CY, Lima JA, Bluemke DA, Burke GL, Hundley WG.. Circ Cardiovasc Imaging. 2016;9(8):e004325.

Is myocardial fibrosis a new frontier for discovery in cardiotoxicity related to the administration of anthracyclines? [editorial]. Melendez GC, Hundley WG.. Circ Cardiovasc Imaging. 2016;9(12):e005797.

Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Melendez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR.. Menopause. 2015;22(3):289-296.

Non-human primate and rat cardiac fibroblasts show similar extracellular matrix-related and cellular adhesion gene responses to substance P. Melendez GC, Manteufel EJ, Dehlin HM, Register TC, Levick SP.. Heart Lung Circ. 2015;24(4):395-403.

Myocardial extracellular volume is elevated in cancer survivors treated with anthracycline-based chemotherapy compared to cancer-free peers and newly diagnosed and untreated cancer patients: a single-center observational study of the. Jordan JH, Vasu S, Morgan T, D'Agostino R, Melendez GC, Hall M, Hamilton C, Arai A, Liu S, Liu C-Y, Lima J, Bluemke D, Hundley W.. J Am Coll Cardiol. 2015;65(10 Suppl):A1081.

Relation of pre-anthracycline serum bilirubin levels to left ventricular ejection fraction after chemotherapy. Vera T, D'Agostino RB Jr, Jordan JH, Whitlock MC, Melendez GC, Lamar ZS, Porosnicu M, Bonkovsky HL, Poole LB, Hundley WG.. Am J Cardiol. 2015;116(11):1752-1755.

Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and future. Clarkson TB, Melendez GC, Appt SE.. Menopause. 2013;20(3):342-353.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Cardiology

Clinical Interests

Cardiac Disease, Cardiovascular Disease Preventions and Genetics

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