Linda J. Metheny-Barlow, Ph.D.Wake Forest School of Medicine

Linda J. Metheny-Barlow, Ph.D.

Associate Professor,

Contact Information

Academic: 336-713-7636 | Department: 336-713-3600


Education & Training

  • B.S., Wheeling Jesuit College, 1991
  • M.S., University of Rochester, 1994
  • Ph.D., University of Rochester, 1996
  • Fellowship, Natl Cancer Institute (NIH), 1999
  • Fellowship, Georgetown University, 2004


  • Am Assn Of Cancer Research
  • Radiation Research Society
Linda J. Metheny-Barlow, Ph.D.

Linda J. Metheny-Barlow, Ph.D.

Associate Professor, Radiation Oncology
Cancer Biology

Research Interests

cancer/oncogenesis, cognition/learning, molecular biology/molecular me, women's health issues

Contact Information

Academic: 336-713-7636 | Department: 336-713-3600


Recent Publications

Devoid HM, McTyre ER, Page BR, Metheny-Barlow L, Ruiz J, Chan MD. Recent advances in radiosurgical management of brain metastases. Front Biosci (Schol Ed). 2016;8():203-214.

Sirkisoon SR, Carpenter RL, Rimkus T, Miller L, Metheny-Barlow L, Lo HW. EGFR and HER2 signaling in breast cancer brain metastasis. Front Biosci (Elite Ed). 2016;8():245-263.

Naczki C, Chen WH, Choudhary M, Metheny-Barlow L. Connexin 43 deficiency decreases tumor vessel stability and augments angiogenesis and metastasis [abstract]. Clin Exp Metastasis. 2015;32(3):223-224.

Choudhary M, Naczki C, Chen W, Barlow KD, Case LD, Metheny-Barlow LJ. Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. BMC Cancer. 2015;15():427.

Deng G, Metheny-Barlow L, Gallagher PE, Tallant EA. Angiotensin-(1-7) targets c-Met signaling by up-regulating the phosphatase PTP1b to reduce triple negative breast cancer [abstract]. Cancer Res. 2015;75(15 Suppl):4981.

Kooshki M, Naczki C, Robbins ME [deceased], Metheny-Barlow LJ. Radiation-induced downregulation of GLT-1 glutamate transporter mRNA expression is reversed by renin-angiotensin system inhibitors [abstract]. Cancer Res. 2015;75(15 Suppl):1792.

Moore ED, Kooshki M, Wheeler KT, Metheny-Barlow LJ, Robbins ME [deceased]. Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiat Res. 2014;181(1):21-32.

Greene-Schloesser DM, Kooshki M, Payne V, D'Agostino RB Jr, Wheeler KT, Metheny-Barlow LJ, Robbins ME [deceased]. Cellular response of the rat brain to single doses of (137)Cs gamma rays does not predict its response to prolonged 'biologically equivalent' fractionated doses. Int J Radiat Biol. 2014;90(9):790-798.

Wheeler KT, Payne V, D'Agostino RB Jr, Walb MC, Munley MT, Metheny-Barlow LJ, Robbins ME [deceased]. Impact of breathing 100% oxygen on radiation-induced cognitive impairment. Radiat Res. 2014;182(5):580-585.

Barlow KD, Sanders AM, Soker S, Ergun S, Metheny-Barlow LJ. Pericytes on the tumor vasculature: Jekyll or Hyde?. Cancer Microenviron. 2013;6(1):1-17.

Vincent A, Lesser G, Brown D, Vern-Gross T, Metheny-Barlow L, Lawrence J, Chan M. Prolonged regression of metastatic leptomeningeal breast cancer that has failed conventional therapy: a case report and review of the literature. J Breast Cancer. 2013;16(1):122-126.

Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME [deceased]. Angiotensin-(1-7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Free Radic Biol Med. 2013;65():1060-1068.

Chen W, McMahan CN, Barlow KD, Juarez D, Metheny-Barlow LJ. Identification of p75NTR/TrkB-BDNF axis in breast cancer brain metastasis [abstract]. Cancer Res. 2013;73(3 Suppl):A64.

Buchanan CF, Szot CS, Wilson TD, Akman S, Metheny-Barlow LJ, Robertson JL, Freeman JW, Rylander MN. Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro. J Cell Biochem. 2012;113(4):1142-1151.

Arter AA, Metheny-Barlow L, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits proliferative and fibrotic signaling mechanisms in triple negative breast cancer [abstract]. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 5224.

Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL [deceased], Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. J Neurooncol. 2012;110(3):381-388.

Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cancer Res. 2010;70(21):8319-8328.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Radiation Oncology

Linda J. Metheny-Barlow, Ph.D.

Linda J. Metheny-Barlow, Ph.D.

Associate Professor, Radiation Oncology
Cancer Biology

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