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Linda J. Metheny-Barlow, Ph.D.Wake Forest School of Medicine

Linda J. Metheny-Barlow, Ph.D.

Associate Professor,

Contact Information

Academic: 336-713-7636 | Department: 336-713-3600


Education & Training

  • B.S., Wheeling Jesuit College, 1991
  • M.S., University of Rochester, 1994
  • Ph.D., University of Rochester, 1996
  • Fellowship, Natl Cancer Institute (NIH), 1999
  • Fellowship, Georgetown University, 2004


  • Am Assn Of Cancer Research
  • Radiation Research Society
Linda J. Metheny-Barlow, Ph.D.

Linda J. Metheny-Barlow, Ph.D.

Associate Professor, Radiation Oncology
Cancer Biology

Research Interests

Endothelium, Vascular; Breast Neoplasms; Angiopoietin-1; Myocytes, Smooth Muscle; Gap Junctions
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Contact Information

Academic: 336-713-7636 | Department: 336-713-3600


Recent Publications

Cerebrovascular remodeling and neuroinflammation is a late effect of radiation-induced brain injury in non-human primates. Andrews RN, Metheny-Barlow LJ, Peiffer AM, Hanbury DB, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM.. Radiat Res. 2017;187(5):599-611.

Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR.. J Clin Neurosci. 2017;43():6-10.

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW.. Oncotarget. 2017;8(43):73947-63.

Determination of tumor gene expression in non-small cell lung cancer patients who develop brain metastasis diagnosis: analysis of a prospective trial [abstract]. Dohm AE, Su J, McTyre E, Soike M, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow L, Watabe K, Chan MD, Ruiz J, Pasche B.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E453.

Hippocampal dose volume histogram predicts Hopkins Verbal Learning Test scores after brain irradiation. Okoukoni C, McTyre ER, Ayala Peacock DN, Peiffer AM, Strowd R, Cramer C, Hinson WH, Rapp S, Metheny-Barlow L, Shaw EG, Chan MD.. Adv Radiat Oncol. 2017;2(4):624-629.

Recent advances in radiosurgical management of brain metastases. Devoid HM, McTyre ER, Page BR, Metheny-Barlow L, Ruiz J, Chan MD.. Front Biosci (Schol Ed). 2016;8():203-214.

EGFR and HER2 signaling in breast cancer brain metastasis. Sirkisoon SR, Carpenter RL, Rimkus T, Miller L, Metheny-Barlow L, Lo HW.. Front Biosci (Elite Ed). 2016;8():245-263.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

Toxicity results of a phase 1 safety study of pioglitazone as a cytoprotective agent against radiation-induced cognitive decline [abstract]. Sullivan NA, Page BR, Peiffer AM, Isom S, Metheny-Barlow L, Brown DR, Blackstock AW, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E595.

Connexin 43 deficiency decreases tumor vessel stability and augments angiogenesis and metastasis [abstract]. Naczki C, Chen WH, Choudhary M, Metheny-Barlow L.. Clin Exp Metastasis. 2015;32(3):223-224.

Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. Choudhary M, Naczki C, Chen W, Barlow KD, Case LD, Metheny-Barlow LJ.. BMC Cancer. 2015;15():427.

Angiotensin-(1-7) targets c-Met signaling by up-regulating the phosphatase PTP1b to reduce triple negative breast cancer [abstract]. Deng G, Metheny-Barlow L, Gallagher PE, Tallant EA.. Cancer Res. 2015;75(15 Suppl):4981.

Radiation-induced downregulation of GLT-1 glutamate transporter mRNA expression is reversed by renin-angiotensin system inhibitors [abstract]. Kooshki M, Naczki C, Robbins ME [deceased], Metheny-Barlow LJ.. Cancer Res. 2015;75(15 Suppl):1792.

Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Moore ED, Kooshki M, Wheeler KT, Metheny-Barlow LJ, Robbins ME [deceased].. Radiat Res. 2014;181(1):21-32.

Cellular response of the rat brain to single doses of (137)Cs gamma rays does not predict its response to prolonged 'biologically equivalent' fractionated doses. Greene-Schloesser DM, Kooshki M, Payne V, D'Agostino RB Jr, Wheeler KT, Metheny-Barlow LJ, Robbins ME [deceased].. Int J Radiat Biol. 2014;90(9):790-798.

Impact of breathing 100% oxygen on radiation-induced cognitive impairment. Wheeler KT, Payne V, D'Agostino RB Jr, Walb MC, Munley MT, Metheny-Barlow LJ, Robbins ME [deceased].. Radiat Res. 2014;182(5):580-585.

Pericytes on the tumor vasculature: Jekyll or Hyde?. Barlow KD, Sanders AM, Soker S, Ergun S, Metheny-Barlow LJ.. Cancer Microenviron. 2013;6(1):1-17.

Prolonged regression of metastatic leptomeningeal breast cancer that has failed conventional therapy: a case report and review of the literature. Vincent A, Lesser G, Brown D, Vern-Gross T, Metheny-Barlow L, Lawrence J, Chan M.. J Breast Cancer. 2013;16(1):122-126.

Angiotensin-(1-7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME [deceased].. Free Radic Biol Med. 2013;65():1060-1068.

Identification of p75NTR/TrkB-BDNF axis in breast cancer brain metastasis [abstract]. Chen W, McMahan CN, Barlow KD, Juarez D, Metheny-Barlow LJ.. Cancer Res. 2013;73(3 Suppl):A64.

Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro. Buchanan CF, Szot CS, Wilson TD, Akman S, Metheny-Barlow LJ, Robertson JL, Freeman JW, Rylander MN.. J Cell Biochem. 2012;113(4):1142-1151.

Angiotensin-(1-7) inhibits proliferative and fibrotic signaling mechanisms in triple negative breast cancer [abstract]. Arter AA, Metheny-Barlow L, Gallagher PE, Tallant EA.. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 5224.

Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL [deceased], Tatter SB, Shaw EG, Urbanic JJ, Chan MD.. J Neurooncol. 2012;110(3):381-388.

Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE.. Cancer Res. 2010;70(21):8319-8328.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Radiation Oncology

Linda J. Metheny-Barlow, Ph.D.

Linda J. Metheny-Barlow, Ph.D.

Associate Professor, Radiation Oncology
Cancer Biology

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