Research Interests
cross(mult/tnslat/inter)discip
,
genetics/genome
,
genomics and proteomics
,
hormones/cytokines/signalling
,
immunology/allergy/inflammatio
,
molecular biology/molecular me
,
nursing research
Recent Publications
Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA.
The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients [letter]. J Allergy Clin Immunol.
2012;
129(2):575-578.
Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP,.
Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med.
2012;
185(4):356-362.
Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, et al.
Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. Am J Respir Crit Care Med.
2011;
183(4):449-454.
Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Bleecker ER, Moore WC, et al.
Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol.
2011;
127(2):382-389.
Liu L, Teague WG, Erzurum S, Fitzpatrick A, Mantri S, Dweik RA, Bleecker ER, Meyers D, Moore W, Peters SP, et al.
Determinants of exhaled breath condensate pH in a large population with asthma. Chest.
2011;
139(2):328-336.
Ortega VE, Hastie A, Sadeghnejad A, Moore W, Hawkins GA, Peters SP, Busse WW, Calhoun WJ, Meyers DA, Bleecker ER, et al.
Rare beta2-adrenergic receptor gene polymorphisms in asthma cases and controls from the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med.
2011;
183(Meeting Abstracts):A1357.
Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Peters SP, Hawkins GA, Bleecker ER, Meyers DA, et al.
Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol.
2011;
127(6):1457-1465.
Comhair SAA, Gaston BM, Ricci KS, Hammel J, Dweik RA, Meyers D, Ampleford EJ, Bleecker ER, Moore W, Peters SP, et al.
Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS ONE.
2011;
6(5):e18574.
Slager RE, Hawkins G, Otulana B, Yen Y, Wenzel SE, Meyers DA, Bleecker ER.
Interleukin 4 receptor polymorphisms predict therapeutic pitrakinra treatment response in moderate to severe asthma [abstract]. Am J Respir Crit Care Med.
2011;
183():A6178.
Slager RE, Li H, Moore W, Hawkins G, Peters SP, Busse WW, Chung K, Erzurum SC, Meyers DA, Bleecker ER, et al.
Predictive model of severe atopic asthma phenotypes using interleukin 4/13 pathway polymorphisms [abstract]. Am J Respir Crit Care Med.
2011;
183():A1332.
Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Li X, Bleecker ER, Meyers DA, et al.
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet.
2011;
43(9):887-892.
Wegmann D, Kessner DE, Veeramah KR, Mathias RA, Nicolae DL, Yanek LR, Sun YV, Torgerson DG, Rafaels N, Meyers DA, et al.
Recombination rates in admixed individuals identified by ancestry-based inference. Nat Genet.
2011;
43(9):847-853.
Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Peters SP, Bleecker ER, et al.
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med.
2010;
181(4):315-323.
Bouzigon E, Forabosco P, Koppelman GH, Cookson WOCM, Dizier M-H, Duffy DL, Evans DM, Ferreira MAR, Kere J, Meyers DA, et al.
Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. Eur J Hum Genet.
2010;
18(6):700-706.
Hawkins GA, Moore WC, Robinson MB, Peters SP, Meyers D, Bleecker ER.
IL6R polymorphisms predict measures of lung function in caucasian asthmatics: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A1298.
Sadeghnejad A, Ohar JA, Bleecker ER, Meyers D.
Replication of an association of the interleukin-1 receptor antagonist gene with asthma in an adult urban admixed population [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A3877.
Slager RE, Pascual RM, Moore WC, Hawkins GA, Peters SP, Meyers D, Bleecker ER.
GATA3 polymorphisms are predictors of steroid use and atopic asthma in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A1301.
Ortega VE, Hawkins GA, Montealegre F, Chardon D, Sadeghnejad A, Moore WC, Peters SP, Meyers D, Bleecker ER.
Rare beta2 adrenergic receptor gene polymorphisms in asthma cases and controls from different ethnic groups [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A1316.
Ortega VE, Liggett SB, Pascual R, Diallo A, Moore WC, Meyers D, Bleecker ER, Hawkins GA.
Epigenetics of the beta2-adrenergic receptor gene [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A1306.
Ortega VE, Hawkins GA, Sadeghnejad A, Moore WC, Meyers D, Bleecker ER.
Characterization of asthma cases and controls with rare ADAM33 gene polymorphisms in a multi-ethnic population [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A1315.
Li X, Howard TD, Ampleford EJ, Peters SP, Bleecker ER, Meyers DA.
Genome-wide association study of asthma severity using proportional odds model identifies TMEM154 [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A3728.
Ohar JA, Howard TD, Ampleford EJ, Bleecker ER, Meyers DA.
Genome wide association study in mesothelioma [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A4340.
Hastie AT, Albon D, Moore WC, Krings J, Smith RV, Meyers DA, Peters SP, Bleecker ER.
Inflammatory protein microarray analysis of sputum from obese subjects with asthma compared with nonobese subjects with asthma [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A6801.
Pascual RM, Moore WC, Peters SP, Li H, Wenzel SE, Meyers DA, Weiss ST, Litonjua AA, Bleecker ER.
Serum vitamin D levels are inversely correlated with FEV1 and FVC in asthma [abstract]. Am J Respir Crit Care Med.
2010;
181(1 Meeting Abstracts):A6800.
Hawkins GA, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER.
Serum levels of soluble IL6R are genetically regulated and correlate with lung function in asthmatics: Severe Asthma Research Program (SARP) [abstract]. J Allergy Clin Immunol.
2010;
125(2 Suppl 1):AB357.
Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Meyers DA, Bleecker ER, et al.
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med.
2010;
363(18):1715-1726.
Slager RE, Hawkins GA, Ampleford EJ, Bowden A, Stevens LE, Morton MT, Tomkinson A, Wenzel SE, Bleecker ER, Meyers DA, et al.
IL-4 receptor alpha polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist [letter]. J Allergy Clin Immunol.
2010;
126(4):875-878.
Slager RE, Hawkins GA, Ampleford EJ, Bowden A, Stevens LE, Morton MT, Tomkinson A, Wenzel SE, Bleecker ER, Meyers DA, et al.
The need for standardization in exercise challenge testing for exercise-induced asthma/bronchoconstriction [letter]. J Allergy Clin Immunol.
2010;
126(4):878-880.
Goldman M, Lawrance RM, Bleecker ER, Meyers DA, Ambrose HJ.
Effect of polymorphisms in the ADRB2 3 ' untranslated region (3 ' UTR) on response to inhaled corticosteroid and long-acting beta(2)-adrenergic agonist (ICS/LABA) combination therapy [abstract]. J Allergy Clin Immunol.
2009;
123(2 Suppl):S137.
Sadeghnejad A, Bleecker E, Meyers DA.
Principles of genetics in allergic diseased and asthma. In: Adkinson NF Jr, Bochner BS, Busse WW, Holgate ST, Lemanske RF Jr, Simons FER, eds. Middleton's allergy: principles & practice. 7th ed.
Philadelphia: Mosby/Elsevier;
2009:
59-72.
Wenzel SE, Barnes PJ, Bleecker ER, Bousquet J, Busse W, Dahlen S-E, Holgate ST, Meyers DA, Rabe KF, Antczak A, et al.
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med.
2009;
179(7):549-558.
Sadeghnejad A, Koppelman GH, Ohar JA, Postma DS, Bleecker ER, Meyers DA.
Role of SERPINE2 in asthma and COPD [abstract]. Am J Respir Crit Care Med.
2009;
179(Online Abstr Issue):A2741.
Ohar JA, Sadeghnejad A, Meyers DA, Bleecker ER.
Symptoms poorly predict the presence of COPD in at-risk smokers [abstract]. Am J Respir Crit Care Med.
2009;
179(Online Abstr Issue):A1471.
Hastie AT, Moore WC, Meyers DA, Vestal PL, Krings JO, Smith RA, Li H, Peters SP, Bleecker ER.
Inflammatory protein analyses of sputum from human subjects with severe or nonsevere asthma [abstract]. Am J Respir Crit Care Med.
2009;
179(Online Abstr Issue):A3925.
Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Bleecker ER, et al.
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med.
2009;
180(10):929-935.
Ortega VE, Hawkins GA, Meyers DA, Bleecker ER.
Characterization of asthma cases and controls with rare beta2 adrenergic receptor gene polymorphisms in a multi-ethnic population [abstract]. Am J Respir Crit Care Med.
2009;
179(1 Meeting Abstracts):A5434.
Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EA, Xu J, Koning H, Bruinenberg M, Bleecker ER, et al.
Identification of protocadherin-1 as a novel susceptibility gene for bronchial hyperresponsiveness and asthma [abstract]. Am J Respir Crit Care Med.
2009;
179(1 Meeting Abstracts):A2447.
Moore WC, Meyers DA, Li H, D'Agostino R, Peters SP, Bleecker ER.
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med.
2009;
179(1 Meeting Abstracts):A2522.
Crowley MB, Moore WC, Smith RV, Meyers DA, Peters SP, Bleeker ER [sic] [Bleecker ER].
The effect of specific air pollutants on FEV1 variability in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med.
2009;
179(1 Meeting Abstracts):A1291.
Moore WC, Meyers DA, Li H, Peters SP, Bleecker ER.
The importance of the 3rd controller medication in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med.
2009;
179(1 Meeting Abstracts):A2806.
Pascual RM, Slager RE, Li H, Hawkins GA, Peters SP, Moore WC, Meyers DA, Bleecker ER.
GATA3 polymorphisms are associated with baseline and maximal post-bronchodilator FEV1 in Severe Asthma Research Program (SARP) asthmatics [abstract]. Am J Respir Crit Care Med.
2009;
179(1 Meeting Abstracts):A2449.
Slager RE, Diallo A, Hawkins GA, Bowden A, Stevens L, Morton M, Tomkinson A, Longphre M, Bleecker ER, Meyers DA.
IL4R polymorphisms are associated with response to IL4/IL13 receptor antagonist (Aerovant) in human asthmatics and non-human primates [abstract]. Am J Respir Crit Care Med.
2009;
179(1 Meeting Abstracts):A5417.
Xu J, Zheng SL, Herrington DM, Bleecker E, Meyers D, Isaacs W, Walsh P, inventors; Wake Forest University Health Sciences, assignee.
Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease. United States patent US 7,579,147. 2009 Aug 25.
2009;
():.
Ortega VE, Meyers DA, Bleecker ER, Hawkins GA.
Methylation-specific sequencing of the beta2 adrenergic receptor gene in asthma cases and controls [abstract]. Am J Respir Crit Care Med.
2009;
179(Meeting Abstracts):A5433.
Zheng SL, Sun J, Smith S, Li G, Hsu F-C, Zhu Y, Kader AK, Turner AR, Liu W, Bleecker ER, Meyers DA, Chang B-L, Xu J, et al.
Cumulative association of five genetic variants with prostate cancer. N Engl J Med.
2008;
358(9):910-919.
Chen S-H, Sun J, Dimitrov L, Turner AR, Adams TS, Meyers DA, Chang B-L, Zheng SL, Xu J, Hsu F-C, et al.
A support vector machine approach for detecting gene-gene interaction. Genet Epidemiol.
2008;
32(2):152-167.
Meyers DA, Hawkins GA, Wenzel SA, Lo K, Watt R, Bleecker ER.
Pharmacogenetic identification of increased responsiveness in severe asthma with anti-TNF (Golimumab) therapy [abstract]. J Allergy Clin Immunol.
2008;
121(3):798.
Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Peters SP, Hawkins GA, Meyers DA, Bleecker ER, et al.
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med.
2008;
178(7):688-694.
Ohar JA, Holian A, Sadeghnejad A, Hamilton RF, Zheng SL, Xu J, Meyers DA, Bleecker ER.
Polymorphisms in MSR1 gene affect macrophage function [abstract]. Am J Respir Crit Care Med.
2008;
177(Online Abstr Issue):A503.
Sadeghnejad A, Ohar JA, Zheng SL, Hawkins GA, Meyers DA, Bleecker ER.
ADAM33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers [abstract]. Am J Respir Crit Care Med.
2008;
177(Online Abstr Issue):A504.
Perry CD, Hawkins GA, Hastie AT, Cauthen CG, Diallo A, Li H, Moore WC, Meyers DA, Peters SP, Bleecker ER.
Genetic variation in pulmonary and activation-regulated chemokine (PARC/CCL18) in asthma [abstract]. Am J Respir Crit Care Med.
2008;
177(Online Abstr Issue):A338.
Ortega VE, Hawkins GA, Harkins M, Meyers DA, Bleecker ER.
Sequencing of the beta2 adrenergic receptor gene and association with asthma susceptibility in a US Hispanic population from New Mexico [abstract]. Am J Respir Crit Care Med.
2008;
177(Meeting Abstracts):A334.
Liu W, Chang B, Li T, Dimitrov L, Kim S, Kim JW, Turner AR, Meyers DA, Zheng SL, Xu J, et al.
Germline copy number polymorphisms involving larger than 100 kb are uncommon in normal subjects. Prostate.
2007;
67(3):227-233.
Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Peters SP, Meyers DA, et al.
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol.
2007;
119(2):405-413.
Wenzel SE, Balzar S, Ampleford E, Hawkins GA, Busse WW, Calhoun WJ, Castro M, Chung KF, Meyers DA, Bleecker ER, et al.
IL4Ralpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med.
2007;
175(6):570-576.
Bleecker ER, Postma DS, Lawrance R, Meyers DA, Ambrose H, Goldman M.
Effect of polymorphisms in the beta2-adrenergic receptor gene (ADRB2) on response to long-acting beta2-agonist (LABA) therapy [abstract]. J Allergy Clin Immunol.
2007;
119(2):524-525.
Ortega VE, Montealegre F, Chardon D, Meyers DA, Diallo AF, Ampleford EJ, Hawkins GA, Bleecker ER.
Sequencing of the beta2 adrenergic receptor gene in Puerto Ricans with asthma [abstract]. Am J Respir Crit Care Med.
2007;
175(Abstr Issue):A461.
McCallister JW, Moore WC, Hastie AT, Vestal PL, Ampleford EJ, Hawkins GA, Wenzel SE, Meyers DA, Bleecker ER.
Association of polymorphisms in the tumor necrosis factor-alpha (TNFalpha) gene with levels of TNFalpha and pulmonary function in asthma [abstract]. Am J Respir Crit Care Med.
2007;
175(Abstr Issue):A462.
Sadeghnejad A, Meyers DA, Bleeker [sic] ER [Bleecker ER], Ohar JA.
IL13 promoter polymorphism enhances the adverse effect of smoking on lung function [abstract]. Am J Respir Crit Care Med.
2007;
175(Abstr Issue):A563.
Smith RS, Li H, Ampleford EA, Peters SP, Moore WC, Meyers DA, Bleecker ER, Hawkins GA.
Steroid complex immunophilia FKBP4 is associated with severe asthma [abstract]. Am J Respir Crit Care Med.
2007;
175(Abstr Issue):A833.
Meyers DA, Wenzel SE, Hawkins GA, Bleecker ER.
ADAM33: association with asthma severity phenotypes, pulmonary function and air trapping in CT scans [abstract]. Am J Respir Crit Care Med.
2007;
175(Abstr Issue):A969.
Duggan D, Zheng SL, Dimitrov L, Cheng Y, Li G, Sun J, Chang B-L, Liu W, Kim JW, Bleecker ER, Meyers DA, Xu J, et al.
Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB21P. J Natl Cancer Inst.
2007;
99(24):1836-1844.
Meyers DA, Bleecker ER.
Asthma. In: Rimoin DL, Connor JM, Pyeritz R, Korf B, eds. Emery and Rimoin's principles and practice of medical genetics, vol II. 5th ed.
Philadephia: Chruchill Livingstone Elsevier;
2007:
1395-1405.
Liu W, Chang B, Sauvageot J, Dimitrov L, Gielzak M, Li T, Yan G, Sun J, Sun J, Adams TS, Turner AR, Kim JW, Meyers DA, Zheng SL, Isaacs WB, Xu J.
Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array. Genes Chromosomes Cancer.
2006;
45(11):1018-1032.
Zheng SL, Liu W, Dimitrov L, Sun J, Sun J, Chang B, Loza M, Turner AR, Bleecker ER, Meyers DA, Xu J, et al.
A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS Study. Prostate.
2006;
66(14):1556-1564.
Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Moore WC, Klanderman B, Liggett SB, Peters SP, Weiss ST, Bleecker ER.
Sequence, haplotype and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med.
2006;
174(10):1101-1109.
Ohar JA, Ampleford EJ, Sterling DA, Bleecker ER, Meyers DA.
ADAM33 is associated with COPD in a large US population [abstract]. In: American Thoracic Society International Conference Abstracts; 2006 May 19-24; San Diego (CA).
2006;
():A620.
All Publications
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.
For a list of earlier publications, visit the Carpenter Library Publication Search.