Profile

Deborah A. Meyers, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.A., Ithaca College, 1971
  • Ph.D., Indiana University School of Medicine, 1976
  • Fellowship, Univ of NC at Chapel Hill, 1978

Memberships

  • Sigma Xi Society
  • Am Soc of Human Genetics
  • Biometric Society
  • Am Academy Of Advancement Of S
  • Am Academy Of Allergy & Immuno
  • Genetics Society Of America
Deborah A. Meyers, Ph.D.

Deborah A. Meyers, Ph.D.

Co-Director, Center for Genomics and Personalized Medicine Research
Professor, Pediatrics - Medical Genetics
Center for Genomics and Personalized Medicine Research
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

Asthma; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Genetic Predisposition to Disease; Genome-Wide Association Study
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Contact Information

Academic: 336-713-7500 | Department: 336-716-2011

Email: dmeyers@wakehealth.edu

Recent Publications

Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B,.. Am J Respir Crit Care Med. 2017;195(3):302-313.

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.. J Asthma. 2016;53(8):775-782.

Common genetic polymorphisms influence blood biomarker measurements in COPD. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ,.. PLoS Genet. 2016;12(8):e1006011.

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C,.. Nat Commun. 2016;7():12522.

Gene expression correlated to severe asthma characteristics reveals heterogeneous mechanisms of severe disease. Modena BD, Bleecker ER, Busse WW, Erzurum SC, Gaston BM, Jarjour NN, Meyers DA, Milosevic J, Tedrow JR, Wu W, Kaminski N, Wenzel SE.. Am J Respir Crit Care Med. 2016;():.

Effects of age and disease severity on systemic corticosteroid responses in asthma. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy J, Fitzpatrick A, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG,.. Am J Respir Crit Care Med. 2016;():.

Clinical and molecular characterization of the Chi3l1/ykl-40 severe asthma endotypes [abstract]. Gomez JL, Crisafi G, Holm C, Jarjour NN, Hawkins GA, Meyers DA, Bleecker E, Reibman J, Cohn LE, Chupp GL.. Am J Respir Crit Care Med. 2016;193():A4346.

Blood eosinophils poorly correlate with sputum eosinophils, and have few associations with spirometry, clinical and quantitated computed tomography measures compared to sputum eosinophils in the spiromics cohort [abstract]. Hastie AT, Alexis NE, Doerschuk C, Hansel NN, Christenson S, Putcha N, Ortega VE, Peters SP, Barr RG, Couper DJ, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Han MK, Meyers DA, Curtis JL, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6168.

Genetic ancestry is associated with baseline lung function, CT-scan emphysema, and COPD risk in African Americans and Hispanics from spiromics [abstract]. Ortega VE, Hoffman EA, Ampleford EJ, Hawkins GA, Barr RG, Couper DJ, Han MK, Kanner R, Kleerup E, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6164.

The bitter taste receptor gene Tas2r42 is a novel asthma severity gene [abstract]. Hawkins GA, Deshpande DA, Ampleford EJ, Li X, Li H, Moore WC, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6681.

Cluster analysis of chronic obstructive pulmonary disease (COPD) related phenotypes in the subpopulations and intermediate outcome measures in COPD Study (spiromics) [abstract]. Li X, Han MK, Ortega VA, Dransfield MT, Li H, Barr RG, Couper DJ, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A3509.

Genome-wide association identifies Rs28929474 (glu342lys) in serpina1 associated with post-bronchodilator Fev1/FVC and percent predicted Fev1 in spiromics [abstract]. Li X, Ortega VE, Ampleford EJ, Barr RG, Couper DJ, Han MK, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Hawkins GA, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2016;193():A4431.

Phenotypic/genetic characteristics of COPD, asthma, and asthma-COPD overlap syndrome (acos) in spiromics and sarp [abstract]. Li X, Ortega VE, Nadia H, Christenson S, Moore WC, Li H, Barr RG, Couper DJ, Hoffman EA, Han MK, Kanner R, Kleerup E, Martinez FJ, Hawkins GA, Woodruff PG, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2016;193():A6237.

Role of tumor necrosis factor-related apoptosis inducing ligand and Th1, Th2 and Th17 inflammation in asthma [abstract]. Marks M, Hastie AT, Steele C, Moore WC, Ampleford EJ, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A1336.

Clinical cluster phenotypes from the severe asthma research program (sarp1/2): reproducibility in sarp 3 and the importance of baseline lung function in disease stability and progression [abstract]. Moore WC, Li X, Li H, Castro M, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Bacharier LB, Fitzpatrick AM, Gaston B, Ly N, Myers RE, Ramratnam S, Phipatanakul W, Teague WG, Mauger D, Wenzel SE, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A7852.

Rare serpina1 variants in the multi-ethnic spiromics population [abstract]. Ortega VE, Li X, O'Neal WK, Pennington EJ, Barr RG, Couper DJ, Han MK, Kanner R, Kleerup E, Martinez FJ, Peters SP Rennard SI, Woodruff PG, Hoffman EA, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A4433.

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. Traister RS, Uvalle CE, Hawkins GA, Meyers DA, Bleecker ER, Wenzel SE.. J Allergy Clin Immunol. 2015;135(1):92-99.e10.

Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B.. Eur Respir J. 2015;45(1):87-97.

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. Pino-Yanes M, Gignoux CR, Galanter JM, Levin AM, Campbell CD, Eng C, Huntsman S, Nishimura KK, Gourraud PA, Mohajeri K, O'Roak BJ, Hu D, Mathias RA, Nguyen EA, Roth LA, Padhukasahasram B, Moreno-Estrada A, Sandoval K, Winkler CA, Lurmann F,.. J Allergy Clin Immunol. 2015;135(6):1502-1510.

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL.. J Allergy Clin Immunol. 2015;136(1):51-58.e10.

Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Ortega VE, Meyers DA, Bleecker ER.. Pharmgenomics Pers Med. 2015;8():9-22.

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Allergy. 2015;70(10):1309-1318.

Imputation from 328 African ancestry genomes reveals new associations with asthma in DPP10 [abstract]. Masuko H, Rafaels NM, Huang LL, Chavan S, Wilson JG, Williams LK, Ware LB, Ober C, Meyers DA, Hartert TV, Foreman M, Ford JG, Burchard EG, Bleecker ER, Dunston G, Taub M, Beaty TH, Ruczinski I, Mathias RA, Barnes KC.. J Allergy Clin Immunol. 2015;135(2 Suppl):AB162.

How well does whole genome sequencing improve ability to detect association with asthma in candidate genes compared to existing GWAS platforms in African American populations? [abstract]. Rafaels NM, Johnston HR, Huang L, Chavan S, Wilson JG, Williams LK, Ware LB, Ober C, Meyers DA, Hartert TV, Foreman M, Ford JG, Burchard EG, Bleecker ER, Taub M, Beaty TH, Ruczinski I, Mathias RA, Barnes KC.. J Allergy Clin Immunol. 2015;135(2 Suppl):AB164.

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Ried JS, Li J, Zuo XB, Zheng XD, Yin XY, Sun LD, McAleer MA, O'Regan GM, Fahy CM, Campbell LE, Macek M, Kurek M, Hu D, Eng C, Postma DS, Feenstra B, Geller F, Hottenga JJ, Middeldorp CM, Hysi P, Bataille V, Spector T, Tiesler CM, Thiering E,.. Nat Genet. 2015;47(12):1449-1456.

Circadian rhythm and clock gene expression are altered in asthmatic epithelium and bronchoalveolar lavage (bal) cells [abstract]. Fajt ML, Tedrow JR, Milosevic J, Trudeau JB, Bleecker ER, Meyers DA, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A3628.

Differential gene expression profiles in the bronchial epithelial cells of severe asthmatics treated with oral corticosteroids [abstract]. Gauthier M, Tedrow JR, Wu W, Milosevic J, Bleecker ER, Meyers DA, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Ray A, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A2481.

The Rs12141494 polymorphism in Chi3l1 is associated with asthma severity and airway expression of Ykl-40 [abstract]. Gomez JL, Crisafi G, Holm C, Meyers DA, Hawkins GA, Bleecker ER, Jarjour NN, Cohn LE, Chupp GL.. Am J Respir Crit Care Med. 2015;191():A1057.

Analyses of COPD severity phenotypes and emphysema in spiromics subjects stratified By sputum granulocytes [abstract]. Hastie AT, Doerschuk CM, Alexis NE, Hansel NN, Peters SP, Barr RG, Couper D, Curtis JL, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Putcha N, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2861.

Blood biomarker quantitative trail loci in chronic obstructive pulmonary disease [abstract]. Jacobson S, Kechris K, Sun W, Yang J, Chen TH, Barr RG, Basta P, Bleecker ER, Couper D, Curtis JL, Doerschuk CM, Drummond MB, Han MK, Hansel NN, Hawkins G, Hoffman EA, Kanner R, Kleerup EC, Martinez FJ, Meyers DA, O'Neal WK, Peters SP,.. Am J Respir Crit Care Med. 2015;191():A3627.

Factor analysis of Chronic Obstructive Pulmonary Disease (COPD) related phenotypes in the subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Li X, Li H, Ampleford J, Dransfield MT, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2439.

Sarp clinical clusters predict steroid responsiveness and risk of asthma exacerbations in the Asthmanet Vida (Vitamin D In Asthma) Trial [abstract]. Moore WC, King TS, Bleecker ER, Meyers DA, Peters SP Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A6055.

The very frequent exacerbator sub-phenotype is seen in all spectrums of asthma severity including milder disease in the Severe Asthma Research Program [abstract]. Opina MD, Bleecker ER, Meyers DA, Li H, Moore WC.. Am J Respir Crit Care Med. 2015;191():A4182.

African ancestry is associated with disease misclassification, airflow obstruction, and CT scan emphysema in African Americans from spiromics [abstract]. Ortega VE, Ampleford EJ, Hawkins G, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A2297.

African ancestry is associated with lung function, healthcare utilization, and airways inflammation in African Americans with asthma [abstract]. Ortega VE, Moore WC, Zein J, Hastie AT, Ampleford E, Peters SP, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A1061.

Rare serpina1 variants are associated with lung function and health care utilization in a multi-ethnic population from the Severe Asthma Research Program (sarp) [abstract]. Pasha S, Orgega VE, Ampleford EJ, Bamshad MJ, Barnes KC, Busse WW, Castro M, Erzurum SC, Israel E, Mathias RA, Nickerson D, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A6057.

The value of whole genome sequencing in identifying genetic determinants of asthma in populations of African ancestry [abstract]. Mathias RA, Johnston HR, Torgerson D, Levin AM, Lange LA, Ortega VE, Hu Y, Caraballo L, Foreman MG, Hartert T, Herrera-Paz E, Knight-Madden JM, Kumar R, Mayorga A, Olopade C, Ware, LB, Marrugo J, Oliveira RR, Yazdanbakhsh M, Wilson JG,.. Am J Respir Crit Care Med. 2015;191():A1063.

Older asthma subjects are less atopic with increased sputum neutrophils [abstract]. Kaur R, Hastie AT, Smith R, Li H, Meyers DA, Bleecker ER, Moore WC.. Am J Respir Crit Care Med. 2015;191():A4324.

Evaluation of genetic variants in Il6 and Il6r in the Nhlbi subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Hawkins GA, Ampleford EJ, Ortega VE, Li X, Peters SP, Barr RG, Couper D, Han MK, Kanner R, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A4693.

Mechanisms for the genetic association between Il1rl1 and human asthma [abstract]. Traister RS, Hawkins G, Meyers DA, Bleecker ER, Zhao Y, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A3629.

Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine. Ortega VE, Meyers DA.. J Allergy Clin Immunol. 2014;133(1):16-26.

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER.. Lancet Respir Med. 2014;2(3):204-213.

GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma [letter]. Hosking L, Bleecker E, Ghosh S, Yeo A, Jacques L, Mosteller M, Meyers D.. J Allergy Clin Immunol. 2014;133(2):587-589.

Asthma genetics and personalised medicine. Meyers DA, Bleecker ER, Holloway JW, Holgate ST.. Lancet Respir Med. 2014;2(5):405-415.

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2014;133(6):1557-1563.

Genome-wide interaction studies reveal sex-specific asthma risk alleles. Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, Del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B,.. Hum Mol Genet. 2014;23(19):5251-5259.

Genetics and asthma. Slager RE, Li X, Meyers DA, Bleecker ER. In: Bernstein JA, Levy ML, eds. Clinical asthma: theory and practice. Boca Raton: CRC Press;2014: 21-28.

An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Voraphani N, Gladwin MT, Contreras AU, Kaminski N, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Ray A, Ray P, Erzurum SC, Busse WW, Zhao J, Trudeau JB, Wenzel SE.. Mucosal Immunol. 2014;7(5):1175-1185.

RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP.. Am J Respir Crit Care Med. 2014;189():A6384.

Defining fungal asthma severity via immune mediator differences in bronchoalveolar lavage fluid and induced sputum from fungal skin test-positive vs. skin test-negative asthmatics [abstract]. Steele C, Dunaway CW, Hastie AT, Ampleford EJ, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A2176.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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