Profile

Deborah A. Meyers, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.A., Ithaca College, 1971
  • Ph.D., Indiana University School of Medicine, 1976
  • Fellowship, Univ of NC at Chapel Hill, 1978

Memberships

  • Sigma Xi Society
  • Am Soc of Human Genetics
  • Biometric Society
  • Am Academy Of Advancement Of S
  • Am Academy Of Allergy & Immuno
  • Genetics Society Of America
Deborah A. Meyers, Ph.D.

Deborah A. Meyers, Ph.D.

Co-Director, Center for Genomics and Personalized Medicine Research
Professor, Pediatrics - Medical Genetics
Center for Genomics and Personalized Medicine Research
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

Asthma; Polymorphism, Single Nucleotide; Genetic Predisposition to Disease; Prostatic Neoplasms; European Continental Ancestry Group
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Contact Information

Academic: 336-713-7500 | Department: 336-716-2011

Email: dmeyers@wakehealth.edu

Recent Publications

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.. J Asthma. 2016;():.

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. Traister RS, Uvalle CE, Hawkins GA, Meyers DA, Bleecker ER, Wenzel SE.. J Allergy Clin Immunol. 2015;135(1):92-99.e10.

Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B.. Eur Respir J. 2015;45(1):87-97.

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. Pino-Yanes M, Gignoux CR, Galanter JM, Levin AM, Campbell CD, Eng C, Huntsman S, Nishimura KK, Gourraud PA, Mohajeri K, O'Roak BJ, Hu D, Mathias RA, Nguyen EA, Roth LA, Padhukasahasram B, Moreno-Estrada A, Sandoval K, Winkler CA, Lurmann F,.. J Allergy Clin Immunol. 2015;135(6):1502-1510.

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL.. J Allergy Clin Immunol. 2015;136(1):51-58.e10.

Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Ortega VE, Meyers DA, Bleecker ER.. Pharmgenomics Pers Med. 2015;8():9-22.

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Allergy. 2015;70(10):1309-1318.

Imputation from 328 African ancestry genomes reveals new associations with asthma in DPP10 [abstract]. Masuko H, Rafaels NM, Huang LL, Chavan S, Wilson JG, Williams LK, Ware LB, Ober C, Meyers DA, Hartert TV, Foreman M, Ford JG, Burchard EG, Bleecker ER, Dunston G, Taub M, Beaty TH, Ruczinski I, Mathias RA, Barnes KC.. J Allergy Clin Immunol. 2015;135(2 Suppl):AB162.

How well does whole genome sequencing improve ability to detect association with asthma in candidate genes compared to existing GWAS platforms in African American populations? [abstract]. Rafaels NM, Johnston HR, Huang L, Chavan S, Wilson JG, Williams LK, Ware LB, Ober C, Meyers DA, Hartert TV, Foreman M, Ford JG, Burchard EG, Bleecker ER, Taub M, Beaty TH, Ruczinski I, Mathias RA, Barnes KC.. J Allergy Clin Immunol. 2015;135(2 Suppl):AB164.

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Ried JS, Li J, Zuo XB, Zheng XD, Yin XY, Sun LD, McAleer MA, O'Regan GM, Fahy CM, Campbell LE, Macek M, Kurek M, Hu D, Eng C, Postma DS, Feenstra B, Geller F, Hottenga JJ, Middeldorp CM, Hysi P, Bataille V, Spector T, Tiesler CM, Thiering E,.. Nat Genet. 2015;47(12):1449-1456.

Circadian rhythm and clock gene expression are altered in asthmatic epithelium and bronchoalveolar lavage (bal) cells [abstract]. Fajt ML, Tedrow JR, Milosevic J, Trudeau JB, Bleecker ER, Meyers DA, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A3628.

Differential gene expression profiles in the bronchial epithelial cells of severe asthmatics treated with oral corticosteroids [abstract]. Gauthier M, Tedrow JR, Wu W, Milosevic J, Bleecker ER, Meyers DA, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Ray A, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A2481.

The Rs12141494 polymorphism in Chi3l1 is associated with asthma severity and airway expression of Ykl-40 [abstract]. Gomez JL, Crisafi G, Holm C, Meyers DA, Hawkins GA, Bleecker ER, Jarjour NN, Cohn LE, Chupp GL.. Am J Respir Crit Care Med. 2015;191():A1057.

Analyses of COPD severity phenotypes and emphysema in spiromics subjects stratified By sputum granulocytes [abstract]. Hastie AT, Doerschuk CM, Alexis NE, Hansel NN, Peters SP, Barr RG, Couper D, Curtis JL, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Putcha N, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2861.

Blood biomarker quantitative trail loci in chronic obstructive pulmonary disease [abstract]. Jacobson S, Kechris K, Sun W, Yang J, Chen TH, Barr RG, Basta P, Bleecker ER, Couper D, Curtis JL, Doerschuk CM, Drummond MB, Han MK, Hansel NN, Hawkins G, Hoffman EA, Kanner R, Kleerup EC, Martinez FJ, Meyers DA, O'Neal WK, Peters SP,.. Am J Respir Crit Care Med. 2015;191():A3627.

Factor analysis of Chronic Obstructive Pulmonary Disease (COPD) related phenotypes in the subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Li X, Li H, Ampleford J, Dransfield MT, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2439.

Sarp clinical clusters predict steroid responsiveness and risk of asthma exacerbations in the Asthmanet Vida (Vitamin D In Asthma) Trial [abstract]. Moore WC, King TS, Bleecker ER, Meyers DA, Peters SP Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A6055.

The very frequent exacerbator sub-phenotype is seen in all spectrums of asthma severity including milder disease in the Severe Asthma Research Program [abstract]. Opina MD, Bleecker ER, Meyers DA, Li H, Moore WC.. Am J Respir Crit Care Med. 2015;191():A4182.

African ancestry is associated with disease misclassification, airflow obstruction, and CT scan emphysema in African Americans from spiromics [abstract]. Ortega VE, Ampleford EJ, Hawkins G, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A2297.

African ancestry is associated with lung function, healthcare utilization, and airways inflammation in African Americans with asthma [abstract]. Ortega VE, Moore WC, Zein J, Hastie AT, Ampleford E, Peters SP, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A1061.

Rare serpina1 variants are associated with lung function and health care utilization in a multi-ethnic population from the Severe Asthma Research Program (sarp) [abstract]. Pasha S, Orgega VE, Ampleford EJ, Bamshad MJ, Barnes KC, Busse WW, Castro M, Erzurum SC, Israel E, Mathias RA, Nickerson D, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A6057.

The value of whole genome sequencing in identifying genetic determinants of asthma in populations of African ancestry [abstract]. Mathias RA, Johnston HR, Torgerson D, Levin AM, Lange LA, Ortega VE, Hu Y, Caraballo L, Foreman MG, Hartert T, Herrera-Paz E, Knight-Madden JM, Kumar R, Mayorga A, Olopade C, Ware, LB, Marrugo J, Oliveira RR, Yazdanbakhsh M, Wilson JG,.. Am J Respir Crit Care Med. 2015;191():A1063.

Older asthma subjects are less atopic with increased sputum neutrophils [abstract]. Kaur R, Hastie AT, Smith R, Li H, Meyers DA, Bleecker ER, Moore WC.. Am J Respir Crit Care Med. 2015;191():A4324.

Evaluation of genetic variants in Il6 and Il6r in the Nhlbi subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Hawkins GA, Ampleford EJ, Ortega VE, Li X, Peters SP, Barr RG, Couper D, Han MK, Kanner R, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A4693.

Mechanisms for the genetic association between Il1rl1 and human asthma [abstract]. Traister RS, Hawkins G, Meyers DA, Bleecker ER, Zhao Y, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A3629.

Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine. Ortega VE, Meyers DA.. J Allergy Clin Immunol. 2014;133(1):16-26.

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER.. Lancet Respir Med. 2014;2(3):204-213.

GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma [letter]. Hosking L, Bleecker E, Ghosh S, Yeo A, Jacques L, Mosteller M, Meyers D.. J Allergy Clin Immunol. 2014;133(2):587-589.

Asthma genetics and personalised medicine. Meyers DA, Bleecker ER, Holloway JW, Holgate ST.. Lancet Respir Med. 2014;2(5):405-415.

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2014;133(6):1557-1563.

Genome-wide interaction studies reveal sex-specific asthma risk alleles. Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, Del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B,.. Hum Mol Genet. 2014;23(19):5251-5259.

Genetics and asthma. Slager RE, Li X, Meyers DA, Bleecker ER. In: Bernstein JA, Levy ML, eds. Clinical asthma: theory and practice. Boca Raton: CRC Press;2014: 21-28.

An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Voraphani N, Gladwin MT, Contreras AU, Kaminski N, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Ray A, Ray P, Erzurum SC, Busse WW, Zhao J, Trudeau JB, Wenzel SE.. Mucosal Immunol. 2014;7(5):1175-1185.

RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP.. Am J Respir Crit Care Med. 2014;189():A6384.

Defining fungal asthma severity via immune mediator differences in bronchoalveolar lavage fluid and induced sputum from fungal skin test-positive vs. skin test-negative asthmatics [abstract]. Steele C, Dunaway CW, Hastie AT, Ampleford EJ, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A2176.

Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M.. Am J Respir Crit Care Med. 2014;189():A4288.

Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2014;189(Meeting Abstracts):A1001.

African ancestry is associated with lower baseline lung function, misclassification of disease severity, and healthcare utilization in African Americans with severe asthma [abstract]. Ortega VE, Moore WC, Hawkins G, Ampleford EJ, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Peters SP, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A6366.

Predictors of response to bronchodilators in children with severe asthma [abstract]. Coverstone AM, Zheng J, Bacharier LB, Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Gaston BM, Bleecker ER, Moore WC, Castro M.. Am J Respir Crit Care Med. 2014;189():A3839.

Complex patterns of Th1 inflammatory biomarker associations with cellular constituents of induced sputum in asthma [abstract]. Hastie AT, Dunaway CW, Moore WC, Foster S, Rector BM, Ampleford E, Bleecker ER, Steele C, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A4236.

Implications of population structure and ancestry on asthma genetic studies. Ortega VE, Meyers DA.. Curr Opin Allergy Clin Immunol. 2014;14(5):381-389.

Asthma in the elderly: what we know and what we have yet to know. Yanez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, Peters S, Niimi A, Ledford DK, Katial R, Fabbri LM, Celedon JC, Canonica GW, Busse P, Boulet LP, Baena-Cagnani CE, Hamid Q, Bachert C, Pawankar R, Holgate ST, Bleecker E, Meyers DA.. World Allergy Organ J. 2014;7(1):8.

Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways. Modena BD, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Wu W, Bar-Joseph Z, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Wenzel SE.. Am J Respir Crit Care Med. 2014;190(12):1363-1372.

P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA,.. Am J Respir Crit Care Med. 2013;187(1):28-33.

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr,.. PLoS One. 2013;8(2):e56179.

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Rieder MJ, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ, Bowden DW, Burke G, Carr J, Goff D, Herrington DM, Liu Y, Bleecker E, Meyers D,.. Nature. 2013;493(7431):216-220.

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL,.. J Allergy Clin Immunol. 2013;131(4):1176-1184.

Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(1):72-80.

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(2):313-320.

Predictors of response to tiotropium versus salmeterol in asthmatic adults. Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF Jr,.. J Allergy Clin Immunol. 2013;132(5):1068-1074.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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