Profile

Deborah A. Meyers, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.A., Ithaca College , 1971
  • Ph.D., Indiana University School of Medicine , 1976
  • Fellowship, Univ of NC at Chapel Hill, 1978

Memberships

  • Sigma Xi Society
  • Am Soc Of Human Genetics
  • Biometric Society
  • Am Academy Of Advancement Of S
  • Am Academy Of Allergy & Immuno
  • Genetics Society Of America
Deborah A. Meyers, Ph.D.

Deborah A. Meyers, Ph.D.

Co-Director, Center for Genomics and Personalized Medicine Research
Professor, Pediatrics - Medical Genetics
Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

genetics/genome, minority health issues, molecular biology/molecular me, nursing research, other, statistics/mathematics

Contact Information

Academic: 336-716-5569 | Department: 336-716-2011

Email: dmeyers@wakehealth.edu

Recent Publications


Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014;2(3):204-213.

Hosking L, Bleecker E, Ghosh S, Yeo A, Jacques L, Mosteller M, Meyers D. GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma [letter]. J Allergy Clin Immunol. 2014;133(2):587-589.

Meyers DA, Bleecker ER, Holloway JW, Holgate ST. Asthma genetics and personalised medicine. Lancet Respir Med. 2014;2(5):405-415.

Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol. 2014;133(6):1557-1563.

Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, Del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B,. Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet. 2014;23(19):5251-5259.

Slager RE, Li X, Meyers DA, Bleecker ER. Genetics and asthma In: Bernstein JA, Levy ML, eds. Clinical asthma: theory and practice. Boca Raton: CRC Press;2014: 21-28.

Voraphani N, Gladwin MT, Contreras AU, Kaminski N, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Ray A, Ray P, Erzurum SC, Busse WW, Zhao J, Trudeau JB, Wenzel SE. An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol. 2014;7(5):1175-1185.

Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP. RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Am J Respir Crit Care Med. 2014;189():A6384.

Steele C, Dunaway CW, Hastie AT, Ampleford EJ, Bleecker ER, Meyers DA. Defining fungal asthma severity via immune mediator differences in bronchoalveolar lavage fluid and induced sputum from fungal skin test-positive vs. skin test-negative asthmatics [abstract]. Am J Respir Crit Care Med. 2014;189():A2176.

Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M. Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Am J Respir Crit Care Med. 2014;189():A4288.

Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER. Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Am J Respir Crit Care Med. 2014;189(Meeting Abstracts):A1001.

Ortega VE, Moore WC, Hawkins G, Ampleford EJ, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Peters SP, Bleecker ER, Meyers DA. African ancestry is associated with lower baseline lung function, misclassification of disease severity, and healthcare utilization in African Americans with severe asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A6366.

Coverstone AM, Zheng J, Bacharier LB, Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Gaston BM, Bleecker ER, Moore WC, Castro M. Predictors of response to bronchodilators in children with severe asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A3839.

Hastie AT, Dunaway CW, Moore WC, Foster S, Rector BM, Ampleford E, Bleecker ER, Steele C, Meyers DA. Complex patterns of Th1 inflammatory biomarker associations with cellular constituents of induced sputum in asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A4236.

Traister RS, Uvalle CE, Hawkins GA, Meyers DA, Bleecker ER, Wenzel SE. Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. J Allergy Clin Immunol. 2014;():.

Ortega VE, Meyers DA. Implications of population structure and ancestry on asthma genetic studies. Curr Opin Allergy Clin Immunol. 2014;14(5):381-389.

Yanez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, Peters S, Niimi A, Ledford DK, Katial R, Fabbri LM, Celedon JC, Canonica GW, Busse P, Boulet LP, Baena-Cagnani CE, Hamid Q, Bachert C, Pawankar R, Holgate ST, Bleecker E, Meyers DA. Asthma in the elderly: what we know and what we have yet to know. World Allergy Organ J. 2014;7(1):8.

Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J. 2014;():.

Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA,. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013;187(1):28-33.

Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr,. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013;8(2):e56179.

Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Rieder MJ, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ, Bowden DW, Burke G, Carr J, Goff D, Herrington DM, Liu Y, Bleecker E, Meyers D,. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature. 2013;493(7431):216-220.

Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL,. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol. 2013;131(4):1176-1184.

Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol. 2013;132(1):72-80.

Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol. 2013;132(2):313-320.

Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF Jr,. Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol. 2013;132(5):1068-1074.

Moore WC, Fitzpatrick AM, Li X, Hastie AT, Li H, Meyers DA, Bleecker ER. Clinical heterogeneity in the severe asthma research program. Ann Am Thorac Soc. 2013;10(Suppl):S118-S124.

Slager RE, Moore WC, Peters SP, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Meyers DA, Bleecker ER. Exome sequencing identifies genes for asthma severity in African-Americans [abstract]. Am J Respir Crit Care Med. 2013;187():A2396.

Hastie AT, Rector B, Moore WC, Li H, Peters SP, Meyers DA, Bleecker ER. Serum and sputum interleukin-33 (IL-33) levels show no association with serum total IgE, positive skin test number, exhaled nitric oxide, or increasing severity of atopic asthma [abstract]. Am J Respir Crit Care Med. 2013;187():A1008.

Ortega VE, Slager RE, Hawkins G, Moore WC, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Peters SP, Meyers DA, Bleecker ER. Exome sequencing of beta2-adrenergic receptor pathway genes reveals rare variants associated with asthma severity In African Americans [abstract]. Am J Respir Crit Care Med. 2013;187():A2129.

Bowers B, Hastie AT, Rector B, Moore WC, Meyers DA, Peters SP, Bleecker ER. Insulin like growth factor binding protein 2 (IGFBP2) is associated with increased sputum cellular infiltrate, increased sputum cytokine levels, and reduced lung function for human subjects with asthma [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2397.

Li X, Moore WC, Ampleford EJ, Li H, Hawkins G, Hastie AT, Boushey HA, Busse WW, Castro M, Erzurum SC, Israel E, Lemanske RF, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Phenotypic/genetic characteristics of atopic/non-atopic early/late onset asthma [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2395.

Ortega VE, Miller SM, Slager RE, Hawkins G, Moore WC, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Peters SP, Bleecker ER, Meyers DA. Whole exome sequencing analysis reveals rare genetic variants associated with response to beta2- adrenergic receptor agonists in African American asthmatics [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2122.

Gower WA, Li X, Li H, Ampleford EJ, Bleecker ER, Meyers DA. Cluster analysis of asthma phenotypes in children ages 6 to 18 years from the EVE Consortium [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A3803.

Moore WC, Smith R, Krings J, Li X, Li H, Peters SP, Wenzel SE, Meyers DA, Bleecker ER. Elderly subjects with asthma are less responsive to albuterol and ipratropium bromide when compared to younger subjects, but have similar responses to the two drugs [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A4215.

Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients [letter]. J Allergy Clin Immunol. 2012;129(2):575-578.

Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP,. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med. 2012;185(4):356-362.

Torgerson DG, Capurso D, Mathias RA, Graves PE, Hernandez RD, Beaty TH, Bleecker ER, Raby BA, Meyers DA, Barnes KC, Weiss ST, Martinez FD, Nicolae DL, Ober C. Resequencing candidate genes implicates rare variants in asthma susceptibility. Am J Hum Genet. 2012;90(2):273-281.

Ortega VE, Hawkins G, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Characterization of rare variants in the Adam33 gene in asthma cases from two ethnic groups [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A5609.

Li X, Moore WC, Li H, Ampleford EJ, Busse WW, Erzurum SC, Wenzel SE, Howard TD, Hawkins GA, Meyers DA, Bleecker ER. Phenotype determinants for asthma severity clusters and genetic association for cluster-based asthma severity in Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2501.

Slager RE, Moore WC, Peters SP, Busse WW, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER. Rare TH1 and TH2 pathway genetic variants contribute to severe allergic asthma [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2509.

Hawkins G, Li X, Slager R, Moore WC, Peters SP, Bleecker ER, Meyers DA. Exome sequencing of asthma candidate genes in chromosome 2q11-12 and 2q33 [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4904.

Moore WC, Hastie AT, Li H, Li X, Busse WW, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The addition of sputum inflammatory cell counts to the SARP cluster analysis results in similar clinical asthma phenotypes with biologic heterogeneity [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3625.

Ortega VE, Hawkins G, Hastie AT, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Effects of rare beta2-adrenergic receptor gene variants and long-acting beta agonists on healthcare utilization and corticosteroid use in two multi-ethnic asthma populations [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2514.

Hastie AT, Moore WC, Li H, Rector BM, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Blood eosinophils, exhaled nitric oxide, and IGE do not accurately predict sputum eosinophils [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3926.

Herrington DM, Meyers DA, Xu J, Zheng SL, Bleecker ER, Isaacs WB, Walsh PC, inventors; Wake Forest University Health Sciences, assignee. Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease. United States patent US 8,192,928. 2012 June 5. 2012;():.

Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The IL6R variation Asp358 Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol. 2012;130(2):510-515.

Slager RE, Otulana BA, Hawkins GA, Yen YP, Peters SP, Wenzel SE, Meyers DA, Bleecker ER. IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor alpha antagonist. J Allergy Clin Immunol. 2012;130(2):516-522.

Himes BE, Jiang X, Hu R, Wu AC, Lasky-Su JA, Klanderman BJ, Ziniti J, Senter-Sylvia J, Lima JJ, Irvin CG, Peters SP, Meyers DA, Bleecker ER, Kubo M, Tamari M, Nakamura Y, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD,. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet. 2012;8(7):e1002824.

Slager RE, Hawkins GA, Li X, Postma DS, Meyers DA, Bleecker ER. Genetics of asthma susceptibility and severity. Clin Chest Med. 2012;33(3):431-443.

Bleecker ER, Meyers DA, Bailey WC, Sims AM, Bujac SR, Goldman M, Martin UJ. ADRB2 polymorphisms and budesonide/formoterol responses in COPD. Chest. 2012;142(2):320-328.


Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF,. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012;308(10):987-997.

Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Rodriguez-Santana JR,. Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. J Allergy Clin Immunol. 2012;130(3):622-629.

Kader AK, Sun J, Reck BH, Newcombe PJ, Kim ST, Hsu FC, D'Agostino RB Jr, Tao S, Zhang Z, Turner AR, Platek GT, Spraggs CF, Whittaker JC, Lane BR, Isaacs WB, Meyers DA, Bleecker ER, Torti FM, Trent JM, McConnell JD,. Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial. Eur Urol. 2012;62(6):953-961.

Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012;130(4):861-868.

Mattheisen M, Bunyavanich S, Himes BE, Gauderman WJ, Bleecker ER, Meyers DA, London SJ, Gilliland FD, Burchard EG, Martinez FD, Williams LK, Barnes KC, Ober C, Nicolae DL, Laird NM, Raby BA, Lasky-Su J, Lange C, Weiss ST. Integrative analysis of case-control and family based association studies--lessons we have learned [abstract]. Ann Hum Genet. 2012;76(Pt 5):419.

Myers RA, Himes BE, Gignoux CR, Yang JJ, Gauderman WJ, Rebordosa C, Xie J, Torgerson DG, Levin AM, Baurley J, Graves PE, Mathias RA, Romieu I, Roth LA, Conti D, Avila L, Eng C, Vora H, LeNoir MA, Soto-Quiros M, Liu J, Celedon JC,. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol. 2012;130(6):1294-301.

Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, et al. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. Am J Respir Crit Care Med. 2011;183(4):449-454.

Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Bleecker ER, Moore WC, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 2011;127(2):382-389.

Liu L, Teague WG, Erzurum S, Fitzpatrick A, Mantri S, Dweik RA, Bleecker ER, Meyers D, Moore W, Peters SP, et al. Determinants of exhaled breath condensate pH in a large population with asthma. Chest. 2011;139(2):328-336.

Ortega VE, Hastie A, Sadeghnejad A, Moore W, Hawkins GA, Peters SP, Busse WW, Calhoun WJ, Meyers DA, Bleecker ER, et al. Rare beta2-adrenergic receptor gene polymorphisms in asthma cases and controls from the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A1357.


Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Peters SP, Hawkins GA, Bleecker ER, Meyers DA, et al. Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol. 2011;127(6):1457-1465.

Comhair SAA, Gaston BM, Ricci KS, Hammel J, Dweik RA, Meyers D, Ampleford EJ, Bleecker ER, Moore W, Peters SP, et al. Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS ONE. 2011;6(5):e18574.

Slager RE, Hawkins G, Otulana B, Yen Y, Wenzel SE, Meyers DA, Bleecker ER. Interleukin 4 receptor polymorphisms predict therapeutic pitrakinra treatment response in moderate to severe asthma [abstract]. Am J Respir Crit Care Med. 2011;183():A6178.

Slager RE, Li H, Moore W, Hawkins G, Peters SP, Busse WW, Chung K, Erzurum SC, Meyers DA, Bleecker ER, et al. Predictive model of severe atopic asthma phenotypes using interleukin 4/13 pathway polymorphisms [abstract]. Am J Respir Crit Care Med. 2011;183():A1332.

Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Li X, Bleecker ER, Meyers DA, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011;43(9):887-892.

Wegmann D, Kessner DE, Veeramah KR, Mathias RA, Nicolae DL, Yanek LR, Sun YV, Torgerson DG, Rafaels N, Meyers DA, et al. Recombination rates in admixed individuals identified by ancestry-based inference. Nat Genet. 2011;43(9):847-853.

Hawkins GA, Robinson MB, Moore W, Hastie A, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Correlation of serum IL6 with lung function and phenotypic asthma clusters: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A6169.

Hatzis CE, Hastie A, Moore W, Rector B, Sousa A, Knowles R, Peters SP, Meyers DA, Bleecker ER. BAL cell lysate IL1b synthesis and processing correlates with blood eosinophil levels in subjects with asthma [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A4453.

Robinson MB, Deshpande DA, Pascual RM, Panettieri RA, Penn R, Meyers DA, Bleecker ER, Hawkins GA. IL6 signaling in human airway smooth muscle (hasm): distinct signaling effected by the soluble IL6 receptor and functional consequences [abstract]. Am J Respir Crit Care Med. 2011;183():A2074.

Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol. 2010;125(2):328-335.

Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Peters SP, Bleecker ER, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181(4):315-323.

Bleecker ER, Nelson HS, Kraft M, Corren J, Meyers DA, Yancey SW, Anderson WH, Emmett AH, Ortega HA. Meeting the obligation to balance bioethics and clinical trial design in asthma [editorial]. Am J Respir Crit Care Med. 2010;181(7):648-650.

Bleecker ER, Nelson HS, Kraft M, Corren J, Meyers DA, Yancey SW, Anderson WH, Emmett AH, Ortega HG. Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. Am J Respir Crit Care Med. 2010;181(7):676-687.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol. 2010;125(5):1028-1036.

Ohar JA, Sadeghnejad A, Meyers DA, Donohue JF, Bleecker ER. Do symptoms predict COPD in smokers?. Chest. 2010;137(6):1345-1353.

Bouzigon E, Forabosco P, Koppelman GH, Cookson WOCM, Dizier M-H, Duffy DL, Evans DM, Ferreira MAR, Kere J, Meyers DA, et al. Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. Eur J Hum Genet. 2010;18(6):700-706.

Ohar JA, Hamilton RF Jr, Zheng S, Sadeghnejad A, Sterling DA, Xu J, Meyers DA, Bleecker ER, Holian A. COPD is associated with a macrophage scavenger receptor-1 gene sequence variation. Chest. 2010;137(5):1098-1107.

Bottema RW, Nolte IM, Howard TD, Koppelman GH, Dubois AE, de Meer G, Kerkhof M, Bleecker ER, Meyers DA, Postma DS. Interleukin 13 and interleukin 4 receptor-alpha polymorphisms in rhinitis and asthma. Int Arch Allergy Immunol. 2010;153(3):259-267.

Hawkins GA, Moore WC, Robinson MB, Peters SP, Meyers D, Bleecker ER. IL6R polymorphisms predict measures of lung function in caucasian asthmatics: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1298.

Sadeghnejad A, Ohar JA, Bleecker ER, Meyers D. Replication of an association of the interleukin-1 receptor antagonist gene with asthma in an adult urban admixed population [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A3877.

Slager RE, Pascual RM, Moore WC, Hawkins GA, Peters SP, Meyers D, Bleecker ER. GATA3 polymorphisms are predictors of steroid use and atopic asthma in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1301.

Ortega VE, Hawkins GA, Montealegre F, Chardon D, Sadeghnejad A, Moore WC, Peters SP, Meyers D, Bleecker ER. Rare beta2 adrenergic receptor gene polymorphisms in asthma cases and controls from different ethnic groups [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1316.

Ortega VE, Liggett SB, Pascual R, Diallo A, Moore WC, Meyers D, Bleecker ER, Hawkins GA. Epigenetics of the beta2-adrenergic receptor gene [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1306.

Ortega VE, Hawkins GA, Sadeghnejad A, Moore WC, Meyers D, Bleecker ER. Characterization of asthma cases and controls with rare ADAM33 gene polymorphisms in a multi-ethnic population [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1315.

Li X, Howard TD, Ampleford EJ, Peters SP, Bleecker ER, Meyers DA. Genome-wide association study of asthma severity using proportional odds model identifies TMEM154 [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A3728.

Ohar JA, Howard TD, Ampleford EJ, Bleecker ER, Meyers DA. Genome wide association study in mesothelioma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A4340.

Hastie AT, Albon D, Moore WC, Krings J, Smith RV, Meyers DA, Peters SP, Bleecker ER. Inflammatory protein microarray analysis of sputum from obese subjects with asthma compared with nonobese subjects with asthma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6801.

Pascual RM, Moore WC, Peters SP, Li H, Wenzel SE, Meyers DA, Weiss ST, Litonjua AA, Bleecker ER. Serum vitamin D levels are inversely correlated with FEV1 and FVC in asthma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6800.

Meyers DA. Genetics of asthma and allergy: what have we learned?. J Allergy Clin Immunol. 2010;126(3):439-446.

Hawkins GA, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER. Serum levels of soluble IL6R are genetically regulated and correlate with lung function in asthmatics: Severe Asthma Research Program (SARP) [abstract]. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB357.

Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Meyers DA, Bleecker ER, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010;363(18):1715-1726.

Slager RE, Hawkins GA, Ampleford EJ, Bowden A, Stevens LE, Morton MT, Tomkinson A, Wenzel SE, Bleecker ER, Meyers DA, et al. IL-4 receptor alpha polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist [letter]. J Allergy Clin Immunol. 2010;126(4):875-878.

Slager RE, Hawkins GA, Ampleford EJ, Bowden A, Stevens LE, Morton MT, Tomkinson A, Wenzel SE, Bleecker ER, Meyers DA, et al. The need for standardization in exercise challenge testing for exercise-induced asthma/bronchoconstriction [letter]. J Allergy Clin Immunol. 2010;126(4):878-880.

Goldman M, Lawrance RM, Bleecker ER, Meyers DA, Ambrose HJ. Effect of polymorphisms in the ADRB2 3 ' untranslated region (3 ' UTR) on response to inhaled corticosteroid and long-acting beta(2)-adrenergic agonist (ICS/LABA) combination therapy [abstract]. J Allergy Clin Immunol. 2009;123(2 Suppl):S137.

Sadeghnejad A, Ohar JA, Zheng SL, Sterling DA, Hawkins GA, Meyers DA, Bleecker ER. Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. Respir Res. 2009;10():article 21.

Sadeghnejad A, Bleecker E, Meyers DA. Principles of genetics in allergic diseased and asthma In: Adkinson NF Jr, Bochner BS, Busse WW, Holgate ST, Lemanske RF Jr, Simons FER, eds. Middleton's allergy: principles & practice. 7th ed. Philadelphia: Mosby/Elsevier;2009: 59-72.

Wenzel SE, Barnes PJ, Bleecker ER, Bousquet J, Busse W, Dahlen S-E, Holgate ST, Meyers DA, Rabe KF, Antczak A, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med. 2009;179(7):549-558.

Sadeghnejad A, Koppelman GH, Ohar JA, Postma DS, Bleecker ER, Meyers DA. Role of SERPINE2 in asthma and COPD [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A2741.

Ohar JA, Sadeghnejad A, Meyers DA, Bleecker ER. Symptoms poorly predict the presence of COPD in at-risk smokers [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A1471.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Krings JO, Smith RA, Li H, Peters SP, Bleecker ER. Inflammatory protein analyses of sputum from human subjects with severe or nonsevere asthma [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A3925.

Hawkins GA, Lazarus R, Smith RS, Tantisira KG, Meyers DA, Peters SP, Weiss ST, Bleecker ER. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. J Allergy Clin Immunol. 2009;123(6):1376-1383.

Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Bleecker ER, et al. Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med. 2009;180(10):929-935.

Ortega VE, Hawkins GA, Meyers DA, Bleecker ER. Characterization of asthma cases and controls with rare beta2 adrenergic receptor gene polymorphisms in a multi-ethnic population [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A5434.

Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EA, Xu J, Koning H, Bruinenberg M, Bleecker ER, et al. Identification of protocadherin-1 as a novel susceptibility gene for bronchial hyperresponsiveness and asthma [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2447.

Moore WC, Meyers DA, Li H, D'Agostino R, Peters SP, Bleecker ER. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2522.

Crowley MB, Moore WC, Smith RV, Meyers DA, Peters SP, Bleeker ER [sic] [Bleecker ER]. The effect of specific air pollutants on FEV1 variability in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A1291.

Moore WC, Meyers DA, Li H, Peters SP, Bleecker ER. The importance of the 3rd controller medication in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2806.

Pascual RM, Slager RE, Li H, Hawkins GA, Peters SP, Moore WC, Meyers DA, Bleecker ER. GATA3 polymorphisms are associated with baseline and maximal post-bronchodilator FEV1 in Severe Asthma Research Program (SARP) asthmatics [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2449.

Slager RE, Diallo A, Hawkins GA, Bowden A, Stevens L, Morton M, Tomkinson A, Longphre M, Bleecker ER, Meyers DA. IL4R polymorphisms are associated with response to IL4/IL13 receptor antagonist (Aerovant) in human asthmatics and non-human primates [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A5417.

Xu J, Zheng SL, Herrington DM, Bleecker E, Meyers D, Isaacs W, Walsh P, inventors; Wake Forest University Health Sciences, assignee. Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease. United States patent US 7,579,147. 2009 Aug 25. 2009;():.

Ortega VE, Meyers DA, Bleecker ER, Hawkins GA. Methylation-specific sequencing of the beta2 adrenergic receptor gene in asthma cases and controls [abstract]. Am J Respir Crit Care Med. 2009;179(Meeting Abstracts):A5433.

Zheng SL, Sun J, Smith S, Li G, Hsu F-C, Zhu Y, Kader AK, Turner AR, Liu W, Bleecker ER, Meyers DA, Chang B-L, Xu J, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med. 2008;358(9):910-919.

Chen S-H, Sun J, Dimitrov L, Turner AR, Adams TS, Meyers DA, Chang B-L, Zheng SL, Xu J, Hsu F-C, et al. A support vector machine approach for detecting gene-gene interaction. Genet Epidemiol. 2008;32(2):152-167.

Meyers DA, Hawkins GA, Wenzel SA, Lo K, Watt R, Bleecker ER. Pharmacogenetic identification of increased responsiveness in severe asthma with anti-TNF (Golimumab) therapy [abstract]. J Allergy Clin Immunol. 2008;121(3):798.


Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Peters SP, Hawkins GA, Meyers DA, Bleecker ER, et al. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med. 2008;178(7):688-694.

Reijmerink NE, Postma DS, Bruinenberg M, Nolte IM, Meyers DA, Bleecker ER, Koppelman GH. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy [letter]. J Allergy Clin Immunol. 2008;122(3):651-654.

Smith AK, Lange LA, Ampleford EJ, Meyers DA, Bleecker ER, Howard TD. Association of polymorphisms in CASP10 and CASP8 with FEV1/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics. Clin Exp Allergy. 2008;38(11):1738-1744.

Ohar JA, Holian A, Sadeghnejad A, Hamilton RF, Zheng SL, Xu J, Meyers DA, Bleecker ER. Polymorphisms in MSR1 gene affect macrophage function [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A503.

Sadeghnejad A, Ohar JA, Zheng SL, Hawkins GA, Meyers DA, Bleecker ER. ADAM33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A504.

Perry CD, Hawkins GA, Hastie AT, Cauthen CG, Diallo A, Li H, Moore WC, Meyers DA, Peters SP, Bleecker ER. Genetic variation in pulmonary and activation-regulated chemokine (PARC/CCL18) in asthma [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A338.

Ortega VE, Hawkins GA, Harkins M, Meyers DA, Bleecker ER. Sequencing of the beta2 adrenergic receptor gene and association with asthma susceptibility in a US Hispanic population from New Mexico [abstract]. Am J Respir Crit Care Med. 2008;177(Meeting Abstracts):A334.

Liu W, Chang B, Li T, Dimitrov L, Kim S, Kim JW, Turner AR, Meyers DA, Zheng SL, Xu J, et al. Germline copy number polymorphisms involving larger than 100 kb are uncommon in normal subjects. Prostate. 2007;67(3):227-233.

Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Peters SP, Meyers DA, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2007;119(2):405-413.

Wenzel SE, Balzar S, Ampleford E, Hawkins GA, Busse WW, Calhoun WJ, Castro M, Chung KF, Meyers DA, Bleecker ER, et al. IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med. 2007;175(6):570-576.

Bleecker ER, Postma DS, Lawrance R, Meyers DA, Ambrose H, Goldman M. Effect of polymorphisms in the beta2-adrenergic receptor gene (ADRB2) on response to long-acting beta2-agonist (LABA) therapy [abstract]. J Allergy Clin Immunol. 2007;119(2):524-525.

Smith RS, Meyers DA, Peters SP, Moore WC, Wenzel SA, Bleecker ER, Hawkins GA. Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population. DNA Seq. 2007;18(1):47-53.

Ortega VE, Montealegre F, Chardon D, Meyers DA, Diallo AF, Ampleford EJ, Hawkins GA, Bleecker ER. Sequencing of the beta2 adrenergic receptor gene in Puerto Ricans with asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A461.

McCallister JW, Moore WC, Hastie AT, Vestal PL, Ampleford EJ, Hawkins GA, Wenzel SE, Meyers DA, Bleecker ER. Association of polymorphisms in the tumor necrosis factor-alpha (TNFalpha) gene with levels of TNFalpha and pulmonary function in asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A462.

Sadeghnejad A, Meyers DA, Bleeker [sic] ER [Bleecker ER], Ohar JA. IL13 promoter polymorphism enhances the adverse effect of smoking on lung function [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A563.

Smith RS, Li H, Ampleford EA, Peters SP, Moore WC, Meyers DA, Bleecker ER, Hawkins GA. Steroid complex immunophilia FKBP4 is associated with severe asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A833.

Meyers DA, Wenzel SE, Hawkins GA, Bleecker ER. ADAM33: association with asthma severity phenotypes, pulmonary function and air trapping in CT scans [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A969.

Sadeghnejad A, Meyers DA, Bottai M, Sterling DA, Bleecker ER, Ohar JA. IL13 promoter polymorphism -1112C/T modulates the adverse effect of tobacco smoking on lung function. Am J Respir Crit Care Med. 2007;176(8):748-752.

Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, Goldman M. Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet. 2007;370(9605):2118-2125.

Duggan D, Zheng SL, Dimitrov L, Cheng Y, Li G, Sun J, Chang B-L, Liu W, Kim JW, Bleecker ER, Meyers DA, Xu J, et al. Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB21P. J Natl Cancer Inst. 2007;99(24):1836-1844.

Meyers DA, Bleecker ER. Asthma In: Rimoin DL, Connor JM, Pyeritz R, Korf B, eds. Emery and Rimoin's principles and practice of medical genetics, vol II. 5th ed. Philadephia: Chruchill Livingstone Elsevier;2007: 1395-1405.

Liu W, Chang B, Sauvageot J, Dimitrov L, Gielzak M, Li T, Yan G, Sun J, Sun J, Adams TS, Turner AR, Kim JW, Meyers DA, Zheng SL, Isaacs WB, Xu J. Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array. Genes Chromosomes Cancer. 2006;45(11):1018-1032.

Zheng SL, Liu W, Dimitrov L, Sun J, Sun J, Chang B, Loza M, Turner AR, Bleecker ER, Meyers DA, Xu J, et al. A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS Study. Prostate. 2006;66(14):1556-1564.

Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Moore WC, Klanderman B, Liggett SB, Peters SP, Weiss ST, Bleecker ER. Sequence, haplotype and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med. 2006;174(10):1101-1109.

Ohar JA, Ampleford EJ, Sterling DA, Bleecker ER, Meyers DA. ADAM33 is associated with COPD in a large US population [abstract]. In: American Thoracic Society International Conference Abstracts; 2006 May 19-24; San Diego (CA). 2006;():A620.

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