Profile

Michael E. Miller, Ph.D.Wake Forest School of Medicine

Michael E. Miller, Ph.D.

Professor,


Contact Information

Academic: 336-716-6837 | Department: 336-716-2011

Email: mmiller@wakehealth.edu

Education & Training

  • B.A., College of Wooster , 1983
  • M.S., University of Cincinnati , 1985
  • Ph.D., University of Michigan/Ann Arbor , 1988

Memberships

  • Soc Of Clinical Trial Research
  • Am Statistical Assn
  • Biometric Society
Michael E. Miller, Ph.D.

Michael E. Miller, Ph.D.

Professor, Department of Biostatistics
Sticht Center on Aging
Translational Science Institute

Research Interests

aging, cognition/learning, diabetes, fitness/physical, neurosciences/behavior, other

Contact Information

Academic: 336-716-6837 | Department: 336-716-2011

Email: mmiller@wakehealth.edu

Recent Publications

Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. JAMA Intern Med. 2014;174(3):324-333.

Grosicki GJ, Miller ME, Marsh AP. Resistance exercise performance variability at submaximal intensities in older and younger adults. Clin Interv Aging. 2014;9():209-218.


Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB. Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Diabetes Care. 2014;37(3):634-643.

Beisswenger PJ, Howell SK, Russell G, Miller ME, Rich SS, Mauer M. Detection of diabetic nephropathy from advanced glycation endproducts (AGEs) differs in plasma and urine, and is dependent on the method of preparation. Amino Acids. 2014;46(2):311-319.

Pamukoff DN, Haakonssen EC, Zaccaria JA, Madigan ML, Miller ME, Marsh AP. The effects of strength and power training on single-step balance recovery in older adults: a preliminary study. Clin Interv Aging. 2014;9():697-704.

Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311(23):2387-2396.

Bryan RN, Bilello M, Davatzikos C, Lazar RM, Murray A, Horowitz K, Lovato J, Miller ME, Williamson J, Launer LJ. Effect of diabetes on brain structure: the action to control cardiovascular risk in diabetes MR imaging baseline data. Radiology. 2014;272(1):210-216.

Beavers KM, Miller ME, Rejeski WJ, Nicklas BJ, Krichevsky SB [sic] [Kritchevsky SB]. Fat mass loss predicts gain in physical function with intentional weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013;68(1):80-86.

Callahan K, Kritchevsky S, Yaffe K, Miller ME, Hire D, Ayonayon H, Cawthon P, Duncan P, Harris T, Rosano C, Satterfield S, Williamson J. Preclinical cognitive impairment: a risk factor for rehospitalization [abstract]. J Am Geriatr Soc. 2013;61(Suppl 1):S106.

Daly M, Vidt ME, Eggebeen JD, Simpson WG, Miller ME, Marsh AP, Saul KR. Upper extremity muscle volumes and functional strength after resistance training in older adults. J Aging Phys Act. 2013;21(2):186-207.

Marsh AP, Shea MK, Vance Locke RM, Miller ME, Isom S, Miller GD, Nicklas BJ, Lyles MF, Carr JJ, Kritchevsky SB. Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013;68(7):828-836.

Shea MK, Booth SL, Miller ME, Burke GL, Chen H, Cushman M, Tracy RP, Kritchevsky SB. Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2013;98(1):197-208.

Rejeski WJ, Axtell R, Fielding R, Katula J, King AC, Manini TM, Marsh AP, Pahor M, Rego A, Tudor-Locke C, Newman M, Walkup MP, Miller ME. Promoting physical activity for elders with compromised function: the Lifestyle Interventions and Independence for Elders (LIFE) Study physical activity intervention. Clin Interv Aging. 2013;8():1119-1131.

Beisswenger PJ, Howell SK, Russell GB, Miller ME, Rich SS, Mauer M. Early progression of diabetic nephropathy correlates with methylglyoxal-derived advanced glycation end products. Diabetes Care. 2013;36(10):3234-3239.

Seaquist ER, Miller ME, Fonseca V, Ismail-Beigi F, Launer LJ, Punthakee Z, Sood A. Effect of thiazolidinediones and insulin on cognitive outcomes in ACCORD-MIND. J Diabetes Complications. 2013;27(5):485-491.

Sullivan MD, Katon WJ, Lovato LC, Miller ME, Murray AM, Horowitz KR, Bryan RN, Gerstein HC, Marcovina S, Akpunonu BE, Johnson J, Yale JF, Williamson J, Launer LJ. Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORD-MIND trial. JAMA Psychiatry. 2013;70(10):1041-1047.

Kritchevsky SB, Miller ME. Designing clinical trials to evaluate new treatments to improve physical function: twenty-years of lessons learned [abstract]. Gerontologist. 2013;53(Suppl 1):102.

Miller ME, Walkup MP, Barnes DE, Johnson KC, Lopez OL, Williamson JD, Pahor M, Espeland MA. Using external data to project the incidence of dementia in the life cohort [abstract]. Gerontologist. 2013;53(Suppl 1):549.

Seaquist ER, Miller ME, Bonds DE, Feinglos M, Goff DC Jr, Peterson K, Senior P. The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study. Diabetes Care. 2012;35(2):409-414.

Vidt ME, Daly M, Miller ME, Davis CC, Marsh AP, Saul KR. Characterizing upper limb muscle volume and strength in older adults: a comparison with young adults. J Biomech. 2012;45(2):334-341.

Punthakee Z, Miller ME, Launer LJ, Williamson JD, Lazar RM, Cukierman-Yaffee T, Seaquist ER, Ismail-Beigi F, Sullivan MD, Lovato LC, Bergenstal RM, Gerstein HC. Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial. Diabetes Care. 2012;35(4):787-793.

Brenes GA, Miller ME, Williamson JD, McCall WV, Knudson M, Stanley MA. A randomized controlled trial of telephone-delivered cognitive-behavioral therapy for late-life anxiety disorders. Am J Geriatr Psychiatry. 2012;20(8):707-716.

Bonds DE, Miller ME, Dudl J, Feinglos M, Ismail-Beigi F, Malozowski S, Seaquist E, Simmons DL, Sood A. Severe hypoglycemia symptoms, antecedent behaviors, immediate consequences and association with glycemia medication usage: secondary analysis of the ACCORD clinical trial data. BMC Endocr Disord. 2012;12():5.

Fragoso C, Miller ME, Endeshaw Y, Rice TB, King A, Kritchevsky SB, Gill TM. Sleep-wake complaints and sleep-apnea risk among older persons with functional limitations (LIFE Study) [abstract]. Gerontologist. 2012;52(Suppl 1):305.

Houston DK, Tooze JA, Hausman DB, Johnson MA, Nicklas BJ, Miller ME, Neiberg RH, Marsh AP, Newman AB, Kritchevsky SB, et al. Change in 25-hydroxyvitamin D and physical performance in older adults. J Gerontol A Biol Sci Med Sci. 2011;66(4):430-436.

Gerstein HC, Miller ME, Genuth S, Ismail-Beigi F, Buse JB, Goff DC Jr, Probstfield JL, Cushman WC, Ginsberg HN, Byington RP, et al. Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med. 2011;364(9):818-828.

Gerstein HC, Miller ME, Rosenberg YD. Intensive glucose lowering and cardiovascular outcomes [reply to letter]. N Engl J Med. 2011;364(23):2264.

Shea MK, Nicklas BJ, Marsh AP, Houston DK, Miller GD, Isom S, Miller ME, Carr JJ, Lyles MF, Kritchevsky SB, et al. The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss. Obesity (Silver Spring). 2011;19(8):1636-1646.

Shea MK, Nicklas BJ, Houston DK, Miller ME, Davis CC, Kitzman DW, Espeland MA, Appel LJ, Kritchevsky SB. The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial. Am J Clin Nutr. 2011;94(3):839-846.

Murray AM, Barzilay JI, Lovato JF, Williamson JD, Miller ME, Marcovina S, Launer LJ. Biomarkers of renal function and cognitive impairment in patients with diabetes. Diabetes Care. 2011;34(8):1827-1832.

Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Cognitive function and fine motor speed in older women with diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging. J Womens Health. 2011;20(10):1435-1443.

Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein H, Ding J, Lovato LC, Lovato J, Coker L, Maldjian J, et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 2011;10(11):969-977.

Marsh AP, Rejeski WJ, Espeland MA, Miller ME, Church TS, Fielding RA, Gill TM, Guralnik JM, Newman AB, Pahor M. Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P). J Gerontol A Biol Sci Med Sci. 2011;66(12):1376-1383.

Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu F-C, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci. 2011;66(11):1226-1237.

Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Domain-specific cognitive function and fine motor speed in women 65 years and older with type 2 diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging [abstract]. Diabetes. 2011;60(Suppl 1):A69-A70.

Shea M, Houston DK, Nicklas B, Miller ME, Messier SP, Espeland MA, Kritchevsky SB. The effect of intentional weight loss on total mortality in older adults: a pooled analysis of two randomized-controlled trials [abstract]. Gerontologist. 2011;51(Suppl 2):518.

Miller ME, Bonds DE, Gerstein HC, Seaquist ER, Bergenstal RM, Calles-Escandon J, Childress RD, Craven TE, Cuddihy RM, Dailey G, et al. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ. 2010;340():b5444.

Phillips EM, Katula J, Miller ME, Walkup MP, Brach JS, King AC, Rejeski WJ, Church T, Fielding RA. Interruption of physical activity because of illness in the Lifestyle Interventions and Independence for Elders Pilot Trial. J Aging Phys Act. 2010;18(1):61-74.

Ambrosius WT, Danis RP, Goff DC Jr, Greven CM, Gerstein HC, Cohen RM, Riddle MC, Miller ME, Buse JB, Perdue LH, et al. Lack of association between thiazolidinediones and macular edema in type 2 diabetes: the ACCORD eye substudy. Arch Ophthalmol. 2010;128(3):312-318.

Shea MK, Houston DK, Nicklas BJ, Messier SP, Davis CC, Miller ME, Harris TB, Kitzman DW, Kennedy K, Kritchevsky SB. The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study. J Gerontol A Biol Sci Med Sci. 2010;65(5):519-525.

Berry MJ, Rejeski WJ, Miller ME, Adair NE, Lang W, Foy CG, Katula JA. A lifestyle activity intervention in patients with chronic obstructive pulmonary disease. Respir Med. 2010;104(6):829-839.

Bonds DE, Miller ME, Bergenstal RM, Buse JB, Byington RP, Cutler JA, Dudl RJ, Ismail-Beigi F, Kimel AR, Hoogwerf B, et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ. 2010;340():b4909.

Alvarez-Munoz P, Mauer M, Kim Y, Rich SS, Miller ME, Russell GB, Lopez-Novoa JM, Caramori ML. Cellular basis of diabetic nephropathy: V. Endoglin expression levels and diabetic nephropathy risk in patients with Type 1 diabetes. J Diabetes Complications. 2010;24(4):242-249.

Shea MK, Kritchevsky S, Miller M. Response to letter: randomized trial of weight loss and total mortality. J Gerontol A Biol Sci Med Sci. 2010;65(8):905.

Chale-Rush A, Guralnik JM, Walkup MP, Miller ME, Rejeski WJ, Katula JA, King AC, Glynn NW, Manini TM, Blair SN, et al. Relationship between physical functioning and physical activity in the Lifestyle Interventions and Independence for Elders pilot. J Am Geriatr Soc. 2010;58(10):1918-1924.

Hsu F-C, Rejeski WJ, Ip EH, Katula JA, Fielding R, Jette AM, Studenski SA, Blair SN, Miller ME. Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Health Qual Life Outcomes. 2010;8():115.

Brenes GA, Miller ME, McCall V, Knudson M, Williamson J, Stanley M. Recruitment of anxious older adults into an RCT of psychotherapy [abstract]. Am J Geriatr Psychiatry. 2010;18(3 Suppl 1):S64-S65.

Rejeski WJ, Marsh AP, Chmelo E, Prescott AJ, Dobrosielski M, Walkup MP, Espeland M, Miller ME, Kritchevsky S. The Lifestyle Interventions and Independence for Elders Pilot (LIFE-P): 2-year follow-up. J Gerontol A Biol Sci Med Sci. 2009;64(4):462-467.

Brinkley TE, Leng X, Miller ME, Kitzman DW, Pahor M, Berry MJ, Marsh AP, Kritchevsky SB, Nicklas BJ. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009;64(4):455-461.

Brenes GA, Miller ME, Stanley MA, Williamson JD, Knudson M, McCall V. Insomnia in older adults with generalized anxiety disorder [abstract]. Am J Geriatr Psychiatry. 2009;17(3 Suppl 1):A57.

Cukierman-Yaffe T, Gerstein HC, Williamson JD, Lazar RM, Lovato L, Miller ME, Coker LH, Murray A, Sullivan MD, Marcovina SM, et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial. Diabetes Care. 2009;32(2):221-226.

Brenes GA, Miller ME, Stanley MA, Williamson JD, Knudson M, McCall WV. Insomnia in older adults with generalized anxiety disorder. Am J Geriatr Psychiatry. 2009;17(6):465-472.

Conaway MR, Rejeski WJ, Miller ME. Statistical issues in measuring adherence: methods for incomplete longitudinal data In: Shumaker SA, Ockene JK, Riekert KA, eds. The handbook of health behavior change. 3rd ed. New York: Springer;2009: 375-391.

Shea MK, Davis CC, Nicklas BJ, Kitzman DW, Miller ME, Kennedy K, Kritchevsky SB. The effect of intentional weight-loss on total mortality in older adults [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S122.

Williamson JD, Espeland M, Kritchevsky SB, Newman AB, King AC, Pahor M, Guralnik JM, Pruitt LA, Miller ME. Changes in cognitive function in a randomized trial of physical activity: results of the Lifestyle Interventions and Independence for Elders pilot study. J Gerontol A Biol Sci Med Sci. 2009;64(6):688-694.

Houston DK, Tooze J, Neiberg R, Hausman D, Johnson MA, Nicklas B, Miller M, Marsh A, Bartali B, Kritchevsky SB, et al. Change in vitamin D status is associated with improved physical performance over one year: the LIFE-P study [abstract]. FASEB J. 2009;23(Meeting Abstracts):108.3.

Marsh AP, Miller ME, Rejeski WJ, Hutton SL, Kritchevsky SB. Lower extremity muscle function after strength or power training in older adults. J Aging Phys Act. 2009;17(4):416-443.

Brenes GA, Knudson M, McCall V, Williamson J, Miller M, Stanley MA. Age and racial differences in the presentation and treatment of generalized anxiety disorder in primary care [abstract]. Am J Geriatr Psychiatry. 2008;16(3 Suppl 1):A88-A89.

Rejeski WJ, King AC, Katula JA, Kritchevsky S, Miller ME, Walkup MP, Glynn NW, Pahor M. Physical activity in prefrail older adults: confidence and satisfaction related to physical function. J Gerontol B Psychol Sci Soc Sci. 2008;63(1):P19-P26.

Rejeski WJ, Ip EH, Marsh AP, Miller ME, Farmer DF. Measuring disability in older adults: the International Classification System of Functioning, Disability and Health (ICF) framework. Geriatr Gerontol Int. 2008;8(1):48-54.

Houston DK, Hausman DB, Johnson MA, Nicklas BJ, Miller ME, Marsh AP, Bartali B, Newman AB, Blair SN, Kritchevsky SB. Vitamin D insufficiency is associated with poorer physical performance: the LIFE-P study [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl):S169.

Kritchevsky SB, Nicklas B, Denise H [sic] [Houston D], Melanie B [sic] [Bopp M], Anthony MP [sic] [Marsh AP], Gary MD [sic] [Miller GD], Lyles MF, Michael ME [sic] [Miller ME], Carr J. Evaluating strategies to optimize the body composition of older adults during voluntary weight loss [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl 1):S162.

Brenes GA, Knudson M, McCall WV, Williamson JD, Miller ME, Stanley MA. Age and racial differences in the presentation and treatment of Generalized Anxiety Disorder in primary care. J Anxiety Disord. 2008;22(7):1128-1136.

Coker LH, Felton D, Andrews LA, Tooze J, Lovato J, Lovato L, Woolard N, Williamson J, Lazar RM, Miller M, et al. Quality assurance of cognitive outcomes in a randomized clinical trial: the Action to Control Cardiovascular Risk in Diabetes--Memory in Diabetes (ACCORD-MIND) trial [abstract]. Clin Trials. 2008;5(4):399-400.

Rejeski WJ, Ip EH, Marsh AP, Zhang Q, Miller ME. Obesity influences transitional states of disability in older adults with knee pain. Arch Phys Med Rehabil. 2008;89(11):2102-2107.

Houston D, Hausman D, Johnson M, Tooze J, Nicklas B, Marsh A, Miller M, Bartali B, Newman A, Kritchevsky S, et al. Vitamin D insufficiency is associated with poorer physical performance over 1 year of follow-up [abstract]. Gerontologist. 2008;48(Special Issue 3):198.

Kritchevsky SB, Nicklas BJ, Lyles MF, Marsh AP, Miller GD, Miller ME, Leng X. Effect of PPAR gamma use during a hypocaloric diet for weight loss on reductions in total and visceral fat in older men and women [abstract]. Diabetes. 2008;57(Suppl 1):A482.

Kritchevsky SB, Leng I, Miller ME, Ding JZ, Kitzman D. DXA derived body composition measures are consistently associated with physical performance across 4 older populations [abstract]. FASEB J. 2007;21(6):A1068.

Williamson JD, Miller ME, Bryan N, Lazar RM, Coker LH, Johnson J, Cukierman T, Horowitz KR, Murray A, Launer LJ. The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods. Am J Cardiol. 2007;99(12 Suppl):112i-122i.

Bonds DE, Kurashige EM, Bergenstal R, Brillon D, Domanski M, Felicetta JV, Fonseca VA, Hall K, Hramiak I, Miller ME, et al. Severe hypoglycemia monitoring and risk management procedures in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am J Cardiol. 2007;99(12A Suppl):80i-89i.

Espeland MA, Gill TM, Guralnik J, Miller ME, Fielding R, Newman AB, Pahor M. Designing clinical trials of interventions for mobility disability: results from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Trial. J Gerontol A Biol Sci Med Sci. 2007;62(11):1237-1243.

Fielding RA, Katula J, Miller ME, Abbott-Pillola K, Jordan A, Glynn NW, Goodpaster B, Walkup MP, King AC, Rejeski WJ. Activity adherence and physical function in older adults with functional limitations. Med Sci Sports Exerc. 2007;39(11):1997-2004.

Bopp M, Nicklas B, Miller G, Miller M, Marsh A, Houston D, Carr JJ, Kritchevsky S. Associations among changes in regional fat depots as a result of weight loss in older obese and overweight women [abstract]. Obesity. 2007;15(Suppl 1):A95.

Katula JA, Rejeski WJ, Miller ME, Walkup M, King A, Glynn N, Frierson G, Kritchevsky S. The impact of physical activity on self-efficacy in older adults at risk for mobility disability: the Life-P study [abstract]. Ann Behav Med. 2007;33(Suppl 1):S190.

Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, Kritchevsky SB, Miller ME, Rejeski WJ, et al. Effects of a physical activity intervention on measures of physical performance: results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study. J Gerontol A Biol Sci Med Sci. 2006;61A(11):1157-1165.

Marsh AP, Miller ME, Saikin AM, Rejeski WJ, Hu N, Lauretani F, Bandinelli S, Guralnik JM, Ferrucci L. Lower extremity strength and power are associated with 400-meter walk time in older adults: the InCHIANTI Study. J Gerontol A Biol Sci Med Sci. 2006;61A(11):1186-1193.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.