Profile

Michael E. Miller, Ph.D.Wake Forest School of Medicine

Michael E. Miller, Ph.D.

Professor,


Contact Information

Academic: 336-716-6837 | Department: 336-716-2011

Email: mmiller@wakehealth.edu

Education & Training

  • B.A., College of Wooster, 1983
  • M.S., University of Cincinnati, 1985
  • Ph.D., University of Michigan/Ann Arbor, 1988

Memberships

  • Soc Of Clinical Trial Research
  • Am Statistical Assn
  • Biometric Society
Michael E. Miller, Ph.D.

Michael E. Miller, Ph.D.

Professor, Biostatistical Sciences
Sticht Center on Aging
Translational Science Institute

Research Interests

aging, cross(mult/tnslat/inter)discip, diabetes, fitness/physical, other, statistics/mathematics

Contact Information

Academic: 336-716-6837 | Department: 336-716-2011

Email: mmiller@wakehealth.edu

Recent Publications

Erus G, Battapady H, Zhang T, Lovato J, Miller ME, Williamson JD, Launer LJ, Bryan RN, Davatzikos C. Spatial patterns of structural brain changes in type 2 diabetic patients and their longitudinal progression with intensive control of blood glucose. Diabetes Care. 2015;38(1):97-104.

Williamson JD, Launer LJ, Miller ME. Faster brain shrinkage in the ACCORD MIND study [reply to letter]. JAMA Intern Med. 2015;175(1):144-145.

Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ. Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. PLoS One. 2015;10(3):e0121993.

Gerstein HC, Miller ME. Effects of intensive glycaemic control on ischaemic heart disease [reply to letter]. Lancet. 2015;385(9974):1180-1181.

Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ. The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Chow LS, Chen H, Miller ME, Marcovina SM, Seaquist ER. Biomarkers related to severe hypoglycaemia and lack of good glycaemic control in ACCORD. Diabetologia. 2015;58(6):1160-1166.

Vaz Fragoso CA, Miller ME, King AC, Kritchevsky SB, Liu CK, Myers VH, Nadkarni NK, Pahor M, Spring BJ, Gill TM. Effect of structured physical activity on sleep-wake behaviors in sedentary elderly adults with mobility limitations. J Am Geriatr Soc. 2015;63(7):1381-1390.

Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. JAMA Intern Med. 2014;174(3):324-333.

Grosicki GJ, Miller ME, Marsh AP. Resistance exercise performance variability at submaximal intensities in older and younger adults. Clin Interv Aging. 2014;9():209-218.

Brenes GA, Danhauer SC, Lyles MF, Miller ME. Telephone-delivered psychotherapy for rural-dwelling older adults with generalized anxiety disorder: study protocol of a randomized controlled trial. BMC Psychiatry. 2014;14():34.

Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB. Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Diabetes Care. 2014;37(3):634-643.

Beisswenger PJ, Howell SK, Russell G, Miller ME, Rich SS, Mauer M. Detection of diabetic nephropathy from advanced glycation endproducts (AGEs) differs in plasma and urine, and is dependent on the method of preparation. Amino Acids. 2014;46(2):311-319.

Pamukoff DN, Haakonssen EC, Zaccaria JA, Madigan ML, Miller ME, Marsh AP. The effects of strength and power training on single-step balance recovery in older adults: a preliminary study. Clin Interv Aging. 2014;9():697-704.

Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311(23):2387-2396.

Bryan RN, Bilello M, Davatzikos C, Lazar RM, Murray A, Horowitz K, Lovato J, Miller ME, Williamson J, Launer LJ. Effect of diabetes on brain structure: the action to control cardiovascular risk in diabetes MR imaging baseline data. Radiology. 2014;272(1):210-216.

Gerstein HC, Miller ME, Ismail-Beigi F, Largay J, McDonald C, Lochnan HA, Booth GL. Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial. Lancet. 2014;384(9958):1936-1941.

Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J. The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Diabetes Care. 2014;37(12):3244-3252.

Punthakee Z, Miller ME, Simmons DL, Riddle MC, Ismail-Beigi F, Brillon DJ, Bergenstal RM, Savage PJ, Hramiak I, Largay JF, Sood A, Gerstein HC. Durable change in glycaemic control following intensive management of type 2 diabetes in the ACCORD clinical trial. Diabetologia. 2014;57(10):2030-2037.

Zhang Z, Lovato J, Battapady H, Davatzikos C, Gerstein HC, Ismail-Beigi F, Launer LJ, Murray A, Punthakee Z, Tirado AA, Williamson J, Bryan RN, Miller ME. Effect of hypoglycemia on brain structure in people with type 2 diabetes: epidemiological analysis of the ACCORD-MIND MRI trial. Diabetes Care. 2014;37(12):3279-3285.

Beavers KM, Miller ME, Rejeski WJ, Nicklas BJ, Krichevsky SB [sic] [Kritchevsky SB]. Fat mass loss predicts gain in physical function with intentional weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013;68(1):80-86.

Callahan K, Kritchevsky S, Yaffe K, Miller ME, Hire D, Ayonayon H, Cawthon P, Duncan P, Harris T, Rosano C, Satterfield S, Williamson J. Preclinical cognitive impairment: a risk factor for rehospitalization [abstract]. J Am Geriatr Soc. 2013;61(Suppl 1):S106.

Daly M, Vidt ME, Eggebeen JD, Simpson WG, Miller ME, Marsh AP, Saul KR. Upper extremity muscle volumes and functional strength after resistance training in older adults. J Aging Phys Act. 2013;21(2):186-207.

Marsh AP, Shea MK, Vance Locke RM, Miller ME, Isom S, Miller GD, Nicklas BJ, Lyles MF, Carr JJ, Kritchevsky SB. Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013;68(7):828-836.

Shea MK, Booth SL, Miller ME, Burke GL, Chen H, Cushman M, Tracy RP, Kritchevsky SB. Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2013;98(1):197-208.

Rejeski WJ, Axtell R, Fielding R, Katula J, King AC, Manini TM, Marsh AP, Pahor M, Rego A, Tudor-Locke C, Newman M, Walkup MP, Miller ME. Promoting physical activity for elders with compromised function: the Lifestyle Interventions and Independence for Elders (LIFE) Study physical activity intervention. Clin Interv Aging. 2013;8():1119-1131.

Beisswenger PJ, Howell SK, Russell GB, Miller ME, Rich SS, Mauer M. Early progression of diabetic nephropathy correlates with methylglyoxal-derived advanced glycation end products. Diabetes Care. 2013;36(10):3234-3239.

Seaquist ER, Miller ME, Fonseca V, Ismail-Beigi F, Launer LJ, Punthakee Z, Sood A. Effect of thiazolidinediones and insulin on cognitive outcomes in ACCORD-MIND. J Diabetes Complications. 2013;27(5):485-491.

Sullivan MD, Katon WJ, Lovato LC, Miller ME, Murray AM, Horowitz KR, Bryan RN, Gerstein HC, Marcovina S, Akpunonu BE, Johnson J, Yale JF, Williamson J, Launer LJ. Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORD-MIND trial. JAMA Psychiatry. 2013;70(10):1041-1047.

Kritchevsky SB, Miller ME. Designing clinical trials to evaluate new treatments to improve physical function: twenty-years of lessons learned [abstract]. Gerontologist. 2013;53(Suppl 1):102.

Miller ME, Walkup MP, Barnes DE, Johnson KC, Lopez OL, Williamson JD, Pahor M, Espeland MA. Using external data to project the incidence of dementia in the life cohort [abstract]. Gerontologist. 2013;53(Suppl 1):549.

Seaquist ER, Miller ME, Bonds DE, Feinglos M, Goff DC Jr, Peterson K, Senior P. The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study. Diabetes Care. 2012;35(2):409-414.

Vidt ME, Daly M, Miller ME, Davis CC, Marsh AP, Saul KR. Characterizing upper limb muscle volume and strength in older adults: a comparison with young adults. J Biomech. 2012;45(2):334-341.

Punthakee Z, Miller ME, Launer LJ, Williamson JD, Lazar RM, Cukierman-Yaffee T, Seaquist ER, Ismail-Beigi F, Sullivan MD, Lovato LC, Bergenstal RM, Gerstein HC. Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial. Diabetes Care. 2012;35(4):787-793.

Brenes GA, Miller ME, Williamson JD, McCall WV, Knudson M, Stanley MA. A randomized controlled trial of telephone-delivered cognitive-behavioral therapy for late-life anxiety disorders. Am J Geriatr Psychiatry. 2012;20(8):707-716.

Bonds DE, Miller ME, Dudl J, Feinglos M, Ismail-Beigi F, Malozowski S, Seaquist E, Simmons DL, Sood A. Severe hypoglycemia symptoms, antecedent behaviors, immediate consequences and association with glycemia medication usage: secondary analysis of the ACCORD clinical trial data. BMC Endocr Disord. 2012;12():5.

Fragoso C, Miller ME, Endeshaw Y, Rice TB, King A, Kritchevsky SB, Gill TM. Sleep-wake complaints and sleep-apnea risk among older persons with functional limitations (LIFE Study) [abstract]. Gerontologist. 2012;52(Suppl 1):305.

Houston DK, Tooze JA, Hausman DB, Johnson MA, Nicklas BJ, Miller ME, Neiberg RH, Marsh AP, Newman AB, Kritchevsky SB, et al. Change in 25-hydroxyvitamin D and physical performance in older adults. J Gerontol A Biol Sci Med Sci. 2011;66(4):430-436.

Gerstein HC, Miller ME, Genuth S, Ismail-Beigi F, Buse JB, Goff DC Jr, Probstfield JL, Cushman WC, Ginsberg HN, Byington RP, et al. Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med. 2011;364(9):818-828.

Gerstein HC, Miller ME, Rosenberg YD. Intensive glucose lowering and cardiovascular outcomes [reply to letter]. N Engl J Med. 2011;364(23):2264.

Shea MK, Nicklas BJ, Marsh AP, Houston DK, Miller GD, Isom S, Miller ME, Carr JJ, Lyles MF, Kritchevsky SB, et al. The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss. Obesity (Silver Spring). 2011;19(8):1636-1646.

Shea MK, Nicklas BJ, Houston DK, Miller ME, Davis CC, Kitzman DW, Espeland MA, Appel LJ, Kritchevsky SB. The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial. Am J Clin Nutr. 2011;94(3):839-846.

Murray AM, Barzilay JI, Lovato JF, Williamson JD, Miller ME, Marcovina S, Launer LJ. Biomarkers of renal function and cognitive impairment in patients with diabetes. Diabetes Care. 2011;34(8):1827-1832.

Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Cognitive function and fine motor speed in older women with diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging. J Womens Health. 2011;20(10):1435-1443.

Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein H, Ding J, Lovato LC, Lovato J, Coker L, Maldjian J, et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 2011;10(11):969-977.

Marsh AP, Rejeski WJ, Espeland MA, Miller ME, Church TS, Fielding RA, Gill TM, Guralnik JM, Newman AB, Pahor M. Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P). J Gerontol A Biol Sci Med Sci. 2011;66(12):1376-1383.

Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu F-C, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci. 2011;66(11):1226-1237.

Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Domain-specific cognitive function and fine motor speed in women 65 years and older with type 2 diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging [abstract]. Diabetes. 2011;60(Suppl 1):A69-A70.

Shea M, Houston DK, Nicklas B, Miller ME, Messier SP, Espeland MA, Kritchevsky SB. The effect of intentional weight loss on total mortality in older adults: a pooled analysis of two randomized-controlled trials [abstract]. Gerontologist. 2011;51(Suppl 2):518.

Miller ME, Bonds DE, Gerstein HC, Seaquist ER, Bergenstal RM, Calles-Escandon J, Childress RD, Craven TE, Cuddihy RM, Dailey G, et al. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ. 2010;340():b5444.

Phillips EM, Katula J, Miller ME, Walkup MP, Brach JS, King AC, Rejeski WJ, Church T, Fielding RA. Interruption of physical activity because of illness in the Lifestyle Interventions and Independence for Elders Pilot Trial. J Aging Phys Act. 2010;18(1):61-74.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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