Profile

Carolanne E. Milligan, Ph.D.Wake Forest School of Medicine

Carolanne E. Milligan, Ph.D.

Professor,


Contact Information

Academic: 336-716-0499 | Department: 336-716-0499

Email: milligan@wakehealth.edu

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Education & Training

  • B.S., Saint Joseph's University, 1985
  • Ph.D., Medical College of Pennsylvania, 1992
  • Fellowship, University of Massachusetts-Am, 1995

Memberships

  • Society for Neuroscience
  • Western Nc Chpt Soc For Neuros
Carolanne E. Milligan, Ph.D.

Carolanne E. Milligan, Ph.D.

Professor, Neurobiology & Anatomy
Maya Angelou Center for Health Equity
Office of Women in Medicine and Science

Research Interests

Motor Neurons; Spinal Cord; Astrocytes; HSP70 Heat-Shock Proteins; Amyotrophic Lateral Sclerosis
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Contact Information

Academic: 336-716-0499 | Department: 336-716-0499

Email: milligan@wakehealth.edu

Related Links

Recent Publications

The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence. Gmeiner WH, Debinski W, Milligan C, Caudell D, Pardee TS.. Future Oncol. 2016;():.

SOD1 nanozyme with reduced toxicity and MPS accumulation. Jiang Y, Arounleut P, Rheiner S, Bae Y, Kabanov AV, Milligan C, Manickam DS.. J Control Release. 2016;231():38-49.

Inducing muscle heat shock protein 70 improves insulin sensitivity and muscular performance in aged mice. Silverstein MG, Ordanes D, Wylie AT, Files DC, Milligan C, Presley TD, Kavanagh K.. J Gerontol A Biol Sci Med Sci. 2015;70(7):800-808.

Isolation and functional analysis of mitochondria from cultured cells and mouse tissue [video article]. Lampl T, Crum JA, Davis TA, Milligan C, Del Gaizo Moore V.. J Vis Exp. 2015;(97):.

Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors. Gmeiner WH, Lema-Tome C, Gibo D, Jennings-Gee J, Milligan C, Debinski W.. J Neurooncol. 2014;116(3):447-454.

Neuronal death and rescue: neurotropic factors and anti-apoptotic mechanisms. Gould TW, Milligan CE. In: Selzer ME, Clarke S, Cohen LG, Kwakkel G, Miller RH, eds. Textbook of neural repair and rehabilitation. 2nd ed. Cambridge: Cambridge University Press;2014: 255-273.

Programmed cell death and neurotrophic factors. Oppenheim RW, Milligan CE, von Bartheld CS. In: Squire LR, Berg D, Bloom FE, Du Lac S, Ghosh A, Spitzer NC, eds. Fundamental neuroscience. 4th ed. Boston: Elsevier/Academic Press;2013: 405-435.

Characterization of early pathogenesis in the SOD1G93A mouse model of ALS: part I, background and methods. Vinsant S, Mansfield C, Jimenez-Moreno R, Moore VDG, Yoshikawa M, Hampton TG, Prevette D, Caress J, Oppenheim RW, Milligan C.. Brain Behav. 2013;3(4):335-350.

Characterization of early pathogenesis in the SOD1G93A mouse model of ALS: part II, results and discussion. Vinsant S, Mansfield C, Jimenez-Moreno R, Moore VDG, Yoshikawa M, Hampton TG, Prevette D, Caress J, Oppenheim RW, Milligan C.. Brain Behav. 2013;3(4):431-457.

Muscle fiber-type regulation of maintenance of neuromuscular junction innervation [abstract]. Milligan C, Strupe J, Mansfield C, Robinson M, Oppenheim R, Rodrigues AZ, Kudo R.. Soc Neurosci Abstr. 2013;():243.19.

Motoneuron programmed cell death in response to proBDNF. Taylor AR, Gifondorwa DJ, Robinson MB, Strupe JL, Prevette D, Johnson JE, Hempstead B, Oppenheim RW, Milligan CE.. Dev Neurobiol. 2012;72(5):699-712.

Administration of recombinant heat shock protein 70 delays peripheral muscle denervation in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Gifondorwa DJ, Jimenz-Moreno R, Hayes CD, Rouhani H, Robinson MB, Strupe JL, Caress J, Milligan C.. Neurol Res Int. 2012;2012():170426.

Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo. Hicks AN, Lorenzetti D, Gilley J, Lu B, Andersson KE, Miligan C, Overbeek PA, Oppenheim R, Bishop CE.. PLoS One. 2012;7(10):e47869.

Proposed BioRepository platform solution for the ALS research community. Sherman A, Bowser R, Grasso D, Power B, Milligan C, Jaffa M, Cudkowicz M.. Amyotroph Lateral Scler. 2011;12(1):11-16.

Mechanisms of the motoneuron stress response and its relevance in neurodegeneration. Robinson MB, Gifondorwa DJ, Milligan C. In: McNeill AS, ed. Neurodegeneration: theory, disorders, and treatments. New York: Nova Biomedical;2011: 45-62.

Isolation and culture of postnatal spinal motoneurons. Milligan C, Gifondorwa D.. Methods Mol Biol. 2011;793(Pt 2):77-85.

Programmed cell death during nervous system development: mechanisms, regulation, functions, and implications for neurobehavioral ontogeny. Oppenheim RW, Milligan C, Sun W. In: Blumberg MS, Freeman JH, Robinson SR, eds. Oxford handbook of developmental behavioral neuroscience. New York: Oxford University Press;2010: 76-107.

A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis. Markert CD, Kim E, Gifondorwa DJ, Childers MK, Milligan CE.. J Med Food. 2010;13(5):1081-1085.

Early changes in ALS: where does the end begin? [abstract]. Oppenheim R, Milligan C.. J Physiol Sci. 2010;60(Suppl 1):S22.

Increased intramuscular nerve branching and inhibition of programmed cell death of chick embryo motoneurons by immunoglobulins from patients with motoneuron disease. Hernandez S, Texido L, Caldero J, Ciutat D, Piedrafita L, Casanovas A, Caress J, Prevette D, Oppenheim RW, Milligan C, et al.. J Neuroimmunol. 2010;229(1-2):157-168.

Programmed cell death. Oppenheim R, Milligan C. In: Squire LR, ed. Encyclopedia of neuroscience, vol 7. Berlin: Elsevier/Academic Press;2009: 1117-1124.

Identification of changes in muscle, neuromuscular junctions and spinal cord at early pre-symptomatic stages in the mutant SOD1 mouse model of ALS may provide novel insight for diagnosis and treatment development [abstract]. Yoshikawa M, Vinsant S, Mansfield CM, Gifondorwa DJ, Pace L, Messi LM [sic] [Messi ML], Caress J, Cartwright M, Delbono O, Oppenheim RW, Milligan CE, et al.. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Motorneuron maintenance in the absence of the JNK1 or JNK2 isoforms [abstract]. Hayes CD, Milligan CE.. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Exogenous Hsc70, but not thermal preconditioning, confers protection to motoneurons subjected to oxidative stress. Robinson MB, Taylor AR, Gifondorwa DJ, Tytell M, Milligan CE.. Dev Neurobiol. 2008;68(1):1-17.

Release of heat shock proteins and their effects when in the extracellular space in the nervous system. Tytell M, Robinson MB, Milligan CE. In: Asea AAA, Brown IR, eds. Heat shock proteins and the brain: implications for neurodegenerative diseases and neuroprotection. Dordrecht (Netherlands): Springer;2008: 257-272.

Fewer active motors per vesicle may explain slowed vesicle transport in chick motoneurons after three days in vitro. Macosko JC, Newbern JM, Rockford J, Chisena EN, Brown CM, Holzwarth GM, Milligan CE.. Brain Res. 2008;1211():6-12.

Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival. Taylor AR, Gifondorwa DJ, Newbern JM, Robinson MB, Strupe JL, Prevette D, Oppenheim RW, Milligan CE.. J Neurosci. 2007;27(3):634-644.

In vitro methods to prepare astrocyte and motoneuron cultures for the investigation of potential in vivo interactions. Taylor AR, Robinson MB, Milligan CE.. Nat Protoc. 2007;2(6):1499-1507.

c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Newbern J, Taylor A, Robinson M, Lively MO, Milligan CE.. Neuroscience. 2007;147(3):680-692.

Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases. Taylor AR, Robinson MB, Gifondorwa DJ, Tytell M, Milligan CE.. Dev Neurobiol. 2007;67(13):1815-1829.

Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis. Gifondorwa DJ, Robinson MB, Hayes CD, Taylor AR, Prevette DM, Oppenheim RW, Caress J, Milligan CE.. J Neurosci. 2007;27(48):13173-80.

Absence of individual JNK isoforms results in altered spinal motoneuron programmed cell death [abstract]. Hayes CD, Gifondorwa DJ, Herdegen TM, Milligan CE.. Soc Neurosci Abstr. 2007;2007(Abstr Viewer):.

Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. Gould TW, Buss RR, Vinsant S, Prevette D, Sun W, Knudson CM, Milligan CE, Oppenheim RW.. J Neurosci. 2006;26(34):8774-8786.

Astrocyte- and muscle-secreated factors differentially regulate motoneuron survival [abstract]. Taylor AR, Robinson MB, Prevette D, Gifondorwa D, Newbern JM, Strupe J, Oppenheim RW, Milligan CE.. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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