Steven B. Mizel, Ph.D., Professor Microbiology and Immunology

Steven B. Mizel, Ph.D.

Professor, Microbiology & Immunology
Translational Science Institute
Translational Science Institute
Infectious Diseases

Contact Information

Academic: 336-716-2216 | Department: 336-716-2011

Email: smizel@wakehealth.edu

Education & Training

A.B., University of California-Berkeley , 1969
Ph.D., Stanford University , 1973
Fellowship, Colorado State University, 1974
Fellowship, Israel, 1976

Memberships

Am Assn Of Advancement Of Scie
Am Assn Of Immunologists
Assn Of Med Schl Dept Chairmen

Steven B. Mizel, Ph.D.

Professor, Microbiology & Immunology Translational Science Institute
Translational Science Institute
Infectious Diseases

Research Interests

drugs/therapeutic agents pharm, immunology/allergy/inflammatio, vaccines

Contact Information

Academic: 336-716-2216 | Department: 336-716-2011

Email: smizel@wakehealth.edu

Recent Publications

Honko AN, Mizel SB, inventors; Wake Forest University Health Sciences, assignee. Use of flagellin in the immunotherapy of Yersinia Pestis. United States patent US 8,198,424. 2012 June 12; Australia patent AU 2005325715. 2012 Jan 19. 2012;():.

Mizel SB, Bates JT. Response to comment on 'Flagellin as an adjuvant: cellular mechanisms and potential' [letter]. J Immunol. 2011;186(3):1299.

Bates JT, Graff AH, Phipps JP, Grayson JM, Mizel SB. Enhanced antigen processing of flagellin fusion proteins promotes the antigen-specific CD8+ T cell response independently of TLR5 and MyD88. J Immunol. 2011;186(11):6255-6262.

Clark KM, Johnson JB, Kock ND, Mizel SB, Parks GD. Parainfluenza virus 5-based vaccine vectors expressing vaccinia virus (VACV) antigens provide long-term protection in mice from lethal intranasal VACV challenge. Virology. 2011;419(2):97-106.

Braxton CL, Puckett SH, Mizel SB, Lyles DS. Protection against lethal vaccinia virus challenge by using an attenuated matrix protein mutant vesicular stomatitis virus vaccine vector expressing poxvirus antigens. J Virol. 2010;84(7):3552-3561.

Delaney KN, Phipps JP, Johnson JB, Mizel SB. A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice. Viral Immunol. 2010;23(2):201-210.

Ahmed M, Puckett S, Arimilli S, Braxton CL, Mizel SB, Lyles DS. Stimulation of human dendritic cells by wild-type and M protein mutant vesicular stomatitis viruses engineered to express bacterial flagellin. J Virol. 2010;84(22):12093-98.

Mizel SB, Bates JT. Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol. 2010;185(10):5677-5682.

Mizel S, Honko AN, inventors; Wake Forest University Health Sciences, assignee. Use of flagellin in the immunotherapy of yersinia pestis. United States patent US 7,794,731. 2010 Sept 14. 2010;():.

Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol. 2009;16(1):21-28.

Weimer ET, Lu H, Kock ND, Wozniak DJ, Mizel SB. A fusion protein vaccine containing OprF epitope 8, OprI, and type A and B flagellins promotes enhanced clearance of nonmucoid Pseudomonas aeruginosa. Infect Immun. 2009;77(6):2356-2366.

Bates JT, Uematsu S, Akira S, Mizel SB. Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. J Immunol. 2009;182(12):7539-7547.

Weimer ET, Ervin SE, Wozniak DJ, Mizel SB. Immunization of young African green monkeys with OprF epitope 8-OprI-type A- and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonas aeruginosa. Vaccine. 2009;27(48):6762-6769.

Bates JT, Honko AN, Graff AH, Kock ND, Mizel SB. Mucosal adjuvant activity of flagellin in aged mice. Mech Ageing Dev. 2008;129(5):271-281.

Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD. Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. J Virol. 2008;82(22):10975-85.

Hickman CL, High KP, Wells JD, Mizel SB. Serum modulation of flagellin-induced human dendritic cell maturation [abstract]. J Immunol. 2006;176(Suppl):S64.

Bates JT, Mizel SB. Flagellin induces a robust innate respiratory immune response in aged mice [abstract]. J Immunol. 2006;176(Suppl):S246-S247.