Profile

Michael J. Morykwas, Ph.D.Wake Forest School of Medicine

Michael J. Morykwas, Ph.D.

Professor,


Contact Information

Academic: 336-716-5848 | Department: 336-716-4171

Email: mmorykwa@wakehealth.edu

Education & Training

  • B.S., University of Detroit-Mercy, 1981
  • M.S., University of Michigan/Ann Arbor, 1983
  • Ph.D., University of Michigan/Ann Arbor, 1988

Memberships

  • New York Academy Of Sciences
  • Am Assn Of Advancement Of Scie
  • Plastic Surgery Research Counc
  • Wound Healing Society
  • Am Burn Assn
  • Am Chemical Society
  • Am Cleft Palate-Craniofacial A
  • Am Soc Of Materials Internatio
  • Am Soc Of Plastic & Reconst.Su
Michael J. Morykwas, Ph.D.

Michael J. Morykwas, Ph.D.

Professor, Plastic & Reconstructive Surgery
Institute for Regenerative Medicine
Biomedical Engineering

Research Interests

Negative-Pressure Wound Therapy; Wound Healing; Resuscitation; Brain Injuries; Bandages
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Contact Information

Academic: 336-716-5848 | Department: 336-716-4171

Email: mmorykwa@wakehealth.edu

Recent Publications

Ameliorating spinal cord injury in an animal model with mechanical tissue resuscitation. Zheng ZL, Morykwas MJ, Tatter S, Gordon S, McGee M, Green H, Argenta LC.. Neurosurgery. 2016;78(6):868-876.

Local fluid transfer regulation in heart extracellular matrix. McGee MP, Morykwas MJ, Jordan JE, Wang R, Argenta LC.. J Physiol Biochem. 2016;72(2):255-268.

Measuring hydraulic conductance and hydration potential of brain extracellular matrix by osmotic stress [abstract]. McGee MP, Morykwas M, Argenta L.. Biophys J. 2016;110(3 Suppl 1):149A-150A.

Mechanical tissue resuscitation increases neuronal expression of brain-derived neurotrophic factor (BDNF) in traumatic brain injury [abstract]. Zheng ZL Morykwas M, Argenta L.. Brain Inj. 2016;30(5-6):675.

Novel nanofiber-based material for endovascular scaffolds. Wang R, Levi-Polyanchenko N, Morykwas M, Argenta L, Wagner WD.. J Biomed Mater Res A. 2015;103(3):1150-1158.

Mechanical tissue resuscitation (MTR): a nonpharmacological approach to treatment of acute myocardial infarction. Jordan JE, Pereira BD, Lane MR, Morykwas MJ, McGee M, Argenta LC.. J Card Surg. 2015;30(8):659-667.

Structural and mechanical characterization of bioresorbable, elastomeric nanocomposites from poly(glycerol sebacate)/nanohydroxyapatite for tissue transport applications. Rosenbalm TN, Teruel M, Day CS, Donati GL, Morykwas M, Argenta L, Kuthirummal N, Levi-Polyachenko N.. J Biomed Mater Res B Appl Biomater. 2015;():.

Spine fusion using a soft elastomeric nanofibrous composite of collagen, poly (1,8-octanediol-co-citrate) and chondroitin 6-sulfate [abstract]. Wagner W, Morykwas M, Argenta L, Campbell D, Wang R.. FASEB J. 2015;29(Suppl 1):1029.15.

Correlating heart interstitium structure and function using hydration and Magnetic Resonance Image (MRI) analyses [abstract]. McGee MP, Morykwas M, Jordan J, Argenta L.. Biophys J. 2015;108(2 Suppl 1):148A.

Properties of single electrospun poly (diol citrate)-collagen-proteoglycan nanofibers for arterial repair and in applications requiring viscoelasticity. Liu J, Argenta L, Morykwas M, Wagner WD.. J Biomater Appl. 2014;28(5):729-738.

Mechanical tissue resuscitation protects against myocardial ischemia-reperfusion injury. Jordan JE, Mays JJ, Shelton JE, Bryant AK, Lane MR, Morykwas MJ, Argenta LC.. J Card Surg. 2014;29(1):116-123.

Interstitial-matrix edema in burns: mechanistic insights from subatmospheric pressure treatment in vivo. McGee MP, Morykwas M, Campbell D, Hoge K, Argenta L.. Wound Repair Regen. 2014;22(1):96-102.

Mechanical tissue resuscitation at the site of traumatic brain injuries reduces the volume of injury and hemorrhage in a swine model. Zheng ZL, Morykwas M, Campbell D, McGee M, Hollingsworth C, Adams F, Mays J, Tatter S, Argenta L.. Neurosurgery. 2014;75(2):152-162.

External fixation assembly and method of use. Webb LX, Argenta LC, Morykwas MJ, inventors; Wake Forest University Health Sciences, assignee.. Monaco patent MC 2,094,179. 2014 Aug 1 (patent also held in Luxembourg, Italy, Ireland, France, Switzerland, Australia, Spain, and EPO). 2014;():.

Water potential of cell microenvironments modulates their proliferation [abstract]. McGee MP, Morykwas M, McCabe E, Kearns M, Argenta L.. Biophys J. 2014;106(2 Suppl 1):174A.

Interstitial-matrix' fluid-fluxes in vivo: subatmospheric pressure reverses hydration-potential in heat-denatured dermis [abstract]. McGee MP, Morykwas M, Hoge K, Campbell D, Argenta L.. Biophys J. 2013;104(2 Suppl 1):336A.

Apparatus and method for wound treatment employing periodic sub-atmospheric pressure. Argenta LO, Morykwas MJ, Webb LX, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 8,377,016. 2013 Feb 19. 2013;():.

Mechanical Tissue Resuscitation (MTR) activates the RISK pathway and widens the therapeutic window for treating acute myocardial infarction [abstract]. Jordan JE, Pereira BD, Morykwas MJ, Lane MR, Mays JI, Colmer G, Hollingsworth C, Argenta LC.. FASEB J. 2013;27():1130.4.

Cerebral blood flow quantification in swine using pseudo-continuous arterial spin labeling. Johnston ME, Zheng Z, Maldjian JA, Whitlow CT, Morykwas MJ, Jung Y.. J Magn Reson Imaging. 2013;38(5):1111-1118.

Interstitial matrix flow-regulation: myocardial fibroblasts respond to colloidosmotic pressure [abstract]. McGee MP, Morykwas M, Wang R, Jordan J, Argenta L.. Circ Res. 2013;113(4 Suppl):A061.

A new method for modulating traumatic brain injury with mechanical tissue resuscitation. Argenta LC, Zheng Z, Bryant A, Tatter SB, Morykwas MJ.. Neurosurgery. 2012;70(5):1281-1295.

Collagen unfolding accelerates water influx, determining hydration in the interstitial matrix. McGee MP, Morykwas M, Shelton J, Argenta L.. Biophys J. 2012;103(10):2157-2166.

Production of a biodegradable electrospun biomaterial with tensile strength and elasticity [abstract]. Wagner WD, Argenta LC, Morykwas MJ, Levi-Polyachenko N.. FASEB J. 2012;26(Meeting Abstracts Suppl):905.2.

Ischemia-reperfusion injury decreases myocardial hydration potential without changing flow resistance in the interstitial matrix [abstract]. McGee MP, Morykwas M, Jordan J, Argenta L.. Circ Res. 2012;111(4 Suppl):235.

Apparatus and method for wound treatment employing periodic sub-atmospheric pressure. Morykwas MJ, Argenta LC, inventors; Wake Forest University Health Sciences, assignee.. Israel patent IL 199,715. 2012 Nov 1. 2012;():.

Device and method for treating central nervous system pathology. Argenta LC, Carroll DL, Levi NH, Liu J, Morykwas MJ, Tatter S, Wagner WD, inventors; Wake Forest University Health Sciences and Wake Forest University, assignees.. United States patent 8,267,960. 2012 Sept 8. 2012;():.

The local pathology of interstitial edema: surface tension increases hydration potential in heat-damaged skin. McGee MP, Morykwas MJ, Argenta LC.. Wound Repair Regen. 2011;19(3):358-367.

External fixation assembly and method of use. Webb LX, Argenta LC, Morykwas MJ, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 7,931,651. 2011 Apr 26. 2011;():.

Development of a biodegradable foam for use in negative pressure wound therapy. Liu J, Morykwas MJ, Argenta LC, Wagner WD.. J Biomed Mater Res B Appl Biomater. 2011;98B(2):316-322.

Directed tissue growth employing reduced pressure. Webb LX, Argenta LC, Morykwas MJ, inventors; Wake Forest University Health Sciences, assignee.. Sweden patent SE 1,517,660. 2011 Aug 24; (patent also held in Germany, Netherlands, Italy, United Kingdom, Austria, Spain, Ireland, Switzerland, Monaco, France, Greece, European Patent Office, Canada). 2011;():.

Reduction of myocardial ischemia-reperfusion injury by mechanical tissue resuscitation using sub-atmospheric pressure. Argenta LC, Morykwas MJ, Mays JJ, Thompson EA, Hammon JW, Jordan JE.. J Card Surg. 2010;25(2):247-252.

Loxoscelism and negative pressure wound therapy (vacuum-assisted closure): an experimental study. Wong SL, Schneider AM, Argenta LC, Morykwas MJ.. Int Wound J. 2010;7(6):488-492.

Fluid transport in the extracellular matrix: kinetic changes induced by metabolic inhibitors [abstract]. McGee MP, Morykwas M, Argenta L.. Biophys J. 2009;96(3 Suppl 1):626a.

Swelling and pressure-volume relationships in the dermis measured by osmotic-stress technique. McGee MP, Morykwas M, Levi-Polyachenko N, Argenta L.. Am J Physiol Regul Integr Comp Physiol. 2009;296(6):R1907-1913.

Biodegradable polymers useful in wound repair requiring negative pressure wound therapy [abstract]. Wagner WD, Liu J, Morykwas M, Argenta L.. FASEB J. 2009;23(Meeting Abstracts):469.7.

Production of a nanocomposite for tissue repair application requiring viscoelasticity [abstract]. Liu J, Argenta L, Morykwas M, Carroll D, Wagner W.. FASEB J. 2009;23(Meeting Abstracts):468.2.

Mechanical tissue resuscitation (MTR) reduces myocardial reperfusion injury [abstract]. Jordan JE, Morykwas MJ, Mays JJ, Thompson EA, Argenta LC.. FASEB J. 2009;23(Meeting Abstracts):793.1.

Loxoscelism and negative pressure wound therapy (vacuum-assisted closure): a clinical case series. Wong SL, Defranzo AJ, Morykwas MJ, Argenta LC.. Am Surg. 2009;75(11):1128-1131.

Controlled negative pressure reduces brain edema and modulates brain metabolites in a brain injury model [abstract]. Argenta L, Morykwas M, Zheng Z-l, Wagner W, Tatter S.. J Neurotrauma. 2008;25(7):930.

Coagulation responses during tissue injury and repair: water potential as an independent variable across biological scales [abstract]. McGee MP, Morykwas M, Argenta L.. In: Abstract Booklet of the 18th Annual Growth Factor and Signal Transduction Symposium: Systems Biology: Integrative, Comparative, and Multi-Scale Modeling; 2008 Sept 18-21; Ames (IA). 2008;():27.

The use of negative-pressure wound therapy (NPWT) in the temporary treatment of soft-tissue injuries associated with high-energy open tibial shaft fractures. Dedmond BT, Kortesis B, Punger K, Simpson J, Argenta J, Kulp B, Morykwas M, Webb LX.. J Orthop Trauma. 2007;21(1):11-17.

Dynamic spring mediated cranioplasty in an experimental model with resorbable foot plates. Sanger C, Argenta A, Morykwas M, Glazier SS, Argenta LC, David LR.. J Craniofac Surg. 2007;18(1):54-59.

Wound treatment employing reduced pressure. Argenta L, Morykwas M, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 7,198,046. 2007 Apr 3. 2007;():.

Wound treatment employing reduced pressure. Argenta L, Morykwas M, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 7,216,651. 2007 May 15. 2007;():.

Vacuum-assisted closure: state of basic research and physiologic foundation. Morykwas MJ, Simpson J, Punger K, Argenta A, Kremers L, Argenta J.. Plast Reconstr Surg. 2006;117(7 Suppl):121S-126S.

Subatmospheric pressure dressings in the temporary treatment of soft tissue injuries associated with type III open tibial shaft fractures in children. Dedmond BT, Kortesis B, Punger K, Simpson J, Argenta J, Kulp B, Morykwas M, Webb LX.. J Pediatr Orthop. 2006;26(6):728-732.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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