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Michael J. Morykwas, Ph.D.Wake Forest School of Medicine

Michael J. Morykwas, Ph.D.

Professor,


Contact Information

Academic: 336-716-5848 | Department: 336-716-4171

Email: mmorykwa@wakehealth.edu

Education & Training

  • B.S., University of Detroit-Mercy, 1981
  • M.S., University of Michigan/Ann Arbor, 1983
  • Ph.D., University of Michigan/Ann Arbor, 1988

Memberships

  • New York Academy Of Sciences
  • Am Assn Of Advancement Of Scie
  • Plastic Surgery Research Counc
  • Wound Healing Society
  • Am Burn Assn
  • Am Chemical Society
  • Am Cleft Palate-Craniofacial A
  • Am Soc Of Materials Internatio
  • Am Soc Of Plastic & Reconst.Su
Michael J. Morykwas, Ph.D.

Michael J. Morykwas, Ph.D.

Professor, Plastic & Reconstructive Surgery
Institute for Regenerative Medicine
Biomedical Engineering

Research Interests

Negative-Pressure Wound Therapy; Resuscitation; Wound Healing; Brain Injuries; Myocardial Reperfusion Injury
More »

Contact Information

Academic: 336-716-5848 | Department: 336-716-4171

Email: mmorykwa@wakehealth.edu

Recent Publications

Age-dependent changes in brain hydration and synaptic plasticity. Vashisht A, Morykwas M, Hegde AN, Argenta L, McGee MP.. Brain Res. 2018;1680():46-53.

Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage. Carroll DL, Jordan JE, Argenta LC, Morykwas MJ, Wagner WD, inventors; Wake Forest University Health Sciences, assignee.. Germany patent DE 2,313,008. 2017 Apr 12 (patent also held in Austria, France, Netherlands, Switzerland, United Kingdom, and European patent office. 2017;():.

Application of localized sub-atmospheric pressure to the brain and spinal cord. Morykwas MJ, Argenta LC, Tatter SB, inventors; Wake Forest University Health Sciences, assignee.. Israel patent IL 206899. 2017 Mar 30. 2017;():.

Device and method for treating central nervous system pathology. Argenta LC, Morykwas MJ, Tatter SB, inventors; Wake Forest University Health Sciences, assignee.. Australia patent AU 2.01E+09. 2017 Apr 20. 2017;():.

External fixation assembly and method of use. Argenta LC, Morykwas MJ, Webb LX, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9,566,089. 2017 Feb 14. 2017;():.

Hydration control in brain extracellular matrix: astrocytes, perycites, and fibroblasts adjust their contractile responses to local water activity [abstract]. McGee MP, Kearns M, Morykwas M, Argenta L.. Biophys J. 2017;112(3 Suppl 1):437A.

Structural and mechanical characterization of bioresorbable, elastomeric nanocomposites from poly(glycerol sebacate)/nanohydroxyapatite for tissue transport applications. Rosenbalm TN, Teruel M, Day CS, Donati GL, Morykwas M, Argenta L, Kuthirummal N, Levi-Polyachenko N.. J Biomed Mater Res B Appl Biomater. 2016;104(7):1366-1373.

Ameliorating spinal cord injury in an animal model with mechanical tissue resuscitation. Zheng ZL, Morykwas MJ, Tatter S, Gordon S, McGee M, Green H, Argenta LC.. Neurosurgery. 2016;78(6):868-876.

Local fluid transfer regulation in heart extracellular matrix. McGee MP, Morykwas MJ, Jordan JE, Wang R, Argenta LC.. J Physiol Biochem. 2016;72(2):255-268.

Measuring hydraulic conductance and hydration potential of brain extracellular matrix by osmotic stress [abstract]. McGee MP, Morykwas M, Argenta L.. Biophys J. 2016;110(3 Suppl 1):149A-150A.

Mechanical tissue resuscitation increases neuronal expression of brain-derived neurotrophic factor (BDNF) in traumatic brain injury [abstract]. Zheng ZL Morykwas M, Argenta L.. Brain Inj. 2016;30(5-6):675.

Novel nanofiber-based material for endovascular scaffolds. Wang R, Levi-Polyanchenko N, Morykwas M, Argenta L, Wagner WD.. J Biomed Mater Res A. 2015;103(3):1150-1158.

Mechanical tissue resuscitation (MTR): a nonpharmacological approach to treatment of acute myocardial infarction. Jordan JE, Pereira BD, Lane MR, Morykwas MJ, McGee M, Argenta LC.. J Card Surg. 2015;30(8):659-667.

Spine fusion using a soft elastomeric nanofibrous composite of collagen, poly (1,8-octanediol-co-citrate) and chondroitin 6-sulfate [abstract]. Wagner W, Morykwas M, Argenta L, Campbell D, Wang R.. FASEB J. 2015;29(Suppl 1):1029.15.

Correlating heart interstitium structure and function using hydration and Magnetic Resonance Image (MRI) analyses [abstract]. McGee MP, Morykwas M, Jordan J, Argenta L.. Biophys J. 2015;108(2 Suppl 1):148A.

Properties of single electrospun poly (diol citrate)-collagen-proteoglycan nanofibers for arterial repair and in applications requiring viscoelasticity. Liu J, Argenta L, Morykwas M, Wagner WD.. J Biomater Appl. 2014;28(5):729-738.

Mechanical tissue resuscitation protects against myocardial ischemia-reperfusion injury. Jordan JE, Mays JJ, Shelton JE, Bryant AK, Lane MR, Morykwas MJ, Argenta LC.. J Card Surg. 2014;29(1):116-123.

Interstitial-matrix edema in burns: mechanistic insights from subatmospheric pressure treatment in vivo. McGee MP, Morykwas M, Campbell D, Hoge K, Argenta L.. Wound Repair Regen. 2014;22(1):96-102.

Mechanical tissue resuscitation at the site of traumatic brain injuries reduces the volume of injury and hemorrhage in a swine model. Zheng ZL, Morykwas M, Campbell D, McGee M, Hollingsworth C, Adams F, Mays J, Tatter S, Argenta L.. Neurosurgery. 2014;75(2):152-162.

External fixation assembly and method of use. Webb LX, Argenta LC, Morykwas MJ, inventors; Wake Forest University Health Sciences, assignee.. Monaco patent MC 2,094,179. 2014 Aug 1 (patent also held in Luxembourg, Italy, Ireland, France, Switzerland, Australia, Spain, and EPO). 2014;():.

Water potential of cell microenvironments modulates their proliferation [abstract]. McGee MP, Morykwas M, McCabe E, Kearns M, Argenta L.. Biophys J. 2014;106(2 Suppl 1):174A.

Interstitial-matrix' fluid-fluxes in vivo: subatmospheric pressure reverses hydration-potential in heat-denatured dermis [abstract]. McGee MP, Morykwas M, Hoge K, Campbell D, Argenta L.. Biophys J. 2013;104(2 Suppl 1):336A.

Apparatus and method for wound treatment employing periodic sub-atmospheric pressure. Argenta LO, Morykwas MJ, Webb LX, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 8,377,016. 2013 Feb 19. 2013;():.

Mechanical Tissue Resuscitation (MTR) activates the RISK pathway and widens the therapeutic window for treating acute myocardial infarction [abstract]. Jordan JE, Pereira BD, Morykwas MJ, Lane MR, Mays JI, Colmer G, Hollingsworth C, Argenta LC.. FASEB J. 2013;27():1130.4.

Cerebral blood flow quantification in swine using pseudo-continuous arterial spin labeling. Johnston ME, Zheng Z, Maldjian JA, Whitlow CT, Morykwas MJ, Jung Y.. J Magn Reson Imaging. 2013;38(5):1111-1118.

Interstitial matrix flow-regulation: myocardial fibroblasts respond to colloidosmotic pressure [abstract]. McGee MP, Morykwas M, Wang R, Jordan J, Argenta L.. Circ Res. 2013;113(4 Suppl):A061.

A new method for modulating traumatic brain injury with mechanical tissue resuscitation. Argenta LC, Zheng Z, Bryant A, Tatter SB, Morykwas MJ.. Neurosurgery. 2012;70(5):1281-1295.

Collagen unfolding accelerates water influx, determining hydration in the interstitial matrix. McGee MP, Morykwas M, Shelton J, Argenta L.. Biophys J. 2012;103(10):2157-2166.

Production of a biodegradable electrospun biomaterial with tensile strength and elasticity [abstract]. Wagner WD, Argenta LC, Morykwas MJ, Levi-Polyachenko N.. FASEB J. 2012;26(Meeting Abstracts Suppl):905.2.

Ischemia-reperfusion injury decreases myocardial hydration potential without changing flow resistance in the interstitial matrix [abstract]. McGee MP, Morykwas M, Jordan J, Argenta L.. Circ Res. 2012;111(4 Suppl):235.

Apparatus and method for wound treatment employing periodic sub-atmospheric pressure. Morykwas MJ, Argenta LC, inventors; Wake Forest University Health Sciences, assignee.. Israel patent IL 199,715. 2012 Nov 1. 2012;():.

Device and method for treating central nervous system pathology. Argenta LC, Carroll DL, Levi NH, Liu J, Morykwas MJ, Tatter S, Wagner WD, inventors; Wake Forest University Health Sciences and Wake Forest University, assignees.. United States patent 8,267,960. 2012 Sept 8. 2012;():.

The local pathology of interstitial edema: surface tension increases hydration potential in heat-damaged skin. McGee MP, Morykwas MJ, Argenta LC.. Wound Repair Regen. 2011;19(3):358-367.

External fixation assembly and method of use. Webb LX, Argenta LC, Morykwas MJ, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 7,931,651. 2011 Apr 26. 2011;():.

Development of a biodegradable foam for use in negative pressure wound therapy. Liu J, Morykwas MJ, Argenta LC, Wagner WD.. J Biomed Mater Res B Appl Biomater. 2011;98B(2):316-322.

Directed tissue growth employing reduced pressure. Webb LX, Argenta LC, Morykwas MJ, inventors; Wake Forest University Health Sciences, assignee.. Sweden patent SE 1,517,660. 2011 Aug 24; (patent also held in Germany, Netherlands, Italy, United Kingdom, Austria, Spain, Ireland, Switzerland, Monaco, France, Greece, European Patent Office, Canada). 2011;():.

Reduction of myocardial ischemia-reperfusion injury by mechanical tissue resuscitation using sub-atmospheric pressure. Argenta LC, Morykwas MJ, Mays JJ, Thompson EA, Hammon JW, Jordan JE.. J Card Surg. 2010;25(2):247-252.

Loxoscelism and negative pressure wound therapy (vacuum-assisted closure): an experimental study. Wong SL, Schneider AM, Argenta LC, Morykwas MJ.. Int Wound J. 2010;7(6):488-492.

Fluid transport in the extracellular matrix: kinetic changes induced by metabolic inhibitors [abstract]. McGee MP, Morykwas M, Argenta L.. Biophys J. 2009;96(3 Suppl 1):626a.

Swelling and pressure-volume relationships in the dermis measured by osmotic-stress technique. McGee MP, Morykwas M, Levi-Polyachenko N, Argenta L.. Am J Physiol Regul Integr Comp Physiol. 2009;296(6):R1907-1913.

Biodegradable polymers useful in wound repair requiring negative pressure wound therapy [abstract]. Wagner WD, Liu J, Morykwas M, Argenta L.. FASEB J. 2009;23(Meeting Abstracts):469.7.

Production of a nanocomposite for tissue repair application requiring viscoelasticity [abstract]. Liu J, Argenta L, Morykwas M, Carroll D, Wagner W.. FASEB J. 2009;23(Meeting Abstracts):468.2.

Mechanical tissue resuscitation (MTR) reduces myocardial reperfusion injury [abstract]. Jordan JE, Morykwas MJ, Mays JJ, Thompson EA, Argenta LC.. FASEB J. 2009;23(Meeting Abstracts):793.1.

Loxoscelism and negative pressure wound therapy (vacuum-assisted closure): a clinical case series. Wong SL, Defranzo AJ, Morykwas MJ, Argenta LC.. Am Surg. 2009;75(11):1128-1131.

Controlled negative pressure reduces brain edema and modulates brain metabolites in a brain injury model [abstract]. Argenta L, Morykwas M, Zheng Z-l, Wagner W, Tatter S.. J Neurotrauma. 2008;25(7):930.

Coagulation responses during tissue injury and repair: water potential as an independent variable across biological scales [abstract]. McGee MP, Morykwas M, Argenta L.. In: Abstract Booklet of the 18th Annual Growth Factor and Signal Transduction Symposium: Systems Biology: Integrative, Comparative, and Multi-Scale Modeling; 2008 Sept 18-21; Ames (IA). 2008;():27.

The use of negative-pressure wound therapy (NPWT) in the temporary treatment of soft-tissue injuries associated with high-energy open tibial shaft fractures. Dedmond BT, Kortesis B, Punger K, Simpson J, Argenta J, Kulp B, Morykwas M, Webb LX.. J Orthop Trauma. 2007;21(1):11-17.

Dynamic spring mediated cranioplasty in an experimental model with resorbable foot plates. Sanger C, Argenta A, Morykwas M, Glazier SS, Argenta LC, David LR.. J Craniofac Surg. 2007;18(1):54-59.

Wound treatment employing reduced pressure. Argenta L, Morykwas M, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 7,198,046. 2007 Apr 3. 2007;():.

Wound treatment employing reduced pressure. Argenta L, Morykwas M, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 7,216,651. 2007 May 15. 2007;():.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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