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Chor Yin Ng, Ph.D.Wake Forest School of Medicine

Chor Yin Ng, Ph.D.

Associate Professor,

Clinical Interests

Genetic Factors in Kidney Disease and Diabetes, Genetics, Cardiovascular Disease Preventions and Genetics

Contact Information

Academic: 336-716-6310 | Department: 336-716-2011

Email: mng@wakehealth.edu

Additional Languages

Chinese-Cantonese

Education & Training

  • Ph.D., The Chinese University of Hong Kong, 1997
  • Fellowship, The Chinese Univ of Hong Kong, 1999

Memberships

  • Am Soc of Human Genetics
Chor Yin Ng, Ph.D.

Chor Yin Ng, Ph.D.

Associate Professor, Center for Genomics and Personalized Medicine Research

Research Interests

Transcription Factors; Muscle Proteins; Asian Continental Ancestry Group; Polymorphism, Single Nucleotide; Homeodomain Proteins
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Contact Information

Academic: 336-716-6310 | Department: 336-716-2011

Email: mng@wakehealth.edu

Recent Publications

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF,.. Nat Genet. 2018;50(1):26-41.

The African Descent and Glaucoma Evaluation Study (ADAGES) III: contribution of genotype to glaucoma phenotype in African Americans: study design and baseline data. Zangwill LM, Ayyagari R, Liebmann JM, Girkin CA, Feldman R, Dubiner H, Dirkes KA, Holmann M, Williams-Steppe E, Hammel N, Saunders LJ, Vega S, Sandow K, Roll K, Slight R, Auerbach D, Samuels BC, Panarelli JF, Mitchell JP, Al-Aswad LA,.. Ophthalmology. 2018;():.

Genetic variants in sex hormone pathways and the risk of type 2 diabetes among African-American, Hispanic-American, and European-American postmenopausal women in the United States. Goto A, Chen BH, Chan KK, Lee C, Nelson SC, Crenshaw A, Bookman E, Margolis KL, Sale MM, Ng MCY, Reiner AP, Liu S.. J Diabetes. 2018;():.

Metabolomics identifies distinctive metabolite signatures for measures of glucose homeostasis: the Insulin Resistance Atherosclerosis Family Study (IRAS-FS). Palmer ND, Okut H, Hsu FC, Ng MCY, Ida Chen YD, Goodarzi MO, Taylor KD, Norris JM, Lorenzo C, Rotter JI, Bergman RN, Langefeld CD, Wagenknecht LE, Bowden DW.. J Clin Endocrinol Metab. 2018;():.

Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. J Hum Genet. 2017;62(2):175-184.

Analysis of whole exome sequencing with cardiometabolic traits using family-based linkage and association in the IRAS Family Study. Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW.. Ann Hum Genet. 2017;81(2):49-58.

Rare and low-frequency coding variants alter human adult height. Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rueger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NG,.. Nature. 2017;542(7640):186-190.

A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women. Haddad SA, Palmer JR, Lunetta KL, Ng MC, Ruiz-Narvaez EA.. PLoS One. 2017;12(3):e0172577.

Genetics of type 2 diabetes in U.S. Hispanic/Latino individuals: results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Qi Q, Stilp AM, Sofer T, Moon JY, Hidalgo B, Szpiro AA, Wang T, Ng MC, Guo X, Ida Chen YD, Taylor KD, Aviles-Santa ML, Papanicolaou G, Pankow JS, Schneiderman N, Laurie CC, Rotter JI, Kaplan RC.. Diabetes. 2017;66(5):1419-1425.

A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk. Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Vinuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK, Teslovich TM, Blackwell TW,.. Diabetes. 2017;66(7):2019-2032.

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G,.. PLoS Genet. 2017;13(4):e1006719.

Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms. Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, Centeno-Cruz F, Zerrweck C,.. Cell. 2017;170(1):.

Discovery and fine-mapping of type 2 diabetes susceptibility loci across diverse populations [abstract]. Below JE, Kitajima H, Mahajan A, Sim XL, Ng M, Zhang WH, Taliun D, Gaulton KJ, Morris AP.. Genet Epidemiol. 2017;41(7):650.

Discovery and fine-mapping of type 2 diabetes susceptibility loci across diverse population [abstract]. Kitajima H, Mahajan A, Sim X, Ng MC, Zhang W, Below JE, Taliun D, Gaulton KJ, Morris AP.. Diabetologia. 2017;60(Suppl 1):S8.

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE,.. Sci Data. 2017;4():170179.

Genetic and clinical variables identify predictors for chronic kidney disease in type 2 diabetes. Jiang G, Hu C, Tam CH, Lau ES, Wang Y, Luk AO, Yang X, Kong AP, Ho JS, Lam VK, Lee HM, Wang J, Zhang R, Tsui SK, Ng MC, Szeto CC, Jia W, Fan X, So WY, Chan JC, Ma RC.. Kidney Int. 2016;89(2):411-420.

Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM,.. Hum Genet. 2016;135(8):869-880.

Trans-ethnic meta-analysis and functional annotation illuminates the genetic architecture of fasting glucose and insulin. Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen WM, Dauriz M,.. Am J Hum Genet. 2016;99(1):56-75.

Association analysis of the cubilin (CUBN) and megalin (LRP2) genes with ESRD in African Americans. Ma J, Guan M, Bowden DW, Ng MC, Hicks PJ, Lea JP, Ma L, Gao C, Palmer ND, Freedman BI.. Clin J Am Soc Nephrol. 2016;11(6):1034-1043.

The genetic architecture of type 2 diabetes. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Fernandez Tajes J, Highland HM,.. Nature. 2016;536(7614):41-47.

Association of kidney structure-related gene variants with type 2 diabetes-attributed end-stage kidney disease in African Americans. Guan M, Ma J, Keaton JM, Dimitrov L, Mudgal P, Stromberg M, Bonomo JA, Hicks PJ, Freedman BI, Bowden DW, Ng MC.. Hum Genet. 2016;135(11):1251-1262.

Genome-wide interaction with insulin secretion loci reveals novel loci for type 2 diabetes in African Americans. Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YD, Taylor KD, Rich SS, Wagenknecht LE, Freedman B, Bowden DW.. PLoS One. 2016;11(7):e0159977.

Genome-wide interaction with selected type 2 diabetes loci reveals novel loci for type 2 diabetes in African Americans. Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YI, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW.. Pac Symp Biocomput. 2016;22():242-253.

Lack of association of the APOL1 G3 haplotype in African Americans with ESRD. Palmer ND, Ng MC, Langefeld CD, Divers J, Lea JP, Okusa MD, Kimberly RP, Bowden DW, Freedman BI.. J Am Soc Nephrol. 2015;26(5):1021-1025.

Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW.. Hum Genet. 2015;134(2):203-213.

Genome-wide gene-gene interaction with insulin secretion loci reveals novel loci contributing to type 2 diabetes etiology in African Americans [abstract]. Keaton JM, Ng MC, Palmer N, Pankow J, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW.. Diabetes. 2015;64(Suppl 1):A465.

Genetics of type 2 diabetes in African Americans. Ng MC.. Curr Diab Rep. 2015;15(10):74.

Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease. Palmer ND, Ng MC, Hicks PJ, Mudgal P, Langefeld CD, Freedman BI, Bowden DW.. PLoS One. 2014;9(2):e88273.

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Mahajan A, Go MJ, Zhang W, Below JE,Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, NG MCY, Prokopenko I, Saleheen D, Wang XU, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Anung T, Baldassarre D, Balkau B, Bao Y.. Nat Genet. 2014;46(3):234-244.

Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study. Cox AJ, Hsu FC, Ng MC, Langefeld CD, Freedman BI, Carr JJ, Bowden DW.. Diabetes Care. 2014;37(4):1157-1164.

Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes. Wang Y, Luk AO, Ng MCY, Pang CC, Lam V, Lee SC, Lam DS, Choy KW, Ma RC, So WY, Chan JC.. J Diabetes Complications. 2014;28(2):147-151.

Analysis of common and coding variants with cardiovascular disease in the diabetes heart study. Adams JN, Raffield LM, Freedman BI, Langefeld CD, Ng MC, Carr JJ, Cox AJ, Bowden DW.. Cardiovasc Diabetol. 2014;13(1):77.

Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk. Hellwege JN, Palmer ND, Raffield LM, Ng MC, Hawkins GA, Long J, Lorenzo C, Norris JM, Ida Chen YD, Speliotes EK, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. Genet Epidemiol. 2014;38(4):345-352.

Analysis of coding variants identified from exome sequencing resources for association with diabetic and non-diabetic nephropathy in African Americans. Cooke Bailey JN, Palmer ND, Ng MC, Bonomo JA, Hicks PJ, Hester JM, Langefeld CD, Freedman BI, Bowden DW.. Hum Genet. 2014;133(6):769-779.

Coding variants in nephrin (NPHS1) and susceptibility to nephropathy in African Americans. Bonomo JA, Ng MC, Palmer ND, Keaton JM, Larsen CP, Hicks PJ, Langefeld CD, Freedman BI, Bowden DW.. Clin J Am Soc Nephrol. 2014;9(8):1434-1440.

The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. Bonomo JA, Guan M, Ng MC, Palmer ND, Hicks PJ, Keaton JM, Lea JP, Langefeld CD, Freedman BI, Bowden DW.. Hum Mol Genet. 2014;23(24):6441-6447.

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL, Wagenknecht L, Yang L, Snively BM, Palmer ND, Mudgal P,.. PLoS Genet. 2014;10(8):e1004517.

A comparison of type 2 diabetes risk allele load between African Americans and European Americans. Keaton JM, Cooke Bailey JN, Palmer ND, Freedman BI, Langefeld CD, Ng MC, Bowden DW.. Hum Genet. 2014;133(12):1487-1495.

The apolipoprotein L1 gene G3 haplotype is not associated with end-stage kidney disease (ESKD) in African Americans [abstract]. Palmer ND, Ng M, Langefeld CD, Divers J, Lea JP, Okusa MD, Kimberly RP, Bowden DW, Freedman BI.. J Am Soc Nephrol. 2014;25(Abstract Suppl):416A.

Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes. Ma RC, So WY, Tam CH, Luk AO, Ho JS, Wang Y, Lam VK, Lee HM, Kong AP, Tong PC, Xu G, Chow CC, Ng MC, Yang XL, Chan JC.. Diabetes Res Clin Pract. 2014;103(2):328-337.

Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese. Ma RC, Lee HM, Lam VK, Tam CH, Ho JS, Zhao HL, Guan J, Kong AP, Lau E, Zhang G, Luk A, Wang Y, Tsui SK, Chan TF, Hu C, Jia WP, Park KS, Lee HK, Furuta H, Nanjo K, Tai ES, Ng DP, Tang NL, Woo J, Leung PC, Xue H, Wong J, Leung PS, Lau TC, Tong PC,.. PLoS One. 2014;9(1):e84770.

Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study. Ng MCY, Saxena R, Li J, Palmer ND, Dimitrov L, Xu J, Rasmussen-Torvik LJ, Zmuda JM, Siscovick DS, Patel SR, Crook ED, Sims M, Chen YD, Bertoni AG, Li M, Grant SF, Dupuis J, Meigs JB, Psaty BM, Pankow JS, Langefeld CD,.. Diabetes. 2013;62(3):965-976.

Role of DNA secondary structures in fragile site breakage along human chromosome 10. Dillon LW, Pierce LC, Ng MCY, Wang Y-H.. Hum Mol Genet. 2013;22(7):1443-1456.

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Monda KL, Chen GK, Taylor KC, Ng MCY, Liu Y, Freedman BI, Howard TD, Langefeld CD, Lohman K, Palmer ND, Shriner DA, Burke G, Ding J, et al.. Nat Genet. 2013;45(6):690-696.

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Ma RC, Hu C, Tam CH, Zhang R, Kwan P, Leung TF, Thomas GN, Go MJ, Hara K, Sim X, Ho JS, Wang C, Li H, Lu L, Wang Y, Li JW, Wang Y, Lam VK, Wang J, Yu W, Kim YJ, Ng DP, Fujita H, Panoutsopoulou K, Day-Williams AG,.. Diabetologia. 2013;56(6):1291-1305.

Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. Raffield LM, Cox AJ, Hsu FC, Ng MC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW.. Cardiovasc Diabetol. 2013;12():95.

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC, Bowden DW.. Atherosclerosis. 2013;229(1):155-160.

RREB1, a modulator of the renin-angiotensin system (RAS), is a novel nephropathy gene in African Americans [abstract]. Bonomo JA, Ng M, Freedman BI, Bowden DW.. J Am Soc Nephrol. 2013;24(Abstract Suppl):248A.

Novel coding variants in NPHS1 are associated with diabetic and all-cause end-stage kidney disease (ESKD) in African Americans [abstract]. Bonomo JA, Ng M, Palmer ND, Freedman BI, Bowden DW.. J Am Soc Nephrol. 2013;24(Abstract Suppl):712A.

Is genetic testing of value in predicting and treating obesity? [invited commentary]. Ng MC, Bowden DW.. N C Med J. 2013;74(6):530-533.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Center for Genomics and Personalized Medicine Research

Clinical Interests

Genetic Factors in Kidney Disease and Diabetes, Genetics, Cardiovascular Disease Preventions and Genetics
Chor Yin Ng, Ph.D.

Chor Yin Ng, Ph.D.

Associate Professor, Center for Genomics and Personalized Medicine Research

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