Profile

Barbara Nicklas, Ph.D.Wake Forest School of Medicine

Barbara Nicklas, Ph.D.

Deputy Director,
Professor,

Contact Information

Academic: 336-713-8584 | Department: 336-713-8570

Education & Training

  • B.S.E., Truman State University, 1983
  • M.S., Iowa State University, 1987
  • Ph.D., University of Maryland-College Park, 1994
  • Fellowship, Geriatric Medicine, University of Maryland-Baltimo, 1994
  • Fellowship, Geriatric Medicine, University of Maryland-Baltimo, 1996

Memberships

  • Am Coll Of Sports Medicine
  • Am Diabetes Assn
  • Am Physiological Society
  • Gerontological Society Of Amer
Barbara Nicklas, Ph.D.

Barbara Nicklas, Ph.D.

Deputy Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Center on Diabetes, Obesity, and Metabolism

Research Interests

aging, arthritis, fitness/physical, nutrition, physical/muscular function

Contact Information

Academic: 336-713-8584 | Department: 336-713-8570

Recent Publications

Jefferson ME, Nicklas BJ, Chmelo EA, Crotts CI, Shaltout HA, Diz DI, Marsh AP, Brinkley TE. Effects of resistance training with and without caloric restriction on arterial stiffness in overweight and obese older adults. Am J Hypertens. 2016;29(4):494-500.

Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O. Intramyocellular lipid and impaired myofiber contraction in normal weight and obese older adults. J Gerontol A Biol Sci Med Sci. 2016;71(4):557-564.

Irby MB, Bond DS, Lipton RB, Nicklas B, Houle TT, Penzien DB. Aerobic exercise for reducing migraine burden: mechanisms, markers, and models of change processes. Headache. 2016;56(2):357-369.

Sergeant S, Ruczinski I, Ivester P, Lee TC, Morgan TM, Nicklas BJ, Mathias RA, Chilton FH. Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. Br J Nutr. 2016;115(2):251-261.

Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G [sic] [Hundley WG], Kraus WE, Eggebeen J, Nicklas BJ. Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2016;315(1):36-46.

Sohl SJ, Danhauer SC, Birdee GS, Nicklas BJ, Yacoub G, Aklilu M, Avis NE. A brief yoga intervention implemented during chemotherapy: a randomized controlled pilot study. Complement Ther Med. 2016;25():139-142.

Chmelo EA, Beavers DP, Lyles MF, Marsh AP, Nicklas BJ, Beavers KM. Legacy effects of short-term intentional weight loss on total body and thigh composition in overweight and obese older adults. Nutr Diabetes. 2016;6():e203.

Loeser R, Pathmasiri W, Sumner SJ, McRitchie S, Beavers D, Saxena P, Nicklas BJ, Jordan J, Guermazi A, Hunter DJ, Messier SP. Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study. Osteoarthritis Cartilage. 2016;():.

Messier SP, Beavers D, Mihalko SL, Miller GD, Nicklas BJ, Lyles M, Hunter DJ, Carr JJ, Eckstein F, Guermazi A, Loeser RF, DeVita P. Does long-term intensive diet and exercise reduce the biomechanical burden in overweight and obese adults with knee osteoarthritis? The Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Osteoarthritis Cartilage. 2016;24(Suppl):S47-S48.

Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW. Skeletal muscle mitochondrial content, oxidative capacity, and Mfn2 expression are reduced in older patients with heart failure and preserved ejection fraction and are related to exercise intolerance. JACC Heart Fail. 2016;():.

Murillo ALP, Wirth W, Beavers DP, Dannhauer T, Loeser RF Jr, Nicklas BJ, Mihalko SL, Miller GD, Hunter DJ, Eckstein F, Messier SP. At which location is the infrapatellar fat pad most sensitive to reduction by diet and exercise intervention - data from the Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Osteoarthritis Cartilage. 2016;24(Suppl):S242.

Loeser R, Beavers D, Bay-Jensen AC, Karsdal M, Nicklas B, Hunter D, Messier S. Effects of exercise and weight loss on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis Trial (IDEA) [abstract]. Osteoarthritis Cartilage. 2016;24(Suppl):S32-S33.

Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP. Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure: a randomized clinical trial. JAMA. 2016;315(24):2694-2702.

Dougherty A, Brinkley TE, Lyles MF, Nicklas BJ, Williams JA, Hugenschmidt CE. Insulin resistance correlations with executive functioning in sedentary older adults: the INFINITE study [abstract]. J Am Geriatr Soc. 2016;64(Suppl 1):S262-S263.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. Respirometric profiling of muscle mitochondria and blood cells are associated with differences in gait speed among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2015;70(11):1394-1399.

Beavers KM, Beavers DP, Newman JJ, Anderson AM, Loeser RF Jr, Nicklas BJ, Lyles MF, Miller GD, Mihalko SL, Messier SP. Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis. Osteoarthritis Cartilage. 2015;23(2):249-256.

Zhang T, Birbrair A, Wang ZM, Messi ML, Marsh AP, Leng I, Nicklas BJ, Delbono O. Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. Exp Gerontol. 2015;62():7-13.

Beavers KM, Gordon MM, Easter L, Beavers DP, Hairston KG, Nicklas BJ, Vitolins MZ. Effect of protein source during weight loss on body composition, cardiometabolic risk and physical performance in abdominally obese, older adults: a pilot feeding study. J Nutr Health Aging. 2015;19(1):87-95.

Botoseneanu A, Ambrosius WT, Beavers DP, de Rekeneire N, Anton S, Church T, Folta SC, Goodpaster BH, King AC, Nicklas BJ, Spring B, Wang X, Gill TM. Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. J Am Geriatr Soc. 2015;63(2):222-232.

Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ. Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc. 2015;63(3):462-469.

Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ. Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. PLoS One. 2015;10(3):e0121993.

Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP. Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Am J Clin Nutr. 2015;101(5):991-999.

Wang X, You T, Murphy K, Lyles MF, Nicklas BJ. Addition of exercise increases plasma adiponectin and release from adipose tissue. Med Sci Sports Exerc. 2015;47(11):2450-2455.

Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP. The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Osteoarthritis Cartilage. 2015;23(7):1090-1098.

Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ. The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Normandin E, Houstin DK, Nicklas BJ. Caloric restriction for treatment of geriatric obesity: do the benefits outweigh the risks?. Curr Nutr Rep. 2015;4(2):143-155.

Murillo ALP, Wirth W, Beavers D, Loeser RF, Nicklas BJ, Miller GD, Hunter D, Eckstein F, Messier SP. Impact of diet and/or exercise intervention on infra-patellar fat pad morphology - data from the Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Osteoarthritis Cartilage. 2015;23(Suppl 2):A389-A390.

Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,. Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Diabetes. 2015;64(10):3464-3474.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol. 2015;70():84-91.

Sohl S, Danhauer S, Birdee G, Nicklas B, Yacoub G, Aklilu M, Avis N. A brief yoga intervention implemented during chemotherapy for colorectal cancer: a randomized controlled pilot study [abstract]. Psychooncology. 2015;24(Suppl 2):253.

Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ. Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. BMC Obes. 2015;2():40.

Messi ML, Li T, Wang ZM, Marsh AP, Nicklas B, Delbono O. Resistance training enhances skeletal muscle innervation without modifying the number of satellite cells or their myofiber association in obese older adults. J Gerontol A Biol Sci Med Sci. 2015;():.

Centi AJ, Booth SL, Gundberg CM, Saltzman E, Nicklas B, Shea MK. Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women. Endocrine. 2015;50(3):627-632.

Molina AJ, Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh A, Nicklas B. Mitochondrial bioenergetics, inflammation, and physical ability in older adults [abstract]. Gerontologist. 2015;55(Suppl 2):733.

Nicklas B, Houston DK. Dietary interventions for the treatment of geriatric obesity: do the benefits outweigh the risks? [abstract]. Gerontologist. 2015;55(Suppl 2):517.

Nicklas B, Beavers DP, Mihalko SL, Loeser RF, Miller G, Messier SP. Chronic inflammation, habitual physical activity, and self-reported energy levels [abstract]. Gerontologist. 2015;55(Suppl 2):733.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Nicklas B, Molina AJ. Relationships between blood bioenergetic capacity and fat loss after diet and exercise intervention [abstract]. Gerontologist. 2015;55(Suppl 2):163.

Beavers KM, Hsu FC, Serra MC, Yank V, Pahor M, Nicklas BJ. The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability. J Aging Phys Act. 2014;22(1):25-33.

Haykowsky MJ, Kouba EJ, Brubaker PH, Nicklas BJ, Eggebeen J, Kitzman DW. Skeletal muscle composition and its relation to exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Cardiol. 2014;113(7):1211-1216.

Henderson R, Leng I, Chmelo E, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ. Comparison of aerobic versus resistance training for improving gait speed in older adults [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S154.

Beavers KM, Gordon M, Beavers D, Hairston K, Nicklas B, Kritchevsky S, Vitolins M. Relationship between change in body composition and physical function in abdominally obese, older adults undergoing 12-weeks of caloric restriction [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S20.

Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014;306(9):H1364-1370.

Nicklas BJ, Gaukstern JE, Beavers KM, Newman JC, Leng X, Rejeski WJ. Self-monitoring of spontaneous physical activity and sedentary behavior to prevent weight regain in older adults. Obesity (Silver Spring). 2014;22(6):1406-1412.

Beavers DP, Beavers KM, Loeser RF, Walton NR, Lyles MF, Nicklas BJ, Shapses SA, Newman JJ, Messier SP. The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese older adults with osteoarthritis. Osteoarthritis Cartilage. 2014;22(6):726-733.

Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Int J Obes (Lond). 2014;38(11):1397-1402.

Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin JP, Marsh AP, Nicklas B, Delbono O. Human slow troponin T (TNNT1) Pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(12):1437-1447.

You T, Wang X, Murphy KM, Lyles MF, Demons JL, Yang R, Gong DW, Nicklas BJ. Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women. Obesity (Silver Spring). 2014;22(7):1679-1684.

Messier SP, Beavers DP, Loeser RF, Carr JJ, Khajanchi S, Legault C, Nicklas BJ, Hunter DJ, DeVita P. Knee joint loading in knee osteoarthritis: influence of abdominal and thigh fat. Med Sci Sports Exerc. 2014;46(9):1677-1683.

Gordon MM, Chmelo E, Crotts C, Lyles M, Brinkley T, Newman J, Rejeski WJ, Nicklas B. Aerobic exercise training and self-reported fatigue in older, obese adults [abstract]. Med Sci Sports Exerc. 2014;46(5):224.

Messier SP, DeVita P, Nicklas BJ, Beavers D, Miller GD, Hunter DJ, Eckstein F, Guermazi A, Loeser RF. Changes in joint loads, Leptin, and MMP-3 subsequent to long-term intensive weight loss and exercise: secondary outcomes from the intensive diet and exercise for arthritis randomized clinical trial [abstract]. Osteoarthritis Cartilage. 2014;22(Suppl):S83-S84.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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