Profile

Barbara Nicklas, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.S.E., Truman State University , 1983
  • M.S., Iowa State University , 1987
  • Ph.D., University of Maryland-College Park , 1994
  • Fellowship, Geriatric Medicine, University of Maryland-Baltimo, 1994
  • Fellowship, Geriatric Medicine, University of Maryland-Baltimo, 1996

Memberships

  • Am Coll Of Sports Medicine
  • Am Diabetes Assn
  • Am Physiological Society
  • Gerontological Society Of Amer
Barbara Nicklas, Ph.D.

Barbara Nicklas, Ph.D.

Deputy Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Center for Genomics and Personalized Medicine Research
Sticht Center on Aging
Center for Diabetes Research
WFU Primate Center
Center for Integrative Medicine
Translational Science Institute

Research Interests

aging, fitness/physical, metabolism, molecular biology/molecular me, nutrition, obesity

Contact Information

Academic: 336-713-8584 | Department: 336-713-8570

Recent Publications

Beavers KM, Hsu FC, Serra MC, Yank V, Pahor M, Nicklas BJ. The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability. J Aging Phys Act. 2014;22(1):25-33.

Haykowsky MJ, Kouba EJ, Brubaker PH, Nicklas BJ, Eggebeen J, Kitzman DW. Skeletal muscle composition and its relation to exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Cardiol. 2014;113(7):1211-1216.

Henderson R, Leng I, Chmelo E, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ. Comparison of aerobic versus resistance training for improving gait speed in older adults [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S154.

Beavers KM, Gordon M, Beavers D, Hairston K, Nicklas B, Kritchevsky S, Vitolins M. Relationship between change in body composition and physical function in abdominally obese, older adults undergoing 12-weeks of caloric restriction [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S20.

Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014;306(9):H1364-1370.

Nicklas BJ, Gaukstern JE, Beavers KM, Newman JC, Leng X, Rejeski WJ. Self-monitoring of spontaneous physical activity and sedentary behavior to prevent weight regain in older adults. Obesity (Silver Spring). 2014;22(6):1406-1412.

Beavers DP, Beavers KM, Loeser RF, Walton NR, Lyles MF, Nicklas BJ, Shapses SA, Newman JJ, Messier SP. The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese older adults with osteoarthritis. Osteoarthritis Cartilage. 2014;22(6):726-733.

Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Int J Obes (Lond). 2014;():.

You T, Wang X, Murphy KM, Lyles MF, Demons JL, Yang R, Gong DW, Nicklas BJ. Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women. Obesity (Silver Spring). 2014;():.

Messier SP, Beavers DP, Loeser RF, Carr JJ, Khajanchi S, Legault C, Nicklas BJ, Hunter DJ, DeVita P. Knee-joint loading in knee osteoarthritis: influence of abdominal and thigh fat. Med Sci Sports Exerc. 2014;():.

Gordon MM, Chmelo E, Crotts C, Lyles M, Brinkley T, Newman J, Rejeski WJ, Nicklas B. Aerobic exercise training and self-reported fatigue in older, obese adults [abstract]. Med Sci Sports Exerc. 2014;46(5):224.

Messier SP, DeVita P, Nicklas BJ, Beavers D, Miller GD, Hunter DJ, Eckstein F, Guermazi A, Loeser RF. Changes in joint loads, Leptin, and MMP-3 subsequent to long-term intensive weight loss and exercise: secondary outcomes from the intensive diet and exercise for arthritis randomized clinical trial [abstract]. Osteoarthritis Cartilage. 2014;22(Suppl):S83-S84.

Beavers KM, Miller ME, Rejeski WJ, Nicklas BJ, Krichevsky SB [sic] [Kritchevsky SB]. Fat mass loss predicts gain in physical function with intentional weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013;68(1):80-86.

Beavers KM, Beavers DP, Houston DK, Harris TB, Hue TF, Koster A, Newman AB, Simonsick EM, Studenski SA, Nicklas BJ, Kritchevsky SB. Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study. Am J Clin Nutr. 2013;97(3):552-560.

Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

Beavers KM, Hsu FC, Houston DK, Beavers DP, Harris TB, Hue TF, Kim LJ, Koster A, Penninx BW, Simonsick EM, Strotmeyer ES, Kritchevsky SB, Nicklas BJ. The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2013;68(5):617-623.

Beavers DP, Beavers KM, Lyles MF, Nicklas BJ. Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women. J Gerontol A Biol Sci Med Sci. 2013;68(6):691-698.

Marsh AP, Shea MK, Vance Locke RM, Miller ME, Isom S, Miller GD, Nicklas BJ, Lyles MF, Carr JJ, Kritchevsky SB. Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013;68(7):828-836.

Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ. Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults. J Am Geriatr Soc. 2013;61(7):1089-1094.

Centi AJ, Booth SL, Gundberg CM, Nicklas B, Shea MK. Response of serum osteocalcin to caloric restriction with and without exercise in post menopausal women [abstract]. FASEB J. 2013;27():1067.13.

Messier SP, Mihalko SL, Beavers DP, Nicklas BJ, Devita P, Carr JJ, Hunter DJ, Williamson JD, Bennell KL, Guermazi A, Lyles M, Loeser RF. Strength Training for Arthritis Trial (START): design and rationale. BMC Musculoskelet Disord. 2013;14():208.

Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310(12):1263-1273.

Sink K, Chmelo E, Nicklas B, Katula J, Cofman C, Williamson J, Baker L. Pilot trial of buddy-assisted exercise in people with mild cognitive impairment [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P494.

Bharadwaj MS, Nicklas B, Molina AJ. Obesity is accompanied by increased basal mitochondrial respiration in older adults [abstract]. Gerontologist. 2013;53(Suppl 1):273.

Liu C, Hsu F, Beavers KM, Yank V, Stafford RS, Nicklas B, Weiner D, Fielding R. Effectiveness of physical activity on improving a physical performance measure in elders with chronic kidney disease: the lifestyle interventions and independence elders pilot study (LIFE-P) Study [abstract]. Gerontologist. 2013;53(Suppl 1):328.

Brinkley TE, Gordon MM, Chmelo EA, Jefferson M, Lyles MF, Hundley WG, Gregory HW, Nicklas BJ. Aortic stiffness predicts blood pressure responses to exercise in obese older adults [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):11.

Chmelo E, Gordon M, Crotts C, Lyles MF, Brinkley T, Blocker J, Nicklas BJ. Does 400 meter walk time predict Vo(2) peak in obese, older adults? [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):573.

Jefferson ME, Gordon MM, Chmelo EA, Lyles MF, Nicklas BJ, Brinkley TE. Heart rate recovery is associated with central adiposity in obese older adults [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):11.

Sorensen JA, Crotts C, Chmelo E, Lyles MF, Marsh AP, Nicklas BJ. Is gait speed associated with strength, power, and lower extremity function in older, overweight and obese men and women? [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):644.

You TJ, Wang XW, Yang RZ, Gong D, Lyles M, Nicklas B. Effects of weight loss on subcutaneous adipose tissue hormone/cytokine production: depot comparisons [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):418-419.

Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin JP, Marsh AP, Nicklas B, Delbono O. Human slow troponin T (TNNT1) Pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults. J Gerontol A Biol Sci Med Sci. 2013;():.

Prokopy M, Booth SL, Saltzman E, Yeum KJ, Nicklas B, Shea MK. Fat-soluble vitamin status in response to non-surgical weight loss in overweight post-menopausal women [abstract]. FASEB J. 2013;27():360.5.

. Addiction of aerobic exercise to caloric restriction increases adiponectin circulating concentrations and release from abdominal and gluteal adipose tissue in obese/overweight postmenopausal women [abstract]. In: Obesityweek 2013 November 11-16; Atlanta (GA). 2013;():S76.

Nicklas BJ, Gaukstern JE, Legault C, Leng I, Rejeski WJ. Intervening on spontaneous physical activity to prevent weight regain in older adults: design of a randomized, clinical trial. Contemp Clin Trials. 2012;33(2):450-455.

Miller GD, Nicklas BJ, Davis CC, Legault C, Messier SP. Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women. J Nutr Health Aging. 2012;16(2):169-174.

Wang X, Hsu F-C, Isom S, Walkup MP, Kritchevsky SB, Goodpaster BH, Church TS, Pahor M, Stafford RS, Nicklas BJ. Effects of a 12-month physical activity intervention on prevalence of metabolic syndrome in elderly men and women. J Gerontol A Biol Sci Med Sci. 2012;67A(4):417-424.

Cesari M, Kritchevsky SB, Nicklas B, Kanaya AM, Patrignani P, Tacconelli S, Tranah GJ, Tognoni G, Harris TB, Incalzi RA, Newman AB, Pahor M. Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the Health Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2012;67A(6):671-676.

Lyles MF, Demons JL, Murphy KM, Nicklas BJ. Skeletal muscle sampling in elderly research participants with chronic disease [abstract]. J Am Geriatr Soc. 2012;60(Suppl 4):S197.

Hugenschmidt CE, Blocker JN, Williamson JD, Nicklas BJ. Preliminary associations between cognition and glucose regulation in obese elderly at risk for type 2 diabetes [abstract]. Diabetes. 2012;61(Suppl 1):A185.

Messier SP, DeVita P, Nicklas BJ, Beavers D, Mihalko S, Miller GD, Lyles M, Hunter DJ, Eckstein F, Legault C, Williamson JD, Carr JJ, Loeser RF. The Intensive Diet and Exercise for Arthritis Trial (IDEA): effects on knee joint loading and inflammation [abstract]. Osteoarthritis Cartilage. 2012;20(Suppl 1):S28.

Brinkley TE, Hsu FC, Beavers KM, Church TS, Goodpaster BH, Stafford RS, Pahor M, Kritchevsky SB, Nicklas BJ. Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach. J Gerontol A Biol Sci Med Sci. 2012;67(10):1099-1106.

Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ. The effects of a long-term physical activity and weight loss intervention on inflammatory biomarkers in older adults [abstract]. J Aging Phys Act. 2012;20(Suppl):S317.

Hunter DJ, Beavers D, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko S, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP. The Intensive Diet and Exercise for Arthritis Trial (IDEA): 18-month radiographic and MRI outcomes [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S1070.

Stehle JR Jr, Leng X, Kitzman DW, Nicklas BJ, Kritchevsky SB, High KP. Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. J Gerontol A Biol Sci Med Sci. 2012;67(11):1212-1218.

Walton NR, Loeser RF, Beavers D, Nicklas BJ, Lyles M, Messier SP. The effects of intensive diet and exercise on bone density in older adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S1070-71.

Heffernan KS, Manini TM, Hsu FC, Blair SN, Nicklas BJ, Kritchevsky SB, Newman AB, Sutton-Tyrrell K, Church TS, Haskell WL, Fielding RA. Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: findings from the LIFE-P study. PLoS One. 2012;7(11):e49544.

Beavers DP, Nicklas B, Newman J, Messier SP. Weight regain following an 18-month intentional weight loss trial in older overweight/obese adults with knee osteoarthritis: the IDEA follow-up pilot study [abstract]. Gerontologist. 2012;52(Suppl 1):701.

Beavers KM, Beavers DP, Houston DK, Harris TB, Simonsick EM, Newman AB, Nicklas B, Kritchevsky SB. Increasing thigh intermuscular fat is an independent predictor of declines in gait speed: results from the Health ABC study [abstract]. Gerontologist. 2012;52(Suppl 1):447.

Beavers KM, Beavers DP, Lyles MF, Nicklas B. Body composition and cardiometabolic risk factor changes with intentional weight loss and subsequent weight regain [abstract]. Gerontologist. 2012;52(Suppl 1):701.

Botoseneanu A, Ambrosius WT, de Rekeneire N, Goodpaster B, Nicklas B, Church T, Gill TM. Prevalence of metabolic syndrome and its association with physical performance, disability and subjective well-being among Lifestyle Interventions and Independence for Elders (LIFE) Study participants [abstract]. Gerontologist. 2012;52(Suppl 1):206.

Brinkley TE, Kitzman DW, Ding J, Nicklas BJ, Kritchevsky SB, Hundley WG. Epicardial, pericardial and periaortic fat are elevated in older adults at high cardiac risk [abstract]. Arterioscler Thromb Vasc Biol. 2012;32(5 Suppl):A132.

Chmelo E, Nicklas B, Davis C, Miller GD, Legault C, Messier S. Physical activity and physical function in older adults with knee osteoarthritis. J Phys Act Health. 2012;10(6):777-783.

Beavers KM, Nicklas BJ. Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome. Front Biosci (Schol Ed). 2011;3():168-177.

Kerwin DR, Gaussoin SA, Chlebowski RT, Kuller LH, Vitolins M, Coker LH, Kotchen JM, Nicklas BJ, Wassertheil-Smoller S, Espeland MA, et al. Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: results from the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2011;59(1):107-112.

Houston DK, Tooze JA, Hausman DB, Johnson MA, Nicklas BJ, Miller ME, Neiberg RH, Marsh AP, Newman AB, Kritchevsky SB, et al. Change in 25-hydroxyvitamin D and physical performance in older adults. J Gerontol A Biol Sci Med Sci. 2011;66(4):430-436.

Brinkley TE, Ding J, Carr JJ, Nicklas BJ. Pericardial fat loss in postmenopausal women under conditions of equal energy deficit. Med Sci Sports Exerc. 2011;43(5):808-814.

Houston DK, Davis C, Legault C, Hausman DB, Nicklas BJ, Loeser RF, Kritchevsky SB, Messier SP. Serum 25-hydroxyvitamin D and physical function in older adults with knee osteoarthritis [abstract]. FASEB J. 2011;25(Meeting Abstracts):abstr 97.6.

Shea MK, Houston DK, Nicklas BJ, Davis CC, Hsu F-C, Tooze JA, Church TS, Kritchevsky SB. Circulating 25-hydroxyvitamin-D [25(OH)D] and inflammation in older community-dwelling adults [abstract]. FASEB J. 2011;25(Meeting Abstracts):595.2.


Shea MK, Nicklas BJ, Marsh AP, Houston DK, Miller GD, Isom S, Miller ME, Carr JJ, Lyles MF, Kritchevsky SB, et al. The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss. Obesity (Silver Spring). 2011;19(8):1636-1646.

Shea MK, Nicklas BJ, Houston DK, Miller ME, Davis CC, Kitzman DW, Espeland MA, Appel LJ, Kritchevsky SB. The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial. Am J Clin Nutr. 2011;94(3):839-846.

Beavers KM, Lyles MF, Davis CC, Wang X, Beavers DP, Nicklas BJ. Is lost lean mass from intentional weight loss recovered during weight regain in postmenopausal women?. Am J Clin Nutr. 2011;94(3):767-774.

Koster A, Ding J, Stenholm S, Caserotti P, Houston DK, Nicklas BJ, You T, Lee JS, Visser M, Kritchevsky SB, et al. Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults?. J Gerontol A Biol Sci Med Sci. 2011;66(8):888-895.

Miller GD, Nicklas BJ, Fernandez A. Serial changes in inflammatory biomarkers after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2011;7(5):618-624.

Messier SP, Nicklas BJ, Legault C, Mihalko S, Miller GD, DeVita P, Lyles M, Hunter DJ, Eckstein F, Williamson JD, Carr JJ, Loeser RF. The Intensive Diet and Exercise for Arthritis Trial: 18-month clinical outcomes [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S281.


Shea M, Houston DK, Nicklas B, Miller ME, Messier SP, Espeland MA, Kritchevsky SB. The effect of intentional weight loss on total mortality in older adults: a pooled analysis of two randomized-controlled trials [abstract]. Gerontologist. 2011;51(Suppl 2):518.

Stehle JR, Nicklas B, Kritchevsky SB, Kitzman DW, Leng X, High K. Association between microbial translocation and adiposity in healthy elderly adults [abstract]. Gerontologist. 2011;51(Suppl 2):490.

Wang X, You T, Lenchik L, Nicklas BJ. Resting energy expenditure changes with weight loss: racial differences. Obesity (Silver Spring). 2010;18(1):86-91.

Shea MK, Houston DK, Nicklas BJ, Messier SP, Davis CC, Miller ME, Harris TB, Kitzman DW, Kennedy K, Kritchevsky SB. The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study. J Gerontol A Biol Sci Med Sci. 2010;65(5):519-525.

Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010;411(11-12):785-793.

Chughtai HL, Morgan TM, Rocco M, Stacey B, Brinkley TE, Ding J, Nicklas B, Hamilton C, Hundley WG. Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular events. Hypertension. 2010;56(5):901-906.

Wang XW, You TJ, Yang RZ, Lyles MF, Demons J, Gong DW, Nicklas BJ. Muscle strength is associated with adipose tissue gene expression of inflammatory adipokines in postmenopausal women [research letter]. Age Ageing. 2010;39(5):656-659.

Beavers KM, Hsu F-C, Isom S, Kritchevsky SB, Church T, Goodpaster B, Pahor M, Nicklas BJ. Long-term physical activity and inflammatory biomarkers in older adults. Med Sci Sports Exerc. 2010;42(12):2189-2196.

Koster A, Stenholm S, Alley DE, Kim LJ, Simonsick EM, Kanaya AM, Visser M, Houston DK, Nicklas BJ, Tylavsky FA, et al. Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (Silver Spring). 2010;18(12):2354-2361.


Loeser R, Fetrow J, Chou J, Nicklas B, Kritchevsky SB. Using gene microarrays to discover skeletal muscle mechanisms underlying clinical responses to diet and exercise interventions [abstract]. Gerontologist. 2010;50(Suppl 1):80.

Lyles MF, Murphy K, Nicklas B, Hafer-Macko C, Ryan A. Feasibility, efficacy and safety of skeletal muscle acquisition in frail elderly with comorbidities [abstract]. Gerontologist. 2010;50(Suppl 1):80.

Easter L, Nicklas BJ, Lyles MF, Gordon M. Optimizing Weight for Life in Seniors: a unique clinic to improve physical function and mobility in the elderly through weight management [abstract]. J Am Diet Assoc. 2010;110(9 Suppl 2):A-14.

Brinkley TE, Leng X, Miller ME, Kitzman DW, Pahor M, Berry MJ, Marsh AP, Kritchevsky SB, Nicklas BJ. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009;64(4):455-461.

Hsu F-C, Kritchevsky SB, Liu Y, Kanaya A, Newman AB, Perry SE, Visser M, Pahor M, Harris TB, Nicklas BJ. Association between inflammatory components and physical function in the Health, Aging, and Body Composition Study: a principal component analysis approach. J Gerontol A Biol Sci Med Sci. 2009;64(5):581-589.

Nicklas BJ, Wang X, You T, Lyles MF, Demons J, Easter L, Berry MJ, Lenchik L, Carr JJ. Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial. Am J Clin Nutr. 2009;89(4):1043-1052.

Brinkley TE, Nicklas BJ, Kanaya AM, Satterfield S, Lakatta EG, Simonsick EM, Sutton-Tyrrell K, Kritchevsky SB. Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the Health, Aging, and Body Composition Study. Hypertension. 2009;53(5):846-852.

Houston DK, Ding J, Nicklas BJ, Harris TB, Lee JS, Nevitt MC, Rubin SM, Tylavsky FA, Kritchevsky SB. Overweight and obesity over the adult life course and incident mobility limitation in older adults: the Health, Aging and Body Composition Study. Am J Epidemiol. 2009;169(8):927-936.

Penninx BWJH, Nicklas BJ, Newman AB, Harris TB, Goodpaster BH, Satterfield S, de Rekeneire N, Yaffe K, Pahor M, Kritchevsky SB. Metabolic syndrome and physical decline in older persons: results from the Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2009;64(1):96-102.

Brinkley TE, Hsu F, Hawkins GA, Kritchevsky SB, Pahor M, Nicklas BJ. The ACE I/D genotype and improvement in 400-meter walk performance with exercise training in the Lifestyle Intervention and Independence for Elders Pilot (LIFE-P) [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S123.

Brinkley TE, Wang X, Kume N, Mitsuoka H, Nicklas BJ. Weight loss reduces plasma soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese postmenopausal women [abstract]. Circulation. 2009;119(10):e290-e291.

Lyles MF, Wang X, Demons J, Nicklas B. Functional consequences of weight regain 12 months after a successful weight loss intervention [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S160.

Nicklas B, Miller GD, Davis C, Wang X, Legault C, Messier SP. Relationship of daily physical activity to physical function in older overweight adults [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S201.

Shea MK, Davis CC, Nicklas BJ, Kitzman DW, Miller ME, Kennedy K, Kritchevsky SB. The effect of intentional weight-loss on total mortality in older adults [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S122.


Houston DK, Tooze J, Neiberg R, Hausman D, Johnson MA, Nicklas B, Miller M, Marsh A, Bartali B, Kritchevsky SB, et al. Change in vitamin D status is associated with improved physical performance over one year: the LIFE-P study [abstract]. FASEB J. 2009;23(Meeting Abstracts):108.3.

Puntawagkoon C, Kitzman DW, Kritchevsky SB, Hamilton CA, Nicklas B, Leng X, Brubaker PH, Hundley WG. Exercise limb blood flow is reduced despite adequate cardiac output in elderly patients with heart failure [abstract]. J Card Fail. 2009;15(6 Suppl 1):S69.

Miller GD, Nicklas BJ, You T, Fernandez A. Physical function improvements after laparoscopic Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2009;5(5):530-537.

Nicklas BJ, Brinkley TE. Exercise training as a treatment for chronic inflammation in the elderly. Exerc Sport Sci Rev. 2009;37(4):165-170.

Messier SP, Legault C, Mihalko S, Miller GD, Loeser RF, DeVita P, Lyles M, Eckstein F, Williamson JD, Nicklas BJ, et al. The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale. BMC Musculoskelet Disord. 2009;10():article 93.

Houston DK, Nicklas BJ, Zizza CA. Weighty concerns: the growing prevalence of obesity among older adults. J Am Diet Assoc. 2009;109(11):1886-1895.

Puntawangkoon C, Kitzman DW, Kritchevsky SB, Hamilton CA, Nicklas B, Leng X, Brubaker PH, Hundley WG. Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure. J Cardiovasc Magn Reson. 2009;11(1):article 48.

Koster A, Stenholm S, Alley D, Visser M, Simonsick E, Nicklas B, Kanaya A, Harris T. Body composition differences among obese older persons with and without metabolic syndrome [abstract]. Gerontologist. 2009;49(Suppl 2):293.

Brinkley TE, Ding J, Carr JJ, Nicklas BJ. Caloric restriction with and without aerobic exercise decreases pericardial fat in overweight and obese postmenopausal women [abstract]. Obesity (Silver Spring). 2009;17(Suppl 2):S263.

Koster A, Stenholm S, Houston DK, Kanaya A, Nicklas BJ, Tylavsky F, Satterfield S, Goodpaster B, Ferrucci L, Harris T, et al. Body fat differences among metabolically healthy and unhealthy obese older persons [abstract]. Obesity (Silver Spring). 2009;17(Suppl 2):S143.

Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, Lee JS, Sahyoun NR, Visser M, Kritchevsky SB. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87(1):150-155.

Giaccaglia V, Nicklas B, Kritchevsky S, Mychalecky J, Messier S, Bleecker E, Pahor M. Interaction between angiotensin converting enzyme insertion/deletion genotype and exercise training on knee extensor strength in older individuals. Int J Sports Med. 2008;29(1):40-44.

Schaap LA, Pluijm SMF, Deeg DJH, Penninx BW, Nicklas BJ, Lips P, Harris TB, Newman AB, Kritchevsky SB, Cauley JA, et al. Low testosterone levels and decline in physical performance and muscle strength in older men: findings from two prospective cohort studies. Clin Endocrinol. 2008;68(1):42-50.


You T, Nicklas BJ. Effects of exercise on adipokines and the metabolic syndrome. Curr Diab Rep. 2008;8(1):7-11.

Houston DK, Hausman DB, Johnson MA, Nicklas BJ, Miller ME, Marsh AP, Bartali B, Newman AB, Blair SN, Kritchevsky SB. Vitamin D insufficiency is associated with poorer physical performance: the LIFE-P study [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl):S169.

Kritchevsky SB, Nicklas B, Denise H [sic] [Houston D], Melanie B [sic] [Bopp M], Anthony MP [sic] [Marsh AP], Gary MD [sic] [Miller GD], Lyles MF, Michael ME [sic] [Miller ME], Carr J. Evaluating strategies to optimize the body composition of older adults during voluntary weight loss [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl 1):S162.

Lyles MF, Wang X, Demons JL, Nicklas BJ. Functional consequences of weight regain: changes 6 months after a successful weight loss intervention [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl):S20.

You T, Nicklas BJ, Ding J, Penninx BWJH, Goodpaster BH, Bauer DC, Tylavsky FA, Harris TB, Kritchevsky SB. The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity. J Gerontol A Biol Sci Med Sci. 2008;63(4):414-419.

Bopp MJ, Houston DK, Lenchik L, Easter L, Kritchevsky SB, Nicklas BJ. Lean mass loss is associated with low protein intake during dietary-induced weight loss in postmenopausal women. J Am Diet Assoc. 2008;108(7):1216-1220.

Wang X, Lyles MF, You T, Berry MJ, Rejeski WJ, Nicklas BJ. Weight regain is related to decreases in physical activity during weight loss. Med Sci Sports Exerc. 2008;40(10):1781-1788.

Gordon MM, Czerwinski MJ, Bopp G, Easter L, Miller GD, Lyles MF, Houston DK, Nicklas BJ, Kritchevsky SB. Effects of dietary protein on the composition of weight loss in post-menopausal women. J Nutr Health Aging. 2008;12(8):505-509.

Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008;20(4):302-309.

Nicklas BJ, Hsu F-C, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, Pahor M. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc. 2008;56(11):2045-2052.

Anderson AS, Loeser R, Carr J, Claudine L [sic] [Legault C], Nicklas B, Stephen M [sic] [Messier S]. Quadriceps muscle quality correlates with physical performance in obese and overweight adults with knee osteoarthritis: preliminary data from the IDEA study [abstract]. Arthritis Rheum. 2008;58(12):3992.

Houston D, Hausman D, Johnson M, Tooze J, Nicklas B, Marsh A, Miller M, Bartali B, Newman A, Kritchevsky S, et al. Vitamin D insufficiency is associated with poorer physical performance over 1 year of follow-up [abstract]. Gerontologist. 2008;48(Special Issue 3):198.

Nicklas B, Hsu F, Church T, Kritchevsky S, Pahor M. Association between changes in inflammation and risk for mobility disability [abstract]. Gerontologist. 2008;48(Special Issue 3):198.

Nicklas BJ, Brinkley T, Leng X, Miller M, Kitzrnan D [sic] [Kitzman D], Berry M, Marsh A, Pahor M, Kritchevsky S. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities [abstract]. Gerontologist. 2008;48(Special Issue 3):491-492.

Silverman N, Ryan A, Nicklas B. Addition of aerobic exercise to weight loss increases BMD with associated reduction in inflammation in postmenopausal women [abstract]. Gerontologist. 2008;48(Special Issue 3):468.

Ellis TJ [Brinkley TE], Nicklas BJ, Kanaya AM, Satterfield S, Simonsick EM, Sutton-Tyrrell K, Kritchevsky SB. High plasma oxidized low-density lipoprotein levels are associated with increased arterial stiffness: is physical activity a mediator? [abstract]. Circulation. 2008;117(11):e280.

Ferrara CM, Goldberg AP, Nicklas BJ, Sorkin JD, Ryan AS. Sex differences in insulin action and body fat distribution in overweight and obese middle-aged and older men and women. Appl Physiol Nutr Metab. 2008;33(4):784-790.

Lyles M, Wang X, Nicklas B. Changes in weight and body composition 12 months following completion of a weight loss intervention [abstract]. Obesity (Silver Spring). 2008;16(Suppl 1):S207.

Nicklas BJ, Wang XW, You TJ, Lyles MF, Demons J. Effect of aerobic exercise intensity on loss of visceral fat and metabolic risk factors in women [abstract]. Diabetes. 2008;57(Suppl 1):A93.

Kritchevsky SB, Nicklas BJ, Lyles MF, Marsh AP, Miller GD, Miller ME, Leng X. Effect of PPAR gamma use during a hypocaloric diet for weight loss on reductions in total and visceral fat in older men and women [abstract]. Diabetes. 2008;57(Suppl 1):A482.

Ding J, Kritchevsky SB, Newman AB, Taaffe DR, Nicklas BJ, Visser M, Lee JS, Nevitt M, Tylavsky FA, Rubin SM, et al. Effects of birth cohort and age on body composition in a sample of community-based elderly. Am J Clin Nutr. 2007;85(2):405-410.

Lyles MF, Wang X, You T, Lenchik L, Demons JL, Nicklas BJ. Changes in weight and body composition 12 months following completion of a weight loss intervention [abstract]. J Am Geriatr Soc. 2007;55(4 Suppl):S165-S166.

Demons JL, Wang X, Lyles MF, Kritchevsky SB, Nicklas BJ. Effects of weight loss on physical performance in obese postmenopausal women [abstract]. J Am Geriatr Soc. 2007;55(4 Suppl):S164.

Carnagey KM, Miller GD, Nicklas BJ, Loeser RF. Inflammatory biomarkers and physical function in older obese adults with knee osteoarthritis following intensive weight loss therapy [abstract]. FASEB J. 2007;21(6):A1072.

Wang X, You T, Lyles M, Demons J, Nicklas BJ. Adipose tissue production of inflammatory mediators is related to aerobic fitness and muscle strength in obese postmenopausal women [abstract]. Med Sci Sports Exerc. 2007;39(5 Suppl):S68.

Wang X, Miller GD, Messier SP, Nicklas BJ. Knee strength maintained despite loss of lean body mass during weight loss in older obese adults with knee osteoarthritis. J Gerontol A Biol Sci Med Sci. 2007;62(8):866-871.

Li R, Nicklas B, Pahor M, Newman A, Sutton-Tyrrell K, Harris T, Lakatta E, Bauer DC, Ding J, Kritchevsky SB, et al. Polymorphisms of angiotensinogen and angiotensin-converting enzyme associated with lower extremity arterial disease in the Health, Aging and Body Composition study. J Hum Hypertens. 2007;21(8):673-682.

Houston DK, Ding J, Nicklas BJ, Harris TB, Lee JS, Nevitt MC, Rubin SM, Tylavsky FA, Kritchevsky SB. The association between weight history and physical performance in the Health, Aging and Body Composition study. Int J Obes. 2007;31(11):1680-1687.

Morsink LFJ, Vogelzangs N, Nicklas BJ, Beekman ATF, Satterfield S, Rubin SM, Yaffe K, Simonsick E, Newman AB, Kritchevsky SB, et al. Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: results from the Health ABC study. Psychoneuroendocrinology. 2007;32(8-10):874-883.

Ramsay O, Loeser R, Nicklas B, Legault C, Messier S. Physical function status is related to body fat mass, but not lean mass, in older adults with knee osteoarthritis [abstract]. Arthritis Rheum. 2007;56(12):4262.

Houston D, Bopp M, Easter L, Kritchevsky S, Nicklas B. Lean mass loss is associated with low protein intake during dietary-induced weight loss in postmenopausal women [abstract]. Obesity. 2007;15(Suppl 1):A157-A158.

Bopp M, Nicklas B, Miller G, Miller M, Marsh A, Houston D, Carr JJ, Kritchevsky S. Associations among changes in regional fat depots as a result of weight loss in older obese and overweight women [abstract]. Obesity. 2007;15(Suppl 1):A95.

Miller GD, Nicklas B, Fernandez A, You T, Carr JJ. Regional fat depot and thigh muscle volume changes as a result of weight loss from laparoscopic Roux-en-Y gastric bypass surgery [abstract]. Obesity. 2007;15(Suppl 1):A87.

You T, Wang X, Lyles M, Demons J, Nicklas B. Inflammatory proteins released by abdominal and gluteal subcutaneous adipose tissue: regional differences and relationships with metabolic risk factors [abstract]. Obesity. 2007;15(Suppl 1):A80-A81.

Nicklas BJ. Changes in walking speed with weight loss are associated with selective loss of visceral fat in postmenopausal women [abstract]. Gerontologist. 2007;47(Special Issue I):173.

Nicklas BJ, Pahor M. Influence of exercise on inflammatory biomarkers in the elderly [abstract]. Gerontologist. 2007;47(Special Issue I):477.

Miller GD, Nicklas BJ, Davis C, Loeser RF, Lenchik L, Messier SP. Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity. 2006;14(7):1219-1230.

You T, Murphy KM, Lyles MF, Demons JL, Lenchik L, Nicklas BJ. Addition of aerobic exercise to dietary weight loss preferentially reduces abdominal adipocyte size. Int J Obes. 2006;30(8):1211-1216.

Yang R-Z, Lee M-J, Hu H, Pollin TI, Ryan AS, Nicklas BJ, Snitker S, Horenstein RB, Hull K, Goldberg NH, et al. Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med. 2006;3(6):e287.

Schaap LA, Visser M, Pluijm MF, Deeg DJH, Penninx BWJH, Nicklas BJ, Newman AB, Harris TB, Cauley JA, Kritchevsky SB, et al. Low total and free testosterone levels and decline in physical performance and muscle strength in older men and women [abstract]. Eur J Epidemiol. 2006;21(Suppl):31.

Kanaya AM, Fyr CW, Vittinghoff E, Havel PJ, Cesari M, Nicklas B, Harris T, Newman AB, Satterfield S, Cummings SR. Serum adiponectin and coronary heart disease risk in older black and white Americans. J Clin Endocrinol Metab. 2006;91(12):5044-5050.

Ding J, Nicklas BJ, Fallin MD, de Rekeneire N, Kritchevsky SB, Pahor M, Rodondi N, Li R,Zmuda JM, Harris TB. Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke. Am Heart J. 2006;152(6):1109-1115.

Houston D, Ding J, Nicklas B, Harris T, Lee JS, Nevitt M, Rubin S, Tylavsky F, Kritchevsky S. Weight change from middle to late adulthood predicts incident mobility limitations in older adults: the Health ABC Study [abstract]. Obesity. 2006;14(Abstr Suppl):A10-A11.

Nicklas B, Miller G, Houston D, Kritchevsky S. Epidemiology of obesity in old age: biological, clinical, social and policy implications: clinical treatment of obesity in the elderly [abstract]. Gerontologist. 2006;46(Special Issue 1):357.

Nicklas B, You T, Lyles M, Demons J, Wang X. Weight loss via caloric restriction and aerobic exercise reduces prevalence of metabolic syndrome in older, obese women. Gerontologist. 2006;46(Special Issue 1):550.

Ryan AS, Nicklas BJ, Berman DM. Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women. Obesity. 2006;14(6):1064-1072.

Wang X, Miller G, Messier S, Nicklas B. Knee strength maintained despite loss of muscle mass during intensive weight loss in older obese adults [abstract]. Obesity. 2006;14(Abstr Suppl):A43.

Yang RZ, Lee MJ, Hu H, Zhu DL, Nicklas B, Ryan A, Shuldiner AR, Fried SK, Gong DW. Retinol binding protein 4: serum concentration, adipose secretion, and its relationship to obesity [abstract]. Diabetes. 2006;55(Suppl 1):A87.

You T, Yang R, Gong D, Nicklas B. Effect of exercise intensity on adipose tissue hormone sensitive lipase gene expression in obese women undergoing weight loss [abstract]. Obesity. 2006;14(Abstr Suppl):A25.

You T, Nicklas BJ. Chronic inflammation: role of adipose tissue and modulation by weight loss. Curr Diabetes Rev. 2006;2(1):29-37.

Johnson JW, You T, Parraway E, Berry MJ, Nicklas BJ. Racial differences in daily physical activity level and body composition in obese, postmenopausal women [abstract]. Med Sci Sports Exerc. 2006;38(5 Suppl):S459-S460.

Penninx BW, Nicklas BJ, Goodpaster B, Yaffe K, Harris T, Satterfield S, de Rekeniere N, Newman A, Kritchevsky S. Metabolic syndrome increases onset of mobility limitations [abstract]. Gerontologist. 2006;46(Special Issue I):549.

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For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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