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Barbara Nicklas, Ph.D.Wake Forest School of Medicine

Barbara Nicklas, Ph.D.

Deputy Director,
Professor,


Ctr for Vaccines at Extremes

Contact Information

Academic: 336-713-8570 | Department: 336-713-8570

Email: bnicklas@wakehealth.edu

Education & Training

  • B.S.E., Truman State University, 1983
  • M.S., Iowa State University, 1987
  • Ph.D., University of Maryland-College Park, 1994
  • Fellowship, Geriatric Medicine, University of Maryland-Baltimo, 1994
  • Fellowship, Geriatric Medicine, University of Maryland-Baltimo, 1996

Memberships

  • Am Coll Of Sports Medicine
  • Am Diabetes Assn
  • Am Physiological Society
  • Gerontological Society Of Amer
Barbara Nicklas, Ph.D.

Barbara Nicklas, Ph.D.

Deputy Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Center on Diabetes, Obesity, and Metabolism
Office of Women in Medicine and Science
Ctr for Vaccines at Extremes

Research Interests

Weight Loss; Obesity; Exercise; Body Composition; Adipose Tissue
More »

Contact Information

Academic: 336-713-8570 | Department: 336-713-8570

Email: bnicklas@wakehealth.edu

Recent Publications

Effect of resistance training and caloric restriction on the metabolic syndrome. Normandin E, Chmelo E, Lyles MF, Marsh AP, Nicklas BJ.. Med Sci Sports Exerc. 2017;49(3):413-419.

Physiological aging: links among adipose tissue dysfunction, diabetes, and frailty. Stout MB, Justice JN, Nicklas BJ, Kirkland JL.. Physiology (Bethesda). 2017;32(1):9-19.

Circulating MiRNAs as biomarkers of gait speed responses to aerobic exercise training in obese older adults. Zhang T, Brinkley TE, Liu K, Feng X, Marsh AP, Kritchevsky S, Zhou X, Nicklas BJ.. Aging (Albany NY). 2017;9(3):900-913.

Change in bone mineral density during weight loss with resistance versus aerobic exercise training in older adults. Beavers KM, Beavers DP, Martin SB, Marsh AP, Lyles MF, Lenchik L, Shapses SA, Nicklas BJ.. J Gerontol A Biol Sci Med Sci. 2017;():.

Effect of metabolic syndrome on the mobility benefit of a structured physical activity intervention-the Lifestyle Interventions and Independence for Elders randomized clinical trial. Botoseneanu A, Chen H, Ambrosius WT, Allore HG, Anton S, Folta SC, King AC, Nicklas BJ, Spring BJ, Strotmeyer ES, Gill TM.. J Am Geriatr Soc. 2017;65(6):1244-1250.

Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG.. Metabolism. 2017;70():98-106.

Impact of diet and/or exercise intervention on infrapatellar fat pad morphology: secondary analysis from the Intensive Diet and Exercise for Arthritis (IDEA) trial. Pogacnik Murillo AL, Eckstein F, Wirth W, Beavers D, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Hunter DJ, Messier SP.. Cells Tissues Organs. 2017;203(4):258-266.

Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women. Justice JN, Gregory H, Tchkonia T, LeBrasseur NK, Kirkland JL, Kritchevsky SB, Nicklas BJ.. J Gerontol A Biol Sci Med Sci. 2017;():.

Effects of resistance training with and without caloric restriction on arterial stiffness in overweight and obese older adults. Jefferson ME, Nicklas BJ, Chmelo EA, Crotts CI, Shaltout HA, Diz DI, Marsh AP, Brinkley TE.. Am J Hypertens. 2016;29(4):494-500.

Resistance training enhances skeletal muscle innervation without modifying the number of satellite cells or their myofiber association in obese older adults. Messi ML, Li T, Wang ZM, Marsh AP, Nicklas B, Delbono O.. J Gerontol A Biol Sci Med Sci. 2016;71(10):1273-1280.

Intramyocellular lipid and impaired myofiber contraction in normal weight and obese older adults. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O.. J Gerontol A Biol Sci Med Sci. 2016;71(4):557-564.

Aerobic exercise for reducing migraine burden: mechanisms, markers, and models of change processes. Irby MB, Bond DS, Lipton RB, Nicklas B, Houle TT, Penzien DB.. Headache. 2016;56(2):357-369.

Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. Sergeant S, Ruczinski I, Ivester P, Lee TC, Morgan TM, Nicklas BJ, Mathias RA, Chilton FH.. Br J Nutr. 2016;115(2):251-261.

Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G [sic] [Hundley WG], Kraus WE, Eggebeen J, Nicklas BJ.. JAMA. 2016;315(1):36-46.

A brief yoga intervention implemented during chemotherapy: a randomized controlled pilot study. Sohl SJ, Danhauer SC, Birdee GS, Nicklas BJ, Yacoub G, Aklilu M, Avis NE.. Complement Ther Med. 2016;25():139-142.

Legacy effects of short-term intentional weight loss on total body and thigh composition in overweight and obese older adults. Chmelo EA, Beavers DP, Lyles MF, Marsh AP, Nicklas BJ, Beavers KM.. Nutr Diabetes. 2016;6():e203.

Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study. Loeser R, Pathmasiri W, Sumner SJ, McRitchie S, Beavers D, Saxena P, Nicklas BJ, Jordan J, Guermazi A, Hunter DJ, Messier SP.. Osteoarthritis Cartilage. 2016;24(8):1479-1486.

Does long-term intensive diet and exercise reduce the biomechanical burden in overweight and obese adults with knee osteoarthritis? The Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Messier SP, Beavers D, Mihalko SL, Miller GD, Nicklas BJ, Lyles M, Hunter DJ, Carr JJ, Eckstein F, Guermazi A, Loeser RF, DeVita P.. Osteoarthritis Cartilage. 2016;24(Suppl):S47-S48.

Skeletal muscle mitochondrial content, oxidative capacity, and Mfn2 expression are reduced in older patients with heart failure and preserved ejection fraction and are related to exercise intolerance. Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW.. JACC Heart Fail. 2016;4(8):636-645.

At which location is the infrapatellar fat pad most sensitive to reduction by diet and exercise intervention - data from the Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Murillo ALP, Wirth W, Beavers DP, Dannhauer T, Loeser RF Jr, Nicklas BJ, Mihalko SL, Miller GD, Hunter DJ, Eckstein F, Messier SP.. Osteoarthritis Cartilage. 2016;24(Suppl):S242.

Effects of exercise and weight loss on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis Trial (IDEA) [abstract]. Loeser R, Beavers D, Bay-Jensen AC, Karsdal M, Nicklas B, Hunter D, Messier S.. Osteoarthritis Cartilage. 2016;24(Suppl):S32-S33.

Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure: a randomized clinical trial. Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP.. JAMA. 2016;315(24):2694-2702.

Insulin resistance correlations with executive functioning in sedentary older adults: the INFINITE study [abstract]. Dougherty A, Brinkley TE, Lyles MF, Nicklas BJ, Williams JA, Hugenschmidt CE.. J Am Geriatr Soc. 2016;64(Suppl 1):S262-S263.

Relationship of objectively-measured habitual physical activity to chronic inflammation and fatigue in middle-aged and older adults. Nicklas BJ, Beavers DP, Mihalko SL, Miller GD, Loeser RF, Messier SP.. J Gerontol A Biol Sci Med Sci. 2016;71(11):1437-1443.

Caloric restriction during aerobic training enhances cardiorespiratory fitness in obese, older adults: a randomized controlled trial: 1529 Board #182 June 2, 9: 00 AM - 10: 30 AM [abstract]. Nicklas BJ, Crotts C, Chmelo EA, Yow D, Gordon M, Lyles MF, Beavers KM, Houston DK, Hugenschmidt C, Leng I, Brinkley TE.. Med Sci Sports Exerc. 2016;48(5 Suppl 1):416-417.

Impact on weight and physical function of intensive medical weight loss in older adults with stage II and III obesity. Ard JD, Cook M, Rushing J, Frain A, Beavers K, Miller G, Miller ME, Nicklas B.. Obesity (Silver Spring). 2016;24(9):1861-1866.

Gait speed response to aerobic versus resistance exercise training in older adults. Henderson RM, Leng XI, Chmelo EA, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ.. Aging Clin Exp Res. 2016;():.

Research muscle biopsy tissue yields in older adults: associations with participant characteristics [abstract]. Lyles MF, Demons JL, Murphy KM, Gregory H, Stone J, Nicklas B.. Gerontologist. 2016;56(Suppl 3):350.

Adipose p16+cell burden in older women: physical function and effect of resistance training [abstract]. Justice J, Gregory H, Kritchevsky S, Nicklas B, Tchkonia T, Kirkland J.. Gerontologist. 2016;56(Suppl 3):.

The weightiness of fatigability: findings from the Baltimore Longitudinal Study of Aging (BLSA) [abstract]. Simonsick EM, Jerome G, Nicklas B, Schrack J, Studenski S, Ferrucci L.. Gerontologist. 2016;56(Suppl 3):241.

Respirometric profiling of muscle mitochondria and blood cells are associated with differences in gait speed among community-dwelling older adults. Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ.. J Gerontol A Biol Sci Med Sci. 2015;70(11):1394-1399.

Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis. Beavers KM, Beavers DP, Newman JJ, Anderson AM, Loeser RF Jr, Nicklas BJ, Lyles MF, Miller GD, Mihalko SL, Messier SP.. Osteoarthritis Cartilage. 2015;23(2):249-256.

Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. Zhang T, Birbrair A, Wang ZM, Messi ML, Marsh AP, Leng I, Nicklas BJ, Delbono O.. Exp Gerontol. 2015;62():7-13.

Effect of protein source during weight loss on body composition, cardiometabolic risk and physical performance in abdominally obese, older adults: a pilot feeding study. Beavers KM, Gordon MM, Easter L, Beavers DP, Hairston KG, Nicklas BJ, Vitolins MZ.. J Nutr Health Aging. 2015;19(1):87-95.

Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. Botoseneanu A, Ambrosius WT, Beavers DP, de Rekeneire N, Anton S, Church T, Folta SC, Goodpaster BH, King AC, Nicklas BJ, Spring B, Wang X, Gill TM.. J Am Geriatr Soc. 2015;63(2):222-232.

Heterogeneity of physical function responses to exercise training in older adults. Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ.. J Am Geriatr Soc. 2015;63(3):462-469.

Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ.. PLoS One. 2015;10(3):e0121993.

Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP.. Am J Clin Nutr. 2015;101(5):991-999.

Addition of exercise increases plasma adiponectin and release from adipose tissue. Wang X, You T, Murphy K, Lyles MF, Nicklas BJ.. Med Sci Sports Exerc. 2015;47(11):2450-2455.

The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP.. Osteoarthritis Cartilage. 2015;23(7):1090-1098.

The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ.. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Caloric restriction for treatment of geriatric obesity: do the benefits outweigh the risks?. Normandin E, Houstin DK, Nicklas BJ.. Curr Nutr Rep. 2015;4(2):143-155.

Impact of diet and/or exercise intervention on infra-patellar fat pad morphology - data from the Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Murillo ALP, Wirth W, Beavers D, Loeser RF, Nicklas BJ, Miller GD, Hunter D, Eckstein F, Messier SP.. Osteoarthritis Cartilage. 2015;23(Suppl 2):A389-A390.

Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,.. Diabetes. 2015;64(10):3464-3474.

Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ.. Exp Gerontol. 2015;70():84-91.

A brief yoga intervention implemented during chemotherapy for colorectal cancer: a randomized controlled pilot study [abstract]. Sohl S, Danhauer S, Birdee G, Nicklas B, Yacoub G, Aklilu M, Avis N.. Psychooncology. 2015;24(Suppl 2):253.

Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ.. BMC Obes. 2015;2():40.

Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women. Centi AJ, Booth SL, Gundberg CM, Saltzman E, Nicklas B, Shea MK.. Endocrine. 2015;50(3):627-632.

Mitochondrial bioenergetics, inflammation, and physical ability in older adults [abstract]. Molina AJ, Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh A, Nicklas B.. Gerontologist. 2015;55(Suppl 2):733.

Dietary interventions for the treatment of geriatric obesity: do the benefits outweigh the risks? [abstract]. Nicklas B, Houston DK.. Gerontologist. 2015;55(Suppl 2):517.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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