Barbara Nicklas, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.S.E., Truman State University, 1983
  • M.S., Iowa State University, 1987
  • Ph.D., University of Maryland-College Park, 1994
  • Fellowship, Geriatric Medicine, University of Maryland-Baltimo, 1994
  • Fellowship, Geriatric Medicine, University of Maryland-Baltimo, 1996


  • Am Coll Of Sports Medicine
  • Am Diabetes Assn
  • Am Physiological Society
  • Gerontological Society Of Amer
Barbara Nicklas, Ph.D.

Barbara Nicklas, Ph.D.

Deputy Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Center for Genomics and Personalized Medicine Research
Sticht Center on Aging
Center for Diabetes Research
Center for Comparative Medicine Research
Center for Integrative Medicine
Translational Science Institute

Research Interests

aging, arthritis, fitness/physical, nutrition

Contact Information

Academic: 336-713-8584 | Department: 336-713-8570

Recent Publications

Beavers KM, Beavers DP, Newman JJ, Anderson AM, Loeser RF Jr, Nicklas BJ, Lyles MF, Miller GD, Mihalko SL, Messier SP. Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis. Osteoarthritis Cartilage. 2015;23(2):249-256.

Zhang T, Birbrair A, Wang ZM, Messi ML, Marsh AP, Leng I, Nicklas BJ, Delbono O. Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. Exp Gerontol. 2015;62():7-13.

Beavers KM, Gordon MM, Easter L, Beavers DP, Hairston KG, Nicklas BJ, Vitolins MZ. Effect of protein source during weight loss on body composition, cardiometabolic risk and physical performance in abdominally obese, older adults: a pilot feeding study. J Nutr Health Aging. 2015;19(1):87-95.

Botoseneanu A, Ambrosius WT, Beavers DP, de Rekeneire N, Anton S, Church T, Folta SC, Goodpaster BH, King AC, Nicklas BJ, Spring B, Wang X, Gill TM. Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. J Am Geriatr Soc. 2015;63(2):222-232.

Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ. Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc. 2015;63(3):462-469.

Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ. Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. PLoS One. 2015;10(3):e0121993.

Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP. Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Am J Clin Nutr. 2015;101(5):991-999.

Wang X, You T, Murphy K, Lyles MF, Nicklas BJ. Addition of exercise increases plasma adiponectin and release from adipose tissue. Med Sci Sports Exerc. 2015;():.

Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP. The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Osteoarthritis Cartilage. 2015;23(7):1090-1098.

Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ. The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Normandin E, Houstin DK, Nicklas BJ. Caloric restriction for treatment of geriatric obesity: do the benefits outweigh the risks?. Curr Nutr Rep. 2015;4(2):143-155.

Murillo ALP, Wirth W, Beavers D, Loeser RF, Nicklas BJ, Miller GD, Hunter D, Eckstein F, Messier SP. Impact of diet and/or exercise intervention on infra-patellar fat pad morphology - data from the Intensive Diet and Exercise for Arthritis (IDEA) trial [abstract]. Osteoarthritis Cartilage. 2015;23(Suppl 2):A389-A390.

Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,. Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Diabetes. 2015;64(10):3464-3474.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol. 2015;():.

Sohl S, Danhauer S, Birdee G, Nicklas B, Yacoub G, Aklilu M, Avis N. A brief yoga intervention implemented during chemotherapy for colorectal cancer: a randomized controlled pilot study [abstract]. Psychooncology. 2015;24(Suppl 2):253.

Beavers KM, Hsu FC, Serra MC, Yank V, Pahor M, Nicklas BJ. The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability. J Aging Phys Act. 2014;22(1):25-33.

Haykowsky MJ, Kouba EJ, Brubaker PH, Nicklas BJ, Eggebeen J, Kitzman DW. Skeletal muscle composition and its relation to exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Cardiol. 2014;113(7):1211-1216.

Henderson R, Leng I, Chmelo E, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ. Comparison of aerobic versus resistance training for improving gait speed in older adults [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S154.

Beavers KM, Gordon M, Beavers D, Hairston K, Nicklas B, Kritchevsky S, Vitolins M. Relationship between change in body composition and physical function in abdominally obese, older adults undergoing 12-weeks of caloric restriction [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S20.

Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014;306(9):H1364-1370.

Nicklas BJ, Gaukstern JE, Beavers KM, Newman JC, Leng X, Rejeski WJ. Self-monitoring of spontaneous physical activity and sedentary behavior to prevent weight regain in older adults. Obesity (Silver Spring). 2014;22(6):1406-1412.

Beavers DP, Beavers KM, Loeser RF, Walton NR, Lyles MF, Nicklas BJ, Shapses SA, Newman JJ, Messier SP. The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese older adults with osteoarthritis. Osteoarthritis Cartilage. 2014;22(6):726-733.

Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Int J Obes (Lond). 2014;38(11):1397-1402.

Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin JP, Marsh AP, Nicklas B, Delbono O. Human slow troponin T (TNNT1) Pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(12):1437-1447.

You T, Wang X, Murphy KM, Lyles MF, Demons JL, Yang R, Gong DW, Nicklas BJ. Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women. Obesity (Silver Spring). 2014;22(7):1679-1684.

Messier SP, Beavers DP, Loeser RF, Carr JJ, Khajanchi S, Legault C, Nicklas BJ, Hunter DJ, DeVita P. Knee joint loading in knee osteoarthritis: influence of abdominal and thigh fat. Med Sci Sports Exerc. 2014;46(9):1677-1683.

Gordon MM, Chmelo E, Crotts C, Lyles M, Brinkley T, Newman J, Rejeski WJ, Nicklas B. Aerobic exercise training and self-reported fatigue in older, obese adults [abstract]. Med Sci Sports Exerc. 2014;46(5):224.

Messier SP, DeVita P, Nicklas BJ, Beavers D, Miller GD, Hunter DJ, Eckstein F, Guermazi A, Loeser RF. Changes in joint loads, Leptin, and MMP-3 subsequent to long-term intensive weight loss and exercise: secondary outcomes from the intensive diet and exercise for arthritis randomized clinical trial [abstract]. Osteoarthritis Cartilage. 2014;22(Suppl):S83-S84.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. Respirometric profiling of muscle mitochondria and blood cells are associated with differences in gait speed among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2014;():.

Buford TW, Hsu FC, Brinkley TE, Carter CS, Church TS, Dodson JA, Goodpaster BH, McDermott MM, Nicklas BJ, Yank V, Johnson JA, Pahor M. The angiotensin-converting enzyme I/D polymorphism and exercise-induced changes in physical function among Caucasian older adults [abstract]. Med Sci Sports Exerc. 2014;46(5 Suppl 1):598.

You TJ, Wang XW, Nicklas B. Effect of aerobic exercise intensity on prevalence of metabolic syndrome in obese older women under caloric restriction [abstract]. Med Sci Sports Exerc. 2014;46(5 Suppl 1):795.

Dhar S, Nicklas B, Lyles M, Morris P, Delbono O, Files DC. Skeletal muscle ultrasound as a tool to assess muscle function [abstract]. Crit Care Med. 2014;42(12 Suppl 1):A1528.

Beavers KM, Miller ME, Rejeski WJ, Nicklas BJ, Krichevsky SB [sic] [Kritchevsky SB]. Fat mass loss predicts gain in physical function with intentional weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013;68(1):80-86.

Beavers KM, Beavers DP, Houston DK, Harris TB, Hue TF, Koster A, Newman AB, Simonsick EM, Studenski SA, Nicklas BJ, Kritchevsky SB. Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study. Am J Clin Nutr. 2013;97(3):552-560.

Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

Beavers KM, Hsu FC, Houston DK, Beavers DP, Harris TB, Hue TF, Kim LJ, Koster A, Penninx BW, Simonsick EM, Strotmeyer ES, Kritchevsky SB, Nicklas BJ. The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2013;68(5):617-623.

Beavers DP, Beavers KM, Lyles MF, Nicklas BJ. Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women. J Gerontol A Biol Sci Med Sci. 2013;68(6):691-698.

Marsh AP, Shea MK, Vance Locke RM, Miller ME, Isom S, Miller GD, Nicklas BJ, Lyles MF, Carr JJ, Kritchevsky SB. Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013;68(7):828-836.

Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ. Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults. J Am Geriatr Soc. 2013;61(7):1089-1094.

Centi AJ, Booth SL, Gundberg CM, Nicklas B, Shea MK. Response of serum osteocalcin to caloric restriction with and without exercise in post menopausal women [abstract]. FASEB J. 2013;27():1067.13.

Messier SP, Mihalko SL, Beavers DP, Nicklas BJ, Devita P, Carr JJ, Hunter DJ, Williamson JD, Bennell KL, Guermazi A, Lyles M, Loeser RF. Strength Training for Arthritis Trial (START): design and rationale. BMC Musculoskelet Disord. 2013;14():208.

Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310(12):1263-1273.

Sink K, Chmelo E, Nicklas B, Katula J, Cofman C, Williamson J, Baker L. Pilot trial of buddy-assisted exercise in people with mild cognitive impairment [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P494.

Bharadwaj MS, Nicklas B, Molina AJ. Obesity is accompanied by increased basal mitochondrial respiration in older adults [abstract]. Gerontologist. 2013;53(Suppl 1):273.

Liu C, Hsu F, Beavers KM, Yank V, Stafford RS, Nicklas B, Weiner D, Fielding R. Effectiveness of physical activity on improving a physical performance measure in elders with chronic kidney disease: the lifestyle interventions and independence elders pilot study (LIFE-P) Study [abstract]. Gerontologist. 2013;53(Suppl 1):328.

Brinkley TE, Gordon MM, Chmelo EA, Jefferson M, Lyles MF, Hundley WG, Gregory HW, Nicklas BJ. Aortic stiffness predicts blood pressure responses to exercise in obese older adults [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):11.

Chmelo E, Gordon M, Crotts C, Lyles MF, Brinkley T, Blocker J, Nicklas BJ. Does 400 meter walk time predict Vo(2) peak in obese, older adults? [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):573.

Jefferson ME, Gordon MM, Chmelo EA, Lyles MF, Nicklas BJ, Brinkley TE. Heart rate recovery is associated with central adiposity in obese older adults [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):11.

Sorensen JA, Crotts C, Chmelo E, Lyles MF, Marsh AP, Nicklas BJ. Is gait speed associated with strength, power, and lower extremity function in older, overweight and obese men and women? [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):644.

You TJ, Wang XW, Yang RZ, Gong D, Lyles M, Nicklas B. Effects of weight loss on subcutaneous adipose tissue hormone/cytokine production: depot comparisons [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):418-419.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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