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Michelle M.  Nicolle, Ph.D.

Michelle M. Nicolle, Ph.D.

Associate Professor, Geriatrics & Gerontology
Contact Information
Appointment:
336-713-8250
Office:
336-716-8503
Fax:
336-713-8588
Education & Training
  BA University of North Carolina-Chapel Hill 1988
  PhD University of North Carolina-Chapel Hill 1996
Memberships
American Association of Advancement of Science
Society of Neuroscience
American Psychological Association
Michelle M.  Nicolle, Ph.D.

Michelle M. Nicolle, Ph.D.

Associate Professor, Geriatrics & Gerontology
Contact Information
Appointment:
336-713-8250
Office:
336-716-8503
Fax:
336-713-8588
Research Interests
aging , neurosciences/behavior
Recent Publications
Nieves-Martinez E, Haynes K, Childers SR, Sonntag WE, Nicolle MM. Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats. Behav Brain Res. 2012; 227(1):258-264.

Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM. Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats. J Gerontol A Biol Sci Med Sci. 2011; 66(5):521-533.

Shi L, Olson J, D'Agostino R Jr, Linville C, Nicolle MM, Robbins ME, Wheeler KT, Brunso-Bechtold JK. Aging masks detection of radiation-induced brain injury. Brain Res. 2011; 1385():307-316.

Montgomery KS, Simmons RK, Edwards G III, Nicolle MM, Bluck MA, Myers CE, Bizon JL. Novel age-dependent learning deficits in a mouse model of Alzheimer's disease: implications for translational research. Neurobiol Aging. 2011; 32(7):1273-1285.

McQuail JA, Riddle DR, Nicolle MM. Neuroinflammation not associated with cholinergic degeneration in aged-impaired brain. Neurobiol Aging. 2011; 32(12):2322.e1-4.

Nieves-Martinez E, Sonntag WE, Wilson A, Donahue A, Molina DP, Brunso-Bechtold J, Nicolle MM. Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. J Endocrinol. 2010; 204(1):31-36.

LaSarge C, Nicolle MM. Comparison of different cognitive rat models in human aging. In: Bizon JL, Woods AG, eds. Animal models of human cognitive aging. New York: Humana Press; 2009: 73-112.

McQuail JA, Riddle DR, Nicolle MM. Microglial activation but no loss of cholinergic neurons in basal forebrain of aged-impaired F344 x Brown Norway F1 rats [abstract]. Soc Neurosci Abstr. 2009; 2009(Neuroscience Meeting Planner):.

Mitschelen M, Garteiser P, Carnes BA, Farley JA, Doblas S, DeMoe JH, Warrington JP, Yan H, Nicolle MM, Towner R, et al. Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents. Neuroscience. 2009; 164(3):918-928.

Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Watson ML, Nicolle MM, et al. A selective allosteric potentiator of the M-1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J Neurosci. 2009; 29(45):14271-86.

Zhuo JM, Prakasam A, Murray ME, Zhang HY, Baxter MG, Sambamurti K, Nicolle MM. An increase in A beta 42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice. Curr Alzheimer Res. 2008; 5(4):385-391.

Nieves E, Wilson A, Donahue A, Molina DP, Brunso-Bechtold J, Sonntag WE, Nicolle MM. Identification of a critical period for the effects of growth hormone on memory changes associated with age [abstract]. Soc Neurosci Abstr. 2008; 2008(Neuroscience Meeting Planner):.

Montgomery KS, Simmons RK, Egbejimi AA, Walls KJ, Nicolle MM, Gluck MA, Myers CE, Bizon JL. Early detection of age-related cognitive decline in a mouse model using the transfer task [abstract]. Soc Neurosci Abstr. 2008; 2008(Neuroscience Meeting Planner):.


Bizon J, Prescott S, Nicolle MM. Intact spatial learning in adult Tg2576 mice. Neurobiol Aging. 2007; 28(3):440-446.

Nicolle MM, Zhang H-Y, Bizon JL. Assessment of second messenger function in the hippocampus of aged rates with cognitive impairment. In: Riddle DR, ed. Brain aging models, methods, and mechanisms. Boca Raton (FL): CRC Press; 2007: 213-228.

Zhuo J-M, Prescott SL, Murray ME, Zhang H-Y, Baxter MG, Nicolle MM. Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice. Neurobiol Aging. 2007; 28(8):1248-1257.

Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 2007; 8():article 54.

Shi L, Adams MM, Long A, Carter CC, Bennett C, Sonntag WE, Nicolle MM, Robbins M, D'Agostino R Jr, Brunso-Bechtold JK. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res. 2006; 166(6):892-899.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Last Updated 1/19/2012
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