Emmanuel C. Opara, Ph.D., Professor Institute for Regenerative Medicine

Emmanuel C. Opara, Ph.D.

Professor, Institute for Regenerative Medicine
Center for Biomolecular Imaging
Center for Diabetes Research

Contact Information

Department: 336-716-2011

Email: eopara@wakehealth.edu

Education & Training

Ph.D., London Hospital Medical Coll-United Kingdom , 1983
Master's Degree, University of Surrey-United Kingdom , 1980
Fellowship, Endocrinology, Mayo Clinic School of Medicine, 1986

Emmanuel C. Opara, Ph.D.

Professor, Institute for Regenerative Medicine Center for Biomolecular Imaging
Center for Diabetes Research

Research Interests

biotechnology, cell growth, differentiation,d, diabetes, engineering/bioengineering, medical technology/devices, transplantation

Contact Information

Department: 336-716-2011

Email: eopara@wakehealth.edu

Recent Publications

Sittadjody S, Saul JM, Joo S, Yoo JJ, Atala A, Opara EC. Engineered multilayer ovarian tissue that secretes sex steroids and peptide hormones in response to gonadotropins. Biomaterials. 2013;34(10):2412-2420.

Liu G, Pareta RA, Wu R, Shi Y, Zhou X, Liu H, Deng C, Sun X, Atala A, Opara EC, Zhang Y. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials. 2013;34(4):1311-1326.

Opara EC, McQuilling JP, Farney AC. Microencapsulation of pancreatic islets for use in a bioartificial pancreas. Methods Mol Biol. 2013;1001():261-266.

Moya ML, Morley M, Khanna O, Opara EC, Brey EM. Stability of alginate microbead properties in vitro. J Mater Sci Mater Med. 2012;23(4):903-912.

Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH IV, Koch K, Macchiarini P, Mirmalek Sani S-H, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D,. Regenerative medicine as applied to general surgery. Ann Surg. 2012;255(5):867-880.

Tendulkar S, Mirmalek-Sani SH, Childers C, Saul J, Opara EC, Ramasubramanian MK. A three-dimensional microfluidic approach to scaling up microencapsulation of cells. Biomed Microdevices. 2012;14(3):461-469.

Joo S, Helms A, Sivanandane S, Jackson JD, Soker S, Lee SJ, Atala A, Opara E, Yoo JJ. Development of ovarian follicle-like structures [abstract]. J Tissue Eng Regen Med. 2012;6(Suppl 1):131.

Sivanandane S, Saul J, Joo S, Pareta R, Arenas J, Marshall N, Yoo J, Atala A, Opara E. Encapsulated ovarian endocrine cells produced sustained levels of steroid hormones in vivo [abstract]. J Tissue Eng Regen Med. 2012;6(Suppl 1):410.

Joo S, Sivanandane S, Opara EC, Jackson JD, Yoo JJ, Atala A. In vitro generation of three-dimensional functional ovarian structures [abstract]. J Am Coll Surg. 2012;215(3 Suppl):S65.

Pareta R, Sanders B, Babbar P, Soker T, Booth C, McQuilling J, Sivanandane S, Stratta RJ, Orlando G, Opara EC. Immunoisolation: where regenerative medicine meets solid organ transplantation. Expert Rev Clin Immunol. 2012;8(7):685-692.

Orlando G, Baptista P, Birchall M, De Coppi P, Farney A, Opara E, Rogers J, Stratta RJ, Atala A, Soker S, et al. Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int. 2011;24(3):223-232.

McQuilling JP, Arenas-Herrera J, Childers C, Pareta RA, Khanna O, Jiang B, Brey EM, Farney AC, Opara EC. New alginate microcapsule system for angiogenic protein delivery and immunoisolation of islets for transplantation in the rat omentum pouch. Transplant Proc. 2011;43(9):3262-3264.

Tendulkar S, McQuilling JP, Childers C, Pareta R, Opara EC, Ramasubramanian MK. A scalable microfluidic device for the mass production of microencapsulated islets. Transplant Proc. 2011;43(9):3184-3187.

Moya ML, Cheng M-H, Huang J-J, Francis-Sedlak ME, Kao S-w, Opara EC, Brey EM. The effect of FGF-1 loaded alginate microbeads on neovascularization and adipogenesis in a vascular pedicle model of adipose tissue engineering. Biomaterials. 2010;31(10):2816-2826.

Moya ML, Garfinkel MR, Liu X, Lucas S, Opara EC, Greisler HP, Brey EM. Fibroblast growth factor-1 (FGF-1) loaded microbeads enhance local capillary neovascularization. J Surg Res. 2010;160(2):208-212.

Opara EC, Mirmalek-Sani SH, Khanna O, Moya ML, Brey EM. Design of a bioartificial pancreas. J Investig Med. 2010;58(7):831-837.

Khanna O, Moya ML, Opara EC, Brey EM. Synthesis of multilayered alginate microcapsules for the sustained release of fibroblast growth factor-1. J Biomed Mater Res A. 2010;95(2):632-640.

Khanna O, Moya ML, Greisler HP, Opara EC, Brey EM. Multilayered microcapsules for the sustained-release of angiogenic proteins from encapsulated cells. Am J Surg. 2010;200(5):655-658.

Moya ML, Lucas S, Francis-Sedlak M, Liu X, Garfinkel MR, Huang J-J, Cheng M-H, Opara EC, Brey EM. Sustained delivery of FGF-1 increases vascular density in comparison to bolus administration. Microvasc Res. 2009;78(2):142-147.