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Profile

Profile
Research

Ronald Oppenheim, Ph.D.

Professor, Neurobiology & Anatomy
Orthopaedics
Neurology

Contact Information

Academic: 336-716-4405 | Department: 336-716-4405

Email: roppenhm@wakehealth.edu

Education & Training

B.A., Drake University , 1962
Ph.D., Washington University , 1967
Fellowship, Washington University, 1968

Memberships

Am Assn Of Anatomists
Society for Neuroscience

Ronald Oppenheim, Ph.D.

Professor, Neurobiology & Anatomy Orthopaedics
Neurology

Research Interests

cell growth, differentiation,d, degenerative disorders, growth & development, neurosciences/behavior

Contact Information

Academic: 336-716-4405 | Department: 336-716-4405

Email: roppenhm@wakehealth.edu

Recent Publications

Oppenheim RW, Milligan CE, von Bartheld CS. Programmed cell death and neurotrophic factors In: Squire LR, Berg D, Bloom FE, Du Lac S, Ghosh A, Spitzer NC, eds. Fundamental neuroscience. 4th ed. Boston: Elsevier/Academic Press;2013: 405-435.

Choi SY, Kim JY, Kim HW, Cho B, Cho HM, Oppenheim RW, Kim H, Rhyu IJ, Sun W. Drp1-mediated mitochondrial dynamics and survival of developing chick motoneurons during the period of normal programmed cell death. FASEB J. 2013;27(1):51-62.

Taylor AR, Gifondorwa DJ, Robinson MB, Strupe JL, Prevette D, Johnson JE, Hempstead B, Oppenheim RW, Milligan CE. Motoneuron programmed cell death in response to proBDNF. Dev Neurobiol. 2012;72(5):699-712.

Hicks AN, Lorenzetti D, Gilley J, Lu B, Andersson KE, Miligan C, Overbeek PA, Oppenheim R, Bishop CE. Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo. PLoS One. 2012;7(10):e47869.

Kim WR, Chun SK, Kim TW, Kim H, Ono K, Takebayashi H, Ikenaka K, Oppenheim RW, Sun W. Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the postnatal mouse brain. Eur J Neurosci. 2011;33(4):599-611.

Gould TW, Oppenheim RW. Motor neuron trophic factors: therapeutic use in ALS?. Brain Res Rev. 2011;67(1-2):1-39.

Hicks A, Lorenzetti D, Lu B, Andersson K-E, Overbeek P, Oppenheim R, Bishop C. Nervous system defects in the novel bloated bladder mouse mutant (BLAD) [abstract]. Soc Neurosci Abstr. 2011;2011(Neuroscience Meeting Planner):33.15.

Oppenheim RW, Milligan C, Sun W. Programmed cell death during nervous system development: mechanisms, regulation, functions, and implications for neurobehavioral ontogeny In: Blumberg MS, Freeman JH, Robinson SR, eds. Oxford handbook of developmental behavioral neuroscience. New York: Oxford University Press;2010: 76-107.

An MC, Lin W, Yang J, Dominguez B, Padgett D, Sugiura Y, Aryal P, Gould TW, Oppenheim RW, Hester ME, et al. Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A. 2010;107(23):10702-7.

Oppenheim R, Milligan C. Early changes in ALS: where does the end begin? [abstract]. J Physiol Sci. 2010;60(Suppl 1):S22.

Suzuki H, Aoyama Y, Senzaki K, Vincler M, Wittenauer S, Yoshikawa M, Ozaki S, Oppenheim RW, Shiga T. Characterization of sensory neurons in the dorsal root ganglia of Bax-deficient mice. Brain Res. 2010;1362():23-31.

Hernandez S, Texido L, Caldero J, Ciutat D, Piedrafita L, Casanovas A, Caress J, Prevette D, Oppenheim RW, Milligan C, et al. Increased intramuscular nerve branching and inhibition of programmed cell death of chick embryo motoneurons by immunoglobulins from patients with motoneuron disease. J Neuroimmunol. 2010;229(1-2):157-168.

Creer R, Payne V, Molina D, Shi L, Oppenheim RW, Robbins M, Brunso-Bechtold J. Reduction in hippocampal neuron number in a pediatric model of fractionated whole brain irradiation [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Kim WR, Park O-h, Choi S, Choi S-Y, Park SK, Lee KJ, Rhyu IJ, Kim H, Lee YK, Oppenheim RW, et al. The maintenance of specific aspects of neuronal function and behavior is dependent on programmed cell death of adult-generated neurons in the dentate gyrus. Eur J Neurosci. 2009;29(7):1408-1421.

Oppenheim R, Milligan C.Programmed cell death

Liu Y, Oppenheim RW, Sugiura Y, Lin W. Abnormal development of the neuromuscular junction in Nedd4-deficient mice. Dev Biol. 2009;330(1):153-166.

de Castro BM, De Jaeger X, Martins-Silva C, Lima RDF, Amaral E, Menezes C, Lima P, Neves CML, Gould TW, Oppenheim RW, et al. The vesicular acetylcholine transporter is required for neuromuscular development and function. Mol Cell Biol. 2009;29(19):5238-5250.

Liu Y, Oppenheim RW, Sugiura Y, Lin W. The role of Nedd4 in neuromuscular junction formation in mice [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Yoshikawa M, Vinsant S, Mansfield CM, Gifondorwa DJ, Pace L, Messi LM [sic] [Messi ML], Caress J, Cartwright M, Delbono O, Oppenheim RW, Milligan CE, et al. Identification of changes in muscle, neuromuscular junctions and spinal cord at early pre-symptomatic stages in the mutant SOD1 mouse model of ALS may provide novel insight for diagnosis and treatment development [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Gould TW, Yonemura S, Oppenheim RW, Ohmori S, Enomoto H. The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. J Neurosci. 2008;28(9):2131-2146.

Jung A-r, Kim TW, Rhyu IJ, Kim H, Lee YD, Vinsant S, Oppenheim RW, Sun W. Misplacement of Purkinje cells during postnatal development in Bax knock-out mice: a novel role for programmed cell death in the nervous system?. J Neurosci. 2008;28(11):2941-2948.

Oppenheim RW, Blomgren K, Ethell DW, Koike M, Komatsu M, Prevette D, Roth KA, Uchiyama Y, Vinsant S, Zhu C. Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy. J Neurosci. 2008;28(6):1490-1497.

Oppenheim RW, Caldero J, Cuitat D, Esquerda J, McArdle JJ, Olivera BM, Prevette D, Teichert RW. The rescue of developing avian motoneurons from programmed cell death by a selective inhibitor of the fetal muscle-specific nicotinic acetylcholine receptor. Dev Neurobiol. 2008;68(7):972-980.

Oppenheim RW, Von Bartheld CS. Programmed cell death and neurotrophic factors In: Squire L, Berg D, Bloom F, Du Lac S, Ghosh A, Spitzer N, eds. Fundamental neuroscience. 3rd ed. Boston: Elsevier/Academic Press;2008: 437-468.

Taylor AR, Gifondorwa DJ, Newbern JM, Robinson MB, Strupe JL, Prevette D, Oppenheim RW, Milligan CE. Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival. J Neurosci. 2007;27(3):634-644.

Bateson P, Hofer M, Oppenheim R, Wiedenmayer C. Developing a framework for development: a discussion. Dev Psychobiol. 2007;49(1):77-86.

Brunet N, Tarabal O, Portero-Otin M, Oppenheim RW, Esquerda JE, Caldero J. Survival and death of mature avian motoneurons in organotypic slice culture: trophic requirements for survival and different types of degeneration. J Comp Neurol. 2007;501(5):669-690.

Messi ML, Clark HM, Prevette DM, Oppenheim RW, Delbono O. The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS. Exp Neurol. 2007;207(1):52-63.

Park O-h, Lee KJ, Rhyu IJ, Geum D, Kim H, Buss R, Oppenheim RW, Sun W. Bax-dependent and -independent death of motoneurons after facial nerve injury in adult mice. Eur J Neurosci. 2007;26(6):1421-1432.

Gould TW, Oppenheim RW. Synaptic dysfunction in disease and following injury in the developing and adult nervous system: caveats in the choice of therapeutic intervention. Neurosci Biobehav Rev. 2007;31(8):1073-1087.

Gifondorwa DJ, Robinson MB, Hayes CD, Taylor AR, Prevette DM, Oppenheim RW, Caress J, Milligan CE. Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis. J Neurosci. 2007;27(48):13173-80.

Kim WR, Kim Y, Eun B, Park O-h, Kim H, Kim K, Park C-H, Vinsant S, Oppenheim RW, Sun W. Impaired migration in the rostral migratory stream but spared olfactory function after the elimination of programmed cell death in Bax knock-out mice. J Neurosci. 2007;27(52):14392-403.

Gould TW, Buss RR, Vinsant S, Prevette D, Sun W, Knudson CM, Milligan CE, Oppenheim RW. Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci. 2006;26(34):8774-8786.

Winseck AK, Oppenheim RW. An in vivo analysis of Schwann cell programmed cell death in embryonic mice: the role of axons, glial growth factor, and the pro-apoptotic gene Bax. Eur J Neurosci. 2006;24(8):2105-2117.

Buss RR, Gould TW, Ma J, Vinsant S, Prevette D, Winseck A, Toops KA, Hammaback JA, Smith TL, Oppenheim RW. Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle. J Neurosci. 2006;26(52):13413-27.

Taylor AR, Robinson MB, Prevette D, Gifondorwa D, Newbern JM, Strupe J, Oppenheim RW, Milligan CE. Astrocyte- and muscle-secreated factors differentially regulate motoneuron survival [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Kim W, Kim Y, Eun B, Kim K, Park O, Kim H, Vinsant S, Oppenheim RW, Sun W. Impairments in the RMS migration of adult-produced neuroblasts after genetic elimination of programmed cell death in the Bax-KO mice [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Jung A, Kim H, Geum D, Oppenheim RW, Sun W. Programmed cell death and migration of Purkinje neurons in the Bax-KO cerebellum [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Sato N, Sakuma C, Gould TW, Oppenheim RW, Yaginuma H. Distinct susceptibility of developing neurons to death after Bax overexpression in the chicken embryo [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.