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David A. Ornelles, Ph.D.Wake Forest School of Medicine

David A. Ornelles, Ph.D.

Associate Professor,
Ctr for Vaccines at Extremes

Clinical Interests

Acute and Chronic Leukemia, Cancer Cell Biology

Contact Information

Academic: 336-716-9332 | Department: 336-716-2011


Education & Training

  • B.S., University of Hawaii-Manoa, 1980
  • Ph.D., Massachusetts Institute of Technology, 1987
  • Fellowship, Howard Hughes Medical Institut, 1993
David A. Ornelles, Ph.D.

David A. Ornelles, Ph.D.

Associate Professor, Microbiology & Immunology
Ctr for Vaccines at Extremes

Research Interests

Adenovirus E1B Proteins; Adenoviruses, Human; Adenovirus E4 Proteins; Virus Replication; Adenoviridae
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Contact Information

Academic: 336-716-9332 | Department: 336-716-2011


Recent Publications

Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes. Grayson KM, Blevins LK, Oliver MB, Ornelles DA, Swords WE, Alexander-Miller MA.. Pathog Dis. 2017;75(2):ftx008.

The border-to-border distribution method for analysis of cytoplasmic particles and organelles. Yacovone SK, Ornelles DA, Lyles DS.. Cell Tissue Res. 2016;363(2):351-360.

Limited but durable changes to cellular gene expression in a model of latent adenovirus infection are reflected in childhood leukemic cell lines. Ornelles DA, Gooding LR, Dickherber ML, Policard M, Garnett-Benson C.. Virology. 2016;494():67-77.

Migration of nucleocapsids in vesicular stomatitis virus-infected cells is dependent on both microtubules and actin filaments. Yacovone SK, Smelser AM, Macosko JC, Holzwarth G, Ornelles DA, Lyles DS.. J Virol. 2016;90(13):6159-6170.

Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media. Murrah KA, Turner RL, Pang B, Perez AC, Reimche JL, King LB, Wren J, Gandhi U, Swords WE, Ornelles DA.. Pathog Dis. 2015;73(2):1-8.

Adenovirus replaces mitotic checkpoint controls. Turner RL, Groitl P, Dobner T, Ornelles DA.. J Virol. 2015;89(9):5083-5096.

Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes. Ornelles DA, Gooding LR, Garnett-Benson C.. PLoS One. 2015;10(3):e0119256.

Adenovirus death protein (ADP) is required for lytic infection of human lymphocytes. Murali VK, Ornelles DA, Gooding LR, Wilms HT, Huang W, Tollefson AE, Wold WS, Garnett-Benson C.. J Virol. 2014;88(2):903-912.

E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor. Turner RL, Wilkinson JC, Ornelles DA.. Virology. 2014;456-457():205-219.

Persistently adenovirus-infected lymphoid cells express microRNAs derived from the viral VAI and especially VAII RNA. Furuse Y, Ornelles DA, Cullen BR.. Virology. 2013;447(1-2):140-145.

Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA. Gupta A, Jha S, Engel DA, Ornelles DA, Dutta A.. Oncogene. 2013;32(42):5017-5025.

JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Divers J, Nunez M, High KP, Murea M, Rocco MV, Ma L, Bowden DW, Hicks PJ, Spainhour M, Ornelles DA, Kleiboeker SB, Duncan K, Langefeld CD, Turner J, Freedman BI.. Kidney Int. 2013;84(6):1207-1213.

Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. Murphy AM, Besmer DM, Moerdyk-Schauwecker M, Moestl N, Ornelles DA, Mukherjee P, Grdzelishvili VZ.. J Virol. 2012;86(6):3073-3087.

A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. Whitlock PW, Seyler TM, Parks GD, Ornelles DA, Smith TL, Van Dyke ME, Poehling GG.. J Bone Joint Surg Am. 2012;94(16):1458-1467.

Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Kute T, Stehle Jr JR, Ornelles D, Walker N, Delbono O, Vaughn JP.. Oncoimmunology. 2012;1(6):810-821.

JC polyoma virus interacts with apolipoprotein L1 genetic risk in African Americans with non-diabetic nephropathy [abstract]. Freedman BI, Murea M, Rocco MV, Ma L, Bowden DW, Ornelles DA, Kleiboeker S, Langefeld CD, Turner J, Divers J.. J Am Soc Nephrol. 2012;23():178A.

Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL). Honkaniemi E, Talekar G, Huang W, Bogdanovic G, Forestier E, von Doblen U, Engvall M, Ornelles DA, Gooding LR, Gustafsson B.. Br J Cancer. 2010;102(5):796-798.

Modeling adenovirus latency in human lymphocyte cell lines. Zhang Y, Huang W, Ornelles DA, Gooding LR.. J Virol. 2010;84(17):8799-8810.

Latent species C adenoviruses in human tonsil tissues. Garnett CT, Talekar G, Mahr JA, Huang W, Zhang Y, Ornelles DA, Gooding LR.. J Virol. 2009;83(6):2417-2428.

E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus. Thomas MA, Broughton RS, Goodrum FD, Ornelles DA.. J Virol. 2009;83(6):2406-2416.

Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. Nichols GJ, Schaack J, Ornelles DA.. J Virol. 2009;83(12):5987-5998.

The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection. Spurgeon ME, Ornelles DA.. J Virol. 2009;83(19):9970-9982.

RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. Marshall LJ, Moore AC, Ohki M, Kitabayashi I, Patterson D, Ornelles DA.. J Virol. 2008;82(13):6395-6408.

IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. Henry CJ, Ornelles DA, Mitchell LM, Brzoza-Lewis KL, Hiltbold EM.. J Immunol. 2008;181(12):8576-8584.

The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage. Hart LS, Ornelles D, Koumenis C.. J Biol Chem. 2007;282(9):6061-6067.

Adenovirus DNA is detected at increased frequency in Guthrie cards from children who develop acute lymphoblastic leukaemia. Gustafsson B, Huang W, Bogdanovic G, Gauffin F, Nordgren A, Talekar G, Ornelles DA, Gooding LR.. Br J Cancer. 2007;97(7):992-994.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Microbiology & Immunology

Clinical Interests

Acute and Chronic Leukemia, Cancer Cell Biology
David A. Ornelles, Ph.D.

David A. Ornelles, Ph.D.

Associate Professor, Microbiology & Immunology
Ctr for Vaccines at Extremes

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