David A. Ornelles, Ph.D.Wake Forest School of Medicine

David A. Ornelles, Ph.D.

Associate Professor,

Clinical Interests

Acute and Chronic Leukemia, Cancer Cell Biology

Contact Information

Academic: 336-716-9332 | Department: 336-716-2011


Education & Training

  • B.S., University of Hawaii-Manoa, 1980
  • Ph.D., Massachusetts Institute of Technology, 1987
  • Fellowship, Howard Hughes Medical Institut, 1993
David A. Ornelles, Ph.D.

David A. Ornelles, Ph.D.

Associate Professor, Microbiology & Immunology

Research Interests

cancer/oncogenesis, cell growth, differentiation,d, communication/speech/hearing, growth & development, hearing, infectious diseases, molecular biology/molecular me

Contact Information

Academic: 336-716-9332 | Department: 336-716-2011


Recent Publications

Yacovone SK, Ornelles DA, Lyles DS. The border-to-border distribution method for analysis of cytoplasmic particles and organelles. Cell Tissue Res. 2016;363(2):351-360.

Ornelles DA, Gooding LR, Dickherber ML, Policard M, Garnett-Benson C. Limited but durable changes to cellular gene expression in a model of latent adenovirus infection are reflected in childhood leukemic cell lines. Virology. 2016;494():67-77.

Yacovone SK, Smelser AM, Macosko JC, Holzwarth G, Ornelles DA, Lyles DS. Migration of nucleocapsids in vesicular stomatitis virus-infected cells is dependent on both microtubules and actin filaments. J Virol. 2016;90(13):6159-6170.

Murrah KA, Turner RL, Pang B, Perez AC, Reimche JL, King LB, Wren J, Gandhi U, Swords WE, Ornelles DA. Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media. Pathog Dis. 2015;73(2):1-8.

Turner RL, Groitl P, Dobner T, Ornelles DA. Adenovirus replaces mitotic checkpoint controls. J Virol. 2015;89(9):5083-5096.

Ornelles DA, Gooding LR, Garnett-Benson C. Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes. PLoS One. 2015;10(3):e0119256.

Murali VK, Ornelles DA, Gooding LR, Wilms HT, Huang W, Tollefson AE, Wold WS, Garnett-Benson C. Adenovirus death protein (ADP) is required for lytic infection of human lymphocytes. J Virol. 2014;88(2):903-912.

Turner RL, Wilkinson JC, Ornelles DA. E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor. Virology. 2014;456-457():205-219.

Furuse Y, Ornelles DA, Cullen BR. Persistently adenovirus-infected lymphoid cells express microRNAs derived from the viral VAI and especially VAII RNA. Virology. 2013;447(1-2):140-145.

Gupta A, Jha S, Engel DA, Ornelles DA, Dutta A. Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA. Oncogene. 2013;32(42):5017-5025.

Divers J, Nunez M, High KP, Murea M, Rocco MV, Ma L, Bowden DW, Hicks PJ, Spainhour M, Ornelles DA, Kleiboeker SB, Duncan K, Langefeld CD, Turner J, Freedman BI. JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Kidney Int. 2013;84(6):1207-1213.

Murphy AM, Besmer DM, Moerdyk-Schauwecker M, Moestl N, Ornelles DA, Mukherjee P, Grdzelishvili VZ. Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. J Virol. 2012;86(6):3073-3087.

Whitlock PW, Seyler TM, Parks GD, Ornelles DA, Smith TL, Van Dyke ME, Poehling GG. A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. J Bone Joint Surg Am. 2012;94(16):1458-1467.

Kute T, Stehle Jr JR, Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012;1(6):810-821.

Freedman BI, Murea M, Rocco MV, Ma L, Bowden DW, Ornelles DA, Kleiboeker S, Langefeld CD, Turner J, Divers J. JC polyoma virus interacts with apolipoprotein L1 genetic risk in African Americans with non-diabetic nephropathy [abstract]. J Am Soc Nephrol. 2012;23():178A.

Honkaniemi E, Talekar G, Huang W, Bogdanovic G, Forestier E, von Doblen U, Engvall M, Ornelles DA, Gooding LR, Gustafsson B. Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL). Br J Cancer. 2010;102(5):796-798.

Zhang Y, Huang W, Ornelles DA, Gooding LR. Modeling adenovirus latency in human lymphocyte cell lines. J Virol. 2010;84(17):8799-8810.

Garnett CT, Talekar G, Mahr JA, Huang W, Zhang Y, Ornelles DA, Gooding LR. Latent species C adenoviruses in human tonsil tissues. J Virol. 2009;83(6):2417-2428.

Thomas MA, Broughton RS, Goodrum FD, Ornelles DA. E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus. J Virol. 2009;83(6):2406-2416.

Nichols GJ, Schaack J, Ornelles DA. Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol. 2009;83(12):5987-5998.

Spurgeon ME, Ornelles DA. The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection. J Virol. 2009;83(19):9970-9982.

Marshall LJ, Moore AC, Ohki M, Kitabayashi I, Patterson D, Ornelles DA. RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. J Virol. 2008;82(13):6395-6408.

Henry CJ, Ornelles DA, Mitchell LM, Brzoza-Lewis KL, Hiltbold EM. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol. 2008;181(12):8576-8584.

Hart LS, Ornelles D, Koumenis C. The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage. J Biol Chem. 2007;282(9):6061-6067.

Gustafsson B, Huang W, Bogdanovic G, Gauffin F, Nordgren A, Talekar G, Ornelles DA, Gooding LR. Adenovirus DNA is detected at increased frequency in Guthrie cards from children who develop acute lymphoblastic leukaemia. Br J Cancer. 2007;97(7):992-994.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Microbiology & Immunology

Clinical Interests

Acute and Chronic Leukemia, Cancer Cell Biology
David A. Ornelles, Ph.D.

David A. Ornelles, Ph.D.

Associate Professor, Microbiology & Immunology

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