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Nicholas M. Pajewski, Ph.D.Wake Forest School of Medicine

Nicholas M. Pajewski, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1396 | Department: 336-716-2011


Education & Training

  • Bachelors Degree, Loyola University of Chicago, 2002
  • Ph.D., Medical College of Wisconsin, 2008


  • Am Assn for the Adv of Science
  • Am Soc of Human Genetics
  • Am Statistical Assn
  • Institute Of Mathematical Stat
  • Intl Biometric Soc, ENAR
  • Intl Soc for Bayesian Analysis
Nicholas M. Pajewski, Ph.D.

Nicholas M. Pajewski, Ph.D.

Assistant Professor, Biostatistical Sciences

Research Interests

Anemia, Sickle Cell; Antihypertensive Agents; Health Status; Genome-Wide Association Study; Hypertension
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Contact Information

Academic: 336-713-1396 | Department: 336-716-2011


Recent Publications

Systolic blood pressure and mortality: role of reverse causation [letter]. Supiano MA, Pajewski NM, Williamson JD.. J Am Geriatr Soc. 2018;66(1):205-206.

Limitations of observational data in interpreting SPRINT results [letter]. Pajewski NM, Supiano MA, Williamson JD.. JAMA Intern Med. 2018;178(1):154-155.

Measuring vascular reactivity with resting-state blood oxygenation level-dependent (BOLD) signal fluctuations: a potential alternative to the breath-holding challenge?. Jahanian H, Christen T, Moseley ME, Pajewski NM, Wright CB, Tamura MK, Zaharchuk G.. J Cereb Blood Flow Metab. 2017;37(7):2526-2538.

Effect of intensive versus standard clinic-based hypertension management on ambulatory blood pressure: results from the SPRINT (Systolic Blood Pressure Intervention Trial) ambulatory blood pressure study. Drawz PE, Pajewski NM, Bates JT, Bello NA, Cushman WC, Dwyer JP, Fine LJ, Goff DC Jr, Haley WE, Krousel-Wood M, McWilliams A, Rifkin DE, Slinin Y, Taylor A, Townsend R, Wall B, Wright JT, Rahman M.. Hypertension. 2017;69(1):42-50.

Effect of a long-term intensive lifestyle intervention on cognitive function: Action for Health in Diabetes study. Rapp SR, Luchsinger JA, Baker LD, Blackburn GL, Hazuda HP, Demos-McDermott KE, Jeffery RW, Keller JN, McCaffery JM, Pajewski NM, Evans M, Wadden TA, Arnold SE, Espeland MA.. J Am Geriatr Soc. 2017;65(5):966-972.

Effect of intensive blood pressure control on gait speed and mobility limitation in adults 75 years or older: a randomized clinical trial. Odden MC, Peralta CA, Berlowitz DR, Johnson KC, Whittle J, Kitzman DW, Beddhu S, Nord JW, Papademetriou V, Williamson JD, Pajewski NM.. JAMA Intern Med. 2017;177(4):500-507.

Genetic associations with lipoprotein subfraction measures differ by ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA). Wang Z, Manichukal A, Goff DC Jr, Mora S, Ordovas JM, Pajewski NM, Post WS, Rotter JI, Sale MM, Santorico SA, Siscovick D, Tsai MY, Arnett DK, Rich S, Frazier-Wood AC.. Hum Genet. 2017;136(6):715-726.

APOL1 renal-risk variants do not associate with incident cardiovascular disease or mortality in the Systolic Blood Pressure Intervention Trial. Freedman BI, Rocco MV, Bates JT, Chonchol M, Hawfield AT, Lash JP, Papademetriou V, Sedor JR, Servilla K, Kimmel PL, Wall BM, Pajewski NM.. Kidney Int Rep. 2017;2(4):713-720.

Intensive blood pressure control on gait speed and mobility limitation for older adults [reply to letter]. Odden MC, Williamson JD, Pajewski NM.. JAMA Intern Med. 2017;177(9):1396.

Prediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram. Ayala-Peacock DN, Attia A, Braunstein SE, Ahluwalia MS, Hepel J, Chung C, Contessa J, McTyre E, Peiffer AM, Lucas JT Jr, Isom S, Pajewski NM, Kotecha R, Stavas MJ, Page BR, Kleinberg L, Shen C, Taylor RB, Onyeuku NE, Hyde AT, Gorovets D,.. J Neurooncol. 2017;135(2):403-411.

Effect of intensive blood-pressure treatment on patient-reported outcomes. Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J, Rocco M,.. N Engl J Med. 2017;377(8):733-744.

Geographic and demographic variation in use of ranibizumab versus bevacizumab for neovascular age-related macular degeneration in the United States. Gower EW, Stein JD, Shekhawat NS, Mikkilineni S, Blachley TS, Pajewski NM.. Am J Ophthalmol. 2017;184():157-166.

Using a novel machine learning technique to predict brain metastasis velocity following stereotactic radiosurgery for brain metastases [abstract]. Muhlestein W, Farris M, McTyre E, Pajewski NM, Attia A, Chambless LB, Braunstein SE, Hepel JT, Chung C, Contessa JN, Chao ST, Fiveash JB, Chan MD, Ayala-Peacock DN.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E96.

Using a novel machine learning technique to predict radiation oncology outcomes [abstract]. Muhlestein W, Chambless LB, Pajewski NM, Braunstein SE, Hepel JT, Chung C, Contessa JN, Chao ST, Fiveash JB, Attia A, Chan MD, Ayala-Peacock DN.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E422-E423.

Vitamin D heritability and effect of pregnancy status in vervet monkeys (Chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation. Chittoor G, Pajewski NM, Voruganti VS, Comuzzie AG, Clarkson TB [deceased], Nudy M, Schnatz PF, Kaplan JR, Jorgensen MJ.. Am J Phys Anthropol. 2016;159(4):639-645.

Use of an allostatic neurotechnology by adolescents with postural orthostatic tachycardia syndrome (POTS) is associated with improvements in heart rate variability and changes in temporal lobe electrical activity. Fortunato JE, Tegeler CL, Gerdes L, Lee SW, Pajewski NM, Franco ME, Cook JF, Shaltout HA, Tegeler CH.. Exp Brain Res. 2016;234(3):791-798.

Characterizing frailty status in the systolic blood pressure intervention trial. Pajewski NM, Williamson JD, Applegate WB, Berlowitz DR, Bolin LP, Chertow GM, Krousel-Wood MA, Lopez-Barrera N, Powell JR, Roumie CL, Still C, Sink KM, Tang R, Wright CB, Supiano MA.. J Gerontol A Biol Sci Med Sci. 2016;71(5):649-655.

Prospective association of GLUL rs10911021 with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD study. Huggins GS, Berkowitz RI, Blackburn GL, Bray GA, Cheskin L, Clark JM, Coday M, Espeland MA, Evans M, Foreyt JP, Glasser S, Greenway FL, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitzman DW,.. Diabetes. 2016;65(1):297-302.

Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults. Kurella Tamura M, Pajewski NM, Bryan RN, Weiner DE, Diamond M, Van Buren P, Taylor A, Beddhu S, Rosendorff C, Jahanian H, Zaharchuk G.. Neurology. 2016;86(13):1208-1216.

Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged greater than or equal to 75 years: a randomized clinical trial. Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, Fine LJ, Haley WE, Hawfield AT, Ix JH, Kitzman DW, Kostis JB, Krousel-Wood MA, Launer LJ, Oparil S, Rodriguez CJ, Roumie CL, Shorr RI, Sink KM, Wadley VG,.. JAMA. 2016;315(24):2673-2682.

APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume. Freedman BI, Gadegbeku CA, Bryan RN, Palmer ND, Hicks PJ, Ma L, Rocco MV, Smith SC, Xu J, Whitlow CT, Wagner BC, Langefeld CD, Hawfield AT, Bates JT, Lerner AJ, Raj DS, Sadaghiani MS, Toto RD, Wright JT Jr, Bowden DW, Williamson JD, Sink KM,.. Kidney Int. 2016;90(2):440-449.

Role of a plausible nuisance contributor in the declining obesity-mortality risks over time. Mehta T, Pajewski NM, Keith SW, Fontaine K, Allison DB.. Exp Gerontol. 2016;86():14-21.

Chronic kidney disease classification in systolic blood pressure intervention trial: comparison using modification of diet in renal disease and CKD-epidemiology collaboration definitions. Rocco MV, Chapman A, Chertow GM, Cohen D, Chen J, Cutler JA, Diamond MJ, Freedman BI, Hawfield A, Judd E, Killeen AA, Kirchner K, Lewis CE, Pajewski NM, Wall BM, Yee J.. Am J Nephrol. 2016;44(2):130-140.

Intensive vs standard blood pressure control for older adults [reply to letter]. Williamson JD, Supiano MA, Pajewski NM.. JAMA. 2016;316(18):1923.

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. Langefeld CD, Divers J, Pajewski NM, Hawfield AT, Reboussin DM, Bild DE, Kaysen GA, Kimmel PL, Raj DS, Ricardo AC, Wright JT Jr, Sedor JR, Rocco MV, Freedman BI.. Kidney Int. 2015;87(1):169-175.

Immunogenetic influences on acquisition of HIV-1 infection: consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2). Li X, Zhang K, Pajewski NM, Brill I, Prentice HA, Shrestha S, Kilembe W, Karita E, Allen S, Hunter E, Kaslow RA, Tang J.. Genes Immun. 2015;16(3):213-220.

Reduction in menopause-related symptoms associated with use of a noninvasive neurotechnology for autocalibration of neural oscillations. Tegeler CH, Tegeler CL, Cook JF, Lee SW, Pajewski NM.. Menopause. 2015;22(6):650-655.

A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes. Belalcazar LM, Papandonatos GD, McCaffery JM, Peter I, Pajewski NM, Erar B, Allred ND, Balasubramanyam A, Bowden DW, Brautbar A, Pi-Sunyer FX, Ballantyne CM, Huggins GS.. Physiol Genomics. 2015;47(6):215-224.

The impact of post-hospital discharge home visit timing by nurse practitioners and physicians on all-cause readmissions [abstract]. Kumar NR, Pajewski N, Watkins F, Zimmer R, Callahan KE, Williamson JD.. J Am Geriatr Soc. 2015;63(Suppl 1):S270.

Genetic predisposition to weight loss and regain with lifestyle intervention: analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials. Papandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, Ahmad S, Harden M, Chen L, Fontanillas P, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW, Espeland MA, et al.. Diabetes. 2015;64(12):4312-4321.

Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. McCaffery JM, Anderson A, Bantle JP, Berkowitz RI, Bray GA, Cheskin L, Clark JM, Curtis JM, Delahanty LM, Evans M, Foreyt JP, Glasser S, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Huggins GS, Jakicic JM, Jeffery RW, Johnson KC,.. Diabetologia. 2015;58(8):1803-1813.

Genetic predictors of depressive symptoms in the Look AHEAD trial. McCaffery JM, Papandonatos GD, Faulconbridge LF, Erar B, Peter I, Wagenknecht LE, Pajewski NM, Anderson A, Wadden TA, Wing RR, Espeland M.. Psychosom Med. 2015;77(9):982-992.

Patterns of dental service utilization following nontraumatic dental condition visits to the emergency department in Wisconsin Medicaid. Pajewski NM, Okunseri C.. J Public Health Dent. 2014;74(1):34-41.

The Montreal Cognitive Assessment (MoCA) in 8,724 SPRINT participants [abstract]. Sink KM, Chelune G, Coker L, Gaussoin S, Lerner A, Nichols L, Pajewski NM, Rapp S, Wadley V, Williamson J.. J Am Geriatr Soc. 2014;62(Suppl 1):S9-S10.

Personal librarian curriculum [letter]. Edmunds SM, Reynolds PS, Clinch CR, Stewart D, Pajewski NM, Neiberg RH.. Med Teach. 2014;36(8):736-737.

Host genetics and immune control of HIV-1 infection: fine mapping for the extended human MHC region in an African cohort. Prentice HA, Pajewski NM, He D, Zhang K, Brown EE, Kilembe W, Allen S, Hunter E, Kaslow RA, Tang J.. Genes Immun. 2014;15(5):275-281.

Effects of bazedoxifene, conjugated equine estrogens, and a tissue-selective estrogen complex containing both bazedoxifene and conjugated equine estrogens on cerebral artery atherosclerosis in postmenopausal monkeys. Clarkson TB, Ethun KF, Pajewski NM, Golden D, Floyd E, Appt SE.. Menopause. 2014;21(1):8-14.

Obesity and mortality: are the risks declining? Evidence from multiple prospective studies in the United States. Mehta T, Fontaine KR, Keith SW, Bangalore SS, de los Campos G, Bartolucci A, Pajewski NM, Allison DB.. Obes Rev. 2014;15(8):619-629.

The degree of retinopathy is equally predictive for renal and macrovascular outcomes in the ACCORD trial. Mottl AK, Pajewski N, Fonseca V, Ismail-Beigi F, Chew E, Ambrosius WT, Greven C, Schubart U, Buse J.. J Diabetes Complications. 2014;28(6):874-879.

Association between apolipoprotein L1 gene variants with prevalent kidney and cardiovascular disease: systolic blood pressure intervention trial (SPRINT) [abstract]. Langefeld CD, Divers J, Pajewski NM, Hawfield AT, Reboussin D, Bild D, Kaysen GA, Kimmel PL, Raj DS, Ricardo AC, Wright JT, Sedor JR, Rocco MV, Freedman BI.. J Am Soc Nephrol. 2014;25(Abstract Suppl):415A.

Delays in treatment of pediatric appendicitis: a more accurate variable for measuring pediatric healthcare inequalities?. Ladd MR, Pajewski NM, Becher RD, Swanson JM, Gallaher JR, Pranikoff T, Neff LP.. Am Surg. 2013;79(9):875-881.

Host genetics and susceptibility to HIV-1 infection: novel MHC associations among serodiscordant couples [abstract]. Prentice HA, Pajewski NM, Porter T, Zhang K, Brown EE, Allen S, Hunter E, Kaslow RA, Tang J.. AIDS Res Hum Retroviruses. 2013;29(11):A90.

Pilot study of menopause-related symptom reduction through a noninvasive EEG-based technology for auto-calibration of neural oscillations (HIRREM) [abstract]. Tegeler CL, Cook JF, Lee SW, Pajewski NM, Nicholas JN, Tegeler CH.. Menopause. 2013;20(12):1356.

Neural-oscillatory intervention for auto-calibration improves EEG asymmetry and HRV [abstract]. Tegeler CH, Tegeler CL, Lee SW, Shaltout HA, Pejewski NM.. Ann Neurol. 2013;74(Suppl 17):S77.

Case series using high-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) for POTS [abstract]. Fortunato JE, Tegeler CL, Lee SW, Pajewski NM, Franco M, Cook JF, Tegeler CH.. Clin Auton Res. 2013;23(5):269-270.

Design of the value of imaging in enhancing the wellness of your heart (VIEW) trial and the impact of uncertainty on power. Ambrosius WT, Polonsky TS, Greenland P, Goff DC Jr, Perdue LH, Fortmann SP, Margolis KL, Pajewski NM.. Clin Trials. 2012;9(2):232-246.

A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. Pajewski NM, Shrestha S, Quinn CP, Parker SD, Wiener H, Aissani B, McKinney BA, Poland GA, Edberg JC, Kimberly RP, Tang J, Kaslow RA.. Vaccine. 2012;30(32):4778-4784.

Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. Thompson SD, Marion MC, Sudman M, Ryan M, Tsoras M, Howard TD, Barnes MG, Ramos PS, Thomson W, Hinks A, Haas JP, Prahalad S, Bohnsack JF, Wise CA, Punaro M, Rose CD, Pajewski NM, Spigarelli M, Keddache M, Wagner M, Langefeld CD, Glass DN.. Arthritis Rheum. 2012;64(8):2781-2791.

25(OH)D3 and cardiovascular risk factors in female nonhuman primates. Jorgensen MJ, Rudel LL, Nudy M, Kaplan JR, Clarkson TB, Pajewski NM, Schnatz PF.. J Womens Health. 2012;21(9):959-965.

Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder. Pandey A, Davis NA, White BC, Pajewski NM, Savitz J, Drevets WC, McKinney BA.. Transl Psychiatry. 2012;2():e154.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Biostatistical Sciences

Nicholas M. Pajewski, Ph.D.

Nicholas M. Pajewski, Ph.D.

Assistant Professor, Biostatistical Sciences

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