Nicholas M. Pajewski, Ph.D.Wake Forest School of Medicine

Nicholas M. Pajewski, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1396 | Department: 336-716-2011


Education & Training

  • Bachelors Degree, Loyola University of Chicago, 2002
  • Ph.D., Medical College of Wisconsin, 2008


  • Am Assn for the Adv of Science
  • Am Soc of Human Genetics
  • Am Statistical Assn
  • Institute Of Mathematical Stat
  • Intl Biometric Soc, ENAR
  • Intl Soc for Bayesian Analysis
Nicholas M. Pajewski, Ph.D.

Nicholas M. Pajewski, Ph.D.

Assistant Professor, Biostatistical Sciences

Research Interests

aging, cancer/oncogenesis, cardiac function, cognition/learning, diabetes, drugs/therapeutic agents pharm, genetics/genome, health services, research/outc, hypertension, immunology/allergy/inflammatio, medical technology/devices, nutrition, primary care, vaccines

Contact Information

Academic: 336-713-1396 | Department: 336-716-2011


Recent Publications

Chittoor G, Pajewski NM, Voruganti VS, Comuzzie AG, Clarkson TB [deceased], Nudy M, Schnatz PF, Kaplan JR, Jorgensen MJ. Vitamin D heritability and effect of pregnancy status in vervet monkeys (Chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation. Am J Phys Anthropol. 2016;159(4):639-645.

Fortunato JE, Tegeler CL, Gerdes L, Lee SW, Pajewski NM, Franco ME, Cook JF, Shaltout HA, Tegeler CH. Use of an allostatic neurotechnology by adolescents with postural orthostatic tachycardia syndrome (POTS) is associated with improvements in heart rate variability and changes in temporal lobe electrical activity. Exp Brain Res. 2016;234(3):791-798.

Pajewski NM, Williamson JD, Applegate WB, Berlowitz DR, Bolin LP, Chertow GM, Krousel-Wood MA, Lopez-Barrera N, Powell JR, Roumie CL, Still C, Sink KM, Tang R, Wright CB, Supiano MA. Characterizing frailty status in the systolic blood pressure intervention trial. J Gerontol A Biol Sci Med Sci. 2016;71(5):649-655.

Huggins GS, Berkowitz RI, Blackburn GL, Bray GA, Cheskin L, Clark JM, Coday M, Espeland MA, Evans M, Foreyt JP, Glasser S, Greenway FL, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitzman DW,. Prospective association of GLUL rs10911021 with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD Study. Diabetes. 2016;65(1):297-302.

Kurella Tamura M, Pajewski NM, Bryan RN, Weiner DE, Diamond M, Van Buren P, Taylor A, Beddhu S, Rosendorff C, Jahanian H, Zaharchuk G. Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults. Neurology. 2016;86(13):1208-1216.

Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, Fine LJ, Haley WE, Hawfield AT, Ix JH, Kitzman DW, Kostis JB, Krousel-Wood MA, Launer LJ, Oparil S, Rodriguez CJ, Roumie CL, Shorr RI, Sink KM, Wadley VG,. Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged greater than or equal to 75 years: a randomized clinical trial. JAMA. 2016;315(24):2673-2682.

Langefeld CD, Divers J, Pajewski NM, Hawfield AT, Reboussin DM, Bild DE, Kaysen GA, Kimmel PL, Raj DS, Ricardo AC, Wright JT Jr, Sedor JR, Rocco MV, Freedman BI. Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. Kidney Int. 2015;87(1):169-175.

Li X, Zhang K, Pajewski NM, Brill I, Prentice HA, Shrestha S, Kilembe W, Karita E, Allen S, Hunter E, Kaslow RA, Tang J. Immunogenetic influences on acquisition of HIV-1 infection: consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2). Genes Immun. 2015;16(3):213-220.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Pajewski NM. Reduction in menopause-related symptoms associated with use of a noninvasive neurotechnology for autocalibration of neural oscillations. Menopause. 2015;22(6):650-655.

Belalcazar LM, Papandonatos GD, McCaffery JM, Peter I, Pajewski NM, Erar B, Allred ND, Balasubramanyam A, Bowden DW, Brautbar A, Pi-Sunyer FX, Ballantyne CM, Huggins GS. A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes. Physiol Genomics. 2015;47(6):215-224.

Kumar NR, Pajewski N, Watkins F, Zimmer R, Callahan KE, Williamson JD. The impact of post-hospital discharge home visit timing by nurse practitioners and physicians on all-cause readmissions [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S270.

Papandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, Ahmad S, Harden M, Chen L, Fontanillas P, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW, Espeland MA, et al. Genetic predisposition to weight loss and regain with lifestyle intervention: analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials. Diabetes. 2015;64(12):4312-4321.

McCaffery JM, Anderson A, Bantle JP, Berkowitz RI, Bray GA, Cheskin L, Clark JM, Curtis JM, Delahanty LM, Evans M, Foreyt JP, Glasser S, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Huggins GS, Jakicic JM, Jeffery RW, Johnson KC,. Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. Diabetologia. 2015;58(8):1803-1813.

McCaffery JM, Papandonatos GD, Faulconbridge LF, Erar B, Peter I, Wagenknecht LE, Pajewski NM, Anderson A, Wadden TA, Wing RR, Espeland M. Genetic predictors of depressive symptoms in the Look AHEAD trial. Psychosom Med. 2015;77(9):982-992.

Pajewski NM, Okunseri C. Patterns of dental service utilization following nontraumatic dental condition visits to the emergency department in Wisconsin Medicaid. J Public Health Dent. 2014;74(1):34-41.

Sink KM, Chelune G, Coker L, Gaussoin S, Lerner A, Nichols L, Pajewski NM, Rapp S, Wadley V, Williamson J. The Montreal Cognitive Assessment (MoCA) in 8,724 SPRINT participants [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S9-S10.

Edmunds SM, Reynolds PS, Clinch CR, Stewart D, Pajewski NM, Neiberg RH. Personal librarian curriculum [letter]. Med Teach. 2014;36(8):736-737.

Prentice HA, Pajewski NM, He D, Zhang K, Brown EE, Kilembe W, Allen S, Hunter E, Kaslow RA, Tang J. Host genetics and immune control of HIV-1 infection: fine mapping for the extended human MHC region in an African cohort. Genes Immun. 2014;15(5):275-281.

Clarkson TB, Ethun KF, Pajewski NM, Golden D, Floyd E, Appt SE. Effects of bazedoxifene, conjugated equine estrogens, and a tissue-selective estrogen complex containing both bazedoxifene and conjugated equine estrogens on cerebral artery atherosclerosis in postmenopausal monkeys. Menopause. 2014;21(1):8-14.

Mehta T, Fontaine KR, Keith SW, Bangalore SS, de los Campos G, Bartolucci A, Pajewski NM, Allison DB. Obesity and mortality: are the risks declining? Evidence from multiple prospective studies in the United States. Obes Rev. 2014;15(8):619-629.

Mottl AK, Pajewski N, Fonseca V, Ismail-Beigi F, Chew E, Ambrosius WT, Greven C, Schubart U, Buse J. The degree of retinopathy is equally predictive for renal and macrovascular outcomes in the ACCORD trial. J Diabetes Complications. 2014;28(6):874-879.

Langefeld CD, Divers J, Pajewski NM, Hawfield AT, Reboussin D, Bild D, Kaysen GA, Kimmel PL, Raj DS, Ricardo AC, Wright JT, Sedor JR, Rocco MV, Freedman BI. Association between apolipoprotein L1 gene variants with prevalent kidney and cardiovascular disease: systolic blood pressure intervention trial (SPRINT) [abstract]. J Am Soc Nephrol. 2014;25(Abstract Suppl):415A.

Ladd MR, Pajewski NM, Becher RD, Swanson JM, Gallaher JR, Pranikoff T, Neff LP. Delays in treatment of pediatric appendicitis: a more accurate variable for measuring pediatric healthcare inequalities?. Am Surg. 2013;79(9):875-881.

Prentice HA, Pajewski NM, Porter T, Zhang K, Brown EE, Allen S, Hunter E, Kaslow RA, Tang J. Host genetics and susceptibility to HIV-1 infection: novel MHC associations among serodiscordant couples [abstract]. AIDS Res Hum Retroviruses. 2013;29(11):A90.

Tegeler CL, Cook JF, Lee SW, Pajewski NM, Nicholas JN, Tegeler CH. Pilot study of menopause-related symptom reduction through a noninvasive EEG-based technology for auto-calibration of neural oscillations (HIRREM) [abstract]. Menopause. 2013;20(12):1356.

Tegeler CH, Tegeler CL, Lee SW, Shaltout HA, Pejewski NM. Neural-oscillatory intervention for auto-calibration improves EEG asymmetry and HRV [abstract]. Ann Neurol. 2013;74(Suppl 17):S77.

Fortunato JE, Tegeler CL, Lee SW, Pajewski NM, Franco M, Cook JF, Tegeler CH. Case series using high-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) for POTS [abstract]. Clin Auton Res. 2013;23(5):269-270.

Ambrosius WT, Polonsky TS, Greenland P, Goff DC Jr, Perdue LH, Fortmann SP, Margolis KL, Pajewski NM. Design of the value of imaging in enhancing the wellness of your heart (VIEW) trial and the impact of uncertainty on power. Clin Trials. 2012;9(2):232-246.

Pajewski NM, Shrestha S, Quinn CP, Parker SD, Wiener H, Aissani B, McKinney BA, Poland GA, Edberg JC, Kimberly RP, Tang J, Kaslow RA. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. Vaccine. 2012;30(32):4778-4784.

Thompson SD, Marion MC, Sudman M, Ryan M, Tsoras M, Howard TD, Barnes MG, Ramos PS, Thomson W, Hinks A, Haas JP, Prahalad S, Bohnsack JF, Wise CA, Punaro M, Rose CD, Pajewski NM, Spigarelli M, Keddache M, Wagner M, Langefeld CD, Glass DN. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. Arthritis Rheum. 2012;64(8):2781-2791.

Jorgensen MJ, Rudel LL, Nudy M, Kaplan JR, Clarkson TB, Pajewski NM, Schnatz PF. 25(OH)D3 and cardiovascular risk factors in female nonhuman primates. J Womens Health. 2012;21(9):959-965.

Pandey A, Davis NA, White BC, Pajewski NM, Savitz J, Drevets WC, McKinney BA. Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder. Transl Psychiatry. 2012;2():e154.

Irvin MR, Wineinger NE, Rice TK, Pajewski NM, Kabagambe EK, Gu CC, Pankow J, North KE, Wilk JB, Freedman BI, et al. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN Study. PLoS ONE. 2011;6(8):e24052.

Okunseri C, Pajewski NM, Szabo A. Using emergency departments [reply to letter]. J Am Dent Assoc. 2011;142(10):1124-1125.

Okunseri C, Pajewski NM, Szabo A. Missed appointments [reply to letter]. J Am Dent Assoc. 2011;142(10):1125.

Padwal RS, Pajewski NM, Allison DB, Sharma AM. Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ. 2011;183(14):E1059-1066.

Wineinger NE, Pajewski NM, Kennedy RE, Wojczynski MK, Vaughan LK, Hunt SC, Gu CC, Rao DC, Lorier R, Broeckel U, Arnett DK, Tiwari HK. Characterization of autosomal copy-number variation in African Americans: the HyperGEN Study. Eur J Hum Genet. 2011;19(12):1271-1275.

Ramos PS, Criswell LA, Moser KL, Comeau ME, Williams AH, Pajewski NM, Chung SA, Graham RR, Zidovetzki R, Kelly JA, Kaufman KM, Jacob CO, Vyse TJ, Tsao BP, Kimberly RP, Gaffney PM, Alarcon-Riquelme ME, Harley JB, Langefeld CD. A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet. 2011;7(12):e1002406.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Biostatistical Sciences

Nicholas M. Pajewski, Ph.D.

Nicholas M. Pajewski, Ph.D.

Assistant Professor, Biostatistical Sciences

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