Recent Publications
Delta-5 fatty acid desaturase FADS1 impacts metabolic disease by balancing proinflammatory and proresolving lipid mediators. Gromovsky AD, Schugar RC, Brown AL, Helsley RN, Burrows AC, Ferguson D, Zhang R, Sansbury BE, Lee RG, Morton RE, Allende DS, Parks JS, Spite M, Brown JM.. Arterioscler Thromb Vasc Biol. 2018;38(1):218-231.
Targeted deletion of adipocyte Abca1 (ATP-binding cassette transporter A1) impairs diet-induced obesity. Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS.. Arterioscler Thromb Vasc Biol. 2018;38(4):733-743.
Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice. Liu M, Chuang Key CC, Weckerle A, Boudyguina E, Sawyer JK, Gebre AK, Spoo W, Makwana O, Parks JS.. Food Chem Toxicol. 2018;113():287-295.
In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice. Shewale SV, Brown AL, Bi X, Boudyguina E, Sawyer JK, Alexander-Miller MA, Parks JS.. J Lipid Res. 2017;58(1):236-246.
APOL1 renal-risk variants induce mitochondrial dysfunction. Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI.. J Am Soc Nephrol. 2017;28(4):1093-1105.
Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes. Lee SG, Parks JS, Kang HW.. J Nutr Biochem. 2017;42():62-71.
Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis. Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS.. Cell Rep. 2017;19(10):2116-2129.
Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis. Omar I, Rom O, Aviram M, Cohen-Daniel L, Gebre AK, Parks JS, Berger M.. Immunology. 2017;152(3):484-493.
Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer. Zamanian-Daryoush M, Lindner DJ, DiDonato JA, Wagner M, Buffa J, Rayman P, Parks JS, Westerterp M, Tall AR, Hazen SL.. Oncotarget. 2017;8(42):71965-80.
Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion. Liu M, Chung S, Shelness GS, Parks JS.. Biochim Biophys Acta. 2017;1862(10 Pt A):1035-1043.
Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR Jr, Post W, Hoeschele I, Bell DA, Herrington D,.. Nat Commun. 2017;8(1):393.
Genetic regulation of adipose tissue transcript expression is involved in modulating serum triglyceride and HDL-cholesterol. Sajuthi SP, Sharma NK, Comeau ME, Chou JW, Bowden DW, Freedman BI, Langefeld CD, Parks JS, Das SK.. Gene. 2017;632():50-58.
LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, Parks JS, Hammer RE, Boucher P, Tsai S, Herz J.. Elife. 2017;6():e29292.
Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes. Divers J, Palmer ND, Langefeld CD, Brown WM, Lu L, Hicks PJ, Smith SC, Xu J, Terry JG, Register TC, Wagenknecht LE, Parks JS, Ma L, Chan GC, Buxbaum SG, Correa A, Musani S, Wilson JG, Taylor HA, Bowden DW, Carr JJ, Freedman BI.. BMC Genet. 2017;18(1):105.
Dietary cholesterol effects on adipose tissue inflammation. Chung S, Parks JS.. Curr Opin Lipidol. 2016;27(1):19-25.
Characterization of circulating APOL1 protein complexes in African Americans. Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L.. J Lipid Res. 2016;57(1):120-130.
A systematic investigation of structure/function requirements for the apolipoprotein A-I/lecithin cholesterol acyltransferase interaction loop of high-density lipoprotein. Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL.. J Biol Chem. 2016;291(12):6386-6395.
Myeloid deletion of alpha1AMPK exacerbates atherosclerosis in LDL receptor knockout (LDLRKO) mice. Cao Q, Cui X, Wu R, Zha L, Wang X, Parks JS, Yu L, Shi H, Xue B.. Diabetes. 2016;65(6):1565-1576.
Deficiency of ATP-binding cassette transporters A1 and G1 in endothelial cells accelerates atherosclerosis in mice. Westerterp M, Tsuchiya K, Tattersall IW, Fotakis P, Bochem AE, Molusky MM, Ntonga V, Abramowicz S, Parks JS, Welch C, Kitajewski J, Accili D, Tall AR.. Arterioscler Thromb Vasc Biol. 2016;36(7):1328-1337.
MicroRNA-33 regulates the innate immune response via ATP Binding Cassette transporter-mediated remodeling of membrane microdomains. Lai L, Azzam KM, Lin WC, Rai P, Lowe JM, Gabor KA, Madenspacher JH, Aloor JJ, Parks JS, Naar AM, Fessler MB.. J Biol Chem. 2016;291(37):19651-60.
Apolipoprotein M improves survival in congestive heart failure via enhanced Akt signaling [abstract]. Javaheri A, Shewale S, Frej C, Liu MX, Bedi K, Brandimarto J, Mu AB, Wang T, Chen CY, Ma XC, Zamani P, French B, Margulies KB Cappola TP, Prosser BL, Diwan A, Dahlback B, Parks JS, Rader DJ.. J Card Fail. 2016;22(8 Suppl):S1.
Very low density lipoprotein assembly is required for cAMP-responsive element-binding protein H processing and hepatic apolipoprotein A-IV expression. Cheng D, Xu X, Simon T, Boudyguina E, Deng Z, VerHague M, Lee AH, Shelness GS, Weinberg RB, Parks JS.. J Biol Chem. 2016;291(45):.
Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. Ma L, Shelness GS, Snipes JA, Murea M, Antinozzi PA, Cheng D, Saleem MA, Satchell SC, Banas B, Mathieson PW, Kretzler M, Hemal AK, Rudel LL, Petrovic S, Weckerle A, Pollak MR, Ross MD, Parks JS, Freedman BI.. J Am Soc Nephrol. 2015;26(2):339-348.
Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS.. J Biol Chem. 2015;290(12):7861-7870.
Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver. Shewale SV, Boudyguina E, Zhu X, Shen L, Hutchins PM, Barkley RM, Murphy RC, Parks JS.. J Lipid Res. 2015;56(6):1191-1205.
Biogenesis and cytotoxicity of APOL1 renal-risk variant proteins in hepatocytes and hepatoma cells. Cheng D, Weckerle A, Yu Y, Ma L, Zhu X, Murea M, Freedman BI, Parks JS, Shelness GS.. J Lipid Res. 2015;56(8):1583-1593.
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P.. Elife. 2015;4():e08009.
Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,.. Diabetes. 2015;64(10):3464-3474.
Characterization of APOA-I and HDL metabolism in an endothelial specific ABCA1 deficient mouse model [abstract]. Hasballa R, Rohrer L, Fotakis P, Zannis V, Parks J, von Eckardstein A.. Atherosclerosis. 2015;241(1):E43.
Characterization of circulating APOL1 complexes and their kidney distribution in African Americans [abstract]. Ma L, Weckerle A, Snipes JA, Cheng D, Gebre AK, Murea M, Hawkins GA, Parks JS, Freedman BI.. J Am Soc Nephrol. 2015;26(Abstract Suppl):708A.
An abundant dysfunctional apolipoprotein A1 in human atheroma. Huang Y, Didonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF,.. Nat Med. 2014;20(2):193-203.
Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. Liu M, Seo J, Allegood J, Bi X, Zhu X, Boudyguina E, Gebre AK, Avni D, Shah D, Sorci-Thomas MG, Thomas MJ, Shelness GS, Spiegel S, Parks JS.. J Biol Chem. 2014;289(5):2801-2814.
Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice. Bi X, Zhu X, Gao C, Shewale S, Cao Q, Liu M, Boudyguina E, Gebre AK, Wilson MD, Brown AL, Parks JS.. Arterioscler Thromb Vasc Biol. 2014;34(9):1888-1899.
Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development. Cao Q, Rong S, Repa JJ, Clair RS, Parks JS, Mishra N.. Arterioscler Thromb Vasc Biol. 2014;34(9):1871-1879.
Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys. Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS.. Arterioscler Thromb Vasc Biol. 2014;34(9):1880-1887.
Lipoprotein metabolism and transendothelial apolipoprotein A-I transport in mice with an endothelium specific knock-out of ATP binding cassette transporter A1 [abstract]. Hasballa R, Rohrer L, Fotakis P, Zannis VI, Parks JS, von Eckardstein A.. Atherosclerosis. 2014;235(2):e21.
Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B.. Endocrinology. 2014;155(12):4925-4938.
An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. Ma L, Murea M, Snipes JA, Marinelarena A, Kruger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA,.. PLoS One. 2013;8(2):e56193.
Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, Apte RS.. Cell Metab. 2013;17(4):549-561.
Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch C, Fisher EA, Wang N, Yvan-Charvet L, Tall AR.. Circ Res. 2013;112(11):1456-1465.
Increased cholesterol content in gammadelta T lymphocytes differentially regulates their activation. Cheng HY, Wu R, Gebre AK, Hanna RN, Smith DJ, Parks JS, Ley K, Hedrick CC.. PLoS One. 2013;8(5):e63746.
Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apoB100-only low density lipoprotein (LDL) receptor knockout mice. Forrest LM, Lough CM, Chung S, Boudyguina EY, Gebre AK, Smith TL, Colvin PL, Parks JS.. Nutrients. 2013;5(7):2629-2645.
Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models. Zhu X, Chung S, Bi X, Chuang CC, Brown AL, Liu M, Seo J, Cuffe H, Gebre AK, Boudyguina E, Parks JS.. J Lipid Res. 2013;54(10):2708-2717.
ApoL1 protein in non-diseased human podocytes: endogenous synthesis versus uptake? [abstract]. Ma L, Snipes JA, Murea M, Antinozzi PA, Shelness GS, Saleem M, Satchell SC, Banas B, Mathieson PW, Kretzler M, Petrovic S, Ross MD, Pollak MR, Rudel L, Parks JS, Freedman BI.. J Am Soc Nephrol. 2013;24(Abstract Suppl):557A.
Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. Bi X, Zhu X, Duong M, Boudyguina EY, Wilson MD, Gebre AK, Parks JS.. Arterioscler Thromb Vasc Biol. 2013;33(10):2288-2296.
Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice. Iqbal J, Parks JS, Hussain MM.. J Biol Chem. 2013;288(42):30432-44.
Mechanism of the low cholesterol esterification rate in human interstitial fluid (peripheral lymph) [abstract]. Miller NE, Nanjee N, Parks JS, Olszewski WL.. Circulation. 2013;128(22 Suppl):A13029.
Overexpression of apoM in liver stimulates formation of larger, apoM/S1P-enriched plasma HDL [abstract]. Liu MX, Seo JM, Allegood J, Bi X, Zhu XW, Boudyguina E, Gebre AK, Sorci-Thomas M, Thomas MS, Shelness GS, Spiegel S, Parks JS.. Circulation. 2013;128(22 Suppl):A19183.
Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice. Forrest LM, Boudyguina E, Wilson MD, Parks JS.. Atherosclerosis. 2012;220(1):118-121.
CGI-58/ABHD5-derived signaling lipids regulates systemic inflammation and insulin action. Lord CC, Betters JL, Ivanova PT, Milne SB, Myers DS. Madenspacher J, Thomas G, Chung S, Liu M, Davis MA, Lee RG, Crooke RM, Graham MJ, Parks JS, Brasaemle DL, Fessler MB, Brown HA, Brown JM.. Diabetes. 2012;61(2):355-363.
All Publications
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