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Derek Parsonage, Ph.D.Wake Forest School of Medicine

Derek Parsonage, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-2575 | Department: 336-716-2575

Email: parsonag@wakehealth.edu

Education & Training

  • B.Sc., University Birmingham-United Kingdom, 1980
  • Ph.D., University Birmingham-United Kingdom, 1984
  • Fellowship, University of Rochester Sch of, 1988

Memberships

  • Am Soc Of Emergency Radiology
Derek Parsonage, Ph.D.

Derek Parsonage, Ph.D.

Assistant Professor, Biochemistry

Research Interests

Peroxiredoxins; Bacterial Proteins; Salmonella typhimurium; Oxidation-Reduction; Thioredoxins
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Contact Information

Academic: 336-716-2575 | Department: 336-716-2575

Email: parsonag@wakehealth.edu

Recent Publications

Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics. Buchko GW, Perkins A, Parsonage D, Poole LB, Karplus PA.. Biomol NMR Assign. 2016;10(1):57-61.

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM.. J Struct Biol. 2016;194(2):180-190.

Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Parsonage D, Nelson KJ, Ferrer-Sueta G, Alley S, Karplus PA, Furdui CM, Poole LB.. Biochemistry. 2015;54(7):1567-1575.

Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria. Summitt CB, Johnson LC, Jonsson TJ, Parsonage D, Holmes RP, Lowther WT.. Biochem J. 2015;466(2):273-281.

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Perkins A, Nelson KJ, Parsonage D, Poole LB, Karplus PA.. Trends Biochem Sci. 2015;40(8):435-445.

Au-ACRAMTU-PEt3 alters redox balance to inhibit T cell proliferation and function. Langston PK, Yang M, Bierbach U, Parsonage D, Poole LB, Price MJ, Grayson JM.. J Immunol. 2015;195(5):1984-1994.

Structure and proposed mechanism of l-alpha-glycerophosphate oxidase from Mycoplasma pneumoniae. Elkhal CK, Kean KM, Parsonage D, Maenpuen S, Chaiyen P, Claiborne A, Karplus PA.. FEBS J. 2015;282(16):3030-3042.

Kinetic mechanism of l-alpha-glycerophosphate oxidase from Mycoplasma pneumoniae. Maenpuen S, Watthaisong P, Supon P, Sucharitakul J, Parsonage D, Karplus PA, Claiborne A, Chaiyen P.. FEBS J. 2015;282(16):3043-3059.

Structural analysis of Streptococcus pyogenes NADH oxidase: conformational dynamics involved in formation of the C(4a)-peroxyflavin intermediate. Wallen JR, Mallett TC, Okuno T, Parsonage D, Sakai H, Tsukihara T, Claiborne A.. Biochemistry. 2015;54(45):6815-6829.

The high-molecular-weight kininogen domain 5 is an intrinsically unstructured protein and its interaction with ferritin is metal mediated. Huhn AJ, Parsonage D, Horita DA, Torti FM, Torti SV, Hollis T.. Protein Sci. 2014;23(8):1013-1022.

Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates. Nelson KJ, Parsonage D, Karplus PA, Poole LB.. Methods Enzymol. 2013;527():21-40.

Modulation of signaling proteins by reversible cysteine modification [abstract]. Keyes JD, Nelson K, Parsonage D, Daniel L, Furdui C, Poole L.. FASEB J. 2013;27():993.3.

The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin. Perkins A, Nelson KJ, Williams JR, Parsonage D, Poole LB, Karplus PA.. Biochemistry. 2013;52(48):8708-8721.

A new family of membrane electron transporters and its substrates, including a new cell envelope peroxiredoxin, reveal a broadened reductive capacity of the oxidative bacterial cell envelope. Cho S-H, Parsonage D, Thurston C, Dutton RJ, Poole LB, Collet J-F, Beckwith J.. MBio. 2012;3(2):e00291-11.

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, Garcia-Rivera G, Orozco E, Martinez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL.. Nat Med. 2012;18(6):956-960.

Specific residues in peroxiredoxins promote peroxide reactivity through effects on cysteine pKa, transition state stabilization and oligomerization [abstract]. Nelson KJ, Parsonage D, Van Swearingen AED, Yuan Y, Salsbury FR, Hall A, Karplus PA, Poole LB.. Free Radic Biol Med. 2012;53(Suppl 2):S151.

Active site and interface communication regulating peroxiredoxin functions [abstract]. Poole L, Karplus PA, Nelson K, Parsonage D.. Free Radic Biol Med. 2012;53(Suppl 2):S8.

Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry. Nirudodhi S, Parsonage D, Karplus PA, Poole LB, Maier CS.. Int J Mass Spectrom. 2011;302(1-3):93-100.

Measurement of peroxiredoxin activity. Nelson KJ, Parsonage D. In: Costa LG, Davila JC, Lawrence DA, Reed DJ, Hodgson E, Coruzzi G, eds. Current protocols in toxicology, suppl 49. New York: John Wiley & Sons;2011: 7.10.1-28.

Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin. Reeves SA, Parsonage D, Nelson KJ, Poole LB.. Biochemistry. 2011;50(41):8970-8981.

Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum. Parsonage D, Desrosiers DC, Hazlett KRO, Sun Y, Nelson KJ, Cox DL, Radolf JD, Poole LB.. Proc Natl Acad Sci U S A. 2010;107(14):6240-6245.

Engineering of fluorescent reporters into redox domains to monitor electron transfers. Parsonage D, Reeves SA, Karplus PA, Poole LB.. Methods Enzymol. 2010;474():1-21.

Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization. Hall A, Parsonage D, Poole LB, Karplus PA.. J Mol Biol. 2010;402(1):194-209.

Characterization of the N-acetyl-alpha-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis. Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A.. Biochemistry. 2010;49(38):8398-8414.

Regulatory effects of ferritin on angiogenesis. Coffman LG, Parsonage D, D'Agostino RD Jr, Torti FM, Torti SV.. Proc Natl Acad Sci U S A. 2009;106(2):570-575.

Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Hall A, Parsonage D, Horita D, Karplus PA, Poole LB, Barbar E.. Biochemistry. 2009;48(25):5984-5993.

Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A.. Biochemistry. 2009;48(40):9650-9667.

Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase. Colussi T, Parsonage D, Boles W, Matsouka T, Mallett TC, Karplus PA, Claiborne A.. Biochemistry. 2008;47(3):965-977.

Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin. Parsonage D, Karplus PA, Poole LB.. Proc Natl Acad Sci U S A. 2008;105(24):8209-8214.

Cysteine pKa values for the bacterial peroxiredoxin AhpC. Nelson KJ, Parsonage D, Hall A, Karplus A, Poole LB.. Biochemistry. 2008;47(48):12860-68.

Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 angstrom resolution: implications for coenzyme A-dependent redox biology. Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A.. Biochemistry. 2007;46(11):3234-3245.

Substrate specificity and chemical characterization of a bacterial peroxiredoxin, AhpC [abstract]. Parsonage D, Nelson KJ, Day AE, Poole LB.. Free Radic Biol Med. 2007;43(Suppl 1):S113.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Biochemistry

Derek Parsonage, Ph.D.

Derek Parsonage, Ph.D.

Assistant Professor, Biochemistry

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