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Derek Parsonage, Ph.D.

Derek Parsonage, Ph.D.

Assistant Professor, Biochemistry
Contact Information
Office:
336-716-2575
Email: parsonag@wakehealth.edu
Education & Training
  BScUniversity Birmingham-United Kingdom1980
  PhDUniversity Birmingham-United Kingdom1984
FellowshipUniversity of Rochester Sch of Med & Dentistry1988
Memberships
American Society of Emergency Radiology
Derek Parsonage, Ph.D.

Derek Parsonage, Ph.D.

Assistant Professor, Biochemistry
Contact Information
Office:
336-716-2575
Email: parsonag@wakehealth.edu
Recent Publications
Nirudodhi S, Parsonage D, Karplus PA, Poole LB, Maier CS. Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry. Int J Mass Spectrom. 2011; 302(1-3):93-100.


Nelson KJ, Parsonage D. Measurement of peroxiredoxin activity. In: Costa LG, Davila JC, Lawrence DA, Reed DJ, Hodgson E, Coruzzi G, eds. Current protocols in toxicology, suppl 49. New York: John Wiley & Sons; 2011: 7.10.1-28.


Parsonage D, Desrosiers DC, Hazlett KRO, Sun Y, Nelson KJ, Cox DL, Radolf JD, Poole LB. Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum. Proc Natl Acad Sci U S A. 2010; 107(14):6240-6245.


Parsonage D, Reeves SA, Karplus PA, Poole LB. Engineering of fluorescent reporters into redox domains to monitor electron transfers. Methods Enzymol. 2010; 474():1-21.


Hall A, Parsonage D, Poole LB, Karplus PA. Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization. J Mol Biol. 2010; 402(1):194-209.


Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A. Characterization of the N-acetyl-alpha-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis. Biochemistry. 2010; 49(38):8398-8414.


Coffman LG, Parsonage D, D'Agostino RD Jr, Torti FM, Torti SV. Regulatory effects of ferritin on angiogenesis. Proc Natl Acad Sci U S A. 2009; 106(2):570-575.


Hall A, Parsonage D, Horita D, Karplus PA, Poole LB, Barbar E. Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Biochemistry. 2009; 48(25):5984-5993.


Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A. Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Biochemistry. 2009; 48(40):9650-9667.


Colussi T, Parsonage D, Boles W, Matsouka T, Mallett TC, Karplus PA, Claiborne A. Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase. Biochemistry. 2008; 47(3):965-977.


Parsonage D, Karplus PA, Poole LB. Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin. Proc Natl Acad Sci U S A. 2008; 105(24):8209-8214.


Nelson KJ, Parsonage D, Hall A, Karplus A, Poole LB. Cysteine pKa values for the bacterial peroxiredoxin AhpC. Biochemistry. 2008; 47(48):12860-68.


Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A. Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 angstrom resolution: implications for coenzyme A-dependent redox biology. Biochemistry. 2007; 46(11):3234-3245.


Parsonage D, Nelson KJ, Day AE, Poole LB. Substrate specificity and chemical characterization of a bacterial peroxiredoxin, AhpC [abstract]. Free Radic Biol Med. 2007; 43(Suppl 1):S113.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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Last Updated 9/30/2011
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