Skip Navigation

Profile

Boris Claude Pasche, M.D., Ph.D.Wake Forest School of Medicine

Doctor Rating

No Rating Available
Why No Ratings?

Boris Claude Pasche, M.D., Ph.D.

Chair,
Director,
Professor,
Precision Medicine

Clinical Interests

Cancer Genetics, Solid Tumors, Colon and Rectal Cancer, Pancreatic Cancer, Rectal Cancer, Gastrointestinal Oncology

Contact Information

Department: 336-716-7971

Email: bpasche@wakehealth.edu

Insurance Accepted »

Additional Languages

French, German, Swedish

Education & Training

  • M.D., Karolinska Institute-Sweden, 1986
  • Ph.D., Karolinska Institute-Sweden, 1989
  • Fellowship, Medicine, Harvard Medical School, 1992
  • Residency, Medicine, New York Hosp, 1994
  • Fellowship, Hematology And Oncology, Memorial Sloan Kettering Cance, 1997
  • Fellowship, Cell Biology, Howard Hughes Medical Institut, 2000

Board Certifications

  • American Board of Internal Medicine, Medical Oncology

Memberships

  • Am Assn Of Cancer Research
  • Am Assn Of Clinical Oncology
  • Am Soc of Hematology
  • Am Soc of Human Genetics
  • Assn of Professors of Medicine
  • The Bioelectromagnetics Soc
  • Alabama State Medical Assn
  • Eastern Cooperative Onc Grp

NPI Number

  • 1154352615
Boris Claude Pasche, M.D., Ph.D.

Doctor Rating

No Rating Available
Why No Ratings?

Boris Claude Pasche, M.D., Ph.D.

Chair, Cancer Biology
Director, Comprehensive Cancer Center
Professor, Cancer Biology
Precision Medicine
Hematology & Oncology

Research Interests

Receptors, Transforming Growth Factor beta; Protein-Serine-Threonine Kinases; Colorectal Neoplasms; Transforming Growth Factor beta; Neoplasms
More »

Contact Information

Academic: 336-716-7971 | Department: 336-716-7971

Email: bpasche@wakehealth.edu

Recent Publications

Use of non-ionizing electromagnetic fields for the treatment of cancer. Jimenez H, Blackman C, Lesser G, Debinski W, Chan M, Sharma S, Watabe K, Lo HW, Thomas A, Godwin D, Blackstock W, Mudry A, Posey J, O'Connor R, Brezovich I, Bonin K, Kim-Shapiro D, Barbault A, Pasche B.. Front Biosci (Landmark Ed). 2018;23():284-297.

Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW, Lin HK.. Nat Immunol. 2018;19(1):29-40.

Incorporating blood-based liquid biopsy information into cancer staging: time for a TNMB system?. Yang M, Forbes ME, Bitting RL, O'Neill SS, Chou PC, Topaloglu U, Miller LD, Hawkins GA, Grant SC, DeYoung BR, Petty WJ, Chen K, Pasche BC, Zhang W.. Ann Oncol. 2018;29(2):311-323.

Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1 [letter]. Liu L, Ruiz J, O'Neill SS, Grant SC, Petty WJ, Yang M, Chen K, Topaloglu U, Pasche B, Zhang W... Mol Cancer. 2018;17(1):81.

Loss of TGFbeta signaling promotes colon cancer progression and tumor-associated inflammation. Principe DR, DeCant B, Staudacher J, Vitello D, Mangan RJ, Wayne EA, Mascarinas E, Diaz AM, Bauer J, McKinney RD, Khazaie K, Pasche B, Dawson DW, Munshi HG, Grippo PJ, Jung B.. Oncotarget. 2017;8(3):3826-3839.

Genomic testing using cytology vs surgical specimens: a comparative study [abstract]. Steele RM, Topaloglu U, Miller LD, Zhang W, Pasche B, DeYoung BR, Qaseni SA [sic] Qasem SA.. Mod Pathol. 2017;30(Suppl 2):520A.

Genomic testing using cytology vs surgical specimens: a comparative study [abstract]. Steele RM, Tapaloglu U, Miller LD, Zhang W, Pasche B, DeYoung BR, Qasem SA.. Lab Invest. 2017;97(Suppl 1):520A.

Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R Jr, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L,.. Lancet Oncol. 2017;18(6):770-778.

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. Yang M, Topaloglu U, Petty WJ, Pagni M, Foley KL, Grant SC, Robinson M, Bitting RL, Thomas A, Alistar AT, Desnoyers RJ, Goodman M, Albright C, Porosnicu M, Vatca M, Qasem SA, DeYoung B, Kytola V, Nykter M, Chen K, Levine EA, Staren ED,.. J Hematol Oncol. 2017;10(1):100.

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW.. Oncotarget. 2017;8(43):73947-63.

Mutational landscapes of smoking-related cancers in Caucasians and African Americans: precision oncology perspectives at Wake Forest Baptist Comprehensive Cancer Center. Kytola V, Topaloglu U, Miller LD, Bitting RL, Goodman MM, D Agostino RB Jr, Desnoyers RJ, Albright C, Yacoub G, Qasem SA, DeYoung B, Thorsson V, Shmulevich I, Yang M, Shcherban A, Pagni M, Liu L, Nykter M, Chen K, Hawkins GA, Grant SC,.. Theranostics. 2017;7(11):2914-2923.

New promising combination therapy of a mitochondrial metabolism inhibitor with mFOLFIRINOX in pancreatic cancer [abstract]. Alistar AT, Pasche B, D'Agostino R, Pardee T, Luther S, Desnoyer R.. Ann Oncol. 2017;28(Suppl 5):1733PD.

DBF 2.0: A web-based predictive model for distant brain failure, brain metastasis velocity, and early death after radiosurgery for brain metastases [abstract]. Henson A, Ayala-Peacock DN, Chung C, Hepel JT, Chao ST, Contessa JN, Fiveash JB, Attia A, McTyre E, Braunstein SE, Page BR, Shen C, Kleinberg LR, Watabe K, Pasche B, D'Agostino R Jr, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E78-E79.

Clinical outcomes of upfront stereotactic radiosurgery alone for patients with greater than 4 brain metastases [abstract]. Hughes RT, McTyre E, LeCompte MC, Cramer CK, Munley MT, Laxton A, Tatter SB, Ruiz J, Pasche B, Watabe K, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E80-E81.

Multi-institutional validation of brain metastasis velocity, a recently defined predictor of outcomes following stereotactic radiosurgery [abstract]. McTyre E, Farris M, Ayala-Peacock DN, Page BR, Shen C, Kleinberg LR, Contessa JN, Chung C, Ruiz J, Pasche B, Watabe K, Fiveash JB, Hepel JT, Chao ST, Braunstein SE, Attia A, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E93.

Drivers of the cost of management in patients treated with radiosurgery without whole brain radiation therapy for brain metastases [abstract]. Shenker RF, McTyre E, Cramer CK, Munley MT, Ruiz J, Watabe K, Pasche B, Laxton A, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E414-E415.

Determination of tumor gene expression in non-small cell lung cancer patients who develop brain metastasis diagnosis: analysis of a prospective trial [abstract]. Dohm AE, Su J, McTyre E, Soike M, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow L, Watabe K, Chan MD, Ruiz J, Pasche B.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E453.

TGFbeta signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis. Principe DR, DeCant B, Mascarinas E, Wayne E, Diaz A, Akagi N, Hwang RF, Pasche B, Dawson DW, Fang D, Bentrem DJ, Munshi HG, Jung B, Grippo PJ.. Cancer Res. 2016;76(9):2525-2539.

An HF exposure system for mice with improved efficiency. Capstick M, Gong Y, Pasche B, Kuster N.. Bioelectromagnetics. 2016;37(4):223-233.

Lynch syndrome testing: a missed opportunity in the era of precision medicine [editorial]. Pasche B, Pennison MJ, DeYoung B.. JAMA. 2016;316(1):38-39.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

CPI-613 enhances FOLFIRINOX response rate in stage IV pancreatic cancer [abstract]. Alistar AT, Desnoyers R, D'Agostino RJ, Pasche B.. Ann Oncol. 2016;27(Suppl 6):675P.

The anti-proliferative effects of RF EMF amplitude-modulated (AM RF EMF) at tumor specific frequencies on glioblastoma cells [abstract]. Jimenez H, Wang MH, Sharma S, Herpai D, Lesser GJ, Debinski W, Costa F, Barbault A, Blackman C, Pasche B.. Neuro Oncol. 2016;18(Suppl 6):68.

The anti-proliferative effects of RF EMF amplitude-modulated at tumor specific frequencies and mediation by calcium [abstract]. Jimenez H, Zimmerman JW, D'Agostino R, Yi XH, Brezovich I, Wang MH, Pennison MJ, Chen DQ, Kuster N, Costa F, Barbault A, Blackman CF, Pasche B.. J Clin Oncol. 2015;33(15 Suppl):11079.

Non-small cell lung cancer and precision medicine: a model for the incorporation of genomic features into clinical trial design [editorial]. Pasche B, Grant SC.. JAMA. 2014;311(19):1975-1976.

Prevention and treatment of cancer with aspirin: where do we stand?. Pasche B, Wang M, Pennison M, Jimenez H.. Semin Oncol. 2014;41(3):397-401.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

Clinical Interests

Cancer Genetics, Solid Tumors, Colon and Rectal Cancer, Pancreatic Cancer, Rectal Cancer, Gastrointestinal Oncology
Boris Claude Pasche, M.D., Ph.D.

Boris Claude Pasche, M.D., Ph.D.

Chair, Cancer Biology
Director, Comprehensive Cancer Center
Professor, Cancer Biology
Precision Medicine
Hematology & Oncology

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
Wake Forest Baptist Ranked among Nation’s ‘Best Hospitals’  25 Years in a Row by U.S. News & World ReportComprehensive Cancer Centers National Designation is Renewed2017-2018 Best DoctorsNursing Magnet StatusJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.

© Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157. All Rights Reserved.