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Research

Rodolfo M. Pascual, M.D.

Associate Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research

Clinical Specialties

General Pulmonary Diseases, Pulmonary Hypertension

Contact Information

Department: 336-716-2011

Education & Training

M.D., Jefferson Medical College , 1994
B.S., Albright College , 1990
Internship, Thomas Jefferson Univ Hsp, 1995
Residency, Thomas Jefferson Univ Hsp, 1997
Residency, Thomas Jefferson Univ Hsp, 1998
Fellowship, Thomas Jefferson Univ Hsp, 2002

NPI Number

1346223484

Rodolfo M. Pascual, M.D.

Associate Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research

Contact Information

Academic: 336-713-7519 | Department: 336-716-2011

Recent Publications

Hartman JM, Caldwell JW, Pascual RM, Peters SP. Asthma treatment In: Adelman DC, Casale TB, Corren J, eds. Manual of allergy and immunology. 5th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins;2012: 150-172.

Bellinger C, Pascual R, Krings J, Smith R, Burmudez R, Peters SP, Bleecker ER, Moore WC. Similar decrements in FEV1 and FVC in not severe and severe asthma subjects following investigative bronchoscopy [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4178.

Hastie AT, Moore WC, Li H, Rector BM, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Blood eosinophils, exhaled nitric oxide, and IGE do not accurately predict sputum eosinophils [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3926.

Bellinger C, Bowers B, Pascual R, Chin R Jr, Moore W, Conforti J. Bronchoscopy in patients with asthma. Clin Pulm Med. 2012;19(1):1-4.

Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF,. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012;308(10):987-997.

Yan H, Deshpande DA, Misior AM, Miles MC, Saxena H, Riemer EC, Pascual RM, Panettieri RA, Penn RB. Anti-mitogenic effects of beta-agonists and PGE2 on airway smooth muscle are PKA dependent. FASEB J. 2011;25(1):389-397.

Pascual RM, Breit JS. Mechanical ventilation in obstructive lung disease In: Truwit JD, Epstein SK, eds. A practical guide to mechanical ventilation. Chichester (UK): Wiley-Blackwell;2011: 195-203.

Moore WC, Evans MD, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Pascual RM, Peters SP, et al. Safety of investigative bronchoscopy in the Severe Asthma Research Program. J Allergy Clin Immunol. 2011;128(2):328-336.

Pascual RM, Peters SP. Asthma. Med Clin North Am. 2011;95(6):1115-1124.

Hawkins GA, Robinson MB, Moore W, Hastie A, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Correlation of serum IL6 with lung function and phenotypic asthma clusters: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A6169.

Moore WC, Pascual RM. Update in asthma 2009. Am J Respir Crit Care Med. 2010;181(11):1181-1187.

Pascual R. Interferon gamma receptor beta chain (IFNGR2) polymorphisms are associated with FEV1 and FVC in Severe Asthma Research Program (SARP) asthmatics [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1071.

Slager RE, Pascual RM, Moore WC, Hawkins GA, Peters SP, Meyers D, Bleecker ER. GATA3 polymorphisms are predictors of steroid use and atopic asthma in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1301.

Ortega VE, Liggett SB, Pascual R, Diallo A, Moore WC, Meyers D, Bleecker ER, Hawkins GA. Epigenetics of the beta2-adrenergic receptor gene [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1306.

Pascual RM, Moore WC, Peters SP, Li H, Wenzel SE, Meyers DA, Weiss ST, Litonjua AA, Bleecker ER. Serum vitamin D levels are inversely correlated with FEV1 and FVC in asthma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6800.

Pascual RM, Bleecker ER. Pharmacogenetics of asthma. Curr Opin Pharmacol. 2010;10(3):226-235.

Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Meyers DA, Bleecker ER, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010;363(18):1715-1726.

Pascual RM, Peters SP. Management of chronic asthma: in adults In: Barnes P, Drazen J, Rennard S, Thomson N, eds. Asthma and COPD: basic mechanisms and clinical management. 2nd ed. Boston (MA): Elsevier/Academic Press;2009: 763-774.

Misior AM, Deshpande DA, Loza MJ, Pascual RM, Hipp JD, Penn RB. Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle. Am J Respir Cell Mol Biol. 2009;41(1):24-39.

Pascual RM, Peters SP. The irreversible component of persistent asthma. J Allergy Clin Immunol. 2009;124(5):883-890.

Wahla AS, Depriest KL, Pascual RM, Chin R, Conforti JF. Bronchoscopic myths and legends: safety of transbronchial lung biopsy in patients with pulmonary hypertension. Clin Pulm Med. 2009;16(5):281-283.

Pascual RM, Slager RE, Li H, Hawkins GA, Peters SP, Moore WC, Meyers DA, Bleecker ER. GATA3 polymorphisms are associated with baseline and maximal post-bronchodilator FEV1 in Severe Asthma Research Program (SARP) asthmatics [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2449.

Misior AM, Yan H, Pascual RM, Deshpande DA, Panettieri RA, Penn RB. Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. Mol Pharmacol. 2008;73(2):566-574.

Misior AM, Yan H, Pascual RM, Deshpande D, Penn RB. Protein kinase A (PKA) inhibition renders interleukin-1 beta (IL-1 beta) pro-mitogenic to human airway smooth muscle (ASM) cells: role of induced GPCR ligands [abstract]. J Allergy Clin Immunol. 2008;121(2 Suppl 1):S48.

Kong KC, Gandhi U, Martin TJ, Anz CB, Yan H, Misior AM, Pascual RM, Deshpande DA, Penn RB. Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization. Biochemistry. 2008;47(35):9279-88.

Pascual RM, Peters SP. Management of persistent asthma in adults In: Castro M, Kraft M, eds. Clinical asthma. Philadelphia: Mosby/Elsevier;2008: 189-197.

Misior AM, Yan H, Pascual RM, Penn RB. Protein kinase A (PKA) inhibition renders interleukin-1beta (IL-1beta) pro-mitogenic to human airway smooth muscle (ASM) cells [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A268.

Pascual RM, Seeds MC, Panettieri RA, Peters SP, Penn RB. Interleukin-1beta (IL-1beta)-mediated microsomal prostaglandin E2(PGE2) synthase (mPGES) induction regulates cyclooxygenase-2 (COX-2) and PGE2 production in human airway smooth muscle (HASM) [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A663.

Peters S, McCallister J, Pascual R. Treatment of moderate persistent asthma [topic reveiw]. UpToDate [online]. 2007;(version 15.2):.

Deshpande DA, Pascual RM, Wang S-W, Eckman DM, Riemer EC, Funk CD, Penn RB. PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation. FASEB J. 2007;21(10):2335-2342.