Profile

Ann Marie Peiffer, Ph.D.Wake Forest School of Medicine

Ann Marie Peiffer, Ph.D.

Assistant Professor,




Contact Information

Academic: 336-713-6535 | Department: 336-713-3600

Email: apeiffer@wakehealth.edu

Education & Training

  • B.A., Cornell College , 1999
  • M.S., University of Connecticut , 2002
  • Ph.D., University of Connecticut , 2004
Ann Marie Peiffer, Ph.D.

Ann Marie Peiffer, Ph.D.

Assistant Professor, Radiation Oncology
Brain Tumor Center of Excellence
Office of Women in Medicine and Science
Sticht Center on Aging
WFU Primate Center

Research Interests

education outreach, neurosciences/behavior

Contact Information

Academic: 336-713-6535 | Department: 336-713-3600

Email: apeiffer@wakehealth.edu

Recent Publications

Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME [deceased]. The peroxisomal proliferator-activated receptor (PPAR) alpha agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Radiat Res. 2014;181(1):33-44.

Paulsson AK, McMullen KP, Peiffer AM, Hinson WH, Kearns WT, Johnson AJ, Lesser GJ, Ellis TL, Tatter SB, Debinski W, Shaw EG, Chan MD. Limited margins using modern radiotherapy techniques does not increase marginal failure rate of glioblastoma. Am J Clin Oncol. 2014;37(2):177-181.

Ayala-Peacock DN, Peiffer AM, Lucas JT, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD. A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Neuro Oncol. 2014;():.

Leyrer CM, Chan MD, Peiffer AM, Horne E, Harmon M, Carter AF, Hinson WH, Mirlohi S, Duncan SE, Dietrich AM, Lesser GJ. Taste and smell disturbances after brain irradiation: a dose-volume histogram analysis of a prospective observational study. Pract Radiat Oncol. 2014;4(2):130-135.

Paulsson AK, Holmes JA, Peiffer AM, Miller LD, Liu W, Xu J, Hinson WH, Lesser GJ, Laxton AW, Tatter SB, Debinski W, Chan MD. Comparison of clinical outcomes and genomic characteristics of single focus and multifocal glioblastoma. J Neurooncol. 2014;():.

Peiffer AM, Leyrer CM, Greene-Schloesser DM, Shing E, Kearns WT, Hinson WH, Tatter SB, Ip EH, Rapp SR, Robbins ME [deceased], Shaw EG, Chan MD. Neuroanatomical target theory as a predictive model for radiation-induced cognitive decline. Neurology. 2013;80(8):747-753.

Randolph D, Peiffer AM, Klepin H, Ayala-Peacock DN, Lester SC, Laxton AW, Tatter SB, Shaw EG, Chan MD. Impact of radiosurgical management of geriatric patients with brain metastases: clinical and quality of life outcomes [abstract]. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S609.

Linville C, Mintz A, Hampson R, Deadwyler S, Peiffer A. Changes in FDG-PET uptake during a delayed match to samplememory task [abstract]. Neuro Oncol. 2013;15(Suppl 3):95.

Peiffer AM, Burke A, Leyer CM, Shing E, Kearns WT, Hinson WH, Case D, Rapp SR, Shaw EG, Chan MD. Normal tissue complication probability (Ntcp) model of radiation-induced mood disruption [abstract]. Neuro Oncol. 2013;15(Suppl 3):230.

Rapp SR, Case D, Peiffer A, Naughton MJ, Stieber VW, Bayer GK, Bilodeau PA, Moore DF, Falchuk SC, Needles BM , Piephoff J, Edenfield WJ, Giguere JK, Erickson N, Loghin ME, Shaw EG. Phase III randomized, double-blind, placebo-controlled trial of donepezil in irradiated brain tumor survivors [abstract]. J Clin Oncol. 2013;31(15 Suppl):2006.

Eldridge JC, Lack AK, Peiffer AM, Tytell M. RCR curriculum for graduate students at Wake Forest: still evolving after 5 years [abstract]. In: Abstracts of the Quest for Research Excellence 2012 Meeting; 2012 Mar 15-16; Washington (DC). 2012;():82.

Robbins ME, Brunso-Bechtold JK, Peiffer AM, Tsien CI, Bailey JE, Marks LB. Imaging radiation-induced normal tissue injury. Radiat Res. 2012;177(4):449-466.


Greene-Schloesser D, Robbins ME, Peiffer AM, Shaw EG, Wheeler KT, Chan MD. Radiation-induced brain injury: a review. Front Oncol. 2012;2():73.

Loganathan AG, Chan MD, Alphonse N, Peiffer AM, Johnson AJ, McMullen KP, Urbanic JJ, Saconn PA, Bourland JD, Munley MT, Shaw EG, Tatter SB, Ellis TL [deceased]. Clinical outcomes of brain metastases treated with Gamma Knife radiosurgery with 3.0T versus 1.5T MRI-based treatment planning: have we finally optimised detection of occult brain metastases?. J Med Imaging Radiat Oncol. 2012;56(5):554-560.

Ayala-Peacock D, Peiffer AM, Ellis TL [deceased], Tatter SB, Urbanic JJ, Bourland JD, Shaw EG, Chan MC. Predictive factors for distant brain failure after primary radiosurgical management of brain metastases [abstract]. Int J Radiat Oncol Biol Phys. 2012;84(3 Suppl):S296.

Leyrer M, Chan MD, Peiffer AM, Horne E, Harmon M, Carter AF, Hinson WH, Duncan SE, Dietrich AM, Lesser GJ. Radiation-induced taste and smell toxicity: a dose-volume histogram analysis of a prospective observational study [abstract]. Int J Radiat Oncol Biol Phys. 2012;84(3 Suppl):S302.

Linville C, Hampson R, Deadwyler S, Peiffer A. Exploring late effects of brain irradiation with a delayed match to sample paradigm [abstract]. Neuro Oncol. 2012;14(Suppl 6):62.

Paulsson A, Peiffer AM, McMullen KP, Hinson WH, Lesser GJ, Ellis TL [deceased], Tatter SB, Shaw EG, Chan MD. Comparison of clinical outcomes for single focus and multifocal glioblastoma [abstract]. Int J Radiat Oncol Biol Phys. 2012;84(3 Suppl):S274.

Peiffer AM, Case D, Shaw EG, Rapp S. Magnetic resonance imaging associates with differences in neurocognitive performance for cancer survivors complaining of cognitive deficits following brain irradiation [abstract]. Neuro Oncol. 2012;14(Suppl 6):63.

Peiffer AM, Hugenschmidt CE, Laurienti PJ. Ethics in 15 min per week. Sci Eng Ethics. 2011;17(2):289-297.

Leyrer CM, Peiffer AM, Greene-Schloesser DM, Kearns WT, Hinson WH, Tatter SB, Rapp SR, Robbins ME, Shaw EG, Chan MD. Normal tissue complication modeling of the brain: dose-volume histogram analysis of neurocognitive outcomes of two CCOP trials [abstract]. Int J Radiat Oncol Biol Phys. 2011;81(2 Suppl):S184-S185.

Loganathan AG, Chan MD, Alphonse N, Peiffer AM, Johnson A, McMullen KP, Urbanic JJ, Saconn PA, Bourland JD, Munley MT, Shaw EG, Tatter SB, Ellis TL. Clinical outcomes of brain metastases treated with gamma knife radiosurgery with 3.0 T vs. 1.5 T MRI-based treatment planning [abstract]. Neuro Oncol. 2011;13(Suppl 3):129.

Paulsson AK, Chan MD, Peiffer AM, Hinson WH, Kearns WT, Lesser GJ, Ellis TL, Tatter SB, Shaw EG, McMullen KP. Decreased CTV margin size does not affect patterns of failure for glioblastoma treated with concurrent radiotherapy and temozolomide [abstract]. Int J Radiat Oncol Biol Phys. 2011;81(2 Suppl):S183.

Peiffer AM, Leyrer CM, Greene-Schloesser D, Kearns WT, Hinson WH, Tatter SB, Rapp SR, Robbins ME, Shaw EG, Chan MD. Normal tissue complication modeling of the brain: dose-volume histogram analysis of neurocognitive outcomes of two CCOP trials [abstract]. Neuro Oncol. 2011;13(Suppl 3):73.

Mozolic JL, Hugenschmidt CE, Peiffer AM, Laurienti PJ. Multisensory integration and aging In: Murray MM, Wallace MT, eds. The neural basis of multisensory processes. Boca Raton (FL): CRC Press;2011: 381-395.

Hugenschmidt CE, Hayasaka S, Peiffer AM, Laurienti PJ. Applying capacity analyses to psychophysical evaluation of multisensory interactions. Inf Fusion. 2010;11(1 Special Issue):12-20.

Jones NL, Peiffer AM, Lambros A, Guthold M, Johnson AD, Tytell M, Ronca AE, Eldridge JC. Developing a problem-based learning (PBL) curriculum for professionalism and scientific integrity training for biomedical graduate students. J Med Ethics. 2010;36(10):614-619.

Peiffer AM, Shi L, Olson J, Brunso-Bechtold JK. Differential effects of radiation and age on diffusion tensor imaging in rats. Brain Res. 2010;1351():23-31.


Peiffer AM, Hugenschmidt CE, Maldjian JA, Casavona R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ. Aging and the interaction of sensory cortical function and structure. Hum Brain Mapp. 2009;30(1):228-240.

Addicott MA, Yang LL, Peiffer AM, Laurienti PJ. Methodological considerations for the quantification of self-reported caffeine use. Psychopharmacology (Berl). 2009;203(3):571-578.

Addicott MA, Yang LL, Peiffer AM, Burnett LR, Burdette JH, Chen MY, Hayasaka S, Kraft RA, Maldjian JA, Laurienti PJ. The effect of daily caffeine use on cerebral blood flow: how much caffeine can we tolerate?. Hum Brain Mapp. 2009;30(10):3102-3114.

Hugenschmidt CE, Peiffer AM, McCoy TP, Hayasaka S, Laurienti PJ. Preservation of crossmodal selective attention in healthy aging. Exp Brain Res. 2009;198(2-3):273-285.

Peiffer AM, Hugenschmidt CE, Mozolic J, Laurienti PJ. Do structural MRI analyses show evidence for cognitive reserve in the healthy aging brain? [abstract]. Gerontologist. 2009;49(Suppl 2):306.

Jones N, Tytell M, Eldridge JC, Johnson D, Peiffer A, Lambros A. Teaching bioethics and professional conduct through problem-based learning In: Proceedings of the 31st Annual Association for Biology Laboratory Education Conference, vol 31; 2009 June 9-13; Newark (DE). ;2009: 134-161.

Mozolic JL, Hugenschmidt CE, Peiffer AM, Laurienti PJ. Modality-specific selective attention attenuates multisensory integration. Exp Brain Res. 2008;184(1):39-52.

Hugenschmidt CE, Peiffer AM, Kraft RA, Casanova R, Deibler AR, Burdette JH, Maldjian JA, Laurienti PJ. Relating imaging indices of white matter integrity and volume in healthy older adults. Cereb Cortex. 2008;18(2):433-442.

Peiffer AM, Maldjian JA, Laurienti PJ. Resurrecting Brinley plots for a novel use: meta-analyses of functional brain imaging data in older adults. Int J Biomed Imaging. 2008;2008():.

Fitch RH, Threlkeld SW, McClure MM, Peiffer AM. Use of a modified prepulse inhibition paradigm to assess complex auditory discrimination in rodents. Brain Res Bull. 2008;76(1-2):1-7.

Peiffer AM, Tytell M, Eldridge JC, Jones NL. Scientific integrity and professionalism instruction using problem-based learning [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Mozolic JL, Joyner D, Hugenschmidt CE, Peiffer AM, Kraft RA, Maldjian JA, Laurienti PJ. Cross-modal deactivations during modality-specific selective attention. BMC Neurol. 2008;8():article 35.

Peiffer AM, Laurienti PJ, Hugenschmidt CE. Fostering a culture of responsible lab conduct [letter]. Science. 2008;322(5905):1186.

Peiffer AM, Mozolic JL, Hugenschmidt CE, Laurienti PJ. Age-related multisensory enhancement in a simple audiovisual detection task. Neuroreport. 2007;18(10):1077-1081.

Hayasaka S, Peiffer AM, Hugenschmidt CE, Laurienti PJ. Power and sample size calculation for neuroimaging studies by non-central random field theory. Neuroimage. 2007;37(3):721-730.

Srikanth R, Casanova R, Laurienti PJ, Peiffer AM, Maldjian JA. Estimation of false discovery rates for wavelet-denoised statistical parametric maps. Neuroimage. 2006;33(1):72-84.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Radiation Oncology

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