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Stephen Peters, M.D., Ph.D.Wake Forest School of Medicine

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Education & Training

  • B.A., Yale University, 1971
  • Ph.D., University of Pennsylvania School of Medicine, 1976
  • M.D., University of Pennsylvania School of Medicine, 1978
  • Internship, Internal Medicine, Johns Hopkins Hosp, 1980
  • Fellowship, Allergy, Johns Hopkins University Schoo, 1982

Memberships

  • Am Assn Of Immunologists
  • Sigma Xi Society
  • Soc for Leukocyte Biology
  • Am Coll Of Physicians
  • Am Federation Of Clinical Rese
  • American Thoracic Society
  • Am Academy Of Allergy & Immuno

NPI Number

  • 1598740656
Stephen Peters, M.D., Ph.D.

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Stephen Peters, M.D., Ph.D.

Associate Director, Center for Genomics and Personalized Medicine Research
Acting Section Chief, Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Center for Genomics and Personalized Medicine Research
Pediatrics
Translational Science Institute

Research Interests

drugs/therapeutic agents pharm, immunology/allergy/inflammatio

Contact Information

Academic: 336-713-7500 | Department: 336-716-2011

Recent Publications

Dixon AE, Castro M, Cohen RI, Gerald LB, Holbrook JT, Irvin CG, Mohapatra S, Peters SP, Rayapudi S, Sugar EA, Wise RA. Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma. J Allergy Clin Immunol. 2015;135(3):701-709.e5.

Dixon AE, Castro M, Cohen RI, Gerald LB, Holbrook JT, Irvin CG, Mohapatra S, Peters SP, Rayapudi S, Sugar EA, Wise RA. Nasal endoscopy to characterize sinonasal disease [reply to letter]. J Allergy Clin Immunol. 2015;136(1):212-213.

Dahlin A, Litonjua A, Irvin CG, Peters SP, Lima JJ, Kubo M, Tamari M, Tantisira KG. Genome-wide association study of leukotriene modifier response in asthma. Pharmacogenomics J. 2015;():.

Dahlin A, Litonjua A, Lima JJ, Tamari M, Kubo M, Irvin CG, Peters SP, Tantisira KG. Genome-wide association study identifies novel pharmacogenomic loci for therapeutic response to montelukast in asthma. PLoS One. 2015;10(6):e0129385.

Dunn RM, Lehman E, Chinchilli VM, Martin RJ, Boushey HA, Israel E, Kraft M, Lazarus SC, Lemanske RF, Lugogo NL, Peters SP, Sorkness CA, Szefler S, Wechsler ME. Impact of age and gender on response to asthma therapy. Am J Respir Crit Care Med. 2015;():.

Bellinger CR, Peters SP. Outpatient chronic obstructive pulmonary disease management: going for the GOLD. J Allergy Clin Immunol Pract. 2015;3(4):471-478.

Peters SP, Dykewicz MS. Anticholinergic therapies In: Adkinson NF Jr, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O'Hehir RE, Middleton E Jr, eds. Middleton's allergy: principles and practice. 8th ed. Philadelphia: Elsevier/Saunders;2014: 1552-1566.

Duan QL, Lasky-Su J, Himes BE, Qiu W, Litonjua AA, Damask A, Lazarus R, Klanderman B, Irvin CG, Peters SP, Hanrahan JP, Lima JJ, Martinez FD, Mauger D, Chinchilli VM, Soto-Quiros M, Avila L, Celedon JC, Lange C, Weiss ST, Tantisira KG. A genome-wide association study of bronchodilator response in asthmatics. Pharmacogenomics J. 2014;14(1):41-47.

Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014;2(3):204-213.

Park HW, Dahlin A, Tse S, Duan QL, Schuemann B, Martinez FD, Peters SP, Szefler SJ, Lima JJ, Kubo M, Tamari M, Tantisira KG. Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids. J Allergy Clin Immunol. 2014;133(3):664-669.

Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA,. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311(20):2083-2091.

Wu AC, Himes BE, Lasky-Su J, Litonjua A, Peters SP, Lima J, Kubo M, Tamari M, Nakamura Y, Qiu W, Weiss ST, Tantisira K. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. J Allergy Clin Immunol. 2014;133(3):723-728.

O'Neal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, Scholand MB, Tal-Singer R,. Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. J Transl Med. 2014;12():9.

Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol. 2014;133(6):1557-1563.

Peters SP. COPD and irreversible airflow obstruction In: Lockey RF, Ledford DK, eds. Asthma: comorbidities, coexisting conditions, and differential diagnosis. Oxford: Oxford University Press;2014: 80-91.

Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP. RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Am J Respir Crit Care Med. 2014;189():A6384.

Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M. Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Am J Respir Crit Care Med. 2014;189():A4288.

Ortega VE, Moore WC, Hawkins G, Ampleford EJ, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Peters SP, Bleecker ER, Meyers DA. African ancestry is associated with lower baseline lung function, misclassification of disease severity, and healthcare utilization in African Americans with severe asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A6366.

Coverstone AM, Zheng J, Bacharier LB, Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Gaston BM, Bleecker ER, Moore WC, Castro M. Predictors of response to bronchodilators in children with severe asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A3839.

Yanez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, Peters S, Niimi A, Ledford DK, Katial R, Fabbri LM, Celedon JC, Canonica GW, Busse P, Boulet LP, Baena-Cagnani CE, Hamid Q, Bachert C, Pawankar R, Holgate ST, Bleecker E, Meyers DA. Asthma in the elderly: what we know and what we have yet to know. World Allergy Organ J. 2014;7(1):8.

Rank MA, Peters SP. The risks, benefits, and uncertainties of stepping down asthma medications. J Allergy Clin Immunol Pract. 2014;2(5):503-509.

Peters SP. Asthma phenotypes: nonallergic (intrinsic) asthma. J Allergy Clin Immunol Pract. 2014;2(6):650-652.

Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA,. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013;187(1):28-33.

Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung KF, Erzurum SC, Wenzel SE. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med. 2013;187(2):153-159.

Duan QL, Du R, Lasky-Su J, Klanderman BJ, Partch AB, Peters SP, Irvin CG, Hanrahan JP, Lima JJ, Blake KV, Liggett SB, Litonjua AA, Tantisira KG. A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. Pharmacogenomics J. 2013;13(2):130-136.

Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr,. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013;8(2):e56179.

Peters SP, Benninger M, Hankin CS, Wang ZH, Bronstone A, Buck P, Lepore MS. Incidence of oral candidiasis among patients with asthma receiving fluticasone propionate/salmeterol dry powder inhaler versus beclomethasone dipropionate hydrofluoroakane: large-scale retrospective claims analysis [abstract]. J Allergy Clin Immunol. 2013;131(2 Suppl):AB2.

Romeo J, Hastie AT, Foster S, Moore W, Peters SP, Bleecker ER, Dykewicz MS. LIGHT is associated with increased cellular infiltrate and levels of TH1 cytokines as well as well as [sic] reduced lung function in human asthma [abstract]. J Allergy Clin Immunol. 2013;131(2 Suppl):AB203.

Mougey EB, Chen C, Tantisira KG, Blake KV, Peters SP, Wise RA, Weiss ST, Lima JJ. Pharmacogenetics of asthma controller treatment. Pharmacogenomics J. 2013;13(3):242-250.

McGeachie MJ, Stahl EA, Himes BE, Pendergrass SA, Lima JJ, Irvin CG, Peters SP, Ritchie MD, Plenge RM, Tantisira KG. Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. Pharmacogenet Genomics. 2013;23(6):324-328.

Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol. 2013;132(1):72-80.

Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol. 2013;132(2):313-320.

McGeachie MJ, Wu AC, Chang HH, Lima JJ, Peters SP, Tantisira KG. Predicting inhaled corticosteroid response in asthma with two associated SNPs. Pharmacogenomics J. 2013;13(4):306-311.

Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF Jr,. Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol. 2013;132(5):1068-1074.

Peters SP. Tiotropium bromide triple combination therapy improves lung function and decreases asthma exacerbations [commentary]. Evid Based Med. 2013;18(5):179.

Peters SP. When the chief complaint is (or should be) dyspnea in adults. J Allergy Clin Immunol Pract. 2013;1(2):129-136.

Slager RE, Moore WC, Peters SP, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Meyers DA, Bleecker ER. Exome sequencing identifies genes for asthma severity in African-Americans [abstract]. Am J Respir Crit Care Med. 2013;187():A2396.

Hastie AT, Rector B, Moore WC, Li H, Peters SP, Meyers DA, Bleecker ER. Serum and sputum interleukin-33 (IL-33) levels show no association with serum total IgE, positive skin test number, exhaled nitric oxide, or increasing severity of atopic asthma [abstract]. Am J Respir Crit Care Med. 2013;187():A1008.

Ortega VE, Slager RE, Hawkins G, Moore WC, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Peters SP, Meyers DA, Bleecker ER. Exome sequencing of beta2-adrenergic receptor pathway genes reveals rare variants associated with asthma severity In African Americans [abstract]. Am J Respir Crit Care Med. 2013;187():A2129.

Bowers B, Hastie AT, Rector B, Moore WC, Meyers DA, Peters SP, Bleecker ER. Insulin like growth factor binding protein 2 (IGFBP2) is associated with increased sputum cellular infiltrate, increased sputum cytokine levels, and reduced lung function for human subjects with asthma [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2397.

Li X, Moore WC, Ampleford EJ, Li H, Hawkins G, Hastie AT, Boushey HA, Busse WW, Castro M, Erzurum SC, Israel E, Lemanske RF, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Phenotypic/genetic characteristics of atopic/non-atopic early/late onset asthma [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2395.

Ortega VE, Miller SM, Slager RE, Hawkins G, Moore WC, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Peters SP, Bleecker ER, Meyers DA. Whole exome sequencing analysis reveals rare genetic variants associated with response to beta2- adrenergic receptor agonists in African American asthmatics [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2122.

Moore WC, Smith R, Krings J, Li X, Li H, Peters SP, Wenzel SE, Meyers DA, Bleecker ER. Elderly subjects with asthma are less responsive to albuterol and ipratropium bromide when compared to younger subjects, but have similar responses to the two drugs [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A4215.

Hartman JM, Hastie A, Moore WC, Rector B, Peters SP, Bleecker ER, Dykewicz MS. Thioredoxin is positively associated with eosinophils in induced sputum from patients with asthma [abstract]. J Allergy Clin Immunol. 2012;129(2 Suppl):AB209.

Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP,. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med. 2012;185(4):356-362.

Tepper RS, Wise RS, Covar R, Irvin CG, Kercsmar CM, Kraft M, Liu MC, O'Connor GT, Peters SP, Sorkness R, Togias A. Asthma outcomes: pulmonary physiology. J Allergy Clin Immunol. 2012;129(3 Suppl):S65-S87.

Hartman JM, Caldwell JW, Pascual RM, Peters SP. Asthma treatment In: Adelman DC, Casale TB, Corren J, eds. Manual of allergy and immunology. 5th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins;2012: 150-172.

Ortega VE, Hawkins G, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Characterization of rare variants in the Adam33 gene in asthma cases from two ethnic groups [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A5609.

Bellinger C, Pascual R, Krings J, Smith R, Burmudez R, Peters SP, Bleecker ER, Moore WC. Similar decrements in FEV1 and FVC in not severe and severe asthma subjects following investigative bronchoscopy [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4178.

Slager RE, Moore WC, Peters SP, Busse WW, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER. Rare TH1 and TH2 pathway genetic variants contribute to severe allergic asthma [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2509.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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