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Stephen Peters, M.D., Ph.D.Wake Forest School of Medicine

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Stephen Peters, M.D., Ph.D.

Acting Section Chief,
Associate Director,
Professor,


Clinical Interests

Asthma

Contact Information

Department: 336-716-2011

Insurance Accepted »

Education & Training

  • B.A., Yale University, 1971
  • Ph.D., University of Pennsylvania School of Medicine, 1976
  • M.D., University of Pennsylvania School of Medicine, 1978
  • Internship, Internal Medicine, Johns Hopkins Hosp, 1980
  • Fellowship, Allergy, Johns Hopkins University Schoo, 1982

Board Certifications

  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Pulmonary Disease

Memberships

  • Am Assn Of Immunologists
  • Sigma Xi Society
  • Soc for Leukocyte Biology
  • Am Coll Of Physicians
  • Am Federation Of Clinical Rese
  • American Thoracic Society
  • Am Academy Of Allergy & Immuno

NPI Number

  • 1598740656
Stephen Peters, M.D., Ph.D.

Doctor Rating

No Rating Available
Why No Ratings?

Stephen Peters, M.D., Ph.D.

Acting Section Chief, Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Associate Director, Center for Genomics and Personalized Medicine Research
Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Pediatrics
Translational Science Institute

Research Interests

Asthma; Anti-Asthmatic Agents; Bronchodilator Agents; Adrenergic beta-Agonists; Albuterol
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Contact Information

Academic: 336-713-7500 | Department: 336-716-2011

Recent Publications

Genome-wide association study of leukotriene modifier response in asthma. Dahlin A, Litonjua A, Irvin CG, Peters SP, Lima JJ, Kubo M, Tamari M, Tantisira KG.. Pharmacogenomics J. 2016;16(2):151-157.

Vitamin D supplementation and the risk of colds in patients with asthma. Denlinger LC, King TS, Cardet JC, Craig T, Holguin F, Jackson DJ, Kraft M, Peters SP, Ross K, Sumino K, Boushey HA, Jarjour NN, Wechsler ME, Wenzel SE, Castro M, Avila PC.. Am J Respir Crit Care Med. 2016;193(6):634-641.

Overlap of atopic, eosinophilic, and TH2-high asthma phenotypes in a general population with current asthma. Tran TN, Zeiger RS, Peters SP, Colice G, Newbold P, Goldman M, Chipps BE.. Ann Allergy Asthma Immunol. 2016;116(1):37-42.

Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma. Dixon AE, Castro M, Cohen RI, Gerald LB, Holbrook JT, Irvin CG, Mohapatra S, Peters SP, Rayapudi S, Sugar EA, Wise RA.. J Allergy Clin Immunol. 2015;135(3):701-709.e5.

Nasal endoscopy to characterize sinonasal disease [reply to letter]. Dixon AE, Castro M, Cohen RI, Gerald LB, Holbrook JT, Irvin CG, Mohapatra S, Peters SP, Rayapudi S, Sugar EA, Wise RA.. J Allergy Clin Immunol. 2015;136(1):212-213.

Genome-wide association study identifies novel pharmacogenomic loci for therapeutic response to montelukast in asthma. Dahlin A, Litonjua A, Lima JJ, Tamari M, Kubo M, Irvin CG, Peters SP, Tantisira KG.. PLoS One. 2015;10(6):e0129385.

Impact of age and sex on response to asthma therapy. Dunn RM, Lehman E, Chinchilli VM, Martin RJ, Boushey HA, Israel E, Kraft M, Lazarus SC, Lemanske RF, Lugogo NL, Peters SP, Sorkness CA, Szefler S, Wechsler ME.. Am J Respir Crit Care Med. 2015;192(5):551-558.

Outpatient chronic obstructive pulmonary disease management: going for the GOLD. Bellinger CR, Peters SP.. J Allergy Clin Immunol Pract. 2015;3(4):471-478.

Asthma is more severe in older adults. Zein JG, Dweik RA, Comhair SA, Bleecker ER, Moore WC, Peters SP, Busse WW, Jarjour NN, Calhoun WJ, Castro M, Chung KF, Fitzpatrick A, Israel E, Teague WG, Wenzel SE, Love TE, Gaston BM, Erzurum SC.. PLoS One. 2015;10(7):e0133490.

Vitamin D supplementation and the risk of colds in patients with asthma [abstract]. Denlinger LC, King TS, Cardet JC, Craig TJ, Holguin F, Kraft M, Peters SP, Ross KR, Sumino K, Boushey HA Jr, Jackson DJ, Wechsler ME, Castro M, Avila PC.. J Allergy Clin Immunol. 2015;135(2 Suppl):AB109.

Clinical implications of having reduced mid forced expiratory flow rates (FEF25-75), independently of FEV1, in adult patients with asthma. Riley CM, Wenzel SE, Castro M, Erzurum SC, Chung KF, Fitzpatrick AM, Gaston B, Israel E, Moore WC, Bleecker ER, Calhoun WJ, Jarjour NN, Busse WW, Peters SP, Teague WG, Sorkness R, Holguin F.. PLoS One. 2015;10(12):e0145476.

Early administration of azithromycin and prevention of severe lower respiratory tract illnesses in preschool children with a history of such illnesses: a randomized clinical trial. Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CA, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC,.. JAMA. 2015;314(19):2034-2044.

Reliability of multiplex-based blood biomarkers in COPD subjects enrolled in spiromics (subpopulation and intermediate outcome measures in COPD study) [abstract]. Anderson WH, Basta P, Carretta E, Cui G, Davis S, Doerschuk CM, Barr RG, Bleecker ER, Bowler RP, Curtis JL, Drummond MB, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Peters SP, Woodruff PG, Rennard SI, Couper D, O'Neal WK.. Am J Respir Crit Care Med. 2015;191():A2935.

Genome-wide association study identifies novel pharmacogenomic loci for therapeutic response to montelukast in asthma [abstract]. Dahlin A, Litonjua AA, Qiu W, Lima JJ, Tamari M, Kubo M, Irvin CG, Peters SP, Tantisira KG.. Am J Respir Crit Care Med. 2015;191():A1058.

Impact of gender and age on the response to therapy in the asthma clinical research network [abstract]. Dunn RM, Lehman E, Chinchilli VM, Martin RJ, Boushey HA, Israel E, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Peters SP, Sorkness CA, Szefler SJ, Wechsler ME.. Am J Respir Crit Care Med. 2015;191():A4271.

Analyses of COPD severity phenotypes and emphysema in spiromics subjects stratified By sputum granulocytes [abstract]. Hastie AT, Doerschuk CM, Alexis NE, Hansel NN, Peters SP, Barr RG, Couper D, Curtis JL, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Putcha N, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2861.

Blood biomarker quantitative trail loci in chronic obstructive pulmonary disease [abstract]. Jacobson S, Kechris K, Sun W, Yang J, Chen TH, Barr RG, Basta P, Bleecker ER, Couper D, Curtis JL, Doerschuk CM, Drummond MB, Han MK, Hansel NN, Hawkins G, Hoffman EA, Kanner R, Kleerup EC, Martinez FJ, Meyers DA, O'Neal WK, Peters SP,.. Am J Respir Crit Care Med. 2015;191():A3627.

Sarp clinical clusters predict steroid responsiveness and risk of asthma exacerbations in the Asthmanet Vida (Vitamin D In Asthma) Trial [abstract]. Moore WC, King TS, Bleecker ER, Meyers DA, Peters SP Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A6055.

African ancestry is associated with lung function, healthcare utilization, and airways inflammation in African Americans with asthma [abstract]. Ortega VE, Moore WC, Zein J, Hastie AT, Ampleford E, Peters SP, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A1061.

The association between reduced mid-forced expiratory flow rates (fef25-75) with clinical outcomes in patients with asthma participating in the Severe Asthma Research Program (sarp) [abstract]. Riley C, Wenzel SE, Bleecker ER, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston BM, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung K, Holguin F.. Am J Respir Crit Care Med. 2015;191():A4188.

Evaluation of genetic variants in Il6 and Il6r in the Nhlbi subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Hawkins GA, Ampleford EJ, Ortega VE, Li X, Peters SP, Barr RG, Couper D, Han MK, Kanner R, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A4693.

Anticholinergic therapies. Peters SP, Dykewicz MS. In: Adkinson NF Jr, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O'Hehir RE, Middleton E Jr, eds. Middleton's allergy: principles and practice. 8th ed. Philadelphia: Elsevier/Saunders;2014: 1552-1566.

A genome-wide association study of bronchodilator response in asthmatics. Duan QL, Lasky-Su J, Himes BE, Qiu W, Litonjua AA, Damask A, Lazarus R, Klanderman B, Irvin CG, Peters SP, Hanrahan JP, Lima JJ, Martinez FD, Mauger D, Chinchilli VM, Soto-Quiros M, Avila L, Celedon JC, Lange C, Weiss ST, Tantisira KG.. Pharmacogenomics J. 2014;14(1):41-47.

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER.. Lancet Respir Med. 2014;2(3):204-213.

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids. Park HW, Dahlin A, Tse S, Duan QL, Schuemann B, Martinez FD, Peters SP, Szefler SJ, Lima JJ, Kubo M, Tamari M, Tantisira KG.. J Allergy Clin Immunol. 2014;133(3):664-669.

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA,.. JAMA. 2014;311(20):2083-2091.

Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. Wu AC, Himes BE, Lasky-Su J, Litonjua A, Peters SP, Lima J, Kubo M, Tamari M, Nakamura Y, Qiu W, Weiss ST, Tantisira K.. J Allergy Clin Immunol. 2014;133(3):723-728.

Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. O'Neal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, Scholand MB, Tal-Singer R,.. J Transl Med. 2014;12():9.

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2014;133(6):1557-1563.

COPD and irreversible airflow obstruction. Peters SP. In: Lockey RF, Ledford DK, eds. Asthma: comorbidities, coexisting conditions, and differential diagnosis. Oxford: Oxford University Press;2014: 80-91.

RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP.. Am J Respir Crit Care Med. 2014;189():A6384.

Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M.. Am J Respir Crit Care Med. 2014;189():A4288.

African ancestry is associated with lower baseline lung function, misclassification of disease severity, and healthcare utilization in African Americans with severe asthma [abstract]. Ortega VE, Moore WC, Hawkins G, Ampleford EJ, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Peters SP, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A6366.

Predictors of response to bronchodilators in children with severe asthma [abstract]. Coverstone AM, Zheng J, Bacharier LB, Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Gaston BM, Bleecker ER, Moore WC, Castro M.. Am J Respir Crit Care Med. 2014;189():A3839.

Asthma in the elderly: what we know and what we have yet to know. Yanez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, Peters S, Niimi A, Ledford DK, Katial R, Fabbri LM, Celedon JC, Canonica GW, Busse P, Boulet LP, Baena-Cagnani CE, Hamid Q, Bachert C, Pawankar R, Holgate ST, Bleecker E, Meyers DA.. World Allergy Organ J. 2014;7(1):8.

The risks, benefits, and uncertainties of stepping down asthma medications. Rank MA, Peters SP.. J Allergy Clin Immunol Pract. 2014;2(5):503-509.

Asthma phenotypes: nonallergic (intrinsic) asthma. Peters SP.. J Allergy Clin Immunol Pract. 2014;2(6):650-652.

P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA,.. Am J Respir Crit Care Med. 2013;187(1):28-33.

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung KF, Erzurum SC, Wenzel SE.. Am J Respir Crit Care Med. 2013;187(2):153-159.

A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. Duan QL, Du R, Lasky-Su J, Klanderman BJ, Partch AB, Peters SP, Irvin CG, Hanrahan JP, Lima JJ, Blake KV, Liggett SB, Litonjua AA, Tantisira KG.. Pharmacogenomics J. 2013;13(2):130-136.

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr,.. PLoS One. 2013;8(2):e56179.

Incidence of oral candidiasis among patients with asthma receiving fluticasone propionate/salmeterol dry powder inhaler versus beclomethasone dipropionate hydrofluoroakane: large-scale retrospective claims analysis [abstract]. Peters SP, Benninger M, Hankin CS, Wang ZH, Bronstone A, Buck P, Lepore MS.. J Allergy Clin Immunol. 2013;131(2 Suppl):AB2.

LIGHT is associated with increased cellular infiltrate and levels of TH1 cytokines as well as well as [sic] reduced lung function in human asthma [abstract]. Romeo J, Hastie AT, Foster S, Moore W, Peters SP, Bleecker ER, Dykewicz MS.. J Allergy Clin Immunol. 2013;131(2 Suppl):AB203.

Pharmacogenetics of asthma controller treatment. Mougey EB, Chen C, Tantisira KG, Blake KV, Peters SP, Wise RA, Weiss ST, Lima JJ.. Pharmacogenomics J. 2013;13(3):242-250.

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. McGeachie MJ, Stahl EA, Himes BE, Pendergrass SA, Lima JJ, Irvin CG, Peters SP, Ritchie MD, Plenge RM, Tantisira KG.. Pharmacogenet Genomics. 2013;23(6):324-328.

Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(1):72-80.

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(2):313-320.

Predicting inhaled corticosteroid response in asthma with two associated SNPs. McGeachie MJ, Wu AC, Chang HH, Lima JJ, Peters SP, Tantisira KG.. Pharmacogenomics J. 2013;13(4):306-311.

Predictors of response to tiotropium versus salmeterol in asthmatic adults. Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF Jr,.. J Allergy Clin Immunol. 2013;132(5):1068-1074.

Tiotropium bromide triple combination therapy improves lung function and decreases asthma exacerbations [commentary]. Peters SP.. Evid Based Med. 2013;18(5):179.

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