Mark J. Pettenati, Ph.D.Wake Forest School of Medicine

Mark J. Pettenati, Ph.D.


Clinical Interests

Genetics, Cytogenetics, Chromosomes

Contact Information

Academic: 336-716-4321 | Department: 336-716-4311


Education & Training

  • B.S., St Bonaventure University, 1978
  • Ph.D., West Virginia University, 1983
  • Fellowship, Indiana University School of M, 1985
  • Fellowship, University of Chicago Pritzker, 1986


  • North Carolina Medical Genetic
  • Calgb Cytogenetics Committee
  • Cancer & Acute Leukemia Group
  • Childrens' Oncology Group

NPI Number

  • 1255488649
Mark J. Pettenati, Ph.D.

Mark J. Pettenati, Ph.D.

Professor, Pathology
Institute for Regenerative Medicine

Contact Information

Academic: 336-716-4321 | Department: 336-716-4311


Recent Publications

Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A, Soker S. Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. J Tissue Eng Regen Med. 2015;9(5):540-549.

Pang CS, Pettenati MJ, Pardee TS. Clinicopathological analysis of near-tetraploidy/tetraploidy acute myeloid leukaemia. J Clin Pathol. 2015;68(3):236-240.

Palanisamy A, Persad P, Koty PP, Douglas LL, Stratta RJ, Rogers J, Reeves-Daniel AM, Orlando G, Farney AC, Beaty MW, Pettenati MJ, Iskandar SS, Grier DD, Kaczmorski SA, Doares WH, Gautreaux MD, Freedman BI, Powell BL. Donor-derived myeloid sarcoma in two kidney transplant recipients from a single donor. Case Rep Nephrol. 2015;2015():821346.

Philip JKSS, Qasem S, Cappellari J, Pettenati M. A rare case of extraskeletal small cell osteosarcoma: cytohistologic correlation and review of the literature [abstract]. Am J Clin Pathol. 2015;144(Suppl 2):A100.

Ware PL, Snow AN, Gvalani M, Pettenati MJ, Qasem SA. MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors. Am J Clin Pathol. 2014;141(3):334-341.

Schwind S, Edwards CG, Nicolet D, Mrozek K, Maharry K, Wu YZ, Paschka P, Eisfeld AK, Hoellerbauer P, Becker H, Metzeler KH, Curfman J, Kohlschmidt J, Prior TW, Kolitz JE, Blum W, Pettenati MJ, Dal Cin P, Carroll AJ, Caligiuri MA,. inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations. Blood. 2013;121(2):385-391.

Walker A, Mrozek K, Kohlschmidt J, Rao KW, Pettenati MJ, Sterling LJ, Marcucci G, Carroll AJ, Bloomfield CD. New recurrent balanced translocations in acute myeloid leukemia and myelodysplastic syndromes: cancer and leukemia group B 8461. Genes Chromosomes Cancer. 2013;52(4):385-401.

Gentry M, Pettenati M, Pang CS. Biclonal light chain gammopathy with aberrant CD33 expression in secondary plasma cell leukemia. Int J Clin Exp Pathol. 2013;6(10):2224-2229.

Manny JS, Pardee T, Pettenati M, Pang CS. Near-tetraploid/tetraploid acute myeloid leukemia: morphologic, cytogenetic, and prognostic features [abstract]. Mod Pathol. 2012;25(Suppl 2):354A.

Ware P, Snow A, Pettenati M, Qasem S. MDM2 copy numbers in well differentiated and dedifferentiated liposarcoma: where do we draw the line? [abstract]. Mod Pathol. 2012;25(Suppl 2):22A.

Mrozek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitman SP, Metzeler KH, Schwind S, Wu YZ, Kohlschmidt J, Pettenati MJ, Heerema NA, Block AW, Patil SR, Baer MR, Kolitz JE, Moore JO, Carroll AJ, Stone RM, Larson RA, Bloomfield CD. Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol. 2012;30(36):4515-4523.

Johnston-MacAnanny EB, Koty P, Pettenati M, Brady M, Yalcinkaya TM, Schmidt DW. The first case described: monozygotic twin sisters with the fragile X premutation but with a different phenotype for premature ovarian failure. Fertil Steril. 2011;95(7):2431.e13-5.

Edwards CG, Maharry K, Mrozek K, Schwind S, Paschka P, Nicolet D, Kohlschmidt J, Prior TW, Wu Y-Z, Kolitz JE, Blum W, Pettenati MJ, Cin PD, Carroll AJ, Caligiuri MA, Larson RA, Marcucci G, Bloomfield CD. Cytogenetic, molecular and clinical features associated with rare CBFB-MYH11 fusion transcripts in patients (Pts) with acute myeloid leukemia (AML) and inv(16)/t(16;16 [abstract]. Blood. 2011;118(21):1077.

Mrozek K, Marcucci G, Maharry K, Nicolet D, Becker H, Whitman SP, Metzeler KH, Schwind S, Wu Y-Z, Kohlschmidt J, Pettenati MJ, Koduru PRK, Heerema NA, Block AW, Patil SR, Baer MR, Kolitz JE, Moore JO, Carroll AJ, Larson RA, Bloomfield CD. Prognostic utility of the European LeukemiaNet (ELN) genetic-risk classification in adults with de novo acute myeloid leukemia (AML): a study of 1,550 patients (Pts) [abstract]. Blood. 2011;118(21 Suppl):190-191.

Chiou V, Tiegs J, Isom S, Pettenati MJ, Lyerly S, Ellis LR, Pardee T, Dmitriy B, Powell BL, Levitan DA. A single institution analysis of incidence of recurrent chromosomal abnormalities in adult ALL patients according to race, gender, and age [abstract]. Blood. 2011;118(21):4869.

Pang CS, Pettenati MJ, Manavi C, Zamkoff KW. Is relapse of mantle cell lymphoma (MCL) preceded by an 'in situ' pattern in an otherwise reactive lymph node in a patient with history of MCL?. J Hematopathol. 2011;4():221-225.

Keung YK, Beaty MW, Pettenati M, Levitan D, Hurd DD. Possible role of engraftment syndrome and autologous graft-versus-host disease in myelodysplastic syndrome after autologous stem cell transplantations: retrospective analysis and review of the literature. Clin Lymphoma Myeloma Leuk. 2010;10(2):129-133.

Beaty MW, Pettenati M, Hurd DH [sic] [Hurd DD], Keung Y. Possible role of engraftment syndrome in myelodysplastic syndrome after autologous transplants [abstract]. Mod Pathol. 2009;22(Suppl 1):1161.

Korbel JO, Tirosh-Wagner T, Urban AE, Chen X-N, Kasowski M, Dai L, Grubert F, Erdman C, Gao MC, Pettenati MJ, et al. The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies. Proc Natl Acad Sci U S A. 2009;106(29):12031-36.

Mrozek K, Holland KB, Pettenati MJ, Maharry K, Marcucci G, Baer MR, Kolitz JE, Margeson D, Edwards CG, Carroll AJ, et al. Prognostic significance of unbalanced chromosome abnormalities used by 2008 World Health Organization (WHO) classification to define 'acute myeloid leukemia (AML) with myelodysplasia-. Blood. 2009;114(22):1021.

Keung Y, Beaty MW, Pettenati M, Levitan D, Molnar I, Thakuri M, Cruz J, Hurd DD. Possible role of engraftment syndrome in myelodysplastic syndrome after autologous transplants [abstract]. J Clin Oncol. 2008;26(Suppl):a18016.

Mrozek K, Carroll AJ, Maharry K, Rao KW, Patil SR, Pettenati MJ, Watson MS, Arthur DC, Tantravahi R, Heerema NA, et al. Central review of cytogenetics is necessary for cooperative group correlative and clinical studies of adult acute leukemia: the Cancer and Leukemia Group B experience. Int J Oncol. 2008;33(2):239-244.

Dance-Barnes ST, Kock ND, Floyd HS, Moore JE, Mosley LJ, D'Agostino RB Jr, Pettenati MJ, Miller MS. Effects of mutant human Ki-rasG12C gene dosage on murine lung tumorigenesis and signaling to its downstream effectors. Toxicol Appl Pharmacol. 2008;231(1):77-84.

Keung YK, Beaty MW, Pettenati M, Levitan D, Molnar I, Thakuri MC, Cruz J, Hurd DD. Possible role of engraftment syndrome in myelodysplastic syndrome after autologous transplants [abstract]. Blood. 2008;112(11):751.

Brownlee NA, Perkins LA, Stewart W, Jackle B, Pettenati MJ, Koty PP, Iskandar SS, Garvin AJ. Recurring translocation (10;17) and deletion (14q) in clear cell sarcoma of the kidney. Arch Pathol Lab Med. 2007;131(3):446-451.

Chauvenet AR, Martin PL, Devidas M, Linda SB, Bell BA, Kurtzberg J, Pullen J, Pettenati MJ, Carroll AJ, Shuster JJ, et al. Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201. Blood. 2007;110(4):1105-1111.

Heerema NA, Raimondi SC, Anderson JR, Biegel J, Camitta BM, Cooley LD, Gaynon PS, Hirsch B, Magenis RE, Pettenati MJ, et al. Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2007;46(7):684-693.

McLean TW, Farber RS, Lewis ZT, Wofford MM, Pettenati MJ, Pranikoff T, Chauvenet AR. Diagnosis of Burkitt lymphoma in pediatric patients by thoracentesis. Pediatr Blood Cancer. 2007;49(1):90-92.

Hatchwell E, Tegay DH, Wang C, O'Brien JE, Allen W, Tan T, Prucka S, Pettenati MJ, Montagna C, Nowak MJ, et al. Genetic dissection using a novel whole genome tiling path BAC array reveals dramatic heterogeneity in Toriello-Carey syndrome, including a novel microdeletion syndrome at 22q12 [abstract]. Cell Oncol. 2007;29(2):143.

Gastier-Foster JM, Carroll AJ, Ell D, Harvey R, Chen IM, Ketterling R, Meloni-Ehring A, Opheim KE, Pettenati M, et al. Two distinct subsets of dic(9;12)(p12;p11.2) among children with B-cell precursor acute lymphoblastic leukemia (ALL): PAX5-ETV6 and ETV6-RUNX1 rearrangements: a report from the Children's Oncology Group [abstract]. Blood. 2007;110(11 Pt 1):431A.

Connor RF, Hurd D, Pettenati MJ, Koty P, Molnar I. Addition of sargramostim (GM-CSF) to imatinib results in major cytogenetic response in a patient with chronic myeloid leukemia. Leuk Res. 2006;30(10):1249-1252.

Farag SS, Archer KJ, Mrozek K, Ruppert AS, Carroll AJ, Vardiman JW, Pettenati MJ, Baer MR, Qumsiyeh MB, Koduru PR, et al. Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461. Blood. 2006;108(1):63-73.

Graf MD, Christ L, Mascarello JT, Mowrey P, Pettenati M, Stetten G, Storto P, Surti U, Van Dyke DL, Vance GH, et al. Redefining the risks of prenatally ascertained supernumerary marker chromosomes: a collaborative study. J Med Genet. 2006;43(8):660-664.

Bergman S, Brownlee NA, Geisinger KR, Ward WG, Pettenati MJ, Koty P, Ellis E, Beaty MW, Kilpatrick SE. Diagnostic pitfalls associated with fine-needle aspiration biopsy in a patient with the myxoid variant of monophasic fibrous synovial sarcoma. Diagn Cytopathol. 2006;34(11):761-767.

Brownlee NA, Koty P, Buss DH, Pettenati MJ. i(9q) in ALL (isochromosome 9q in precursor B-cell acute lymphoblastic leukemia). Atlas Genet Cytogenet Oncol Haematol. 2006;10(4):589-592.

Lewis ZT, Koty PP, Pettenati MJ. +10 or trisomy 10 (solely) - updated. Atlas Genet Cytogenet Oncol Haematol. 2006;10(4):593-597.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Pathology

Clinical Interests

Genetics, Cytogenetics, Chromosomes
Mark J. Pettenati, Ph.D.

Mark J. Pettenati, Ph.D.

Professor, Pathology
Institute for Regenerative Medicine

Quick Reference

Request an Appointment
New Patients


Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2015-2016Magnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.