Profile

Christopher Porada, Ph.D.Wake Forest School of Medicine

Christopher Porada, Ph.D.

Associate Professor,

Contact Information

Academic: 336-713-1655 | Department: 336-713-1655

Email: cporada@wakehealth.edu

Education & Training

  • B.A., Colgate University, 1991
  • Ph.D., University of Nevada-Reno, 1998

Memberships

  • Int'l Soc of Exp. Hematology
  • Am Soc of Hematology
Christopher Porada, Ph.D.

Christopher Porada, Ph.D.

Associate Professor, Institute for Regenerative Medicine
Biomedical Engineering

Research Interests

Sheep; Retroviridae; Transduction, Genetic; Genetic Vectors; Hemophilia A
More »

Contact Information

Academic: 336-713-1655 | Department: 336-713-1655

Email: cporada@wakehealth.edu

Recent Publications

The hematopoietic system in the context of regenerative medicine. Porada CD, Atala AJ, Almeida-Porada G.. Methods. 2016;99():44-61.

In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application. Almeida-Porada G, Atala A, Porada CD.. Mol Ther Methods Clin Dev. 2016;5():16020.

Boosting hematopoietic engraftment after in utero transplantation through vascular niche manipulation. Mokhtari S, Colletti EJ, Atala A, Zanjani ED, Porada CD, Almeida-Porada G.. Stem Cell Reports. 2016;6(6):957-969.

Sheep CD34+ amniotic fluid cells have hematopoietic potential and engraft after autologous in utero transplantation. Shaw SW, Blundell MP, Pipino C, Shangaris P, Maghsoudlou P, Ramachandra DL, Georgiades F, Boyd M, Thrasher AJ, Porada CD, Almeida-Porada G, Cheng PJ, David AL, de Coppi P.. Stem Cells. 2015;33(1):122-132.

The effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell differentiation. Ross CL, Siriwardane M, Almeida-Porada G, Porada CD, Brink P, Christ GJ, Harrison BS.. Stem Cell Res. 2015;15(1):96-108.

Ionizing particle radiation as a modulator of endogenous bone marrow cell reprogramming: implications for hematological cancers. Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh KX, Yan X, Goukassian D.. Front Oncol. 2015;5():231.

A human bone marrow-derived stromal cell population with hemogenic potential [abstract]. Mokhtari S, Colletti EJ, Sanada C, Lamar ZS, Simmons PJ, Atala A, Krause DS, Zanjani ED, Porada CD, Almeida-Porada G.. Blood. 2015;126(23):1201.

Defining engraftment patterns and interactions between hematopoietic stem cells and stromal cells after in utero transplantation [abstract]. Mokhtari S, Porada CD, Colletti EJ, Almeida-Porada G.. Blood. 2015;126(3):1869.

A new approach to expand cord blood derived hematopoietic stem cells, using bioengineered human fetal liver tissue 3D-constructs [abstract]. Mokhtari S, Baptista P, Vyas D, Freeman CJ, Moran E, Porada CD, Soker S, Almeida-Porada G.. Blood. 2015;126(23):3097.

Perivascular stromal cells as a potential reservoir of human cytomegalovirus. Soland MA, Keyes LR, Bayne R, Moon J, Porada CD, St Jeor S, Almeida-Porada G.. Am J Transplant. 2014;14(4):820-830.

Temporal definition of haematopoietic stem cell niches in a large animal model of in utero stem cell transplantation. Jeanblanc C, Goodrich AD, Colletti E, Mokhtari S, Porada CD, Zanjani ED, Almeida-Porada G.. Br J Haematol. 2014;166(2):268-278.

Evaluation of gene delivery strategies to efficiently overexpress functional HLA-G on human bone marrow stromal cells. Boura JS, Vance M, Yin W, Madeira C, Lobato da Silva C, Porada CD, Almeida-Porada G.. Mol Ther Methods Clin Dev. 2014;1():14041.

Hemophilia A: an ideal disease to correct in utero. Porada CD, Rodman C, Ignacio G, Atala A, Almeida-Porada G.. Front Pharmacol. 2014;5():276.

Mesenchymal stem cells contribute to endogenous FVIII:c production. Sanada C, Kuo CJ, Colletti EJ, Soland M, Mokhtari S, Knovich MA, Owen J, Zanjani ED, Porada CD, Almeida-Porada G.. J Cell Physiol. 2013;228(5):1010-1016.

Mesenchymal stem cells as gene delivery vehicles. Porada C, Almeida-Porada G. In: Molina FM, ed. Gene therapy--tools and potential applications. [S.I.]: InTech;2013: 177-212.

Defining the potential of MSCs with a prenatal large animal model. Almeida-Porada G, Porada CD, Zanjani ED. In: Hematti P, Keating A, eds. Mesenchymal stromal cells. New York: Humana Press;2013: 259-275.

EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool. Colletti E, El Shabrawy D, Soland M, Yamagami T, Mokhtari S, Osborne C, Schlauch K, Zanjani ED, Porada CD, Almeida-Porada G.. FASEB J. 2013;27(6):2111-2121.

Amniotic fluid stem cells for the treatment of hemophilia A [abstract]. Kuo C-J, Mokhtari S, Soland M, Soker S, Yoo J, Owen J, Knovich MA, Atala A, Almeida-Porada G, Porada C.. Mol Ther. 2013;21(Suppl 1):S96-S97.

Regenerative medicine: prospects for the treatment of inflammatory bowel disease. Almeida-Porada G, Soland M, Boura J, Porada CD.. Regen Med. 2013;8(5):631-644.

Characterization of naturally-occurring humoral immunity to AAV in sheep. Tellez J, Van Vliet K, Tseng YS, Finn JD, Tschernia N, Almeida-Porada G, Arruda VR, Agbandje-McKenna M, Porada CD.. PLoS One. 2013;8(9):e75142.

Gene therapy: the promise of a permanent cure [invited commentary]. Porada CD, Stem C, Almeida-Porada G.. N C Med J. 2013;74(6):526-529.

Expression levels of the PiT-2 receptor explain, in part, the gestational age-dependent alterations in transduction efficiency after in utero retroviral-mediated gene transfer. Ozturk F, Park PJ, Tellez J, Colletti E, Eiden MV, Almeida-Porada G, Porada CD.. J Gene Med. 2012;14(3):169-181.

CD34+cells derived from sheep amniotic fluid could engraft in NOD-SCID gamma mice and in lambs after prenatal autologous transplantation [abstract]. Shaw SWS, David AL, Blundell M, Howe S, Pipino C, Maghsoudlou P, Lin J, Porada CD, Thrasher A, De Coppi P.. BJOG. 2012;119(6):e11.

Characterization of naturally-occurring humoral immunity to AAV in sheep [abstract]. Tellez J, Van Vliet K, Tseng Y-s, Finn J, Tschernia N, Almeida-Porada G, Arruda V, Agbandje-McKenna M, Porada C.. Mol Ther. 2012;20(Suppl 1):S101.

Distinct contribution of human cord blood-derived endothelial colony forming cells to liver and gut in a fetal sheep model. Wood JA, Colletti E, Mead LE, Ingram D, Porada CD, Zanjani ED, Yoder MC, Almeida-Porada G.. Hepatology. 2012;56(3):1086-1096.

Treatment of hemophilia A in utero and postnatally using sheep as a model for cell and gene delivery. Porada CD, Almeida-Porada G.. J Genet Syndr Gene Ther. 2012;Suppl 1():011.

Development and characterization of recombinant ovine coagulation factor VIII. Zakas PM, Gangadharan B, Almeida-Porada G, Porada CD, Spencer HT, Doering CB.. PLoS One. 2012;7(11):e49481.

Origin and characterization of CD166+ cells during human marrow ontogeny [abstract]. Mokhtari S, Colletti E, Porada CD, Almeida-Porada G.. Blood. 2012;120(21):1252.

Niche perivascular stromal cells as a potential reservoir and a source of HCMV reactivation [abstract]. Soland M, Keyes L, Porada CD, St Jeor S, Almeida-Porada G.. Blood. 2012;120(21):3464.

Postnatal transplantation of FVIII-expressing MSC phenotypically corrects hemophilia A [abstract]. Porada CD, Sanada C, Kuo C-J, Colletti E, Moot R, Doering C, Spencer HT, Almeida-Porada G.. Mol Ther. 2011;19(7):1364.

Sheep amniotic fluid derived CD34+ stem cells engraft in NOD-SCID gamma mice and in lambs after prenatal autologous transplantation [abstract]. Shaw SW, David AL, Blundell M, Howe S, Pipino C, Maghsoudlou P, Lin J, Porada CD, Thrasher A, De Coppi P.. Hum Gene Ther. 2011;22(10):A34.

Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC. Porada CD, Sanada C, Kuo C-J, Colletti E, Mandeville W, Hasenau J, Zanjani ED, Moot R, Doering C, Spencer HT, Almeida-Porada G.. Exp Hematol. 2011;39(12):1124-1135.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Christopher Porada, Ph.D.

Christopher Porada, Ph.D.

Associate Professor, Institute for Regenerative Medicine
Biomedical Engineering

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
Magnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.