Linda J. Porrino, Ph.D.Wake Forest School of Medicine

Linda J. Porrino, Ph.D.


Contact Information

Academic: 336-716-8590 | Department: 336-716-8506


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Education & Training

  • A.B., Bates College, 1969
  • Ph.D., New York University, 1977
  • Fellowship, Natl Inst Of Mental Health, 1981


  • Nat'L Inst Of Health - Study S
  • Society for Neuroscience
  • Am Psychological Assn
  • Coll on Probs of Drug Dependen
  • Int'l Cannabinoid Society
Linda J. Porrino, Ph.D.

Linda J. Porrino, Ph.D.

Chair, Physiology & Pharmacology
Professor, Physiology & Pharmacology
Office of Women in Medicine and Science
Translational Science Institute

Research Interests

substance abuse

Contact Information

Academic: 336-716-8590 | Department: 336-716-8506


Related Links

Recent Publications

Porrino LJ, Beveridge TJ, Smith HR, Nader MA. Functional consequences of cocaine expectation: findings in a non-human primate model of cocaine self-administration. Addict Biol. 2016;21(3):519-529.

Smith HR, Beveridge TJ, Nader MA, Porrino LJ. Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures. Brain Struct Funct. 2016;221(5):2703-2715.

Wesley MJ, Lile JA, Hanlon CA, Porrino LJ. Abnormal medial prefrontal cortex activity in heavy cannabis users during conscious emotional evaluation. Psychopharmacology (Berl). 2016;233(6):1035-1044.

Porrino LJ, Miller MD, Smith HR, Nader SH, Nader MA. Neural correlates of exposure to cocaine cues in rhesus monkeys: modulation by the dopamine transporter. Biol Psychiatry. 2016;():.

Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ. Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Front Aging Neurosci. 2015;6():341.

Smith HR, Beveridge TJ, Nader MA, Porrino LJ. Regionally-specific alterations in myelin proteins in nonhuman primate white matter following prolonged cocaine self-administration. Drug Alcohol Depend. 2014;137():143-147.

Moussa MN, Wesley MJ, Porrino LJ, Hayasaka S, Bechara A, Burdette JH, Laurienti PJ. Age-related differences in advantageous decision making are associated with distinct differences in functional community structure. Brain Connect. 2014;4(3):193-202.

Beveridge TJ, Smith HR, Nader SH, Nader MA, Porrino LJ. Functional consequences of cocaine re-exposure after discontinuation of cocaine availability. Neuropharmacology. 2014;85():528-537.

Hanlon CA, Shannon EE, Anton RF, Porrino LJ. Elevated working memory burden is associated with elevated activity in the caudate, cingulate, and amygdala of heavy alcohol drinkers [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):234A.

Gill KE, Chappell AM, Beveridge TJ, Porrino LJ, Weiner JL. Chronic methylphenidate treatment during early life is associated with greater ethanol intake in socially isolated rats. Alcohol Clin Exp Res. 2014;38(8):2260-2268.

Siciliano C, Calipari E, Porrino L, Jones S. More than a replacement therapy: amphetamine treatment reverses the behavioral and neurochemical consequences of cocaine self-administration [abstract]. Neuropsychopharmacology. 2014;39(Suppl 1):S601.

Porrino LJ, Hampson RE, Opris I, Deadwyler SA. Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen. Psychopharmacology (Berl). 2013;225(1):105-114.

Beveridge TJ, Smith HR, Porrino LJ. Differential development of tolerance to the functional and behavioral effects of repeated baclofen treatment in rats. Pharmacol Biochem Behav. 2013;106():27-32.

Gill KE, Beveridge TJ, Smith HR, Porrino LJ. The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats. Brain Res. 2013;1527():67-78.

Martelle SE, Porrino LJ, Nader MA. Effects of chronic methylphenidate in adolescence on later methylphenidate self-administration in rhesus monkeys. Behav Pharmacol. 2013;24(5-6):478-481.

Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Porrino LJ, Goudriaan AE. Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study. Addict Biol. 2013;18(6):1013-1023.

Hanlon CA, Beveridge TJ, Porrino LJ. Recovering from cocaine: insights from clinical and preclinical investigations. Neurosci Biobehav Rev. 2013;37(9 Pt A):2037-2046.

Calipari ES, Beveridge TJ, Jones SR, Porrino LJ. Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. Eur J Neurosci. 2013;38(12):3749-3757.

Taber KH, Black DN, Porrino LJ, Hurley RA. Neuroanatomy of dopamine: reward and addiction. J Neuropsychiatry Clin Neurosci. 2012;24(1):1-4.

Gould RW, Porrino LJ, Nader MA. Nonhuman primate models of addiction and PET imaging: dopamine system dysregulation. Curr Top Behav Neurosci. 2012;11():25-44.

Gill KE, Pierre PJ, Daunais J, Bennett AJ, Martelle S, Gage HD, Swanson JM, Nader MA, Porrino LJ. Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates. Neuropsychopharmacology. 2012;37(12):2555-2565.

Gill KE, Beveridge T, Porrino LJ. Interaction of environment and chronic methylphenidate on anxiety-like behavior and dopamine receptors in adolescent rodents [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):844.6.

Wesley MJ, Hanlon CA, Porrino LJ. Poor decision-making by chronic marijuana users is associated with decreased functional responsiveness to negative consequences. Psychiatry Res. 2011;191(1):51-59.

Hampson RE, Porrino LJ, Opris I, Stanford T, Deadwyler SA. Effects of cocaine rewards on neural representations of cognitive demand in nonhuman primates. Psychopharmacology (Berl). 2011;213(1):105-118.

Hanlon CA, Wesley MJ, Stapleton JR, Laurienti PJ, Porrino LJ. The association between frontal-striatal connectivity and sensorimotor control in cocaine users. Drug Alcohol Depend. 2011;115(3):240-243.

Beveridge TJR, Smith HR, Nader MA, Porrino LJ. Group II metabotropic glutamate receptors in the striatum of non-human primates: dysregulation following chronic cocaine self-administration. Neurosci Lett. 2011;496(1):15-19.

Hanlon CA, Dufault DL, Wesley MJ, Porrino LJ. Elevated gray and white matter densities in cocaine abstainers compared to current users. Psychopharmacology (Berl). 2011;218(4):681-692.

Hampson RE, Porrino LJ, Opris I, Stanford TE, Deadwyler SA. Effects of cocaine on neural substrates of cognitive demand in nonhuman primates [abstract]. Behav Pharmacol. 2011;22(Suppl A):e12.

Hanlon CA, Wesley MJ, Roth AJ, Miller MD, Porrino LJ. Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor control. Psychiatry Res. 2010;181(1):15-23.

Fridberg DJ, Queller S, Ahn W-Y, Kim W, Bishara AJ, Busemeyer JR, Porrino L, Stout JC. Cognitive mechanisms underlying risky decision-making in chronic cannabis users. J Math Psychol. 2010;54(1):28-38.

Porrino LJ. Enabling medication development: translating from preclinical to clinical imaging [abstract]. Biol Psychiatry. 2010;67(9 Suppl):24S.

Lack AK, Gill KE, Porrino LJ. Local cerebral glucose utilization in rats exposed to an enriched environment: a comparison to impoverishment. Pharmacol Biochem Behav. 2010;96(4):521-525.

Porrino LJ, Hanlon CA, Gill KE, Beveridge TJR. Parallel studies of neural and cognitive impairment in humans and monkeys In: Robbins TW, Everitt BJ, Nutt DJ, eds. The neurobiology of addiction: new vistas. New York: Oxford University Press;2010: 241-256.

Hampson RE, Espana RA, Rogers GA, Porrino LJ, Deadwyler SA. Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717. Psychopharmacology (Berl). 2009;202(1-3):355-369.

Beveridge TJR, Smith HR, Nader MA, Porrino LJ. Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys. Neuropsychopharmacology. 2009;34(5):1162-1171.

Hanlon CA, Wesley MJ, Porrino LJ. Loss of functional specificity in the dorsal striatum of chronic cocaine users. Drug Alcohol Depend. 2009;102(1-3):88-94.

Shannon EE, Wesley MJ, Hanlon CA, Torrence MC, Ligouri A, Porrino LJ. Impaired decision-making by dependent alcohol users is accompanied by differences in functional brain activation as compared to controls [abstract]. Alcohol Clin Exp Res. 2009;33(Suppl 1):87A.

Beveridge TJR, Gill KE, Hanlon CA, Porrino LJ. Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys. Philos Trans R Soc Lond B Biol Sci. 2008;363(1507):3257-3266.

Smith HR, Porrino LJ. The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala. Brain Struct Funct. 2008;213(1-2):73-91.

Hemby SE, Hanlon CA, Horman B, Sikoski P, Daunais J, Kraft R, Porrino LJ. MRI assessment of chronic antipsychotic administration in rhesus monkeys [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Smith HR, Beveridge TJR, Hanlon CA, Porrino LJ. The dopamine transporter: an anatomical perspective In: Trudell ML, Izenwasser S, eds. Dopamine transporters: chemistry, biology, and pharmacology. Hoboken (NJ): Wiley;2008: 3-28.

Porrino LJ, Smith HR, Nader MA, Beveridge TJR. The effects of cocaine: a shifting target over the course of addiction. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(8):1593-1600.

Deadwyler SA, Porrino L, Siegel JM, Hampson RE. Systemic and nasal delivery of orexin-A (hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci. 2007;27(52):14239-47.

Deadwyler SA, Porrino LJ, Daunais JB, Miller M, Hanlon CA, Morgan AR, Gill KE, Long J, Ramirez S, Todd M, Hampson RE. Evidence for the differential effects of modafinil and the ampakine CX717 on task-related brain glucose metabolism in sleep-deprived monkeys [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Hampson R, Porrino LJ, Daunais JB, Miller M, Hanlon CA, Morgan AR, Gill KE, Long J, Ramirez S, Todd M, Deadwyler SA. Sleep deprivation disrupts brain glucose utilization and performance on high vs. low cognitive load trials during a delayed-match-to-sample (DMS) task in nonhuman primates [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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