Linda J. Porrino, Ph.D.Wake Forest School of Medicine

Linda J. Porrino, Ph.D.


Contact Information

Academic: 336-716-8590 | Department: 336-716-8506


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Education & Training

  • A.B., Bates College, 1969
  • Ph.D., New York University, 1977
  • Fellowship, Natl Inst Of Mental Health, 1981


  • Nat'L Inst Of Health - Study S
  • Society for Neuroscience
  • Am Psychological Assn
  • Coll on Probs of Drug Dependen
  • Int'l Cannabinoid Society
Linda J. Porrino, Ph.D.

Linda J. Porrino, Ph.D.

Chair, Physiology & Pharmacology
Professor, Physiology & Pharmacology
Office of Women in Medicine and Science
Translational Science Institute

Research Interests

Cocaine; Cocaine-Related Disorders; Brain; Dopamine Uptake Inhibitors; Cognition Disorders
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Contact Information

Academic: 336-716-8590 | Department: 336-716-8506


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Recent Publications

Functional consequences of cocaine expectation: findings in a non-human primate model of cocaine self-administration. Porrino LJ, Beveridge TJ, Smith HR, Nader MA.. Addict Biol. 2016;21(3):519-529.

Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures. Smith HR, Beveridge TJ, Nader MA, Porrino LJ.. Brain Struct Funct. 2016;221(5):2703-2715.

Abnormal medial prefrontal cortex activity in heavy cannabis users during conscious emotional evaluation. Wesley MJ, Lile JA, Hanlon CA, Porrino LJ.. Psychopharmacology (Berl). 2016;233(6):1035-1044.

Neural correlates of exposure to cocaine cues in rhesus monkeys: modulation by the dopamine transporter. Porrino LJ, Miller MD, Smith HR, Nader SH, Nader MA.. Biol Psychiatry. 2016;80(9):702-710.

Moderate-heavy alcohol consumption lifestyle in older adults is associated with altered central executive network community structure during cognitive task. Mayhugh RE, Moussa MN, Simpson SL, Lyday RG, Burdette JH, Porrino LJ, Laurienti PJ.. PLoS One. 2016;11(8):e0160214.

Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ.. Front Aging Neurosci. 2015;6():341.

Regionally-specific alterations in myelin proteins in nonhuman primate white matter following prolonged cocaine self-administration. Smith HR, Beveridge TJ, Nader MA, Porrino LJ.. Drug Alcohol Depend. 2014;137():143-147.

Age-related differences in advantageous decision making are associated with distinct differences in functional community structure. Moussa MN, Wesley MJ, Porrino LJ, Hayasaka S, Bechara A, Burdette JH, Laurienti PJ.. Brain Connect. 2014;4(3):193-202.

Functional consequences of cocaine re-exposure after discontinuation of cocaine availability. Beveridge TJ, Smith HR, Nader SH, Nader MA, Porrino LJ.. Neuropharmacology. 2014;85():528-537.

Elevated working memory burden is associated with elevated activity in the caudate, cingulate, and amygdala of heavy alcohol drinkers [abstract]. Hanlon CA, Shannon EE, Anton RF, Porrino LJ.. Alcohol Clin Exp Res. 2014;38(Suppl 1):234A.

Chronic methylphenidate treatment during early life is associated with greater ethanol intake in socially isolated rats. Gill KE, Chappell AM, Beveridge TJ, Porrino LJ, Weiner JL.. Alcohol Clin Exp Res. 2014;38(8):2260-2268.

More than a replacement therapy: amphetamine treatment reverses the behavioral and neurochemical consequences of cocaine self-administration [abstract]. Siciliano C, Calipari E, Porrino L, Jones S.. Neuropsychopharmacology. 2014;39(Suppl 1):S601.

Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen. Porrino LJ, Hampson RE, Opris I, Deadwyler SA.. Psychopharmacology (Berl). 2013;225(1):105-114.

Differential development of tolerance to the functional and behavioral effects of repeated baclofen treatment in rats. Beveridge TJ, Smith HR, Porrino LJ.. Pharmacol Biochem Behav. 2013;106():27-32.

The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats. Gill KE, Beveridge TJ, Smith HR, Porrino LJ.. Brain Res. 2013;1527():67-78.

Effects of chronic methylphenidate in adolescence on later methylphenidate self-administration in rhesus monkeys. Martelle SE, Porrino LJ, Nader MA.. Behav Pharmacol. 2013;24(5-6):478-481.

Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study. Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Porrino LJ, Goudriaan AE.. Addict Biol. 2013;18(6):1013-1023.

Recovering from cocaine: insights from clinical and preclinical investigations. Hanlon CA, Beveridge TJ, Porrino LJ.. Neurosci Biobehav Rev. 2013;37(9 Pt A):2037-2046.

Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. Calipari ES, Beveridge TJ, Jones SR, Porrino LJ.. Eur J Neurosci. 2013;38(12):3749-3757.

Neuroanatomy of dopamine: reward and addiction. Taber KH, Black DN, Porrino LJ, Hurley RA.. J Neuropsychiatry Clin Neurosci. 2012;24(1):1-4.

Nonhuman primate models of addiction and PET imaging: dopamine system dysregulation. Gould RW, Porrino LJ, Nader MA.. Curr Top Behav Neurosci. 2012;11():25-44.

Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates. Gill KE, Pierre PJ, Daunais J, Bennett AJ, Martelle S, Gage HD, Swanson JM, Nader MA, Porrino LJ.. Neuropsychopharmacology. 2012;37(12):2555-2565.

Interaction of environment and chronic methylphenidate on anxiety-like behavior and dopamine receptors in adolescent rodents [abstract]. Gill KE, Beveridge T, Porrino LJ.. FASEB J. 2012;26(Meeting Abstracts Suppl):844.6.

Poor decision-making by chronic marijuana users is associated with decreased functional responsiveness to negative consequences. Wesley MJ, Hanlon CA, Porrino LJ.. Psychiatry Res. 2011;191(1):51-59.

Effects of cocaine rewards on neural representations of cognitive demand in nonhuman primates. Hampson RE, Porrino LJ, Opris I, Stanford T, Deadwyler SA.. Psychopharmacology (Berl). 2011;213(1):105-118.

The association between frontal-striatal connectivity and sensorimotor control in cocaine users. Hanlon CA, Wesley MJ, Stapleton JR, Laurienti PJ, Porrino LJ.. Drug Alcohol Depend. 2011;115(3):240-243.

Group II metabotropic glutamate receptors in the striatum of non-human primates: dysregulation following chronic cocaine self-administration. Beveridge TJR, Smith HR, Nader MA, Porrino LJ.. Neurosci Lett. 2011;496(1):15-19.

Elevated gray and white matter densities in cocaine abstainers compared to current users. Hanlon CA, Dufault DL, Wesley MJ, Porrino LJ.. Psychopharmacology (Berl). 2011;218(4):681-692.

Effects of cocaine on neural substrates of cognitive demand in nonhuman primates [abstract]. Hampson RE, Porrino LJ, Opris I, Stanford TE, Deadwyler SA.. Behav Pharmacol. 2011;22(Suppl A):e12.

Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor control. Hanlon CA, Wesley MJ, Roth AJ, Miller MD, Porrino LJ.. Psychiatry Res. 2010;181(1):15-23.

Cognitive mechanisms underlying risky decision-making in chronic cannabis users. Fridberg DJ, Queller S, Ahn W-Y, Kim W, Bishara AJ, Busemeyer JR, Porrino L, Stout JC.. J Math Psychol. 2010;54(1):28-38.

Enabling medication development: translating from preclinical to clinical imaging [abstract]. Porrino LJ.. Biol Psychiatry. 2010;67(9 Suppl):24S.

Local cerebral glucose utilization in rats exposed to an enriched environment: a comparison to impoverishment. Lack AK, Gill KE, Porrino LJ.. Pharmacol Biochem Behav. 2010;96(4):521-525.

Parallel studies of neural and cognitive impairment in humans and monkeys. Porrino LJ, Hanlon CA, Gill KE, Beveridge TJR. In: Robbins TW, Everitt BJ, Nutt DJ, eds. The neurobiology of addiction: new vistas. New York: Oxford University Press;2010: 241-256.

Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717. Hampson RE, Espana RA, Rogers GA, Porrino LJ, Deadwyler SA.. Psychopharmacology (Berl). 2009;202(1-3):355-369.

Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys. Beveridge TJR, Smith HR, Nader MA, Porrino LJ.. Neuropsychopharmacology. 2009;34(5):1162-1171.

Loss of functional specificity in the dorsal striatum of chronic cocaine users. Hanlon CA, Wesley MJ, Porrino LJ.. Drug Alcohol Depend. 2009;102(1-3):88-94.

Impaired decision-making by dependent alcohol users is accompanied by differences in functional brain activation as compared to controls [abstract]. Shannon EE, Wesley MJ, Hanlon CA, Torrence MC, Ligouri A, Porrino LJ.. Alcohol Clin Exp Res. 2009;33(Suppl 1):87A.

Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys. Beveridge TJR, Gill KE, Hanlon CA, Porrino LJ.. Philos Trans R Soc Lond B Biol Sci. 2008;363(1507):3257-3266.

The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala. Smith HR, Porrino LJ.. Brain Struct Funct. 2008;213(1-2):73-91.

MRI assessment of chronic antipsychotic administration in rhesus monkeys [abstract]. Hemby SE, Hanlon CA, Horman B, Sikoski P, Daunais J, Kraft R, Porrino LJ.. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

The dopamine transporter: an anatomical perspective. Smith HR, Beveridge TJR, Hanlon CA, Porrino LJ. In: Trudell ML, Izenwasser S, eds. Dopamine transporters: chemistry, biology, and pharmacology. Hoboken (NJ): Wiley;2008: 3-28.

The effects of cocaine: a shifting target over the course of addiction. Porrino LJ, Smith HR, Nader MA, Beveridge TJR.. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(8):1593-1600.

Systemic and nasal delivery of orexin-A (hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. Deadwyler SA, Porrino L, Siegel JM, Hampson RE.. J Neurosci. 2007;27(52):14239-47.

Evidence for the differential effects of modafinil and the ampakine CX717 on task-related brain glucose metabolism in sleep-deprived monkeys [abstract]. Deadwyler SA, Porrino LJ, Daunais JB, Miller M, Hanlon CA, Morgan AR, Gill KE, Long J, Ramirez S, Todd M, Hampson RE.. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Sleep deprivation disrupts brain glucose utilization and performance on high vs. low cognitive load trials during a delayed-match-to-sample (DMS) task in nonhuman primates [abstract]. Hampson R, Porrino LJ, Daunais JB, Miller M, Hanlon CA, Morgan AR, Gill KE, Long J, Ramirez S, Todd M, Deadwyler SA.. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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