Profile

Stephen R. Rapp, Ph.D.Wake Forest School of Medicine

Stephen R. Rapp, Ph.D.

Professor,






Clinical Specialties

Cognitive-Behavioral Therapy, Geriatrics, Depression, Stress

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-4551
Department: 336-716-4551

Email: srapp@wakehealth.edu

Insurance Accepted »

Additional Languages

Portuguese

Education & Training

  • B.A., Bradley University , 1970
  • M.A., Bradley University , 1976
  • Ph.D., West Virginia University , 1983
  • Residency, Psychology, University of Mississippi Medi, 1983
  • Fellowship, Yale University School of Medi, 1990

Memberships

  • North Carolina Psychological A
  • Soc Clin Trials
  • Am Psychological Assn
  • Gerontological Society Of Amer
  • Int'L Psychogeriatric Assoc

NPI Number

  • 1659355618
Stephen R. Rapp, Ph.D.

Recent Publications

Klepin HD, Geiger AM, Bandos H, Costantino JP, Rapp SR, Sink KM, Lawrence JA, Atkinson HH, Espeland MA. Cognitive factors associated with adherence to oral antiestrogen therapy: results from the cognition in the study of tamoxifen and raloxifene (Co-STAR) study. Cancer Prev Res (Phila Pa). 2014;7(1):161-168.

Sink KM, Chelune G, Coker L, Gaussoin S, Lerner A, Nichols L, Pajewski NM, Rapp S, Wadley V, Williamson J. The Montreal Cognitive Assessment (MoCA) in 8,724 SPRINT participants [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S9-S10.

Espeland MA, Rapp SR, Bray GA, Houston DK, Johnson KC, Kitabchi AE, Hergenroeder AL, Williamson J, Jakicic JM, van Dorsten B, Kritchevsky SB. Long-term impact of behavioral weight loss intervention on cognitive function. J Gerontol A Biol Sci Med Sci. 2014;():.

Peiffer AM, Leyrer CM, Greene-Schloesser DM, Shing E, Kearns WT, Hinson WH, Tatter SB, Ip EH, Rapp SR, Robbins ME [deceased], Shaw EG, Chan MD. Neuroanatomical target theory as a predictive model for radiation-induced cognitive decline. Neurology. 2013;80(8):747-753.

Vaughan L, Espeland MA, Snively B, Shumaker SA, Rapp SR, Shupe J, Robinson JG, Sarto GE, Resnick SM. The rationale, design, and baseline characteristics of the Women's Health Initiative Memory Study of Younger Women (WHIMS-Y). Brain Res. 2013;1514():3-11.

Wilson V, Espeland M, Rapp S, Oles K, Gass M, Thomas A, Sherwin B, Sink K. Prevalence of anticholinergic drug use and impact on cognition in older women: results from the Women's Health Initiative Memory Study (WHIMS) [abstract]. J Am Geriatr Soc. 2013;61(Suppl 1):S14.

Danhauer SC, Legault C, Bandos H, Kidwell K, Costantino J, Vaughan L, Avis NE, Rapp S, Coker LH, Naughton M, Naylor C, Terracciano A, Shumaker S. Positive and negative affect, depression, and cognitive processes in the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) Trial. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2013;20(5):532-552.

Espeland MA, Katula JA, Rushing J, Kramer AF, Jennings JM, Sink KM, Nadkarni NK, Reid KF, Castro CM, Church T, Kerwin DR, Williamson JD, Marottoli RA, Rushing S, Marsiske M, Rapp SR. Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors. Int J Geriatr Psychiatry. 2013;28(12):1239-1250.

Casanova R, Hsu FC, Sink KM, Rapp SR, Williamson JD, Resnick SM, Espeland MA. Alzheimer's disease risk assessment using large-scale machine learning methods. PLoS One. 2013;8(11):e77949.

Espeland MA, Shumaker SA, Leng I, Manson JE, Brown CM, LeBlanc ES, Vaughan L, Robinson J, Rapp SR, Goveas JS, Wactawski-Wende J, Stefanick ML, Li W, Resnick SM. Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med. 2013;173(15):1429-1436.

Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA. Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Curr Gerontol Geriatr Res. 2013;():495793.

Sink KM, Corbett M, Dugan E, Espeland MA, Hogan P, Rapp S, Vaughan L, Shumaker SA. (CNS) prevalence and predictors of driving among cognitively impaired older adults: the Women's Health Initiative Memory Study-epidemiology of cognitive health outcomes (WHIMS-ECHO) [abstract]. Gerontologist. 2013;53(Suppl 1):7.

Peiffer AM, Burke A, Leyer CM, Shing E, Kearns WT, Hinson WH, Case D, Rapp SR, Shaw EG, Chan MD. Normal tissue complication probability (Ntcp) model of radiation-induced mood disruption [abstract]. Neuro Oncol. 2013;15(Suppl 3):230.

Rapp S, Bray GA, Hergenroeder AL, Houston DK, Jakicic JM, Kitabchi AE, Van Dorsten B, Williamson JD. Impact of a long-term behavioral weight loss intervention on cognitive function: the Action for Health in Diabetes Movement and Memory Study [abstract]. Gerontologist. 2013;53(Suppl 1):389.

Rapp SR, Espeland MA, Manson JE, Resnick SM, Bryan NR, Smoller S, Coker LH, Phillips LS, Stefanick ML, Sarto GE. Educational attainment, MRI changes, and cognitive function in older postmenopausal women from the Women's Health Initiative Memory Study. Int J Psychiatry Med. 2013;46(2):121-143.

Shaw EG, Case D, Bryant D, Grisell D, Lesser G, Monitto DC, Naughton MJ, Rapp SR, Sovano SR, Shah S, Chan MD. Phase II double-blind placebo-controlled study of armodafinil for brain radiation induced fatigue [abstract]. J Clin Oncol. 2013;31(15 Suppl):9505.

Urbanic JJ, Case D, Naughton MJ, Hu JJ, Enevold G, Beech B, Weaver KE, Danhauer S, Rapp SR, Sheidler V, Vitolins M, Lesser G, Shaw EG. Minority accrual on a prospective study targeting a diverse US breast cancer population: an analysis of Wake Forest CCOP research base protocol 97609 [abstract]. J Clin Oncol. 2013;31(15 Suppl):6564.

Rapp SR, Case D, Peiffer A, Naughton MJ, Stieber VW, Bayer GK, Bilodeau PA, Moore DF, Falchuk SC, Needles BM , Piephoff J, Edenfield WJ, Giguere JK, Erickson N, Loghin ME, Shaw EG. Phase III randomized, double-blind, placebo-controlled trial of donepezil in irradiated brain tumor survivors [abstract]. J Clin Oncol. 2013;31(15 Suppl):2006.

Case D, Naughton MJ, Stieber VW, Bayer GK, Bilodeau PA, Moore DF, Falchuk SC, Needles BM, Piephoff J, Edenfield WJ, Giguere JK, Erickson N, Loghin ME, Shaw EG, Rapp SR. Quality of life (QOL) and cognitive status among irradiated brain tumor survivors treated with donepezil or placebo [abstract]. J Clin Oncol. 2013;31(15 Suppl):2051.


Bettermann K, Arnold AM, Williamson J, Rapp S, Sink K, Toole JF, Carlson MC, Yasar S, Dekosky S, Burke G.. Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study. J Stroke Cerebrovasc Dis. 2012;21(6):436-444.

Attia A, Rapp SR, Case LD, D'Agostino R, Lesser G, Naughton M, McMullen K, Rosdhal R, Shaw EG. Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood. J Neurooncol. 2012;109(2):357-363.

Rapp SR, Legault C, Espeland MA, Resnick SM, Hogan PE, Coker LH, Dailey M, Shumaker SA. Validation of a cognitive assessment battery administered over the telephone. J Am Geriatr Soc. 2012;60(9):1616-1623.

Peiffer AM, Case D, Shaw EG, Rapp S. Magnetic resonance imaging associates with differences in neurocognitive performance for cancer survivors complaining of cognitive deficits following brain irradiation [abstract]. Neuro Oncol. 2012;14(Suppl 6):63.

Kuo J, Parisi JM, Nahin R, Fitzpatrick A, Rapp S, Lopez OL, Snitz B, Carlson M. Late-life lifestyle activity as a buffer for cognitive decline and functional impairment [abstract]. Gerontologist. 2012;52(Suppl 1):656.

Espeland MA, Rapp SR, Katula JA, Andrews LA, Felton D, Gaussoin SA, Dagenbach D, Legault C, Jennings JM, Sink KM. Telephone interview for cognitive status (TICS) screening for clinical trials of physical activity and cognitive training: the Seniors Health and Activity Research Program pilot (SHARP-P) study. Int J Geriatr Psychiatry. 2011;26(2):135-143.

O'Neill JL, Chan Y, Rapp SR, Yosipovitch G. Differences in itch characteristics among psoriasis and atopic dermatitis patients: results of a web-based questionnaire [abstract]. J Invest Dermatol. 2011;131(Suppl 1):S39.

Legault C, Jennings JM, Katula JA, Dagenbach D, Gaussoin SA, Sink KM, Rapp SR, Rejeski WJ, Shumaker SA, Espeland MA. Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) Study, a randomized controlled trial. BMC Geriatr. 2011;11(1):article 27.

Katula JA, Lucas A, Jennings JM, Legault C, Gaussoin S, Yamamoto K, Dagenbach D, Sink K, Rapp S, Rejeski J, Espeland M. The role of executive function in 400 M walk performance: the Senior'S Health & Activity Research Program-Pilot (Sharp-P) [abstract]. Ann Behav Med. 2011;41(Suppl 1):s113.

Salmoirago-Blotcher E, Fitchett G, Ockene J, Schnall E, Crawford S, Granek I, Manson J, Ockene I, O'Sullivan MJ, Rapp S, et al. Religion and healthy lifestyle behaviors among post menopausal women [abstract]. Ann Behav Med. 2011;41(Suppl 1):s43.

O'Neill JL, Chan YH, Rapp SR, Yosipovitch G. Differences in itch characteristics between psoriasis and atopic dermatitis patients: results of a web-based questionnaire. Acta Derm Venereol. 2011;91(5):537-540.

Salmoirago-Blotcher E, Fitchett G, Ockene JK, Schnall E, Crawford S, Granek I, Manson J, Ockene I, O'Sullivan MJ, Powell L, Rapp S. Religion and healthy lifestyle behaviors among postmenopausal women: the Women's Health Initiative. J Behav Med. 2011;34(5):360-371.

Leyrer CM, Peiffer AM, Greene-Schloesser DM, Kearns WT, Hinson WH, Tatter SB, Rapp SR, Robbins ME, Shaw EG, Chan MD. Normal tissue complication modeling of the brain: dose-volume histogram analysis of neurocognitive outcomes of two CCOP trials [abstract]. Int J Radiat Oncol Biol Phys. 2011;81(2 Suppl):S184-S185.

Peiffer AM, Leyrer CM, Greene-Schloesser D, Kearns WT, Hinson WH, Tatter SB, Rapp SR, Robbins ME, Shaw EG, Chan MD. Normal tissue complication modeling of the brain: dose-volume histogram analysis of neurocognitive outcomes of two CCOP trials [abstract]. Neuro Oncol. 2011;13(Suppl 3):73.

Danhauer SC, Legault C, Costantino JP, Avis NE, Rapp S, Coker LH, Terracciano A, Shumaker SA. Affect, depression, and cognition in Cognition in the Study of Tamoxifen and Raloxifene (CO-STAR) [abstract]. Gerontologist. 2011;51(Suppl 2):292.

Coker LH, Espeland MA, Rapp SR, Legault C, Resnick SM, Hogan P, Gaussoin S, Dailey M, Shumaker SA. Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS). J Steroid Biochem Mol Biol. 2010;118(4-5):304-310.

Colenda CC, Legault C, Rapp SR, DeBon MW, Hogan P, Wallace R, Hershey L, Ockene J, Whitmer R, Phillips LS, et al. Psychiatric disorders and cognitive dysfunction among older, postmenopausal women: results from the Women's Health Initiative Memory Study. Am J Geriatr Psychiatry. 2010;18(2):177-186.

Atkinson HH, Rapp SR, Williamson JD, Lovato J, Absher JR, Gass M, Henderson VW, Johnson KC, Sink KM, Espeland MA, et al. The relationship between cognitive function and physical performance in older women: results from the Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2010;65(3):300-306.

Espeland MA, Shumaker SA, Limacher M, Rapp SR, Bevers TB, Barad DH, Coker LH, Gaussoin SA, Stefanick ML, Lane DS, et al. Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognition. J Womens Health. 2010;19(3):371-379.

Attia A, Case LD, D'Agostino R Jr, Lesser GJ, McMullen K, Naughton MJ, Rapp SR, Rosdhal R, Shaw EG. Phase II study of ginkgo biloba in irradiated brain tumor survivors: effects on quality of life (QOL), mood, and cognitive function [abstract]. J Clin Oncol. 2010;28(Suppl):e12523.

Rapp SR, Case LD, Loghin ME, Meyers CA, Saphner TJ, Sleckman BG, Stieber VW, Atkins JN, Giguere JK, Shaw EG. Correlation of cognitive symptoms with cognitive performance among brain cancer patients after radiation therapy [abstract]. J Clin Oncol. 2010;28(Suppl 7):abstr 2084.

Case LD, Naughton MJ, Lesser GJ, Rapp SR, Vitolins M, Sheidler VR, Enevold GL, Shaw EG. Recruitment and retention in the Wake Forest University CCOP Research Base [abstract]. J Clin Oncol. 2010;28(Suppl):e19543.

Naughton MJ, Case LD, Meyers CA, Loghin ME, Shaw EG, Saphner TJ, Sleckman BG, Giguere JK, Lesser GJ, Rapp SR. Quality of life (QOL) and cognitive performance among irradiated brain cancer patients [abstract]. J Clin Oncol. 2010;28(Suppl 7):abstr 9131.

Espeland MA, Brunner RL, Hogan PE, Rapp SR, Coker LH, Legault C, Granek I, Resnick SM. Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension. J Am Geriatr Soc. 2010;58(7):1263-1271.

Rapp SR, Legault C, Henderson VW, Brunner RL, Masaki K, Jones B, Absher J, Thal L. Subtypes of mild cognitive impairment in older postmenopausal women: the Women's Health Initiative Memory Study. Alzheimer Dis Assoc Disord. 2010;24(3):248-255.

Rapp S, Espeland MA, Manson JE, Resnick S, Bryan NR, Coker LH, Phillips L, Stefanick ML. Educational attainment, MRI changes and cognitive function in postmenopausal women [abstract]. Gerontologist. 2010;50(Suppl 1):308.

Gaussion S [sic] [Gaussoin S], Espeland MA, Rapp SR, Katula JA, Andrews LA, Felton D, Dagenbach D, Legault C, Sink KM. Use of the telephone interview for cognitive status (TICS) to screen volunteers for clinical trials of physical activity and cognitive training interventions; the Seniors Health and Activity Research Program [abstract]. Clin Trials. 2010;7(4):476.

Dawn A, Papoiu ADP, Chan YH, Rapp SR, Rassette N, Yosipovitch G. Itch characteristics in atopic dermatitis: results of a web-based questionnaire. Br J Dermatol. 2009;160(3):642-644.

Mangieri DA, Williamson J, Lovato J, Fitzpatrick A, Atkinson H, Saxton J, Rapp S, Carlson M, DeKosky S, Sink K, et al. Moderate alcohol intake is associated with lower dementia incidence: results from the Ginkgo Evaluation of Memory Study (GEMS) [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S69-S70.

Snitz BE, Saxton J, Lopez OL, Ives DG, Dunn LO, Rapp SR, Carlson MC, Fitzpatrick AL, DeKosky ST. Identifying mild cognitive impairment at baseline in the Ginkgo Evaluation of Memory (GEM) study. Aging Ment Health. 2009;13(2):171-182.

Resnick SM, Espeland MA, An Y, Maki PM, Coker LH, Jackson R, Stefanick ML, Wallace R, Rapp SR. Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy. J Clin Endocrinol Metab. 2009;94(11):4152-4161.

Snitz BE, O'Meara ES, Carlson MC, Arnold AM, Ives DG, Rapp SR, Saxton J, Lopez OL, Dunn LO, Sink KM, et al. Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA. 2009;302(24):2663-2670.

Vallejos QM, Schulz MR, Quandt SA, Feldman SR, Galvan L, Verma A, Fleischer AB Jr, Rapp SR, Arcury TA. Self report of skin problems among farmworkers in North Carolina. Am J Ind Med. 2008;51(3):204-212.

Quandt SA, Schulz MR, Vallejos QM, Feldman SR, Verma A, Fleischer AB Jr, Rapp SR, Arcury TA. The association of dermatologist-diagnosed and self-reported skin diseases with skin-related quality of life in Latino migrant farmworkers. Int J Dermatol. 2008;47(3):236-241.

Barad DH, Bevers TB, Coker LH, Espeland MA, Jaramillo SA, Limacher M, Lane DS, Rapp S, Maki P, Shumaker SA, et al. Relative effects of tamoxifen, raloxifene, and estrogen therapy on cognition: results from the Women's Health Initiative Memory Study (WHIMS) and the Cognition in the Study of Tamoxifen and Raloxifene (CoSTAR) clinical trials [abstract]. Reprod Sci. 2008;15(2 Suppl):309A.

Atkinson HH, Williamson JD, Rapp SR, Lovato J, Sink KM, Absher JR, Gass M, Henderson V, Johnson KC, Espeland MA, et al. Grip strength predicts dementia in 75 to 80 year-old women: the Women's Health Initiative Memory Study (WHIMS) [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl):S107.

Rijmen F, Ip EH, Rapp S, Shaw EG. Qualitative longitudinal analysis of symptoms in patients with primary and metastatic brain tumours. J R Stat Soc Ser A Stat Soc. 2008;171(Pt 3):739-753.

Keen SBW, Yelverton CB, Rapp SR, Feldman SR. UV light abuse as a substance-related disorder: clinical implications [commentary]. Arch Dermatol. 2008;144(8):1047-1048.

Espeland MA, Bryan NR, Coker LH, Manson J, Phillips LS, Rapp SR, Sarto GE, Stefanick ML, Wassertheil-Smoller S. Influence of educational attainment and occupation on relationships that cognitive function has with MRI-based neuropathology, mild cognitive impairment, and dementia: results from the Women's Health Initative Memory Study [abstract]. Alzheimers Dement. 2008;4(4 Suppl 1):T672.

Arcury TA, Feldman SR, Schulz MR, Vallejos Q, Verma A, Fleischer AB, Rapp SR, Davis SF, Preisser JS, Quandt SA. Diagnosed skin diseases among migrant farmworkers in North Carolina: prevalence and risk factors. J Agric Saf Health. 2007;13(4):407-418.

Gleason JF Jr, Case D, Rapp SR, Ip E, Naughton M, Butler JM Jr, McMullen K, Stieber V, Saconn P, Shaw EG. Symptom clusters in patients with newly-diagnosed brain tumors. J Support Oncol. 2007;5(9):427-33,436.

Butler JM Jr, Case LD, Frizzell B, Lesser G, McMullen K, McQuellon R, Naughton M, Rapp S, Stieber V, Shaw EG, et al. A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy. Int J Radiat Oncol Biol Phys. 2007;69(5):1496-1501.

Butler JM, Rapp SR, Shaw EG. Managing the cognitive effects of brain tumor radiation therapy. Curr Treat Options Oncol. 2006;7(6):517-523.

Espeland MA, Rapp SR, Robertson J, Granek I, Murphy C, Albert M, Bassford T. Benchmarks for designing two-stage studies using modified mini-mental state examinations: experience from the Women's Health Initiative Memory Study. Clin Trials. 2006;3(2):99-106.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Psychiatry and Behavioral Medicine

Clinical Specialties

Cognitive-Behavioral Therapy, Geriatrics, Depression, Stress
Stephen R. Rapp, Ph.D.
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